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Anticancer Effect

Łukasz Lamch, Julita Kulbacka, Magda Dubińska-Magiera, Jolanta Saczko, Kazimiera A Wilk
Targeted and effective drug transport is becoming an attractive option in cancer therapy since it can improve drug efficacy and reduce drugs' side effects in normal tissues. In addition to using specific surface ligand molecules, the selective drug delivery can be accomplished via enhanced permeability and retention effect. Therefore, in our studies, we entrapped zinc (II) phthalocyanine (ZnPc) - a second generation photosensitizer - in folate-functionalized micelles of the biocompatible, FDA-approved for biomedical application diblock copolymer methoxypoly(ethylene oxide)-b-poly(L-lactide) (mPEG-b-PLLA) and its derivative with folate (FA) attached to the end of PEG chain (FA-PEG-b-PLLA)...
February 12, 2019: Photodiagnosis and Photodynamic Therapy
Longbing Ling, Muhammad Ismail, Yawei Du, Chen Yao, Xinsong Li
Liposomes have emerged as a fascinating nanocarriers for the delivery of cancer therapeutics. However, their efficacy for cancer therapy is reduced because of the serum-instability and incomplete drug release. In this study, a novel disulfide cross-linked liposomes (CLs) assembled from dimeric lipoic acid-derived glycerophosphorylcholine (di-LA-PC) conjugate was developed. The conjugate was synthesized by a facial esterification of lipoic acid (LA) and glycerophosphorylcholine (GPC) and characterized by MS, 1 H NMR and 13 C NMR...
February 12, 2019: International Journal of Pharmaceutics
HaiXia Wang, JunTao Luo, WenXia Tian, WenQing Yan, Sheng Ge, YaHui Zhang, WenGuang Sun
Tocotrienols (T3s) are a subgroup of vitamin E and they have been widely tested to inhibit cell growth in various tumor types. Previous studies have shown that T3s inhibit cancer cell growth by targeting multiple signaling transduction and cellular processes. However, the role of T3s in the regulation of cellular bioenergetic processes remains unclear. In this study, we found that γ-T3 interacts with mitochondrial electron transfer chain NDUFB8 (a subunit of complex I) and SDHB (a subunit of complex II) and inhibits oxidative phosphorylation (OXPHOS), and triggers the production of reactive oxygen species (ROS)...
February 12, 2019: Toxicology
Qiao Jiang, Shuai Zhao, Jianbing Liu, Linlin Song, Zhen-Gang Wang, Baoquan Ding
Nanomaterials employed for enhanced drug delivery and therapeutic effects have been extensively investigated in the past decade. The outcome of current anticancer treatments based on conventional nanoparticles is suboptimal, due to the lack of biocompatibility, the deficient tumor targeting, the limited drug accumulation in the diseased region, etc. Alternatively, DNA-based nanocarriers have emerged as a novel and versatile platform to integrate the advantages of nanotechnologies and biological sciences, which shows great promise in addressing the key issues for biomedical studies...
February 12, 2019: Advanced Drug Delivery Reviews
Siva Prasad Panda, Uttam Prasad Panigrahy, Subhranshu Panda, Bikash R Jena
ETHNOPHARMACOLOGICAL RELEVANCE: The plant Tabebuia chrysantha (Jaq.) Nicholson (Bignoniaceae) is commonly known as "Golden Goddess" in the Southern part of India and "Golden Trumpet Tree " in Central America. Stems of this plant have been traditionally used for antioxidant, anti-inflammatory, antimicrobial and anticancer actions. AIM OF THE STUDY: To evaluate the antitumor activity of methanol extract of Tabebuia chrysantha stem (METC). MATERIALS AND METHODS: The in vivo antitumor potential of METC against Ehrlich Ascites Carcinoma (EAC) in Swiss albino mice was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight, hematological parameters, biochemical parameters, and antioxidant parameters...
February 12, 2019: Journal of Ethnopharmacology
Steffen Daum, Johannes Toms, Viktor Reshetnikov, Gizem Hülya, Frank Hampel, Simone Maschauer, Amir H Hakimioun, Frank R Beierlein, Olaf Prante, Andriy Mokhir, Leopold Sellner, Michael Schmitt
N-Alkylaminoferrocene (NAAF)-based prodrugs are activated in the presence of elevated amounts of reactive oxygen species (ROS), that corresponds to cancer specific conditions, with formation of NAAF and p-quinone methide. These both products act synergistically by increasing oxidative stress in cancer cells that causes their death. Though it has been already demonstrated that the best prodrugs of this type retain their antitumor activity in vivo, the effects were found to be substantially weaker than those observed in cell cultures...
February 15, 2019: Bioconjugate Chemistry
Adriana Georgieva Bakalova, Rossen Todorov Buyukliev, Rositsa Petrova Nikolova, Boris Lubomirov Shivachev, Rositsa Asenova Mihaylovac, Spiro Mihaylov Konstantinov
BACKGROUND: The accidental discovery of cisplatin's growth-inhibiting properties a few decades ago led to resurgence of interest in metal-based chemotherapeutics. A number of well-discussed factors such as severe systemic toxicity and unfavourable physicochemical properties further limit the clinical application of the platinating agents. Great efforts have been placed in the development of alternative platinum derivatives with an extended antitumor spectrum and amended toxicity profile as compared to the reference drug cisplatin...
