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Drug Delivery Application

Vigneswaran Narayanamurthy, Fahmi Samsuri, Al'aina Yuhainis Firus Khan, Hairul Aini Hamzah, Madia Baizura Baharom, Kumary Tv, Anil Kumar Pr, Deepa K Raj
Cell imprint lithography (CIL) or cell replica plays a vital role in the fields like biomimetic smart culture substrates, bone tissue engineering, cell guiding, cell adhesion, tissue engineering, cell microenvironment, tissue microenvironment, cell research, drug delivery, diagnostic, therapeutic and many other applications. Herein we report a new formulation of superconductive carbon black photopolymer composite and its characterization towards cell imprint lithography (CIL) process technique. In this article, demonstrated an approach of carbon nanoparticle-polymer composite (CPC) for patterning cells...
March 21, 2019: Bioinspiration & Biomimetics
Wendong Liu, Jiarul Midya, Michael Kappl, Hans-Jürgen Butt, Arash Nikoubashman
When a colloidal suspension droplet evaporates from a solid surface, it leaves a characteristic deposit in the contact region. These deposits are common and important for many applications in printing, coating, or washing. By using superamphiphobic surfaces as a substrate, the contact area can be reduced so that evaporation is almost radially symmetric. While drying, the droplets maintain a nearly perfect spherical shape. Here, we exploit this phenomenon to fabricate supraparticles from bidisperse colloidal aqueous suspensions...
March 21, 2019: ACS Nano
Sanjiv Sharma, Olivia Howells, Natasha Rajendran, Sarah Mcintyre, Sara Amini-Asl, Pauline Henri, Yufei Liu, Owen Guy, Anthony E G Cass, May C Morris
Theranostics involves finding the biomarkers of a disease, fighting them through site specific drug delivery and following them for prognosis of the disease. Microneedle array technology has been used for drug delivery and extended for continuous monitoring of analytes present in the skin compartment. We envisage the use of microneedle arrays for future theranostic applications. The potential of using combined microneedle array-based drug delivery and diagnostics as part of closed-loop control system for the management of diseases and delivery of precision drugs in individual patients, is reported in this paper...
March 21, 2019: Chembiochem: a European Journal of Chemical Biology
Jessica Mendes Nadal, Guilherme Dos Anjos Camargo, Andressa Novatski, William Roger Macenhan, Daniele Toniolo Dias, Fernanda Malaquias Barboza, Amanda Lyra, João Ricardo Roik, Josiane Padilha de Paula, Aloisi Somer, Paulo Vitor Farago
Adapalene (ADAP) is an important drug widely used in the topical treatment of acne. It is a third-generation retinoid and provides keratolytic, anti-inflammatory, and antiseborrhoic action. However, some topical adverse effects such as erythema, dryness, and scaling have been reported with its commercial formula. In this sense, the microencapsulation of this drug using polyesters can circumvent its topical side effects and can lead to the enhancement of drug delivery into sebaceous glands. The goal of this work was to obtain ADAP-loaded poly(ε-caprolactone) (PCL) microparticles prepared by a simple emulsion/solvent evaporation method...
2019: PloS One
Marianna Mamusa, Paolo Tempesti, Arianna Bartolini, Emiliano Carretti, Ahmad F Ghobadi, Johan Smets, Yousef G Aouad, Piero Baglioni
The self-assembly of amphiphilic graft copolymers is generally reported for polymer melts or polymers deposited onto surfaces, while a small number of cases deal with binary mixtures with water. We report on the associative properties of poly(ethylene glycol)-graft-poly(vinyl acetate) (PEG-g-PVAc) comb-like copolymers in water, demonstrating the existence of a percolative behaviour when increasing the PEG-g-PVAc content. Rheology, light- and small-angle X-ray scattering experiments, together with dissipative particle dynamics simulations, reveal a progressive transition from spherical polymer single-chain nanoparticles (SCNPs) towards hierarchically complex structures as the weight fraction of the polymer in water increases...
March 21, 2019: Nanoscale
Qianni Wu, Dong Liu, Xulin Zhang, Dongni Wang, Meimei DongYe, Wan Chen, Duoru Lin, Fangming Zhu, Weirong Chen, Haotian Lin
Tacrolimus has been widely applied to prevent organ rejection after transplantation. However, the conventional pharmaceutical formulation of tacrolimus limits its applications in ocular therapy due to its hydrophobicity and low corneal penetrability. We optimized tacrolimus-loaded methoxy poly (ethylene glycol-block-poly (d, l)-lactic-co-glycolic acid) nanoparticles (TAC-NPs) by simple and effective nanotechnology as a drug delivery system for corneal graft rejection to overcome these drawbacks. The prepared TAC-NPs were 82...
