keyword
https://read.qxmd.com/read/38532901/a-6-year-old-with-childhood-absence-epilepsy-and-motor-hyperactivity
#1
JOURNAL ARTICLE
Stéphane Auvin
A case study of a child with childhood absence epilepsy and hyperactivity introduces the discussion around the psychiatric diagnosis, differential considerations, and pharmacologic treatment options for ADHD/hyperactivity in children with epilepsy. Most of the time, ADHD in children with epilepsy is an inattentive form. The assessment emphasizes the need to differentiate ADHD symptoms from other psychiatric comorbidities. This is also crucial to evaluate when symptoms emerged, their impact on daily life, and if it could be a potential medication side effect...
2024: Epilepsy & behavior reports
https://read.qxmd.com/read/38506810/attention-deficit-hyperactivity-disorder-medications-and-work-disability-and-mental-health-outcomes
#2
JOURNAL ARTICLE
Heidi Taipale, Jakob Bergström, Katalin Gèmes, Antti Tanskanen, Lisa Ekselius, Ellenor Mittendorfer-Rutz, Magnus Helgesson
IMPORTANCE: Individuals with attention-deficit/hyperactivity disorder (ADHD) often have comorbid psychiatric conditions. Relatively little is known about how specific ADHD medications are associated with overall treatment outcomes among these patients. OBJECTIVE: To investigate the association of the use of specific ADHD medications with hospitalization outcomes and work disability among adolescents and adults with ADHD. DESIGN, SETTING, AND PARTICIPANTS: This nationwide register-based cohort study identified individuals (aged 16-65 years) with ADHD from Swedish nationwide registers of inpatient health care, specialized outpatient health care, sickness absence, and disability pension during the years 2006 to 2021...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38504095/individualized-atomoxetine-response-and-tolerability-in-children-with-adhd-receiving-different-dosage-regimens-the-need-for-cyp2d6-genotyping-and-therapeutic-drug-monitoring-to-dance-together
#3
JOURNAL ARTICLE
Hong-Li Guo, Dan-Dan Wu, Di Fu, Yue Li, Jie Wang, Yuan-Yuan Zhang, Wei-Jun Wang, Jian Huang, Wei-Rong Fang, Jing Xu, Ya-Hui Hu, Qian-Qi Liu, Feng Chen
Integrating CYP2D6 genotyping and therapeutic drug monitoring (TDM) is crucial for guiding individualized atomoxetine therapy in children with attention-deficit/hyperactivity disorder (ADHD). The aim of this retrospective study was (1) to investigate the link between the efficacy and tolerability of atomoxetine in children with ADHD and plasma atomoxetine concentrations based on their CYP2D6 genotypes; (2) to offer TDM reference range recommendations for atomoxetine based on the CYP2D6 genotypes of children receiving different dosage regimens...
March 19, 2024: Translational Psychiatry
https://read.qxmd.com/read/38477521/recent-updates-on-treatment-patterns-in-patients-with-treated-attention-deficit-hyperactivity-disorders-from-a-nationwide-real-world-database-in-south-korea
#4
JOURNAL ARTICLE
Yoon Cho, Ah-Young Kim, Sukhyang Lee, Hankil Lee
The prevalence of attention-deficit/hyperactivity disorder (ADHD) is steadily increasing across Korea. We analyzed ADHD patients with ADHD medications (Rx) characteristics and treatment patterns compared to patients without Rx and identified the differences between pediatric-/adult- and active-/transient-patients with Rx. Using a nationwide claims dataset from 2020 to 2021, we conducted a prevalence-based cross-sectional study and analyzed the recent patients' characteristics and patterns among ADHD patients...
