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Antibacterial Effect

Zheng Chen, Xiaomin Dou, Yu Zhang, Min Yang, Dongbin Wei
Spiramycin is a widely used macrolide antibiotic and exists at high concentration in production wastewater. A thermal-acid hydrolytic pretreatment using silicotungstic acid (STA) under microwave (MW) irradiation was suggested to mitigate spiramycin from production wastewater. Positive correlations were observed between STA dosage, MW power, interaction time and the hydrolytic removal efficiencies, and an integrative equation was generalized quantitively. Rapid and complete removal 100 mg/L of spiramycin was achieved after 8 min of reaction with 1...
February 25, 2019: Environmental Pollution
Tamasen Hayward, Alexander Young, Abigail Jiang, Erica J Crespi, Allison B Coffin
Aminoglycoside antibiotics have potent antibacterial properties but cause hearing loss in up to 25% of patients. These drugs are commonly administered in patients with high glucocorticoid stress hormone levels and can be combined with exogenous glucocorticoid treatment. However, the interaction of stress and aminoglycoside-induced hearing loss has not been fully explored. In this study, we investigated the effect of the glucocorticoid stress hormone cortisol on hair cells in the zebrafish lateral line as an important step toward understanding how physiological stressors modulate hair cell survival...
March 6, 2019: Hearing Research
Lin Wang, Xianju Xie, Manlin Qi, Michael D Weir, Mark A Reynolds, Chunyan Li, Chenchen Zhou, Hockin H K Xu
OBJECTIVE: The objectives of this studywere to: (1) develop a novel bioactive nanocomposite for Class V restorations with subgingival margins to inhibit periodontal pathogens; and (2) investigate if the bioactive nanocomposite could inhibit multi-species periodontal biofilms with a potency as strong as that against single species biofilms. METHODS: Nanocomposite was fabricated using dimethylaminohexadecyl methacrylate (DMAHDM), 2-methacryloyloxyethyl phosphorylcholine (MPC) and nanoparticles of amorphous calcium phosphate (NACP)...
March 13, 2019: Dental Materials: Official Publication of the Academy of Dental Materials
Stefan Kranz, André Guellmar, Andrea Voelpel, Tobias Lesser, Silke Tonndorf-Martini, Juergen Schmidt, Christian Schrader, Mathilde Faucon, Ulrich Finger, Wolfgang Pfister, Michael Diefenbeck, Bernd Sigusch
Coating of plasma chemical oxidized titanium (TiOB® ) with gentamicin-tannic acid (TiOB® gta) has proven to be efficient in preventing bacterial colonization of implants. However, in times of increasing antibiotic resistance, the development of alternative antimicrobial functionalization strategies is of major interest. Therefore, the aim of the present study is to evaluate the antibacterial and biocompatible properties of TiOB® functionalized with silver nanoparticles (TiOB® SiOx Ag) and ionic zinc (TiOB® Zn)...
March 15, 2019: Materials
Laetitia Bocquet, Sevser Sahpaz, Natacha Bonneau, Claire Beaufay, Séverine Mahieux, Jennifer Samaillie, Vincent Roumy, Justine Jacquin, Simon Bordage, Thierry Hennebelle, Feng Chai, Joëlle Quetin-Leclercq, Christel Neut, Céline Rivière
New anti-infective agents are urgently needed to fight microbial resistance. Methicillin-resistant Staphylococcus aureus (MRSA) strains are particularly responsible for complicated pathologies that are difficult to treat due to their virulence and the formation of persistent biofilms forming a complex protecting shell. Parasitic infections caused by Trypanosoma brucei and Leishmania mexicana are also of global concern, because of the mortality due to the low number of safe and effective treatments. Female inflorescences of hop produce specialized metabolites known for their antimicrobial effects but underexploited to fight against drug-resistant microorganisms...
March 14, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Diah Ayuningrum, Yang Liu, Riyanti, Mada T Sibero, Rhesi Kristiana, Meezan A Asagabaldan, Zerlina G Wuisan, Agus Trianto, Ocky Karna Radjasa, Agus Sabdono, Till F Schäberle
Tunicates (Ascidians, sea squirts) are marine protochordates, which live sedentary or sessile in colonial or solitary forms. These invertebrates have to protect themselves against predators and invaders. A most successful strategy, to not being eaten by predators and prevent pathogenic microorganisms to settle, is the usage of chemical molecules for defence. To accomplish this, tunicates take advantage of the specialized metabolites produced by the bacteria associated with them. Therefore, the microbiome of the tunicates can be regarded as a promising bioresource for bacterial strains producing compounds with antibacterial activity...
2019: PloS One
Hanyang Liu, Shashank Shukla, Noel Vera-González, Nagendran Tharmalingam, Eleftherios Mylonakis, Beth Burgwyn Fuchs, Anita Shukla
Intravascular catheter related bloodstream infections (CRBSIs) are a leading cause of hospital-acquired infections worldwide, resulting not only in the burden of cost and morbidity for patients but also in the over-consumption of medical resources for hospitals and health care organizations. In this study, a novel auranofin releasing antibacterial and antibiofilm polyurethane (PU) catheter coating was developed and investigated for future use in preventing CRBSIs. Auranofin is an antirheumatic drug with recently identified antimicrobial properties...
