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Feeding And Preterm infant

Damon Klebe, Mahima Tibrewal, Deep R Sharma, Rachna Vanaparthy, Sunil Krishna, Merina Varghese, Bokun Cheng, Peter R Mouton, Jana Velíšková, Kostantin Dobrenis, Patrick R Hof, Praveen Ballabh
Preterm-born children suffer from neurological and behavioral disorders. Herein, we hypothesized that premature birth and non-maternal care of preterm newborns might disrupt neurobehavioral function, hippocampal dendritic arborization, and dendritic spine density. Additionally, we assessed whether 17β-estradiol (E2) replacement or the TrkB receptor agonist, 7,8-dihydroxyflavone (DHF), would reverse compromised dendritic development and cognitive function in preterm newborns. These hypotheses were tested by comparing preterm (E28...
March 16, 2019: Cerebral Cortex
Guido E Moro, Claude Billeaud, Buffin Rachel, Javier Calvo, Laura Cavallarin, Lukas Christen, Diana Escuder-Vieco, Antoni Gaya, David Lembo, Aleksandra Wesolowska, Sertac Arslanoglu, Debbie Barnett, Enrico Bertino, Clair-Yves Boquien, Corinna Gebauer, Anne Grovslien, Gillian A Weaver, Jean-Charles Picaud
Background: A mother's own milk (MOM) is the gold standard for the feeding and nutrition of preterm and full term infants. When MOM is not available or there is not enough, donor human milk (DHM) should be used. Milk delivered to Human Milk Banks (HMBs) should be pasteurized to inactivate viral and bacterial agents. Currently, a pasteurization process at 62.5°C for 30 min (Holder pasteurization, HoP) is recommended in all international HMBs guidelines. State of the art: It is known that HoP affects some of the nutritional and biological components of human milk...
2019: Frontiers in Pediatrics
Lindsay H Allen, Daniela Hampel
Most B vitamins and vitamin C are among the nutrients in milk most strongly affected by maternal status and/or dietary intake. Recent analytical methods are more efficient and valid, revealing major differences in water-soluble vitamins across population groups. An inadequate supply in milk can be detrimental to the breastfed infant's health and development although cutoff points below which risk is increased are often uncertain, and little attention has been paid to adverse effects of low milk water-soluble vitamins on infant health and function...
2019: Nestlé Nutrition Institute Workshop Series
Paula P Meier
The LOVE MOM cohort (Longitudinal Outcomes of VLBW Infants Exposed to Mothers' Own Milk; NIH: R010009; Meier PI) enrolled 430 infants with very low birth weight (VLBW) between 2008 and 2012 to study the impact of the dose and exposure period of MOM during hospitalization in the neonatal intensive care unit (NICU) on potentially preventable complications of prematurity and their associated costs. In this prospective study, MOM and formula feedings were calculated daily (mL), medical diagnoses for NICU morbidities (necrotizing enterocolitis [NEC], late-onset sepsis [sepsis], and bronchopulmonary dysplasia [BPD]) were confirmed independently by 2 neonatologists, and propensity scoring was used to analyze covariates...
2019: Nestlé Nutrition Institute Workshop Series
Alan Lucas
The global drive to promote breastfeeding targeted at all 134 million infants born/year on the planet is one of the most pervasive public health interventions. It is, therefore, critical that the breastfeeding field is rooted in sound evidence. Three important scientific pillars of breastfeeding have been: (1) that human milk (HM) is the product of 200 million years of mammalian evolution; (2) that HM composition should be seen as the gold standard for infant nutritional requirements; and (3) that HM has numerous clinical benefits for the infant...
2019: Nestlé Nutrition Institute Workshop Series
Chunxiao Liao, Austin O Rosner, Jill L Maron, Dongli Song, Steven M Barlow
Background and Objective : The emergence of the nonnutritive suck (NNS) pattern in preterm infants reflects the integrity of the brain and is used by clinicians in the neonatal intensive care unit (NICU) to assess feeding readiness and oromotor development. A critical need exists for an integrated software platform that provides NNS signal preprocessing, adaptive waveform discrimination, feature detection, and batch processing of big data sets across multiple NICU sites. Thus, the goal was to develop and describe a cross-platform graphical user interface (GUI) and terminal application known as NeoNNS for single and batch file time series and frequency-domain analyses of NNS compression pressure waveforms using analysis parameters derived from previous research on NNS dynamics...
