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Panagiotis Drakopoulos, Arne van de Vijver, Jose Parra, Ellen Anckaert, Johan Schiettecatte, Christophe Blockeel, Martin Hund, Wilma D J Verhagen-Kamerbeek, Ying He, Herman Tournaye, Nikolaos P Polyzos
Research Question: What is the effect of gonadotropin-releasing hormone (GnRH)-agonist treatment on serum anti-Müllerian hormone (AMH)? Design: This prospective cohort study conducted in a tertiary university hospital comprised patients ( n = 52) who self-administered daily triptorelin (0.1 mg/0.1 mL) subcutaneously for 14 days from menstrual cycle day 21 ± 3, between July 2015 and March 2016. Enrolled women were 18-43 years old, considered normal ovarian responders, with a planned GnRH agonist controlled ovarian stimulation protocol...
2019: Frontiers in Endocrinology
Teodoro Durá-Travé, Miriam Ortega Pérez, Lotfi Ahmed-Mohamed, Paula Moreno-González, María Jesús Chueca Guindulain, Sara Berrade-Zubiri
INTRODUCTION: There are several controversies regarding the diagnostic tests and management of central precocious puberty (CPP). The aim of this study is to present the experience acquired in a group of girls with CPP treated with triptorelin, and to analyze the auxological characteristics and diagnostic tests. MATERIAL AND METHODS: An observational, retrospective study in a group of 60 girls with CPP was conducted between January 2010 and December 2017. Sociodemographic, auxological and hormonal data were recorded at diagnosis, and pelvic ultrasound and magnetic resonance imaging of the head were performed...
February 23, 2019: Endocrinología, Diabetes y Nutrición
Ozlem Korkmaz, Gulsenem Sari, Ilkin Mecidov, Samim Ozen, Damla Goksen, Sukran Darcan
Background: The effect on final height of gonadotropin-releasing hormone analogues (GnRHa) used in the treatment of precocious puberty is controversial. The aim of this study was to determine whether or not GnRHa therapy would make any contribution to final height in precocious puberty of girls with onset of pubertal characteristic development aged 6 - 8 years. Methods: Age at start of puberty, target height standard deviation score (SDS) presentation, follow-up height SDS, body mass index (BMI) SDS, bone age and predicted adult height of 34 female subjects who had reached their final height and with pubertal findings beginning at the ages of 6 - 8 were evaluated...
February 2019: Journal of Clinical Medicine Research
Hong Ye, Xiu Luo, Li Pei, Fujie Li, Chunli Li, Yueduo Chen, Xiaodong Zhang, Guoning Huang
This prospective randomized clinical trial (RCT) was to evaluate the effect of single-dose gonadotrophin-releasing hormone agonist (GnRHa) in artificial cycle frozen-embryo transfer (AC-FET). A total of 868 FET cycles were included and randomized into two groups: Group A (n = 434) received GnRHa 0.1 mg subcutaneous injection on day 3 after embryo transfer (ET); Group B (n = 434) did not receive GnRHa. The demographic characteristics, primary endpoint (implantation rate) and secondary endpoints (chemical pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate) were compared between two groups and subgroups (aged <35 years and 35-37 years)...
January 31, 2019: Gynecological Endocrinology
Nafiye Karakaş Yılmaz, Mustafa Kara, Necati Hançerlioğulları, Selçuk Erkılınç, Buğra Coşkun, Ayla Sargın, Salim Erkaya
Objective: To evaluate clinical pregnancy rates, miscarriage rates, ongoing pregnancy rates, and in vitro fertilization-intra cytoplasmic sperm injection outcomes of gonadotropin releasing hormone agonist (GnRHa) administration compared with human chorionic gonadotropin (hCG) application for luteal phase support. Materials and Methods: A total of 456 patients were included in the study. The patients were divided into two groups according to luteal phase support type: in group 1 (n=158), single-dose triptorelin acetate 0...
December 2018: Turkish Journal of Obstetrics and Gynecology
Saied Saeed Hosseiny Davarani, Ahmad Pourahadi, Peivand Ghasemzadeh
An electromembrane extraction followed by HPLC-UV technique was developed and validated for quantification of leuprolide and triptorelin in rabbit plasma. The influencing parameters on the extraction efficiency were optimized using experimental design methodology. The optimized conditions were found to be; supported liquid membrane: a mixture of 1-octanol and 2-ethyl hexanol (1:1) containing 10% (v/v) di(2-ethylhexyl) phosphate, applied voltage: 5 V, extraction time: 5 min, pH of the donor phase: 4.5 and pH of the acceptor phase: 1...
January 17, 2019: Electrophoresis
Tianming Ren, Zhi Zhang, John Paul Fawcett, Dong Sun, Jingkai Gu
Triptorelin is a synthetic decapeptide used for the treatment of prostate cancer. Attempts to determine triptorelin in clinical use by liquid chromatography-tandem mass spectrometry with multiple reaction monitoring have encountered problems due to its low concentration in plasma (pg/mL) and interference from endogenous peptides. We have overcome these issues using micro-solid phase extraction (μ-SPE) on Oasis® HLB 96-well μElution plates followed by LC-MS3 . Sample preparation by μ-SPE achieved sample concentration without the need for evaporation and reconstitution steps...
