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Larynx squamous cell carcinoma

Nuwan Dharmawardana, Eng Hooi Ooi, Charmaine Woods, Damian Hussey
Circulating microRNAs have been described as head and neck cancer biomarkers in multiple anatomical subsites including the oral cavity, nasopharynx, larynx, salivary glands and the skin. While there is an expanding volume of published literature showing the significance of individual or panels of microRNAs, the clinical validation of candidate biomarkers is lacking. The various methods used to collect, store, process and interpret these microRNAs are likely introducing bias and contributing to the inconsistent results...
March 14, 2019: Clinical & Experimental Metastasis
Mie Mie Thinn, Chung-Tzu Hsueh, Chung-Tsen Hsueh
BACKGROUND: Squamous cell carcinoma of head and neck (SCCHN) is the fifth most common cancer worldwide. Inhibition of epidermal growth factor receptor signaling has been shown to be a critical component of therapeutic option. Herein, we report a case of durable complete response to erlotinib. CASE SUMMARY: An 81-year-old Caucasian male who presented with metastatic poorly differentiated squamous cell carcinoma of right cervical lymph nodes (levels 2 and 3). Imaging studies including (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (CT) and contrast-enhanced CT scan of neck and chest did not reveal any other disease elsewhere...
March 6, 2019: World Journal of Clinical Cases
Ilona Argirion, Katie R Zarins, Kali Defever, Krittika Suwanrungruang, Joanne T Chang, Donsuk Pongnikorn, Imjai Chitapanarux, Hutcha Sriplung, Patravoot Vatanasapt, Laura S Rozek
PURPOSE: Head and neck cancer is the sixth most common cancer in the world, and the largest burden occurs in developing countries. Although the primary risk factors have been well characterized, little is known about temporal trends in head and neck cancer across Thailand. METHODS: Head and neck squamous cell carcinoma (HNSCC) occurrences diagnosed between 1990 and 2014 were selected by International Classification of Diseases (10th revision; ICD10) code from the Songkhla, Lampang, Chiang Mai, and Khon Kaen cancer registries and the US SEER program for oral cavity (ICD10 codes 00, 03-06), tongue (ICD10 codes 01-02), pharynx (ICD10 codes 09-10, 12-14), and larynx (ICD10 code 32)...
March 2019: Journal of Global Oncology
F El-Salem, M Mansour, M Gitman, B A Miles, M R Posner, R L Bakst, E M Genden, W H Westra
BACKGROUND: Given the propensity for HPV-positive head and neck squamous cell carcinoma (HPV-HNSCC) to metastasize to cervical lymph nodes, fine needle aspiration (FNA) plays an important diagnostic role in their initial detection. Indeed, there is now an unwavering commitment to HPV testing of FNAs even in the absence of clear methodologic guidelines and threshold criteria. A particular difficulty pertains to the interpretation of p16 staining. DESIGN: Data was collected for 210 patients with suspected regionally metastatic HNSCC that had undergone FNA as part of standard clinical care...
March 2019: Oral Oncology
Zachary Mayo, Steven N Seyedin, Nadine Mallak, Sarah L Mott, Yusuf Menda, Michael Graham, Carryn Anderson
OBJECTIVES: The aim of this study was to investigate the utility of pretreatment and 3-month 18 F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) standardized uptake value (SUV) in predicting and assessing recurrence in T3-T4 laryngeal carcinoma treated with definitive radiation therapy (RT). METHODS: Patients with newly diagnosed T3-T4 laryngeal squamous cell carcinoma treated with definitive RT from 2004 to 2014 were reviewed. Patients who underwent pretreatment or 3-month PET/CT 2 to 4 months after treatment were included...
February 27, 2019: Annals of Otology, Rhinology, and Laryngology
Armando De Virgilio, Oreste Iocca, Luca Malvezzi, Pasquale Di Maio, Raul Pellini, Fabio Ferreli, Giovanni Cugini, Giovanni Colombo, Giuseppe Spriano
The aim of this systematic review with meta-analysis was to investigate the available literature on transoral approaches in the treatment of hypopharyngeal squamous cell carcinoma, with a special focus on transoral robotic surgery (TORS). A systematic review was conducted according to the PRISMA (preferred reporting items for systematic reviews and meta-analyses) check-list, and 15 studies were included. Five of the included studies evaluated TORS, while ten studies focused on transoral laser microsurgery (TLM) for the treatment of early or advanced stage hypopharyngeal cancer...
February 18, 2019: Journal of Clinical Medicine
Nabeel Humayun Hassan, Rahila Usman, Muhammad Yousuf, Ahmad Nawaz Ahmad, Ismail Hirani
Objective: To determine the accuracy of transoral flexible laryngoscope (TFL) biopsy and also to identify the safety as office based procedure in terms of complications. Methods: This is a diagnostic study; the type of intervention is outpatient department based biopsy of laryngeal lesions. All patients seen in ENT outpatient department of Lyari General Hospital with suspicious lesions of Larynx were referred for Transoral Flexible Laryngoscopy Biopsy under local anesthesia...