2019: Frontiers in Cellular and Infection Microbiology
Maryam Kaihanfar, Madjid Momeni-Moghaddam, Mohammad Javad Mehdipour Moghaddam, Toktam Hajar, Vahab Dast Pak, Jalal Omrani Bidi
Background and Objectives: Larval therapy refers to the use of Lucilia sericata larvae on chronic wounds, which is a successful method of chronic wounds treatment. The secretions of these larvae contain antibacterial compounds and lead to death or inhibition of bacterial growth. Materials and Methods: In this study, we investigated the antibacterial effects of Lucilia sericata larvae secretions which were in sterilized and multi antibiotic-resistant bacteria-treated forms on Gram-positive Bacillus subtilis bacteria and Gram-negative Escherichia coli bacteria...
December 2018: Iranian Journal of Microbiology
Narjes Sanchooli, Saeide Saeidi, Hashem Khandan Barani, Esmael Sanchooli
Background and Objectives: The use of plants for the synthesis of nanoparticles has received attention. The present study aimed to evaluate the antibacterial effects of silver nanoparticles synthesized by Verbena officinalis leaf extract against Yersinia ruckeri, Vibrio cholerae and Listeria monocytogenes . Materials and Methods: Silver nanoparticles were obtained by reacting silver nitrate solution 2 mM and V. officinalis leaf extract. The AgNPs were characterized by UV-visible spectrophotometer, scanning electron microscopy (SEM), and Fourier transform infrared spectrometer (FTIR)...
December 2018: Iranian Journal of Microbiology
Mansour Miran, Mohammad Mehdi Feizabadi, Hossein Kazemian, Jalil Kardan-Yamchi, Hamid Reza Monsef-Esfahani, Samad Nejad Ebrahimi
Background and Objectives: Essential oils are used for controlling and preventing human diseases and the application of those can often be quite safe and effective with no side effect. The essential oils have been found to have antiparasitic, antifungal, antiviral, antioxidant and especially antibacterial activity including antibacterial activity against tuberculosis. In this study the chemical composition and anti-TB activity of essential oil extracted from Levisticum officinale has been evaluated...
December 2018: Iranian Journal of Microbiology
Priyanka Basera, Meeta Lavania, Anil Agnihotri, Banwari Lal
Indian biodiversity is a hub for medicinal plants. Extensive research has been carried out to select plants with numerous properties which can be used for human welfare. Present research is about Cymbopogon citratus , an economically valuable medicinal plant. In this study Cymbopogon citratus was elected as a subject plant over the five selected plants ( Azadirachta indica , Plumeria obtuse , Sapindus mukorossi , Capsicum annuum and Phyllanthus emblica ) on the basis of antibacterial effect against dominating pathogenic species of gram positive ( Bacillus cereus, Bacillus licheniformis ) and gram negative ( Pseudomonas aeruginosa, Escherichia coli ) bacteria...
2019: Frontiers in Microbiology
Dinglong Yang, Yijing Han, Yongliang Liu, Ruiwen Cao, Qing Wang, Zhijun Dong, Hui Liu, Xiaoli Zhang, Qianqian Zhang, Jianmin Zhao
Peptidoglycan recognition proteins (PGRPs) are important pattern recognition receptors in the innate immune system of invertebrates. In the study, a short PGRP (designed as RpPGRP) was identified and characterized from the manila clam Ruditapes philippinarum. The open reading frame of RpPGRP encoded a polypeptide of 249-amino acids with a calculated molecular mass of 27.2 kDa and an isoelectric point of 6.62. Multiple alignments and phylogenetic analysis strongly suggested that RpPGRP was a new member of the PGRP superfamily...
March 11, 2019: Fish & Shellfish Immunology
Yuki Kondo, Shuichi Ito, Osamu Uehara, Yoshihito Kurashige, Yusuke Fujita, Takashi Saito, Masato Saitoh
OBJECTIVES: The aim of this study was to investigate the chemical and biological properties of newly developed bioactive cements, modified such that they are largely composed of calcium, phosphate and fluoride. We investigated whether newly developed bioactive cements have the potential to further protect surrounding hard tissue and enhance remineralization of demineralized tissue by additional ion release. METHODS: We developed four types of novel GIC based on Fuji VII, modified with phosphate and fluoride and calcium...
March 11, 2019: Dental Materials: Official Publication of the Academy of Dental Materials
Jarmila Harvanová, Lucia Ungvarská Maľučká, Anna Uhrinová, Mária Vilková, Martin Vavra, Martin Pavlík, Martin Rajtar, Anna Furmaníková
There exist about 750 species of Cordyceps at present. A high price of natural Cordyceps and its lack in nature caused that the attention has been focused to its cultivation in laboratory conditions. The demand for this “fungus-parasite” is still quite high nowadays, as shown by the amount of commercial nutritional supplements. Phytochemical diversity has ensured that Cordyceps is used as an immunomodulatory and an antioxidant; it has anti-cancer, anti-inflammatory, anti-diabetic, antibacterial, anti-HIV effects...