December 2019: Drug Delivery
Antonio J Flichy-Fernández, Juan A Blaya-Tárraga, Francisco O'Valle, Miguel Padial-Molina, Miguel Peñarrocha-Diago, Pablo Galindo-Moreno
BACKGROUND: Poly (lactic-co-glycolic acid) (PLGA) is widely used for the development of delivery systems for drugs and therapeutic biomolecules in tissue engineering applications. Particles of biphasic calcium phosphate can be covered by PLGA to change their manipulating characteristics. PURPOSE: Aim of this study was to investigate the radiological and histomorphometric results of the use of PLGA-coated biphasic calcium phosphate granules in sinus floor elevation and to analyze the underlying molecular processes by immunohistochemical staining...
March 20, 2019: Clinical Implant Dentistry and related Research
Le Hong, Shu-Han Luo, Chen-Hao Yu, Yu Xie, Meng-Ying Xia, Ge-Yun Chen, Qiang Peng
In the past decades, nanomaterials have shown great potentials in biomedical fields, especially in drug delivery, imaging and targeted therapy. Recently, the development of novel functional nanomaterials for antibacterial application has attracted much attention. Compared to the traditional direct use of antibiotics, antibacterial nanomaterials either as drug delivery systems or active agents have a higher efficacy and lower side effects. Herein, we will focus on the antibacterial applications of four commonly used nanomaterials, including metal-based nanomaterials, polymeric nanoparticles, graphene oxides or carbon-based nanomaterials and nanogels...
March 20, 2019: Pharmaceutical Nanotechnology
Chenyu Wang, Bozhong Lin, Haopeng Zhu, Fei Bi, Shanshan Xiao, Liyan Wang, Guangqing Gai, Li Zhao
Glucose-sensitive drug platforms are highly attractive in the field of self-regulated drug delivery. Drug carriers based on boronic acid (BA), especially phenylboronic acid (PBA), have been designed for glucose-sensitive self-regulated insulin delivery. The PBA-functionalized gels have attracted more interest in recent years. The cross-linked three-dimensional (3D) structure endows the glucose-sensitive gels with great physicochemical properties. The PBA-based platforms with cross-linked structures have found promising applications in self-regulated drug delivery systems...
March 19, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Phuong Tran, Yong-Chul Pyo, Dong-Hyun Kim, Sang-Eun Lee, Jin-Ki Kim, Jeong-Sook Park
Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic drugs (monoclonal antibodies) and small molecule drugs (nonbiologic anticancer drugs) based on effectiveness and safety profile. Biologic drugs are administered by intravenous (IV) injection due to their large molecular weight, while small molecule drugs are preferentially administered by gastrointestinal route. Even though IV injection is the fastest route of administration and ensures complete bioavailability, this route of administration causes patient inconvenience to visit a hospital for anticancer treatments...
March 19, 2019: Pharmaceutics
Marta Kutwin, Ewa Sawosz, Sławomir Jaworski, Mateusz Wierzbicki, Barbara Strojny, Marta Grodzik, Malwina Ewa Sosnowska, Maciej Trzaskowski, André Chwalibog
Inefficient drug administration into cancer cells is related to the chemoresistance of cancer cells caused by genetic mutations including genes involved in drug transport, enzyme metabolism, and/or DNA damage repair. The objective of the present study was to evaluate the properties of platinum (NP-Pt), graphene oxide (GO), and the nanocomplex of GO functionalized with platinum nanoparticles (GO-NP-Pt) against several genetically, phenotypically, and metabolically different cancer cell lines: Colo205, HT-29, HTC-116, SW480, HepG2, MCF-7, LNCaP, and Hela B...
March 19, 2019: Materials
Andreea Aprodu, Julia Mantaj, Bahijja Raimi-Abraham, Driton Vllasaliu
Biologics have changed the management of Inflammatory Bowel Disease (IBD), but there are concerns regarding unexpected systemic toxicity and loss of therapeutic response following administration by injection. Local delivery of biologics directly to the inflamed mucosa via rectal enema administration addresses the problems associated with systemic administration. Hydrogels are potentially useful delivery vehicles enabling rectal administration of biologics. Here, we prepared a hydrogel system based on methylcellulose (MC) and hyaluronic acid (HA), which possesses mucosal healing properties, incorporating a model macromolecular drug, namely (fluorescently-labeled) bovine serum albumin (BSA)...
March 19, 2019: Pharmaceutics
H L Shen, W Zhao, W L Zhu, S P Zhong, W Y Zhu
Objective: To investigate the value of dynamic monitoring of cervical canal length by transperineal ultrasonography in the decision-making of the timing of delivery in patients with complete placenta previa, then to provide clinical guidance for complete termination of placenta. Methods: A total of 130 patients with complete placenta previa from 28 weeks to 30 weeks of gestation between January 2014 and October 2017 in Jiaxing Maternal and Child Health Hospital were selected. There were 66 patients in the experimental group and 64 in the control group, closely monitor the patient's vital signs, abdominal pain, abdominal distension, vaginal bleeding and fetal intrauterine conditions...
