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Dependance mechanism

Nana Wang, Yuyin Qiu, Tangfu Xiao, Jianqiao Wang, Yuxiao Chen, Xingjian Xu, Zhichao Kang, Lili Fan, Hongwen Yu
Lead pollution in industrial-derived water has become an increasingly serious concern. The development of adsorbents with excellent efficiency, selectivity and separability using diverse microorganisms is ideal for treating lead pollution. In this study, gram-negative bacteria Pseudomonas putida I3, gram-positive bacteria Microbacterium sp. OLJ1 and mycelial fungus Talaromyces amestolkiae Pb served as raw materials to facilely synthesize sponge-like biosorbents via a one-step method at room temperature. SEM, EDS, FTIR, 13 C NMR, XRD and XPS were used for investigating the morphology and surface properties of these three biosorbents...
March 15, 2019: Journal of Hazardous Materials
Ying-Ju Lin, Wen-Miin Liang, Chao-Jung Chen, Hsinyi Tsang, Jian-Shiun Chiou, Xiang Liu, Chi-Fung Cheng, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Jianxin Chen, Fuu-Jen Tsai, Te-Mao Li
BACKGROUND: Chinese herbal medicines (CHMs) are a resource of natural compounds (ingredients) and their potential chemical derivatives with anticancer properties, some of which are already in clinical use. Bei-Mu (BM), Jie-Geng (JG), and Mai-Men-Dong-Tang (MMDT) are important CHMs prescribed for patients with lung cancer that have improved the survival rate. HYPOTHESIS/PURPOSE: The aim of this study was to systemically investigate the mechanisms of action of these CHM products in lung cancer cells...
March 13, 2019: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Nalinrat Petpiroon, Narumol Bhummaphan, Sucharat Tungsukruthai, Tatchakorn Pinkhien, Arnatchai Maiuthed, Boonchoo Sritularak, Pithi Chanvorachote
BACKGROUND: A Lung cancer death account for approximately 1 in 5 of all cancer-related deaths and is particularly virulent due to its enhanced metastasis and resistance to chemotherapy. Chrysotobibenzyl has been reported to decrease cell metastasis, according to the results of an anchorage-independent growth assay; however, its underlying mechanism has not been investigated yet. PURPOSE: The aim of this study was to investigate the effect of chrysotobibenzyl on lung cancer cell migration and drug sensitization and its mechanism...
March 11, 2019: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Caroline A Murphy, Gráinne M Cunniffe, Atul K Garg, Maurice N Collins
Menisci play a major role in the mechanical function of the knee. They are subjected to large compressive forces and as a result and due to its avascular structure, menisci are prone to irreparable damage. Meniscectomy was once a common procedure for damaged menisci, however alternative approaches involving meniscus regeneration to restore function are of current interest. In order to enable these regenerative strategies, it is of utmost importance to initially establish he structure/property/function relationships of native menisci...
February 21, 2019: Journal of the Mechanical Behavior of Biomedical Materials
Gavin Douglas Ferguson, Wallace John Bridge
Advances in the field of redox biology have contributed to the understanding of the complexity of the thiol-based system in mediating signal transduction. The redox environment is the overall spatiotemporal balance of oxidation-reduction systems within the integrated compartments of the cell, tissues and whole organisms. The ratio of the reduced to disulfide glutathione redox couple (GSH:GSSG) is a key indicator of the redox environment and its associated cellular health. The reaction mechanisms of glutathione-dependent and related thiol-based enzymes play a fundamental role in the function of GSH as a redox regulator...
March 16, 2019: Redox Biology
Israel D Souza, He Nan, Maria Eugênia Costa Queiroz, Jared L Anderson
To achieve high separation power of complex samples using multidimensional gas chromatography (MDGC), the selectivity of the employed stationary phases is crucial. The non-polar × polar column combination remains the most popular column set used in MDGC. However, resolution of mixtures containing light analytes possessing very similar properties remains a formidable challenge. The development of stationary phases that offer unique separation mechanisms have the potential to significantly improve MDGC separations, particularly in resolving co-eluted peaks in complex samples...
March 22, 2019: Analytical Chemistry
Robert Saunders, X Gary Tan, Amit Bagchi
Traumatic brain injury analysis in human is exceedingly difficult due to the methods in which data can be collected, thus many researchers commonly implement animal surrogates. However, use of these surrogates is costly and restricted by ethical concerns and test logistics. Computational models and simulations do not have these constraints and can produce significant amounts of data in relatively short periods. This paper shows the development of a human head and neck model and a full body porcine model. Both models are developed from high-resolution CT and MRI scans and the latest low-to-high strain rate mechanical data available in the literature to represent tissue component material behaviors...