March 2019: World Journal of Otorhinolaryngology—Head and Neck Surgery
Grazia Lazzari, Alessandra Briatico Vangosa, Maria Assunta De Cillis, Giovanni Silvano
Wegener's granulomatosis (WG) is an autoimmune disorder characterized by necrotizing granulomas involving mainly the upper-lower respiratory and renal tracts, albeit a potentially life-threatening involvement of other body parts is not rare. Furthermore, there are several reports accounting for an increased risk of solid malignancies due to the autoimmune disease per se, or the immunosuppressive therapies. Among treatments, radiotherapy could be a therapeutic option as proven by its use in typical WG lesions such as solitary granulomas or subglottic stenosis, successfully treated with low radiation dose...
2019: OncoTargets and Therapy
Sidharth V Puram, Neil Bhattacharyya
Although early glottic carcinoma is managed with radiation therapy (RT) or surgery, there is limited data on differences in second primary cancers of the larynx. We utilized the Surveillance, Epidemiology, and End Results (SEER) database to query T1 glottic carcinomas and assess the incidence of second primary laryngeal malignancies. Cumulative hazard for second primary laryngeal malignancies was compared with the log-rank method. Among 844 surgical and 2,272 RT cases, observed-to-expected incidence ratios of laryngeal second primaries were 10...
February 15, 2019: Laryngoscope
J Vukelic, R Dobrila-Dintinjana, A Dekanic, B Marijic, A Cubranic, T Braut
The aim of study was to investigate the expression of the proliferation factor Ki-67 and its relationship with histological grade, cancer stage, and treatment outcome in squamous cell carcinoma of the larynx. Samples from 78 patients with laryngeal cancer were analysed retrospectively. Paraffin sections of tumors were immunohistochemically stained for Ki-67 expression. The patients were divided in two groups according to the proliferative factor values (a low Ki-67 index group - Ki-67≤34 and high Ki-67 index group-Ki-67 >34)...
2019: BioMed Research International
Louise F Wilson, Peter D Baade, Adele C Green, Susan J Jordan, Bradley J Kendall, Rachel E Neale, Catherine M Olsen, Danny R Youlden, Penelope M Webb, David C Whiteman
The International Agency for Research on Cancer first concluded that alcohol causes cancer in humans in 1988. The World Cancer Research Fund has declared that alcohol causes cancer of the oral cavity, pharynx, larynx, oesophagus (squamous cell carcinoma), female breast, colon, rectum, stomach and liver. It recommended that alcohol be avoided altogether to prevent cancer. We aimed to quantify the impact of reducing alcohol consumption on future cancer incidence in Australia. We used PREVENT 3.01 simulation modelling software to estimate the proportion of cancers that could potentially be prevented over a 25-year period under two hypothetical intervention scenarios and two latency periods (20 and 30 years)...
February 12, 2019: International Journal of Cancer. Journal International du Cancer
Nicholas C J Lee, Jacqueline R Kelly, Yi An, Henry S Park, Benjamin L Judson, Barbara A Burtness, Zain A Husain
BACKGROUND: Treatment at high-volume surgical facilities (HVSFs) provides a survival benefit for patients with head and neck squamous cell carcinomas (HNSCCs); however, it is unknown what role postoperative radiation therapy (PORT) plays in achieving the improved outcomes. METHODS: From the National Cancer Database, 6844 patients with locally advanced invasive HNSCCs of the oral cavity, oropharynx, larynx, and hypopharynx who underwent definitive surgery with PORT between 2004 and 2013 were identified...
February 12, 2019: Cancer
Sadamoto Zenda, Yosuke Ota, Naomi Kiyota, Susumu Okano, Masato Fujii, Morimasa Kitamura, Shunji Takahashi, Tsutomu Ueda, Nobuya Monden, Takeharu Yamanaka, Makoto Tahara
Background: Induction chemotherapy (IC) is a treatment option for locally advanced squamous cell carcinoma of the head and neck (LA SCCHN). However, treatment with docetaxel, cisplatin, and 5-FU (TPF) followed by cisplatin and radiotherapy is controversial because of toxicity concerns. The aim of this phase II study was to assess the feasibility of docetaxel, cisplatin, and cetuximab (TPEx) followed by cetuximab and concurrent radiotherapy for LA SCCHN. Patients and Methods: We enrolled patients with histological evidence of squamous cell carcinoma of the oropharynx, hypopharynx, or larynx without distant metastases...