March 19, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
S Shanmugasundar, N Kannan, E Sundaravadivel, Sarang Zsolt, K S Mukunthan, J Manokaran, J Narendranath, V P Kamalakannan, P Kavitha, V Prabhu, N Balasubramanian
BACKGROUND: The application of polymeric materials in medical industry has grown drastically in the last two decades due to their various advantages compared to existing materials. The present research work emphases on the sol-gel technique to formulate the polymethyl methyl acrylate/polystyrene/silica composite membrane. METHODS: The characteristic of the composite was investigated through modern state art of instrumentation. RESULTS: The functional groups attached to the polymer was absorbed by FTIR...
2019: PloS One
Huanhuan Feng, Tingting Zheng, Mingyu Li, Junwei Wu, Hongjun Ji, Jiaheng Zhang, Weiwei Zhao, Jinhong Guo
Microfluidics gets very impressive advance and many progresses in past decades due to its unique and instinctive advantages. Droplet-based microfluidic systems show excellent compatibility with many chemical and biological reagents and capable of performing variety operations that can implement micro-reactor, complex multiple core-shell structure and many applications in biomedical research such as drug encapsulation, targeted drug delivery systems and multi-functionalization on carriers. Droplet-based systems have been directly used to synthesize particles and encapsulate many biological entities for biomedicine applications due to its powerful encapsulation capability and facile versatility...
March 20, 2019: Electrophoresis
Li-Juan Han, Fa-Yuan Ge, Guo-Hao Sun, Xiang-Jing Gao, He-Gen Zheng
Metal-organic frameworks (MOFs) are an exciting class of porous crystallized materials, which have attracted great interest in sustainable energy and environmental remediation. Magnetite (Fe3O4) is one of the best-known magnetic materials and has been extensively studied with respect to properties involving high saturation magnetization, biocompatibility and low toxicity. The combination of MOFs and Fe3O4 has shown its potential applications in drug delivery, catalysis and wastewater treatment. However, only classical porous MOFs are used to encapsulate magnetic nanoparticles, such as MIL-100(Fe), ZIF-8, UiO-66 and so on...
March 20, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Fangfang Fan, Yuan Zhao, Zexing Cao
Naphthalimide derivatives are types of small-molecule anticancer drug candidates; however, their negative factors and potential side effects make their application limited. The pharmacophores select a direct access into the tumor cells as the first choice; this can reduce the side effect of the anti-cancer drugs on the normal cells. Herein, the delivery and binding of the naphthalimide-polyamine complex assisted by the bovine serum albumin (BSA) protein have been studied by combining several molecular dynamic simulations...
March 20, 2019: Physical Chemistry Chemical Physics: PCCP
Daniel Debroy, Jing Liu, Katie Li-Oakey, John Oakey
Hydrogels have been engineered for a variety of biomedical applications including biosensing, drug delivery, cell delivery, and tissue engineering. The fabrication of hydrogels into nanoscale and microscale particles has been a subject of intense activity and promises to extend their range of applicability. As hydrogels are reduced in size, their interfacial properties represent an increasingly significant contribution to their function and behavior. Hydrogel microparticle-based biosensing and drug delivery platforms, for instance, require delicate spatial control over the conjugation of biofunctional groups and network architecture, which impacts their mechanical properties and molecular permeability and diffusivity...
March 15, 2019: IEEE Transactions on Nanobioscience
Christina M Ambrosi, Gouri Sadananda, Julie L Han, Emilia Entcheva
Adeno-associated viruses (AAVs) provide advantages in long-term, cardiac-specific gene expression. However, AAV serotype specificity data is lacking in experimental models relevant to cardiac electrophysiology and cardiac optogenetics. We aimed to identify the optimal AAV serotype (1, 6, or 9) in pursuit of scalable rodent and human models using genetic modifications in cardiac electrophysiology and optogenetics, in particular, as well as to elucidate the mechanism of virus uptake. In vitro syncytia of primary neonatal rat ventricular cardiomyocytes (NRVMs) and human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were infected with AAVs 1, 6, and 9 containing the transgene for eGFP or channelrhodopsin-2 (ChR2) fused to mCherry...
2019: Frontiers in Physiology
Kar En Wong, Siew Ching Ngai, Kok-Gan Chan, Learn-Han Lee, Bey-Hing Goh, Lay-Hong Chuah
Colorectal cancer (CRC) is the third most prevalent form of cancer, after lung cancer and breast cancer, with the second highest death incidence. Over the years, natural compounds have been explored as an alternative to conventional cancer therapies such as surgery, radiotherapy, and chemotherapy. Curcumin, an active constituent of turmeric has been associated with various health benefits. It has gained much attention as an anticancer agent due to its ability to regulate multiple cell signaling pathways, including NF-κB, STAT3, activated protein-1 (AP-1), epidermal growth response-1 (Egr-1), and p53, which are crucial in cancer development and progression...
2019: Frontiers in Pharmacology
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