March 11, 2024: International Clinical Psychopharmacology
https://read.qxmd.com/read/38436168/genotoxic-and-genoprotective-effects-of-some-antipsychotic-drugs-methylphenidate-and-atomoxetine-on-human-lymphocytes-and-hepg2-cells
#5
JOURNAL ARTICLE
S K Sezer, S Yuksel, I Ucuz
OBJECTIVE: Aripiprazole, risperidone, atomoxetine, and methylphenidate are drugs commonly prescribed for many psychiatric conditions and can be used alone or in combination in children and adolescents. This study aimed to investigate comparatively the possible genotoxic effects or genoprotective potentials of these drugs on human lymphocytes and HepG2 cells. MATERIALS AND METHODS: Cytotoxicity analysis was performed with the cell viability test on human lymphocytes and HepG2 cells, and half-maximal inhibitory concentration (IC50) values of the drugs were determined, and three different doses (¼ IC50, ½ IC50, and IC50) were applied for genetic analysis...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38416571/effect-of-biofeedback-intervention-on-neurological-characteristics-of-children-with-attention-deficit-hyperactivity-disorder
#6
JOURNAL ARTICLE
Cai Zhang, Xiaoxuan Zhou, Nanfei Hu, Lin Xu
Objective: To evaluate the effects of biofeedback intervention on the neurological characteristics of children with attention deficit hyperactivity disorder (ADHD). Methods: 150 children aged 6 to 12 years with ADHD were divided into two groups according to the treatment method. The atomoxetine group received atomoxetine drug treatment, and the combined treatment group received EEG biofeedback therapy. Continuous performance Test (CPT), SNAP-IV and WFIRS-P were used to assess attention and behavior, and functional magnetic resonance imaging (fMRI) was used to observe changes in brain activity...
February 28, 2024: International Journal of Neuroscience
https://read.qxmd.com/read/38341903/pharmacological-treatment-for-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#7
REVIEW
Maria Luísa Nobre, Ayane Cristine Alves Sarmento, Priscila Farias de Oliveira, Felipe Ferreira Wanderley, José Diniz Júnior, Ana Katherine Gonçalves
OBJECTIVE: Summarize the evidence on drug therapies for obstructive sleep apnea. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. PubMed, Embase, Scopus, Web of Science, SciELO, LILACS, Scopus, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched on February 17th, 2023. A search strategy retrieved randomized clinical trials comparing the Apnea-Hypopnea Index (AHI) in pharmacotherapies...
2024: Clinics
https://read.qxmd.com/read/38294169/continuation-of-treatment-in-children-with-adhd-a-multicenter-turkish-sample-study
#8
JOURNAL ARTICLE
Saliha Baykal, Cansu Çobanoğlu Osmanlı, Abdullah Bozkurt, Bedia Sultan Önal, Berkan Şahin, Müge Karaçizmeli, Ayşegül Öz Gazi, Koray Karabekiroğlu
OBJECTIVES: The aim of this study was to investigate the variables that may affect treatment continuation in children aged 6 to 12 years who were newly diagnosed with ADHD. METHODS: A total of 132 children diagnosed with ADHD and their parents participated in the study. Sociodemographic and clinical risk factors affecting continuation of treatment were examined using logistic regression analysis. RESULTS: Multiple model examination revealed that greater age increased the risk of treatment discontinuation 1...
January 31, 2024: Journal of Attention Disorders
https://read.qxmd.com/read/38258290/spectrophotometric-quantification-of-atomoxetine-hydrochloride-based-on-nucleophilic-substitution-reaction-with-1-2-naphthoquinone-4-sulfonic-acid-sodium-salt-nqs
#9
JOURNAL ARTICLE
Swathi Naraparaju, Padmavathi Yamjala, Soujanya Chaganti, Durga Panikumar Anumolu
OBJECTIVES: A simple, sensitive, selective, and cost-effective colorimetric method has been established for the quantitative estimation of atomoxetine hydrochloride in bulk and formulation.A simple, sensitive, selective and cost effective colorimetric method has been entrenched for the quantitative estimation of Atomoxetine hydrochloride in bulk and formulation. MATERIALS AND METHODS: It was established based on the visible reaction between atomoxetine hydrochloride and 1,2-naphthoquinone-4-sulfonic acid sodium salt in a basic medium (potassium hydroxide)...
January 19, 2024: Turkish journal of pharmaceutical sciences
https://read.qxmd.com/read/38253774/development-of-a-novel-rodent-rapid-serial-visual-presentation-task-reveals-dissociable-effects-of-stimulant-versus-nonstimulant-treatments-on-attentional-processes
#10
JOURNAL ARTICLE
Abigail Benn, Emma S J Robinson
The rapid serial visual presentation (RSVP) task and continuous performance tasks (CPT) are used to assess attentional impairments in patients with psychiatric and neurological conditions. This study developed a novel touchscreen task for rats based on the structure of a human RSVP task and used pharmacological manipulations to investigate their effects on different performance measures. Normal animals were trained to respond to a target image and withhold responding to distractor images presented within a continuous sequence...
