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Wonhwa Lee, Sumin Yang, Changhun Lee, Eui Kyun Park, Kyung-Min Kim, Sae-Kwang Ku, Jong-Sup Bae
Aloin is the major anthraquinone glycoside obtained from the Aloe species and exhibits anti-inflammatory and anti-oxidative activities. Here, we aimed to determine the effects of aloin on heme oxygenase-1 (HO-1) induction and on the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX) 2 in lipopolysaccharide (LPS)-activated human umbilical vein endothelial cells (HUVECs). To the end, aloin was tested whether aloin reduces iNOS protein expression and inflammatory markers (interleukin (IL)-1β and tumor necrosis factor (TNF)-α) in LPS-treated mice lung tissue...
February 12, 2019: Food and Chemical Toxicology
Cecilia Carubbi, Elena Masselli, Giulia Pozzi, Maria Mattioli, Silvia Martini, Matteo Goldoni, Rosalia Aloe, Gianfranco Cervellin, Marco Vitale, Giuliana Gobbi
A rapid differential diagnosis of the clinical conditions underlying chest pain is a relevant clinical issue. Specifically, a fast rule-in or -out of acute myocardial infarction (AMI) is mandatory to improve diagnostic outcome and cost-effectiveness of patient management. We demonstrated that Protein Kinase C (PKC) epsilon is selectively expressed by platelets from AMI patients, accounting for increased platelet activation. Thus, we hypothesized that PKCepsilon-expressing platelets may represent a pathophysiological marker of AMI that could be utilized in combination with troponin-I, the conventional marker of cardiac injury, to add diagnostic information in chest pain workup...
February 14, 2019: Scientific Reports
S Gunasekaran, A Dinesh, A Silambarasu, V Thirumurugan, S Shankar
Pure and Nd-doped cerium oxides (CeO₂, Ce0.075 Nd0.025 O and Ce0.050 Nd0.050 O) nanoparticles (NPs) were synthesized using Aloe vera leaf extract. X-ray powder diffraction studies were confirmed that synthesized pure and Nd3+ doped CeO₂ NPs and were exhibited cubic structure. FE-SEM image exhibited pure and Nd3+ doped CeO₂ NPs have spherical structure and Nd doped CeO2 NPs small pores were formed in the surface. EDAX spectral analysis used to identify the elemental compositions. FT-IR spectra shows various functional groups and were identified for pure and Nd3+ doped CeO₂ NPs...
July 1, 2019: Journal of Nanoscience and Nanotechnology
Charles Metcalfe
Background: Aloe vera polysaccharides are considered to be the primary active components that provide numerous anecdotal health benefits. Objective : Several analytical methods are currently being used to quantitate the acemannan content of aloe vera processed raw materials. Some involve the use of very expensive and intricate equipment that is not normally found in production facilities. This document describes a single-laboratory validation for a very simple and inexpensive method that will be supported by a future multi-laboratory validation determination...
February 14, 2019: Journal of AOAC International
Gaetano Bottaro, Giuseppe Mazzola, Antonino Gulino, Filippo Di Forti
BACKGROUND: Sore throat frequently occurs in children aged between 4 and 15 years and is often associated to inflammation of the upper respiratory tract mucosa. A reliable approach to limit the damage caused by inflammation and, therefore, to alleviate associated symptoms might be the protection of the mucosa. Aim of this study was to assess the efficacy and tolerability of a medical device, formulated as a gummy lozenge and containing a combination of natural functional components (erysimum, aloe vera and Xilogel®) able to exert a barrier effect on the mucosa, as ancillary treatment in children with sore throat...
February 13, 2019: Minerva Pediatrica
Gunapathy Devi, Ramasamy Harikrishnan, Bilal Ahmad Paray, Mohammad K Al-Sadoon, Seyed Hossein Hoseinifar, Chellam Balasundaram
The effect of aloe-emodin incorporated diets on innate immune response, disease resistance, pro and/or anti-inflammatory cytokine gene transcription in Labeo rohita against Aphanomyces invadans is reported for the first time. In healthy and infected groups fed with 5 mg aloe-emodin enriched diet the white blood cell (WBC) count increased significantly (p > 0.05) after 6th week. In both groups fed with any enriched diet the biochemical parameters such as albumin, globulin, and albumin/globulin ratio did not vary significantly; however with 5 mg aloe-emodin diet the albumin and globulin levels increased significantly (p > 0...
February 9, 2019: Fish & Shellfish Immunology
Almasa Bass, Lynn R Webster, Kyle T Matschke, Bimal K Malhotra, Gernot Wolfram
Background: Abuse of prescription opioids, particularly by intravenous (IV) administration, can cause respiratory depression and death. ALO-02, an abuse-deterrent opioid formulation, is designed to release sequestered naltrexone upon manipulation by crushing, thereby antagonizing the pharmacologic effects of oxycodone. This exploratory post-hoc analysis examined the effects of IV administration of simulated crushed ALO-02 on end-tidal carbon dioxide (EtCO2 ), a surrogate marker of respiratory depression...