2019: Ceská a Slovenská Farmacie
Miroljub Barac, Tanja Vucic, Sladjana Zilic, Mirjana Pesic, Marina Sokovic, Jovana Petrovic, Aleksandar Kostic, Ivana Sredovic Ignjatovic, Danijel Milincic
This study deals with the effect of in vitro digestion on the functional potential of traditional Serbian white-brined cheeses. The total antioxidant capacity, reducing power and iron (II) chelating properties as well as angiotensin-converting enyzme-inhibitory (ACE-inhibitory) and antimicrobial activities of traditional Serbian white-brined cheeses before and after in vitro digestion were assayed. The traditional cheeses had different antioxidant properties as well as different ACE-inhibitory activities. In vitro digestion improved the total antioxidant capacity (8...
March 12, 2019: Foods (Basel, Switzerland)
Ana Beatriz Linard de Carvalho, Cleciana Alves Cruz, Cicero Lucas Almeida de Freitas, José Junior Dos Santos Aguiar, Paula Leticia Wendy de Souza Nunes, Valéria Maria da Silva Lima, Edinardo Fagner Ferreira Matias, Débora Feitosa Muniz, Henrique Douglas Melo Coutinho
The present study aimed to determine the chemical profile and to evaluate the antibacterial activity and antibiotic-modulating action of the hexanic Zea mays silk extract in association with aminoglycosides. Standard Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 strains, as well as multi-resistant Escherichia coli 27, Staphylococcus aureus 35, and Pseudomonas aeruginosa 31 strains, were used in this study. Phytochemical prospection revealed the presence of the following secondary metabolites: tannins, flavones, flavonoids, and xanthones, with the main chemical constituents being identified in plant extracts obtained with apolar organic solvents such as hexane...
March 12, 2019: Antibiotics
Katrina A Muraglia, Rajeev S Chorghade, Bo Ram Kim, Xiao Xiao Tang, Viral S Shah, Anthony S Grillo, Page N Daniels, Alexander G Cioffi, Philip H Karp, Lingyang Zhu, Michael J Welsh, Martin D Burke
Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) compromise epithelial HCO3 - and Cl- secretion, reduce airway surface liquid pH, and impair respiratory host defences in people with cystic fibrosis1-3 . Here we report that apical addition of amphotericin B, a small molecule that forms unselective ion channels, restored HCO3 - secretion and increased airway surface liquid pH in cultured airway epithelia from people with cystic fibrosis. These effects required the basolateral Na+ , K+ -ATPase, indicating that apical amphotericin B channels functionally interfaced with this driver of anion secretion...
March 13, 2019: Nature
Rebeca Madeleine Ebelle Etame, Raymond Simplice Mouokeu, Frank Stève Monthe Poundeu, Igor Kenfack Voukeng, Cedric Laurel Pouaha Cidjeu, Alembert Tchinda Tiabou, Abel Joel Gbaweng Yaya, Rosalie Anne Ngono Ngane, Jules Roger Kuiate, François Xavier Etoa
BACKGROUND: Enantia chlorantha is a plant belonging to Annonaceae Family. The Barks and leaves are used traditionally to treat infectious diseases. Earlier studies highlighted the antibacterial activity of stem barks methanol extract. This study is thus aimed at investigating the effect of fractionation on antibacterial activity of its n-butanol fraction. METHODS: The extract of E. chlorantha stem barks was obtained by maceration in methanol and then subjected to a liquid/liquid partition by successive depletion with solvents of increasing polarity...
March 11, 2019: BMC Complementary and Alternative Medicine
Haet Nim Lim, Seung Bae Baek, Hye Jin Jung
Malignant melanoma is the deadliest form of skin cancer and highly chemoresistant. Melittin, an amphiphilic peptide containing 26 amino acid residues, is the major active ingredient from bee venom (BV). Although melittin is known to have several biological activities such as anti-inflammatory, antibacterial and anticancer effects, its antimelanoma effect and underlying molecular mechanism have not been fully elucidated. In the current study, we investigated the inhibitory effect and action mechanism of BV and melittin against various melanoma cells including B16F10, A375SM and SK-MEL-28...
March 7, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Lijuan Chen, Tao Guo, Rongjiao Xia, Xu Tang, Ying Chen, Cheng Zhang, Wei Xue
A series of novel phosphorylated penta-1,4-dien-3-one derivatives were designed and synthesized. The structures of all title compounds were determined by ¹H-NMR, 13 C-NMR, 31 P-NMR, and high-resolution mass spectrometry (HRMS). Bioassay results showed that several of the title compounds exhibited remarkable antibacterial and antiviral activities. Among these, compound 3g exhibited substantial antibacterial activity against Xanthomonas oryzae pv. Oryzae (Xoo), with a 50% effective concentration (EC50 ) value of 8...
March 7, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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