December 26, 2018: Journal of Pharmaceutical and Biomedical Analysis
Silvia Dellapasqua, Kathryn P Gray, Elisabetta Munzone, Daniela Rubino, Lorenzo Gianni, Harriet Johansson, Giuseppe Viale, Karin Ribi, Jürg Bernhard, Roswitha Kammler, Rudolf Maibach, Manuela Rabaglio-Poretti, Barbara Ruepp, Angelo Di Leo, Alan S Coates, Richard D Gelber, Meredith M Regan, Aron Goldhirsch, Marco Colleoni
PURPOSE: To evaluate endocrine activity in terms of ovarian function suppression (OFS) of degarelix (a gonadotropin-releasing hormone [GnRH] antagonist) versus triptorelin (a GnRH agonist) in premenopausal patients receiving letrozole as neoadjuvant endocrine therapy for breast cancer. PATIENTS AND METHODS: Premenopausal women with stage cT2 to 4b, any N, M0; estrogen receptor and progesterone receptor greater than 50%; human epidermal growth factor receptor 2-negative breast cancer were randomly assigned to triptorelin 3...
February 10, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Renáta Szabó, Denise Börzsei, Zoltán Karácsonyi, Rudolf Gesztelyi, Kolos Nemes, Anikó Magyariné Berkó, Médea Veszelka, Szilvia Török, Krisztina Kupai, Csaba Varga, Béla Juhász, Anikó Pósa
The progression of coronary artery diseases in premenopausal women is lower than in age-matched men; however, its probability increases rapidly after menopause. The aim of our study was to investigate the postconditioning like effects of voluntary physical exercise on postmenopausal cardiovascular outcomes after MI. We used fertile Wistar females (CTRL) and pharmacologically-induced estrogen-deficient (POVX, 750 µg/kg triptorelin, i.m., every 4th week) rats. CTRL and POVX animals were randomly assigned to receive an injection of 0...
December 21, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Huijuan Kong, Linli Hu, Ling Nie, Xiaona Yu, Wei Dai, Jing Li, Caihong Chen, Zhiqin Bu, Hao Shi, Qiongfang Wu, Yichun Guan, Yingpu Sun
BACKGROUND: Endometriosis is the major cause of progressive pelvic pain and subfertility. Up to 50% of reproductive-age women suffer from pelvic pain. Endometriosis is a classic indication for IVF. Compared with women whose inability to procreate is caused by simple tubal infertility, women with endometriosis often have lower pregnancy rates following in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). The administration of gonadotrophin-releasing hormone (GnRH) agonists prior to IVF/ICSI can improve the successful pregnancy rate...
December 20, 2018: Reproductive Health
Luyao Zhang, Ke Cai, Yu Wang, Wen Ji, Zhen Cheng, Guanming Chen, Zhihong Liao
The objective of this study was to compare the effect of pulsatile gonadorelin pump (PGP) and cyclical gonadotropin (human chorionic gonadotropin [HCG]/human menopausal gonadotropin [HMG]) therapy (CGT) on spermatogenesis in congenital hypogonadotropic hypogonadism (CHH) men. Twenty-eight azoospermic CHH males were included in this nonrandomized study. Ten received PGP and 18 received CGT. The primary endpoint was the earliest time spermatogenesis occurred during 24 months of treatment. Spermatogenesis time was significant earlier in the PGP group than the CGT group (median of 6 and 14 months, respectively, χ2 = 6...
January 2019: American Journal of Men's Health
Hady El Hachem, Charlotte Sonigo, Julie Benard, Marion Presse, Christophe Sifer, Nathalie Sermondade, Michael Grynberg
In vitro maturation (IVM) of oocytes retrieved at germinal vesicle or Metaphase I stage, followed by vitrification of Metaphase II (MII) oocytes, has recently emerged as an option for urgent fertility preservation (FP). Priming is usually achieved with an injection of hCG, 10,000 IU, 36 hours before retrieval. This study aimed to assess a new method of priming, using GnRH agonists, and compare it to hCG, in cancer patients undergoing urgent FP. From 2009 to 2015, 373 cancer patients underwent MII oocyte cryopreservation after IVM cycles primed either with GnRHa (triptorelin 0...
2018: PloS One
Charlotte Steenblock, Maria F Rubin de Celis, Luis F Delgadillo Silva, Verena Pawolski, Ana Brennand, Martin Werdermann, Ilona Berger, Alice Santambrogio, Mirko Peitzsch, Cynthia L Andoniadou, Andrew V Schally, Stefan R Bornstein
The adrenal gland is a master regulator of the human body during response to stress. This organ shows constant replacement of senescent cells by newly differentiated cells. A high degree of plasticity is critical to sustain homeostasis under different physiological demands. This is achieved in part through proliferation and differentiation of adult adrenal progenitors. Here, we report the isolation and characterization of a Nestin+ population of adrenocortical progenitors located under the adrenal capsule and scattered throughout the cortex...