January 22, 2024: Cognitive, Affective & Behavioral Neuroscience
https://read.qxmd.com/read/38229445/comparing-pharmacotherapies-for-adhd-in-adults-evidence-from-outcome-focused-analysis-of-food-and-drug-administration-drug-label-registration-trials
#11
JOURNAL ARTICLE
Craig B H Surman, Daniel M Walsh, Joseph B Bond
OBJECTIVE: We appraised whether FDA registration trials for ADHD pharmacotherapy in adults provides comparable information to inform treatment expectations. METHOD: Comparison of ADHD outcome measure patterns in ADHD pharmacotherapy FDA drug label source studies. RESULTS: Among stimulants, from fixed-dose titration data, amphetamine agents had numerically higher placebo-corrected symptom improvement and symptom effect sizes than methylphenidate agents...
January 16, 2024: Journal of Attention Disorders
https://read.qxmd.com/read/38219711/evidence-of-hypothalamic-pituitary-adrenal-and-gonadal-dysfunction-in-cocaine-addicted-men
#12
Karen D Ersche, Jan Stochl, Annette B Brühl, Mark Gurnell
INTRODUCTION: Regular cocaine use has been associated with hormonal dysfunction including hypogonadism, which can lead to fatigue, reduced stamina, sexual dysfunction, and impaired quality of life. However, cocaine's endocrine effects are largely under-reported in the scientific addiction literature and, in many cases, are not addressed within treatment services. The low profile of these adverse effects might be attributable to a lack of awareness and linkage with cocaine use, such that they are recognized only when an acute/emergency problem arises...
January 12, 2024: European Addiction Research
https://read.qxmd.com/read/38204741/effectiveness-and-tolerability-of-combination-pharmacotherapy-with-stimulant-and-non-stimulant-in-children-with-attention-deficit-hyperactivity-disorder
#13
JOURNAL ARTICLE
Hyung Nam Park, Na Yeong Kong, Hee-Cheol Kim, Yang Tae Kim, Sung-Won Jung, Hojun Lee
OBJECTIVES: This study aimed to investigate the effectiveness and safety of combining psychostimulants and nonstimulants for patients under treatment for attention deficit hyperactivity disorder (ADHD). METHODS: The study included 96 patients aged 6-12 years who were diagnosed with ADHD, among whom 34 received combination pharmacotherapy, 32 received methylphenidate monotherapy, and 30 received atomoxetine monotherapy. Statistical analysis was conducted to compare treatment and adverse effects among groups and to analyze changes before and after combination pharmacotherapy...
January 1, 2024: Soa--chʻŏngsonyŏn chŏngsin ŭihak, Journal of child & adolescent psychiatry
https://read.qxmd.com/read/38170320/mice-with-an-autism-associated-r451c-mutation-in-neuroligin-3-show-intact-attention-orienting-but-atypical-responses-to-methylphenidate-and-atomoxetine-in-the-mouse-posner-task
#14
JOURNAL ARTICLE
Shuting Li, Carlos May, Terence Y Pang, Leonid Churilov, Anthony J Hannan, Katherine A Johnson, Emma L Burrows
RATIONALE: Atypical attention orienting has been associated with some autistic symptoms, but the neural mechanisms remain unclear. The human Posner task, a classic attention orienting paradigm, was recently adapted for use with mice, supporting the investigation of the neurobiological underpinnings of atypical attention orienting in preclinical mouse models. OBJECTIVE: The current study tested mice expressing the autism-associated R451C gene mutation in neuroligin-3 (NL3) on the mouse-Posner (mPosner) task...
January 3, 2024: Psychopharmacology
https://read.qxmd.com/read/38126038/a-review-of-recent-treatments-for-adults-living-with-attention-deficit-hyperactivity-disorder
#15
REVIEW
Candice Wakelin, Michele Willemse, Erica Munnik
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a neuro-developmental disorder prevalent among children and adults. Adults living with ADHD can experience significant distress affecting their daily functioning on emotional, physical, interpersonal, familial and financial levels. Intervention programmes may be a way to mitigate these challenges. AIM: This review identified good evidence-based intervention studies for adults with ADHD and described the usefulness of these interventions...