2019: Frontiers in Oncology
Mejd Jumaily, Farhoud Faraji, Donald Zhang, Ronald J Walker, Gregory M Ward
OBJECTIVE: Basaloid squamous cell histology is a rare variant that accounts for about 2% of all head and neck squamous cell laryngeal carcinomas. The purpose of this study was to examine overall survival rates of patients according to treatment, stage, and laryngeal subsite. STUDY DESIGN: Retrospective analysis. SETTING: National Cancer Database (NCDB). SUBJECTS AND METHODS: The NCDB was queried for patients with basaloid squamous cell carcinoma (BSCC) who were treated from 2004 to 2014...
February 5, 2019: Otolaryngology—Head and Neck Surgery
Ollivier Laccourreye, Grégoire Marret, François Rubin, Elizabeth Fabre, Cécile Badoual, Stéphane Oudard, Pierre Bonfils, Quentin Lisan
BACKGROUND: The aim of our study was to document 10-year outcome after curative "exclusive" chemotherapy in N0M0 squamous cell carcinoma of the larynx and pharynx. METHODS: Retrospective nonrandomized analysis of an inception cohort of 191 patients. Platinum salt and 5-fluorouracil were used in all patients. RESULTS: The 3-, 5-, 10-year overall actuarial survival and local control estimates were 83.3%, 74.4%, and 55.4% and 62.1%, 62...
February 1, 2019: Head & Neck
Qi Yu, Ya-Lian Chen, Shui-Hong Zhou, Zhe Chen, Yang-Yang Bao, Han-Jin Yang, Hong-Tian Yao, Ling-Xiang Ruan
BACKGROUND: Collision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma (SCC) and neuroendocrine carcinoma (NEC) colliding in the larynx and review 12 cases of collision carcinoma in the head and neck to further understand collision carcinoma, including its definition, diagnosis, and treatment. CASE SUMMARY: A 61-year-old man presented with a 1-year history of hoarseness. Contrast-enhanced magnetic resonance imaging of the larynx revealed that the right vocal cord had a nodule-like thickening with obvious enhancement...
January 26, 2019: World Journal of Clinical Cases
Chenjie Xu, Yi Wang, Hongxi Yang, Jie Hou, Li Sun, Xinyu Zhang, Xinxi Cao, Yabing Hou, Lan Wang, Qiliang Cai, Yaogang Wang
BACKGROUND: Cancer poses a serious threat to the health of Chinese people, resulting in a major challenge for public health work. Today, people can obtain relevant information from not only medical workers in hospitals, but also the internet in any place in real-time. Search behaviors can reflect a population's awareness of cancer from a completely new perspective, which could be driven by the underlying cancer epidemiology. However, such Web-retrieved data are not yet well validated or understood...
January 29, 2019: Journal of Medical Internet Research
Jun Liu, Dan Lv, Di Deng, Ji Wang, Linke Li, Fei Chen
RATIONALE: After total or near-total laryngectomy and resection of prelaryngeal skin, laryngeal defects and prelaryngeal skin defects often remain a great challenge for head and neck surgeons when considering simultaneous reconstruction of. In this case report, a free bipaddled anterolateral thigh (ALT) was used for such defects reconstruction. PATIENT CONCERNS: For this 50-year-old male patient whose recurrent tumor invaded the cricoid cartilage and the prelaryngeal skin, supracricoid partial laryngectomy with a cricohyoidepiglottopexy would no longer be an option...
January 2019: Medicine (Baltimore)
Joris B W Elbers, Lars I Veldhuis, Patrick A Bhairosing, Ludi E Smeele, Katarzyna Jóźwiak, Michiel W M van den Brekel, Marcel Verheij, Abrahim Al-Mamgani, Charlotte L Zuur
PURPOSE: Salvage surgery for recurrent advanced stage head and neck squamous cell carcinoma (HNSCC) is known to result in poor prognosis. As there are only small and heterogeneous studies available with wide variety in outcome measures, our purpose was to select and pool literature according to specific criteria. METHODS: Systematic review and meta-analysis of clinical outcome after salvage surgery for recurrent advanced stage HNSCC following primary radiotherapy or chemoradiation...
January 23, 2019: European Archives of Oto-rhino-laryngology
Ingar Olsen, Özlem Yilmaz
There is increasing evidence for an association between periodontitis/tooth loss and oral, gastrointestinal, and pancreatic cancers. Periodontal disease, which is characterized by chronic inflammation and microbial dysbiosis, is a significant risk factor for orodigestive carcinogenesis. Porphyromonas gingivalis is proposed as a keystone pathogen in chronic periodontitis causing both dysbiosis and discordant immune response. The present review focuses on the growing recognition of a relationship between P. gingivalis and orodigestive cancers...
2019: Journal of Oral Microbiology
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