February 13, 2019: Anti-cancer Agents in Medicinal Chemistry
Omid Abazari, Adeleh Divsalar, Roohollah Ghobadi
The biological and side effects of a chemotherapeutic drug of oxali-Platin on the structure and function of Bovine Liver Catalase (BLC) was investigated in this study. For exact clarifying of the issue, the interaction between oxali-Platin and BLC in an aqueous solution at two temperatures of 25 and 37 ?C was assessed using various spectroscopic techniques of UV-Visible, fluorescence and circular dichroism (CD) in combination with a molecular docking study. Intrinsic ?uorescence results displayed that by increasing the oxali-Platin concentrations; the intrinsic emission of the enzyme was decreased indicating a signi?cant changes in the three-dimensional environment around the chromophores of the enzyme structure...
February 15, 2019: Journal of Biomolecular Structure & Dynamics
Szu-Yuan Wu, Chia-Ling Chen, Po-Chun Tseng, Chi-Yun Chiu, Yung-En Lin, Chiou-Feng Lin
Fractionated ionizing radiation (FIR) is a radiotherapy regimen that is regularly performed as part of lung cancer treatment. In contrast to the growth inhibition caused by DNA damage, immunomodulation in post-irradiated cancer cells is not well documented. Interferon (IFN)-γ confers anticancer activity by triggering both growth inhibition and cytotoxicity. This study investigated the priming effects of FIR with immunomodulation on the anticancer IFN-γ. Cell morphology, cell growth, and cytotoxicity were observed in FIR-treated A549 lung adenocarcinoma...
February 14, 2019: Journal of Cellular Physiology
Pavel Štarha, Zdeněk Trávníček, Ján Vančo, Zdeněk Dvořák
4-Azaindole (1H-pyrrolo[3,2-b]pyridine; 4aza) and its N1-alkylated derivative N1-isopropyl-4-azaindole (1-(propan-2-yl)-1H-pyrrolo[3,2-b]pyridine; ip4aza) have been used for the preparation of the cis-diiodido-platinum(II) complexes cis-[Pt(4aza)2 I2 ] (1), cis-[PtI2 (ip4aza)2 ] (2), cis-[Pt(4aza)I2 (NH3 )] (3) and cis-[PtI2 (ip4aza)(NH3 )] (4). The prepared complexes were thoroughly characterized (e.g., multinuclear NMR spectroscopy and ESI mass spectrometry) and their in vitro cytotoxicity was assessed at human ovarian carcinoma (A2780), cisplatin-resistant ovarian carcinoma (A2780R) and colon carcinoma (HT-29) cell lines, where they showed, in some cases, significantly higher activity than the used reference-drug cisplatin...
February 14, 2019: Journal of Biological Inorganic Chemistry: JBIC
Jesse A Stoff
Over the years, the treatment of patients with cancer has varied widely as much because of recent advancements in science and medicine as the philosophies that belie their use. This paper briefly describes many of the prevailing approaches in use today with an attempt to offer some perspective of how to apply these disparate methodologies so that they may be more effectively integrated, resulting in consistently better clinical responses.
2019: Journal of Oncology
Yue-Peng Cao, Jing-Ya Sun, Mei-Qian Li, Yu Dong, Yuan-Heng Zhang, Jun Yan, Rui-Min Huang, Xiang Yan
Urinary bladder cancer (UBC) is characterized by frequent recurrence and metastasis despite the standard chemotherapy with gemcitabine and cisplatin combination. Histone modifiers are often dysregulated in cancer development, thus they can serve as an excellent drug targets for cancer therapy. Here, we investigated whether G9a, one of the histone H3 methyltransferases, was associated with UBC development. We first analyzed clinical data from public databases and found that G9a was significantly overexpressed in UBC patients...
February 14, 2019: Acta Pharmacologica Sinica
Thi Thinh Nguyen, Trong Thuan Ung, Shinan Li, Sen Lian, Yong Xia, Sun Young Park, Young Do Jung
Metformin, an inexpensive, well-tolerated oral agent that is a commonly used first-line treatment for type 2 diabetes, has become the focus of intense research as a potential anticancer agent. In this study, we describe the inhibitory effect of metformin in interleukin 8 (IL-8) upregulation by lithocholic acid (LCA) in HCT116 colorectal cancer (CRC) cells. Pharmacological inhibition studies indicated that reactive oxygen species (ROS) were involved in LCA-induced IL-8 upregulation through activation of the transcription factor NF-κB...
February 14, 2019: Scientific Reports
Haiyang Zhang, Song Wang, Nicholas Cacalano, He Zhu, Qiuju Liu, Michael Xie, Mitchell Kamrava, Gottfried Konecny, Shunzi Jin
In this study, we aimed to identify mutations of key genes associated with docetaxel resistance in nine endometrial cancer cell lines. Endometrial cancers are associated with several critical gene mutations, including PIK3A, PTEN, and KRAS. Different gene mutations in endometrial cancer cells have varied responses to anticancer drugs and cancer therapies. The most frequently altered gene in endometrioid endometrial carcinoma tumors is PTEN. PTEN protein has lipid phosphatase and protein phosphatase activity, as well as other functions in the nucleus...