2019: Therapeutic Advances in Drug Safety
S Rosy Christy, L Srimathi Priya, M Durka, A Dinesh, N Babitha, S Arunadevi
In this present study, semiconductor zinc oxide (ZnO) nanoparticles were successfully prepared by microwave irradiation (ZnO-MIM) and conventional combustion (ZnO-CCM) method, respectively using Aloe vera plant extract as reducing agent. Crystal structure, purity and surface morphology of the samples were examined by powder X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) analysis. UV-Visible diffuse reflectance (DRS) and photoluminescence (PL) spectral studies was used to analysis the optical property and band gap energy of the samples...
June 1, 2019: Journal of Nanoscience and Nanotechnology
Dong Hyun Kim, Dong Min Shin, Han Geuk Seo, Sung Gu Han
Objective: The purpose of this study was to investigate whether addition of konjac gel with three different vegetable powders can increase quality of low-fat frankfurter-type sausage. Methods: Low-fat frankfurter-type sausages were manufactured with formulations containing konjac gel and three vegetable powders (aloe vera, cactus pear or wheat sprout) as pork fat replacers. The formulations of frankfurters were as follows: NF (normal-fat; 20% pork fat), LF (low-fat; 10% pork fat), KG (low-fat; 10% pork fat+10% konjac gel), and three konjac gel with vegetable powders (KV), such as KV-AV (10% pork fat+10% konjac gel with aloe vera), KV-CP (10% pork fat+10% konjac gel with cactus pear), and KV-WS (10% pork fat+10% konjac gel with wheat sprout)...
January 4, 2019: Asian-Australasian Journal of Animal Sciences
Haipeng Jiang, Mingshu Bi, Daqing Ma, Bei Li, Haiyong Cong, Wei Gao
The suppression effect of melamine cyanurate (MCA) and melamine polyphosphate (MPP) on the flame propagation of aluminum dust were studied experimentally. The results indicated that the concentration of MPP required to supress the aluminum dust explosion was lower than MCA. As the concentration of suppressant increased, the acceleration and the maximum flame speed extremely decreased, and the flame morphology became isolated spot flames. The MPP addition exerted a stronger suppression effect on the temperature of aluminum flame compared to MCA addition...
February 1, 2019: Journal of Hazardous Materials
Ané Orchard, Guy Kamatou, Alvaro M Viljoen, Namita Patel, Patricia Mawela, Sandy F van Vuuren
The topical use of essential oils requires dilution into a carrier oil; however, scientific evidence regarding the antimicrobial efficacy and cytotoxicity when a carrier oil is combined with an essential oil is lacking. This study sets out to determine the antimicrobial activity and cytotoxicity of 23 essential oils combined with six known carrier oils. Gas chromatography-mass spectrometry/flame ionization detector (GC-MS/FID) was used to characterize the methyl esters of the carrier oils. The antimicrobial activity of the carrier oils alone and in combination with the essential oils was investigated using the broth microdilution assay against 11 skin pathogens and the cytotoxicity was determined using the brine shrimp lethality assay...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Yohannes Kelifa Emiru, Ebrahim Abdela Siraj, Tekleab Teka Teklehaimanot, Gedefaw Getnet Amare
Objective: To evaluate the antibacterial effects of the leaf latex of Aloe weloensis against infectious bacterial strains. Methods: The leaf latex of A. weloensis at different concentrations (400, 500, and 600 mg/ml) was evaluated for antibacterial activities using the disc diffusion method against some Gram-negative species such as Escherichia coli (ATCC 14700) and Pseudomonas aeruginosa (ATCC 35619) and Gram-positive such as Staphylococcus aureus (ATCC 50080) and Enterococcus fecalis (ATCC 4623)...
2019: International Journal of Microbiology
Hui-Qun Xie, Shan-Shan Chu, Liang-Ping Zha, Ming-En Cheng, Lu Jiang, Dan-Dan Ren, Yi Yu, Hua-Sheng Peng, Dai-Yin Peng
Relationships among Fallopia multiflora (Thunb.) Haraldson., F. multiflora var. angulata (S. Y. Liu) H. J. Yan, Z. J. Fang & Shi Xiao Yu., and F. multiflora var. ciliinervis (Nakai) Yonekura & H. Ohashi. were determined based on macroscopic and microscopic morphology, molecular phylogeny, and chemical analysis. The macroscopic and microscopic morphologies of root tubers or rhizomes, stems, and leaves were compared among the three taxa. The content of 11 chemical components (catechin, polydatin, stilbene glucoside, emodin, emodin-8-O-β-D-glucopyranoside, rhein, chrysophanol, aloe-emodin, quercetin, physcion, and resveratrol) in the three taxa was determined by HPLC, and the chemical diversity was further evaluated by principal component and hierarchical cluster analyses...
January 25, 2019: Journal of Pharmaceutical and Biomedical Analysis
Martina Di Pietro, Mariella Dipalo, Marco Bruno Luigi Rocchi, Roberta Musa, Paola Avanzini, Cecilia Gnocchi, Maria Chiara Anelli, Rosalia Aloe
BACKGROUND: The detection of an increase and/or decrease of cardiac troponin (cTnI) values, with at least one value above the 99th percentile of the upper reference limit (URL) have a central role in acute myocardial infarction (AMI) diagnosis. The employment of sex specific 99th percentile URLs and High-sensitivity (Hs) assays are recommended. We assessed sex specific 99th percentile URL for Access Hs-cTnI and AccuTnI3+ (Beckman Coulter) using European donor reference population following recent International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) recommendations...
