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carcinoma of bile duct

Dong Kyun Kim, Bo Ra Kim, Jin Sook Jeong, Yang Hyun Baek
BACKGROUND: Intrahepatic sarcomatoid chonalgiocarcinoma (s-CCC) is an extremely rare disease, accounting for less than 1% of hepatobiliary system malignancies, and its pathophysiology is not well known. On the hypothesis that its clinical, serologic, or radiologic diagnosis are not fully understood and its prognosis is poor, we investigated the distinguishing features of s-CCC compared with those of intrahepatic bile duct adenocarcinoma [cholangiocellular carcinoma (CCC)] in patients from a single center...
February 7, 2019: World Journal of Gastroenterology: WJG
Fady M Kaldas, Islam M Korayem, Tara A Russell, Vatche G Agopian, Antony Aziz, Joseph DiNorcia, Douglas G Farmer, Hasan Yersiz, Jonathan R Hiatt, Ronald W Busuttil
Importance: Anastomotic biliary complications (ABCs) constitute the most common technical complications in liver transplant (LT). Given the ever-increasing acuity of LT, identification of factors contributing to ABCs is essential to minimize morbidity and optimize outcomes. A detailed analysis in a patient population undergoing high-acuity LT is lacking. Objective: To evaluate the rate of, risk factors for, and outcomes of ABCs and acuity level in LT recipients...
February 13, 2019: JAMA Surgery
Eva-Marie Warnken, Michael Uder, Hubert Stein, Michael Wucherer, Michael Lell, Herbert Muschweck, Ralf Adamus
PURPOSE:  The goal of this study was to evaluate the experience of 11 years of wire-guided forceps biopsy via PTCD in patients with obstructive jaundice. MATERIALS AND METHODS:  In a retrospective approach, 56 biopsies in 51 patients were analyzed (22 female, 29 male). Data was collected from 2006 to 2016. Mean age was 71 years (range: 34 - 86 years). Data was extracted from dig. Patients' records (KIS, PACS, RIS) to be analyzed in Microsoft Excel. RESULTS:  All 56 procedures were technically successful...
February 2019: Zeitschrift Für Gastroenterologie
Stefan Fritz, Regina Küper-Steffen, Katharina Feilhauer, Christof M Sommer, Götz M Richter, Alexander Bosse, René Hennig, Jörg Köninger
BACKGROUND: Intraductal tubular papillary neoplasm (ITPN) displays a very rare subtype of epithelial neoplasms of the pancreas. ITPN is characterized by intraductal tubulopapillary growth and cellular dysplasia. In contrast to intraductal papillary neoplasm (IPMN) no overt epithelial mucin production is observed. To date, little is known about ITPN and particularly about pancreatic cancer arising in this tumor entity. CASE PRESENTATION: A 68-year-old male presented at our hospital with a distal bile duct occlusion suspicious for adenocarcinoma of the pancreatic head...
February 5, 2019: International Journal of Surgery Case Reports
Boxuan Li, Ke Pu, Xinan Wu
Hepatocellular carcinoma (HCC) is a highly malignant tumor found in the bile duct epithelial cells, and the second most common tumor of the liver. However, the pivotal roles of most molecules of tumorigenesis in HCC are still unclear. Hence, it is essential to detect the tumorigenic mechanism and develop novel prognostic biomarkers for clinical application. The data of HCC mRNA-seq and clinical information from The Cancer Genome Atlas (TCGA) database were analyzed by weighted gene co-expression network analysis (WGCNA)...
February 11, 2019: Journal of Cellular Biochemistry
David Stillström, Marie Beermann, Jennie Engstrand, Jacob Freedman, Henrik Nilsson
Introduction: Thermal ablation of liver tumours is an established technique used in selected patients with relatively small tumours that can be ablated with margin. Thermal ablation methods are not advisable near larger bile ducts that are sensitive to thermal injury causing strictures and severe morbidity. Irreversible electroporation (IRE) has the possibility to treat these tumours without harming the bile tree. The method is relatively new and has been proven to be feasible and safe with promising oncological results...