February 14, 2019: Scientific Reports
Chowdhury S Abdullah, Shafiul Alam, Richa Aishwarya, Sumitra Miriyala, Mohammad Alfrad Nobel Bhuiyan, Manikandan Panchatcharam, Christopher B Pattillo, A Wayne Orr, Junichi Sadoshima, Joseph A Hill, Md Shenuarin Bhuiyan
Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular dysfunction, and also induce late-onset cardiomyopathy and heart failure. Despite extensive studies, the pathogenic sequelae leading to the progression of Dox-associated cardiomyopathy remains unknown. We assessed temporal changes in autophagy, mitochondrial dynamics, and bioenergetics in mouse models of acute and chronic Dox-cardiomyopathy. Time course study of acute Dox-treatment showed accumulation of LC3B II in heart lysates...
February 14, 2019: Scientific Reports
Yibo Zhao, Liqian Zhang, Xu Li, Yanhui Shi, Ruru Ding, Mengting Teng, Peng Zhang, Changsheng Cao, Peter J Stang
Six tetranuclear rectangular metallacycles were synthesized via the [2+2] coordination-driven self-assembly of imidazole-based ditopic donor 1,4-bis(imidazole-1-yl)benzene and 1,3-bis(imidazol-1-yl)benzene, with dinuclear half-sandwich p -cymene ruthenium(II) acceptors [Ru2 (µ-η4 -oxalato)(η6 - p -cymene)2 ](SO3 CF3 )2 , [Ru2 (µ-η4 -2,5-dioxido-1,4-benzoquinonato)(η6 - p -cymene)2 ](SO3 CF3 )2 and [Ru2 (µ-η4 -5,8-dioxido-1,4-naphtoquinonato)(η6 - p -cymene)2 ](SO3 CF3 )2 , respectively. Likewise, three hexanuclear trigonal prismatic metallacages were prepared via the [2+3] self-assembly of tritopic donor of 1,3,5-tri(1 H -imidazol-1-yl)benzene with these ruthenium(II) acceptors respectively...
February 14, 2019: Proceedings of the National Academy of Sciences of the United States of America
Marco Masi, Ramesh Dasari, Antonio Evidente, Veronique Mathieu, Alexander Kornienko
Ophiobolin A is a fungal secondary metabolite that was found to have significant activity against apoptosis-resistant glioblastoma cells through the induction of a non-apoptotic cell death, offering an innovative strategy to combat this aggressive cancer. The current article aims to make the bridge between the anti-cancer effects of ophiobolin A and its unique reaction with primary amines and suggests that pyrrolylation of lysine residues on its intracellular target protein(s) and/or phosphatidylethanolamine lipid is responsible for its biological effects...
February 7, 2019: Bioorganic & Medicinal Chemistry Letters
Véronique Bourcy, Emmanuelle Boubouloux, Virginie Moiteaux, Fabienne Empereur, David Guillet, Martine Jouin-Bernier, Laure de Decker
Anticancer medicines evolve in terms of their mode of action as well as their galenics. The advent of oral therapies has multiple benefits such as the possibility of taking the treatments at home. However, what are the implications with regard to compliance, the management of side effects and the community-hospital relationship? Elderly patients, often isolated, taking several medicines and frail, are disorientated faced with all these medications and their side effects. A study was undertaken to evaluate the benefit of visits by private practice nurses to support patients taking oral cancer drugs...
January 2019: Soins. Gérontologie
Gray R Lyons, Bradley B Pua
Percutaneous ablation can deliver effective anticancer therapy with minimal side effects; however, undertreatment can lead to disease recurrence and overtreatment can lead to unnecessary complications. Ablation planning software can support the procedure during the planning, treatment, and follow-up phases. In this review, 2 examples of microwave ablation software are described with attention to how the software can influence procedural choices. In the future, ablation software will entail larger source datasets and more refined algorithms to better model the in vivo ablation zone...
March 2019: Techniques in Vascular and Interventional Radiology
Sun Qing, Qiu Shoutian, Gu Hongyan, Yao Ming, Mallappa Kumara Swamy, Uma Rani Sinniah, Ahmad Umar, Mohd Sayeed Akhtar
This study reports the biosynthesis of silver nanoparticles (AgNPs) using methanolic leaf extract of Pogostemon cablin Benth. (Patchouli) as a reducing agent, and their potent biological (antibacterial, antioxidant and anticancer) activities. The P. cablin extract when exposed to silver nitrate reduced silver ions to form crystalline AgNPs within 1 h of incubation at room-temperature. UV-visible spectra showed a sharp surface plasmon resonance (SPR) at around 430 nm for the biosynthesized AgNPs and the XRD pattern indicated the crystalline planes of the face centered cubic silver...
July 1, 2019: Journal of Nanoscience and Nanotechnology
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