January 31, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Vaishnevi Raj, Stephanie Claudine, Arjunan Subramanian, Kimberley Tam, Arijit Biswas, Ariff Bongso, Chui-Yee Fong
We showed in previous studies that human umbilical cord Wharton's jelly stem cells (hWJSCs) improved the healing rates of excisional and diabetic wounds in the mouse model. As an extension of those studies, we report here the more detailed quantitative histological, immunohistochemical, and genomic evaluation of biopsies from those excisional and diabetic wounds in an attempt to understand the mechanisms of the enhanced wound healing aided by hWJSCs. Bright-field microscopic observations and ImageJ software analysis on histological sections of the excisional and diabetic wound biopsies collected at different time points showed that the thickness of the epidermis and dermis, and positive picrosirius-red stained areas for collagen, were significantly greater in the presence of hWJSCs compared with controls (P < 0...
January 31, 2019: Journal of Cellular Biochemistry
Shenda Hou, Rachel L Clement, Alos Diallo, Bruce R Blazar, Alexander Y Rudensky, Arlene H Sharpe, Peter T Sage
Follicular regulatory T (Tfr) cells are a regulatory T cell subset that controls antibody production by inhibiting T follicular helper (Tfh)-mediated help to B cells. Tfh and Tfr cells possess opposing functions suggesting unique programming. Here we elucidated the transcriptional program controlling Tfr suppressive function. We found that Tfr cells have a program for suppressive function fine-tuned by tissue microenvironment. The transcription factor FoxP3 and chromatin-modifying enzyme EZH2 are essential for this transcriptional program but regulate the program in distinct ways...
January 31, 2019: Journal of Experimental Medicine
Fredrick Andrew Attah, Christianah Mopelola Asaleye, Adeleye Dorcas Omisore, Babatope Ayodeji Kolawole, Adeniyi Sunday Aderibigbe, Mathew Alo
BACKGROUND: Neuropathy is a common complication of diabetes mellitus resulting from direct damage by hyperglycemia to the nerves and/or ischemia by microvascular injury to the endoneurial vessels which supply the nerves. Median nerve is one of the peripheral nerves commonly affected in diabetic neuropathy. The median nerve size has been studied in non-Nigerian diabetic populations. In attempt to contribute to existing literature, a study in a Nigerian population is needed. AIM: To evaluate the cross-sectional area (CSA) of the median nerve using B-mode ultrasonography (USS) and the presence of peripheral neuropathy (PN) in a cohort of adult diabetic Nigerians...
January 15, 2019: World Journal of Diabetes
Alberto Pistocchi, Chiara Dorati, Alberto Aloe, Antoni Ginebreda, Rafael Marcé'
In this paper, we build a preliminary inventory of dissolved phase water emissions of 36 of the 45 chemical priority substances under the European Union's Water Framework Directive. For point sources, we consider the European Pollutant Release and Transfer Register (E-PRTR) containing reported emissions from major industrial facilities. We consider all other sources as diffuse, and we estimate European average chemical emission factors from available measurements of dissolved phase concentrations, assuming simple emission patterns such as population and agricultural land...
January 9, 2019: Science of the Total Environment
Valérie Lemay, Maxime Caru, Mariia Samoilenko, Simon Drouin, Nathalie Alos, Geneviève Lefebvre, Emile Levy, Sarah Lippé, Valérie Marcil, Serge Sultan, Laurence Bertout, Maja Krajinovic, Caroline Laverdière, Marie-Josée Raboisson, Daniel Sinnett, Gregor Andelfinger, Daniel Curnier
BACKGROUND: Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of therapy. A regular practice of physical activity and a good cardiorespiratory fitness have the potential to reduce the risk of chronic disease and improve quality of life. The aim of this study was to evaluate in a cohort of ALL survivors, the association between a good cardiorespiratory fitness or the respect of physical activity guidelines and major long-term health outcomes...
January 25, 2019: Journal of Pediatric Hematology/oncology
Shane M Daly, David L Bones, John M C Plane
The reactions between Al+(31S) and O3, O2, N2, CO2 and H2O were studied using the pulsed laser ablation at 532 nm of an aluminium metal target in a fast flow tube, with mass spectrometric detection of Al+ and AlO+. The rate coefficient for the reaction of Al+ with O3 is k(293 K) = (1.4 ± 0.1) × 10-9 cm3 molecule-1 s-1; the reaction proceeds at the ion-dipole enhanced Langevin capture frequency with a predicted T-0.16 dependence. For the recombination reactions, electronic structure theory calculations were combined with Rice-Ramsperger-Kassel-Markus theory to extrapolate the measured rate coefficients to the temperature and pressure conditions of planetary ionospheres...
January 25, 2019: Physical Chemistry Chemical Physics: PCCP
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