2019: Computational and Mathematical Methods in Medicine
Wolfgang Bernhard, Katrin Böckmann, Christoph Maas, Michaela Mathes, Julia Hövelmann, Anna Shunova, Verena Hund, Erwin Schleicher, Christian F Poets, Axel R Franz
OBJECTIVE: Choline and docosahexaenoic acid (DHA) are essential nutrients for preterm infant development. They are metabolically linked via phosphatidylcholine (PC), a constitutive plasma membrane lipid and the major transport form of DHA in plasma. Plasma choline and DHA-PC concentrations rapidly decline after preterm birth. To improve preterm infant nutrition, we evaluated combined compared to exclusive choline and DHA supplementation, and standard feeding. DESIGN: Randomized partially blinded single-center trial...
March 11, 2019: European Journal of Nutrition
K G Holm, J Clemensen, A Brødsgaard, A C Smith, R Maastrup, G Zachariassen
OBJECTIVE: Neonatal tele-homecare implies that parents of clinically stable preterm infants can manage tube feeding and establishment of oral feeding in the home. Support is provided from the neonatal intensive care unit (NICU) through a telehealth service. The aim of this study was to compare growth and breastfeeding rates amongst infants being managed in the NICU (conventional care) and by neonatal tele-homecare. METHODS: A total of 96 preterm infants with tube feeding requirements participated in the observational study of neonatal tele-homecare...
March 7, 2019: Journal of Neonatal-perinatal Medicine
Hadiseh Ghomi, Fariba Yadegari, Farin Soleimani, Brenda Lessen Knoll, Mahdi Noroozi, Ali Mazouri
OBJECTIVE: Given the increase in the birth and survival rate of the premature infants, a need for supportive health care services becomes more evident. The goal of the present study was to examine the effectiveness of the Premature Infant Oral Motor Intervention (PIOMI) in the feeding progression and early intervention. This study was a double-blind randomized clinical trial. METHODS: This clinical trial included premature infants in the neonatal intensive care units (NICUs) of two hospitals in Tehran, who were randomly assigned into intervention and control group, each containing 15 infants...
February 5, 2019: International Journal of Pediatric Otorhinolaryngology
Chenxi Cai, Zhengxiao Zhang, Maria Morales, Yanan Wang, James Friel
Knowledge about the development of the preterm infant gut microbiota is emerging and is critical to their health. Very-low-birth-weight (VLBW; birth weight, <1500 g) infants usually have special dietary needs while showing increased oxidative stress related to intensive care. This prospective cohort study assessed the effect of feeding practice on gut microbiome development and oxidative stress in preterm infants. Fecal samples were collected from each infant in the early (1-2 weeks of enteral feeding) and late (2-4 weeks of enteral feeding) feeding stages...
March 6, 2019: Free Radical Biology & Medicine
Carlo Agostoni, Anat Guz-Mark, Luba Marderfeld, Gregorio P Milani, Marco Silano, Raanan Shamir
The role of both qualitative and quantitative early nutrient intakes on later health has been suggested for decades and supported by observational studies on humans, mainly preterm and low-birth-weight infants, and animal models. However, to date, no comprehensive review has been conducted to evaluate the full impact of nutritional variables on healthy full-term infants. This umbrella review considers meta-analyses and systematic reviews on the health effects of different nutritional exposures or interventions in the first 2 y of life of healthy full-term infants in developed countries...
March 7, 2019: Advances in Nutrition
Marie-Cécile Alexandre-Gouabau, Thomas Moyon, Agnès David-Sochard, François Fenaille, Sophie Cholet, Anne-Lise Royer, Yann Guitton, Hélène Billard, Dominique Darmaun, Jean-Christophe Rozé, Clair-Yves Boquien
Early nutrition impacts preterm infant early growth rate and brain development but can have long lasting effects as well. Although human milk is the gold standard for feeding new born full-term and preterm infants, little is known about the effects of its bioactive compounds on breastfed preterm infants' growth outcomes. This study aims to determine whether breast milk metabolome, glycome, lipidome, and free-amino acids profiles analyzed by liquid chromatography-mass spectrometry had any impact on the early growth pattern of preterm infants...
February 28, 2019: Nutrients
Shabnam Lainwala, Natalia Kosyakova, Kimberly Power, Naveed Hussain, James E Moore, James I Hagadorn, Elizabeth A Brownell
OBJECTIVE:  To compare neurodevelopmental outcomes in preterm infants at 18 to 26 months corrected age (CA) who did versus did not achieve full oral feedings at 40 weeks postmenstrual age (PMA). STUDY DESIGN:  This retrospective study included infants born between 2010 and 2015 with gestational age <32 weeks and followed between 18 and 26 months CA. Achievement of full oral feedings was defined as oral intake >130 mL/kg/d for >72 hours by 40 weeks PMA...