2023: South African Journal of Psychiatry: SAJP
https://read.qxmd.com/read/38117180/population-pharmacokinetic-analysis-of-atomoxetine-and-its-metabolites-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder
#16
JOURNAL ARTICLE
Shen Cheng, Mahmoud Al-Kofahi, J Steven Leeder, Jacob T Brown
Atomoxetine (ATX) is a non-stimulant used to treat attention-deficit/hyperactivity disorder (ADHD) and systemic exposure is highly variable due to polymorphic cytochrome P450 2D6 (CYP2D6) activity. The objective of this study was to characterize the time course of ATX and metabolites (4-hydroxyatomoxetine (4-OH); N-desmethylatomoxetine (NDA); and 2-carboxymethylatomoxetine (2-COOH)) exposure following oral ATX dosing in children with ADHD to support individualized dosing. A nonlinear mixed-effect modeling approach was used to analyze ATX, 4-OH, and NDA plasma and urine, and 2-COOH urine profiles obtained over 24-72 hours from children with ADHD (n = 23) following a single oral ATX dose...
December 20, 2023: Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38084080/cardiovascular-safety-of-atomoxetine-and-methylphenidate-in-patients-with-attention-deficit-hyperactivity-disorder-in-japan-a-self-controlled-case-series-study
#17
JOURNAL ARTICLE
Yunlong Zheng, Toshiki Fukasawa, Fumitaka Yamaguchi, Masato Takeuchi, Koji Kawakami
OBJECTIVE: To investigate the association between atomoxetine or methylphenidate use and arrhythmia, heart failure (HF), stroke, and myocardial infarction (MI) in attention-deficit/hyperactivity disorder (ADHD) patients mainly focused on the people of working age. METHODS: In a self-controlled case series study using a Japanese claims database, we identified events of arrhythmia, HF, stroke, and MI among 15,472 atomoxetine new users and 12,059 methylphenidate new users...
February 2024: Journal of Attention Disorders
https://read.qxmd.com/read/38057838/nano-level-assay-of-attention-deficit-hyperactivity-disorder-medicament-atomoxetine-by-molecular-size-based-resonance-rayleigh-scattering-strategy-employment-in-content-uniformity-dosage-form-and-plasma-analysis
#18
JOURNAL ARTICLE
Ahmed A Abu-Hassan
The psychoanaleptic medication atomoxetine (ATX) is prescribed to cure attention-deficit hyperactivity syndrome. ATX works by selective prevention of norepinephrine reuptake. It acts by raising the brain's natural level of norepinephrine, which is necessary for behavior regulation. In this study, a sensitive and practical experimental method was employed to analyze the presence of ATX. The approach utilized a green chemistry-compatible technique, known as a one-pot experiment. The main principle behind this method was the use of molecular-size-dependant resonance Rayleigh scattering (RRS) phenomenon, which occurred due to the interaction between the dual complex of Cilefa Pink B and ATX...
December 6, 2023: BMC chemistry
https://read.qxmd.com/read/38052746/dopaminergic-modulation-of-sensitivity-to-immediate-and-delayed-punishment-during-decision-making
#19
JOURNAL ARTICLE
Grace L Minnes, Anna J Wiener, Anna E Liley, Nicholas W Simon
Effective decision-making involves careful consideration of all rewarding and aversive outcomes. Importantly, negative outcomes often occur later in time, leading to underestimation, or "discounting," of these consequences. Despite the frequent occurrence of delayed outcomes, little is known about the neurobiology underlying sensitivity to delayed punishment during decision-making. The Delayed Punishment Decision-making Task (DPDT) addresses this by assessing sensitivity to delayed versus immediate punishment in rats...
December 5, 2023: Cognitive, Affective & Behavioral Neuroscience
https://read.qxmd.com/read/38044665/treatment-with-psychostimulants-and-atomoxetine-in-people-with-psychotic-disorders-reassessing-the-risk-of-clinical-deterioration-in-a-real-world-setting
#20
JOURNAL ARTICLE
Olivier Corbeil, Sébastien Brodeur, Josiane Courteau, Laurent Béchard, Maxime Huot-Lavoie, Elaine Angelopoulos, Samanta Di Stefano, Erica Marrone, Alain Vanasse, Marie-Josée Fleury, Emmanuel Stip, Alain Lesage, Ridha Joober, Marie-France Demers, Marc-André Roy
BACKGROUND: Although attention-deficit hyperactivity disorder (ADHD) is often comorbid with schizophrenia spectrum and other psychotic disorders (SZSPD), concerns about an increased risk of psychotic events have limited its treatment with either psychostimulants or atomoxetine. AIMS: To examine whether the risk of hospital admission for psychosis in people with SZSPD was increased during the year following the introduction of such medications compared with the year before...
March 2024: British Journal of Psychiatry
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