Felice Rivellese, Alessandra Nerviani, Giovanni Giorli, Louise Warren, Edyta Jaworska, Michele Bombardieri, Myles J Lewis, Frances Humby, Arthur G Pratt, Andrew Filer, Nagui Gendi, Alberto Cauli, Ernest Choy, Iain McInnes, Patrick Durez, Christopher J Edwards, Maya H Buch, Elisa Gremese, Peter C Taylor, Nora Ng, Juan D Cañete, Sabrina Raizada, Neil D McKay, Deepak Jadon, Pier Paolo Sainaghi, Richard Stratton, Michael R Ehrenstein, Pauline Ho, Joaquim P Pereira, Bhaskar Dasgupta, Claire Gorman, James Galloway, Hector Chinoy, Désirée van der Heijde, Peter Sasieni, Anne Barton, Costantino Pitzalis
BACKGROUND: Despite highly effective targeted therapies for rheumatoid arthritis, about 40% of patients respond poorly, and predictive biomarkers for treatment choices are lacking. We did a biopsy-driven trial to compare the response to rituximab, etanercept, and tocilizumab in biologic-naive patients with rheumatoid arthritis stratified for synovial B cell status. METHODS: STRAP and STRAP-EU were two parallel, open-label, biopsy-driven, stratified, randomised, phase 3 trials done across 26 university centres in the UK and Europe...
November 2023: Lancet Rheumatology