March 1, 2019: American Journal of Perinatology
Dongli Song, Priya Jegatheesan, Suhas Nafday, Kaashif A Ahmad, Jonathan Nedrelow, Mary Wearden, Sheri Nemerofsky, Sunshine Pooley, Diane Thompson, Daniel Vail, Tania Cornejo, Zahava Cohen, Balaji Govindaswami
OBJECTIVE: To evaluate the effect of patterned, frequency-modulated oro-somatosensory stimulation on time to full oral feeds in preterm infants born 26-30 weeks gestation. STUDY DESIGN: This is a multicenter randomized controlled trial. The experimental group (n = 109) received patterned, frequency-modulated oral stimulation via the NTrainer system through a pulsatile pacifier and the control group (n = 101) received a non-pulsatile pacifier. Intent-to-treat analysis (n = 210) was performed to compare the experimental and control groups and the outcomes were analyzed using generalized estimating equations...
2019: PloS One
Leah Apalodimas, Benjamin Rush Waller Iii, Ranjit Philip, Judy Crawford, Jorden Cunningham, Shyam Sathanandam
OBJECTIVES: Patent ductus arteriosus (PDA) is a common finding in preterm infants. A hemodynamically significant PDA may require intervention for closure. This article aims to describe a transcatheter PDA closure (TCPC) program for preterm infants and the components of a comprehensive outpatient follow-up strategy. SETTING: A multidisciplinary team approach including neonatology, cardiology, anesthesiology, medical transport team, pulmonology, cardiac surgery, neurodevelopmental specialist, nutrition, speech therapy, social work, research collaborators, and other health care specialists is integral to the dedicated care and promotion of wellness of extremely low birth weight (ELBW) infants...
January 2019: Congenital Heart Disease
Verena Walsh, Jennifer Valeska Elli Brown, William McGuire
BACKGROUND: Parenteral nutrition solutions, artificial formulas, and human breast milk contain insufficient iodine to meet recommended intakes for preterm infants. Iodine deficiency may exacerbate transient hypothyroxinaemia in preterm infants and this may be associated with adverse neonatal and longer-term outcomes. OBJECTIVES: To assess the evidence from randomised controlled trials that dietary supplementation with iodine reduces mortality and morbidity in preterm infants...
February 26, 2019: Cochrane Database of Systematic Reviews
Xi-Hong Liu, Shu-Ping Han, Qiu-Fen Wei, Feng-Ying Zheng, Ting Zhang, Hui-Min Chen, Meng Mao
BACKGROUND: Human milk banks (HMB) have been established for over 100 years in North America and Europe. This study aimed to describe and summarize the operation and characteristics of the HMBs in mainland China since the first nonprofit HMB operated in 2013. METHODS: Operation of HMB in mainland China is based on the standards and guidelines of the Human Milk Banking Association of North America and some countries in Europe and was modified to meet the needs and circumstances in China such as donation only in the local HMB by medical staff...
February 22, 2019: World Journal of Pediatrics: WJP
Jenny Bellodas Sanchez, Mark Kadrofske
Necrotizing enterocolitis (NEC) is an acute inflammatory disease of the intestine which primarily affects preterm infants and is a leading cause of morbidity and mortality in the neonatal intensive care unit. From a clinical standpoint, and during the early course of the disease, NEC can be difficult to distinguish from other diseases and conditions common to the preterm infant, and this warrants the need for specific disease biomarkers. The pathogenesis of NEC is only partly understood but likely involves an altered intestinal barrier immune response to feeding and the developing microbiome...
March 2019: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Mariana M Oliveira, Davi C Aragon, Vanessa S Bomfim, Tânia M B Trevilato, Larissa G Alves, Anália R Heck, Francisco E Martinez, José S Camelo
Breast milk is considered the gold standard nutritional resource for very low birth weight (VLBW) infants in terms of nutrients and protective factors. If mother's milk is not available, the second choice is donated and fortified human milk (HM) from the Human Milk Bank (HMB). This study hypothesized that HM could be lyophilized and used as an additive to increase the levels of macronutrients and micronutrients available to VLBW infants. This study aimed to constitute a lyophilized HM concentrate and determine the osmolality and the concentration of macronutrients and micronutrients in HM samples at "baseline" and in "HM concentrates", analyzed immediately (HMCI), and after 3 (HMC3m) and 6 (HMC6m) months of freezing...
2019: PloS One
Roopali Soni, Anastasia Katana, Joe I Curry, Paul D Humphries, Angela Huertas-Ceballos
Necrotising enterocolitis (NEC) in preterm babies is a serious gastrointestinal emergency with potentially devastating consequences. Prompt and accurate diagnosis continues to be a challenge for health professionals. Early identification of clinical warning signs is extremely important, but the diagnosis relies heavily on the interpretation of abdominal radiographs. Postgraduate training of paediatricians and neonatologists in neonatal abdominal radiography is scarce, and there is variability of radiological input to neonatal services...
February 18, 2019: Archives of Disease in Childhood. Education and Practice Edition
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