March 1, 2019: Military Medicine
Jacob Herrmann, Merryn H Tawhai, David W Kaczka
Primary blast lung injury (PBLI) caused by exposure to high-intensity pressure waves is associated with parenchymal tissue injury and severe ventilation-perfusion mismatch. Although supportive ventilation is often required in patients with PBLI, maldistribution of gas flow in mechanically heterogeneous lungs may lead to further injury due to increased parenchymal strain and strain rate, which are difficult to predict in vivo. In this study, we developed a computational lung model with mechanical properties consistent with healthy and PBLI conditions...
March 1, 2019: Military Medicine
Shan Sun, Djanybek Adyshev, Steve Dudek, Amit Paul, Andrew McColloch, Michael Cho
Cell mechanics has been shown to regulate stem cell differentiation. We have previously reported that altered cell stiffness of mesenchymal stem cells can delay or facilitate biochemically directed differentiation. One of the factors that can affect the cell stiffness is cholesterol. However, the effect of cholesterol on differentiation of human mesenchymal stem cells (hMSCs) remains elusive. In this paper, we demonstrate that cholesterol is involved in the modulation of the cell stiffness and subsequent adipogenic differentiation...
March 22, 2019: Journal of Biomechanical Engineering
Holger Kühnhold, Nuri Steinmann, Yi-Hsuan Huang, Lisa Indriana, Achim Meyer, Andreas Kunzmann
The Aerobic Scope (AS), which reflects the functional capacity for biological fitness, is a highly relevant proxy to determine thermal tolerance in various taxa. Despite the importance of this method, its implementation is often hindered, due to lacking techniques to accurately measure standard- (SMR) and maximal- (MMR) metabolic rates, especially in sluggish marine invertebrates with low oxygen consumption rates, such as sea cucumbers. In this study the AS concept was modified to define a Temperature-induced Aerobic Scope (TAS), based on metabolic rate changes due to temperature adjustments rather than traditionally used physical activity patterns...
2019: PloS One
Zhongsheng Zhu, Jinyu Li, Xiaorong Zhang
BACKGROUND Endothelial injury is the main mechanism of atherosclerosis, and is caused by oxidized low-density lipoprotein (ox-LDL). Astragaloside IV (AS-IV) is the primary active ingredient of the Chinese herb Huangqi, and exhibits antioxidant and anti-inflammatory properties in cardiovascular diseases. This study investigated the protective effect of AS-IV in human umbilical vein endothelial cells (HUVECs). MATERIAL AND METHODS HUVEC cells were induced with ox-LDL to establish an in vitro atherosclerosis model...
March 22, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Igor Kaidashev, Liudmyla G Savchenko, Nataliia I Digtiar, Liudmyla G Selikhova, Elvira I Kaidasheva, Oksana A Shlykova, Liudmyla E Vesnina
INTRODUCTION: Liraglutide (L) is the analogue of human glucagon-like peptide 1 which stimulates glucose-dependent insulin secretion and can modify a level of inflammatory biomarkers. L can influence NF-kB inflammatory cascade, but the mechanisms of anti-inflammatory activities of L remain to be determined. In animal models L influenced an activity of Sirtuin 1(SIRT1). Moreover, recent evidences strongly suggest that SIRT1 up-regulation may serve as a potent therapeutic approach against development and progression of diabetic complications ...
January 1, 2019: Romanian Journal of Internal Medicine
Livius V d'Uscio, Zvonimir S Katusic
The amyloid precursor protein (APP) is expressed in blood vessel wall but the physiological function of APP is not completely understood. Moreover, previous studies established that APP has amine oxidase activity responsible for degradation of catecholamines. In the present study, we characterized vascular phenotype of APP-knockout (APP-/- ) mice. We demonstrate that circulating levels of catecholamines are significantly increased in male as compared to female APP-/- mice. Studies of vasomotor function in isolated aortas revealed that contractions to α1 -receptor agonist, phenylephrine, were significantly reduced in male APP-/- mice but not in females...
March 22, 2019: American Journal of Physiology. Heart and Circulatory Physiology
Jiafa Ren, Steven D Crowley
The contributions of T lymphocytes to the pathogenesis of salt-sensitive hypertension has been well established. Under hypertensive stimuli, naïve T cells develop into different subsets, including Th1, Th2, Th17, Treg and cytotoxic CD8+ T cells, depending on the surrounding microenviroment in organs. Distinct subsets of T cells may play totally different roles in tissue damage and hypertension. The underlying mechanisms by which hypertensive stimuli activate naïve T cells involve many events and different organs, such as neoantigen presentation by dendritic cells, high salt concentration, the milieu of oxidative stress in the kidney and vasculature...