December 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
Steven Lehrer, Peter H Rheinstein, Kenneth E Rosenzweig
Background: Two large studies suggest that risk is not increased. But other studies have found increased risk of Alzheimer's disease and impaired cognition. Objective: To determine whether androgen deprivation therapy increases the risk of impaired cognition or Alzheimer's disease in men with prostate cancer. Methods: We used data from MedWatch, the Food and Drug Administration (FDA) Safety Information and Adverse Event Reporting Program. Machine-readable data from MedWatch, including adverse drug reaction reports from manufacturers, are part of a public database...
June 30, 2018: JAD Reports
Raphael Ouede, Blaise Demine Alexandre, Ayegnon Kouakou Gregoire, Landry Kohou-Kone, Edouard N'guessan, Maurice Gabin Kouacou, Jean-Marcel Ahui Brou, Flavien Kouassi Kendja, Yves Tanauh
This study aims to propose a therapeutic approach for catamenial pneumothorax based on outcomes reported in 18 cases. We conducted a retrospective study of 18 female elderly patients with an average age of 32.2 years who had undergone surgery for right (16 cases) and bilateral catamenial pneumothorax (2 cases) from January 1994 to December 2016. The patients were divided into 3 groups on the basis of the evolution of our surgical capability over time: group 1(G1) from January 1994 to June 2006, group 2 (G2) from July 2006 to February 2008, group 3(G3) from March 2008 to December 2016, these groups were composed of 5, 2 and 11 patients respectively...
2018: Pan African Medical Journal
N K Akhkubekova, A S Kaysinova, A A Fedorov, N B Efimenko, I I Gaidamaka, E N Chalaja, L A Cherevashchenko, L V Tsallagova, E E Urvacheva, A B Ovsienko
BACKGROUND: The use of agonists of gonadotropin-releasing hormone (GnRH) for the rehabilitation treatment of the patients presenting with endometriosis genitalis externa is known to significantly enhance the risk of development of hypoestrogenism. The so-called 'add-back-therapy' is carried out as a preventive measure to eliminate hypoestrogenism caused by the intake of GnRH agonists without detriment to the effectiveness of anti-hormonal therapy. AIM: The objective of the present study was to estimate the effectiveness of the new method ('add-back hormone replacement therapy') in comparison with anti-hormonal therapy with the use of GRH agonists at the stage of the early postoperative medical rehabilitation based on the drinking of mineral waters (MW) and radon therapy (RT) in the patients who had undergone the laparoscopic interventions for the treatment of endometrioid heterotopies of the ovaries (1-3 months post-operatively)...
2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Shuhui Zheng, Hang Zhou, Bo Gao, Yongyong Li, Zhiheng Liao, Taifeng Zhou, Chengjie Lian, Zizhao Wu, Deying Su, Tingting Wang, Peiqiang Su, Caixia Xu
This study aimed to verify the effects of estrogen on the onset and development of adolescent idiopathic scoliosis and the mechanisms associated with these effects by constructing a pubescent bipedal rat model. Experiments were conducted to investigate whether scoliosis progression was prevented by a Triptorelin treatment. One hundred twenty bipedal rats were divided into female, OVX (ovariectomy), OVX + E2, Triptorelin, sham, and male groups. According to a spinal radiographic analysis, the scoliosis rates and curve severity of the female and OVX + E2 groups were higher than those in the OVX, Triptorelin, and male groups...
November 7, 2018: Experimental & Molecular Medicine
Jingjing Jiang, Shanshan Gao, Jin Xu
BACKGROUND The aim of this study was to compare the efficacy and safety of 2 GnRH agonists - triptorelin acetate and cetrorelix acetate - in assisted reproduction. MATERIAL AND METHODS A total of 182 females who received in vitro fertilization and embryo transfer (IVF+ET) from March 2014 to July 2014 were involved, and their clinical data were retrospectively analyzed. Among them, 91 patients received treatment with short-acting triptorelin (group A) and another 91 patients were treated with cetrorelix acetate (group B)...
November 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Peter B Østergren, Caroline Kistorp, Mikkel Fode, Finn N Bennedbaek, Jens Faber, Jens Sønksen
OBJECTIVES: To compare the metabolic changes between men with advanced prostate cancer commenced on a gonadotropin-releasing hormone (GnRH) agonist and those treated with orchiectomy. PATIENTS AND METHODS: Fifty-eight hormone-naive men with advanced prostate cancer were randomly assigned (1:1) to either subcapsular orchiectomy or triptorelin 22.5 mg/24 week depot injections. The participants were followed for 48 weeks, with study visits at baseline, 12, 24 and 48 weeks...
November 2, 2018: BJU International
Huiling Xue, Meiyun Liu, Wanjiao Hao, Ye Li
Objective: To investigate the effects of laparoscopic surgery combined with triptorelin acetate, gestrinone and mifepristone on pregnancy rate, pregnancy outcome, long-term recurrence and adverse reactions in patients with endometriosis (EMT) complicated with infertility. Methods: In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group...
September 2018: Pakistan Journal of Medical Sciences Quarterly
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