March 22, 2019: American Journal of Physiology. Heart and Circulatory Physiology
Adalberto Vasconcelos Sanches de Araujo, Antonio Carlos Borin
The photochemical reaction path approach, the MS-CASPT2 quantum-chemical method, and double-ζ basis sets (cc-pVDZ) were used to study 9H-8-azaguanine and 8H8-azaguanine relaxation pathways. Several potential energy hypersurfaces were characterized by means of equilibrium geometries, surface crossings (conical intersections and intersystem crossings), minimum energy paths, and linear interpolation in internal coordinates. The 9H-8-azaguanine main photochemical event begins with the direct population of the 1 (ππ∗ La ) state, which evolves towards a conical intersection with the ground state after surmounting a small energy barrier, explaining why it is non fluorescent...
March 22, 2019: Journal of Physical Chemistry. A
Zuzanna Frydzińska, Aleksandra Owczarek, Katarzyna Winiarska
Sirtuins are - in mammals - a family of seven enzymes (sirtuin 1-7) involved in post-translational modification of proteins (mainly deacetylation, but also: polyADP-ribosylation, demalonylation or lipoamidation), and thus - in the regulation of many metabolic processes. The activity of all sirtuins depends on the availability of NAD+. However, the function of individual isoforms is different, even mutually antagonistic. In this article the role of sirtuins in the regulation of glucose and lipid metabolism and in DNA repair mechanisms is described in detail...
March 22, 2019: Postepy Biochemii
Sebastian P Sacharowski, Tomasz J Sarnowski
Genomic DNA is highly packaged in eukaryotic cells and occurs in the form of nucleoprotein complex called chromatin. Although high DNA compaction allows to store large amount of genomic information in the cell nuclei, it also restricts the access to DNA regulatory sequences. Therefore, to overcome this issue, chromatin must be subjected to various alterations which are dependent on few interrelated factors: DNA modification, histones variants and modifications, ncRNA, chromatin remodeling complexes and chromatin architecture in nuclei...
March 22, 2019: Postepy Biochemii
Alsagher O A Ali, Lisa Murphy, Abigail Stear, Karen Fairlie-Clarke, Gholamreza Nikbakht Brujeni, Katarzyna Donskow-Łysoniewska, David Groth, Johannes Buitkamp, Michael J Stear
Nematode infection is one of the principal diseases suffered by sheep and the class II region of the MHC has been repeatedly associated with differences in susceptibility and resistance to infection. The aim of this study was to examine the association of MHC class II haplotypes in a flock of Texel sheep with faecal egg counts and antibody responsiveness. Two haplotypes carried the DRB1*11:01 allele which has previously been associated with reduced egg counts in Scottish Blackface and Suffolk sheep. One of the two haplotypes was associated with reduced egg counts in the Texel breed and both haplotypes were associated with reduced IgA activity against an extract from fourth-stage larvae...
March 22, 2019: Parasite Immunology
Kim V Korrell, Jolande Disser, Kristina Parley, Auguste Vadisiute, Maï-Carmen Requena-Komuro, Harriet Fodder, Charlotte Pollart, Graham Knott, Zoltán Molnár, Anna Hoerder-Suabedissen
Myelination of axons by oligodendrocytes in the central nervous system is crucial for fast, saltatory conduction of action potentials. As myelination is central for brain development and plasticity, and deficits are implicated in several neural disorders such as multiple sclerosis, major depressive disorder, bipolar disorder and schizophrenia, it is important to elucidate the underlying mechanisms regulating myelination. Numerous mechanisms have been proposed by which the communication between oligodendrocytes and active axons may regulate the onset and maintenance of activity-dependent myelination...
March 22, 2019: Journal of Anatomy
Daedu Lee, Jaebeom Lee, Junghyun Song, Myungsam Jen, Yoonsoo Pang
Homogeneous silver colloidal films (SCFs), composed of silver nanoparticles 67-193 nm in diameter, were synthesized by a seeded-growth method as the substrates for metal-enhanced fluorescence (MEF). The homogeneity and uniform particle distribution of the SCFs showed many advantages for the exploration of the MEF mechanism. The fluorescence enhancement of 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran (DCM) and rhodamine 700 (Rh700) dyes dispersed in a thin layer of polystyrene (PS) with the SCFs was observed by time-resolved fluorescence spectroscopy...
March 22, 2019: Physical Chemistry Chemical Physics: PCCP
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