2019: European Journal of Radiology Open
Chiara Sartor, Laura Bachelot, Cécile Godard, Franck Lager, Gilles Renault, Frank J Gonzalez, Christine Perret, Angélique Gougelet, Sabine Colnot
BACKGROUND/AIMS: Loss of hepatocyte nuclear factor-4α (HNF4α), a critical factor driving liver development and differentiation, is frequently associated with hepatocellular carcinoma (HCC). Our recent data revealed that HNF4α level was decreased in mouse and human HCCs with activated β-catenin signaling. In addition, increasing HNF4α level by miR-34a inhibition slowed tumor progression of β-catenin activated HCC in mice. METHODS: We generated a Hnf4aflox/flox/ Apcflox/flox /TTR-CreERT 2 (Hnf4a/Apc∆Hep ) mouse line and evaluated the impact of Hnf4a disruption on HCC development and liver homeostasis...
February 5, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
Pierleone Lucatelli, Renato Argirò, Gianluca De Rubeis, Bianca Rocco, Stefano Ginanni Corradini, Mario Corona, Pier Giorgio Nardis, Luca Saba, Gianluca Mennini, Francesco Fiorentino, Alessandro Corsi, Carlo Catalano, Mario Bezzi
PURPOSE: To report clinical effectiveness, toxicity profile, and prognostic factors of combined 100 μm ± 25 and 200 μm ± 50 epirubicin-loaded polyethylene glycol (PEG) microsphere drug-eluting embolic transcatheter arterial chemoembolization protocol in patients with hepatocellular carcinoma. MATERIALS AND METHODS: In this prospective, single-center, single-arm study with 18 months of follow-up, 36 consecutive patients (mean age 69.9 y ± 10.8; 26 men, 10 women; 54 naïve lesions) were treated...
January 31, 2019: Journal of Vascular and Interventional Radiology: JVIR
Norihide Yoneda, Osamu Matsui, Satoshi Kobayashi, Azusa Kitao, Kazuto Kozaka, Dai Inoue, Kotaro Yoshida, Tetsuya Minami, Wataru Koda, Toshifumi Gabata
Hepatocellular carcinoma (HCC) is heterogeneous in terms of its biological nature. Various factors related to its biological nature, including size, multifocality, macroscopic morphology, grade of differentiation, macro/microvascular invasion, bile duct invasion, intra-tumoral fat and molecular factors, and their value as prognostic imaging biomarkers have been reported. And recently, genome-based molecular HCC classification correlated with clinical outcome has been elucidated. The imaging biomarkers suggesting a less aggressive nature of HCC are smaller size, solitary tumor, smooth margin suggesting small nodular type with indistinct margin and simple nodular type with distinct margin, capsule, imaging biomarkers predicting early or well-differentiated grade, intra-tumoral fat detection, and low fluorodeoxyglucose (FDG) accumulation...
February 2, 2019: Japanese Journal of Radiology
Yang Xiao, Juan Zhao, Hong Wu, Kun-Lin Xie, Ying Wan, Xue-Wen Xu, Yan-Ge Zhang
BACKGROUND: Biliary papillomatosis (BP) is a rare disease characterized by multiple papillary adenomas in the intrahepatic and extrahepatic biliary tree and has a high risk of malignant transformation. Early diagnosis and treatment for BP are challenges, as it spreads along the biliary tract. A radical resection with an adequate resection margin is advocated in patients with malignant BP. CASE SUMMARY: We report a case of BP with malignant transformation in a 52-year-old female patient who presented with emaciation, severe malnutrition, and a T-tube for biliary drainage that was placed for almost 2 years at the time she visited us...
January 26, 2019: World Journal of Clinical Cases
Bing-Jie Lu, Xue-Dong Cao, Nong Yuan, Ning-Ning Liu, Nisma L Azami, Ming-Yu Sun
BACKGROUND: Infiltrative adenosquamous carcinoma (ASC) of the extrahepatic bile duct is reported infrequently, which is an unusual variant of the ordinary adenocarcinoma. The simultaneous development of ASC and cystadenocarcinoma in the extrahepatic biliary tree is rare. In addition, the accurate preoperative diagnosis of concomitant carcinoma in the multiple biliary trees at an early stage is often difficult. Thus, awareness of the risk of the multiplicity of biliary tumors is perhaps the most important factor in identifying these cases...
January 26, 2019: World Journal of Clinical Cases
M-W You, S J Yun
AIM: To identify magnetic resonance imaging (MRI) features for differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (IHCC) and summarise their diagnostic accuracy. MATERIALS AND METHODS: PubMed and EMBASE were searched for studies that employed MRI features to differentiate HCC from IHCC. Overlapping descriptors used to denote the same imaging finding in different studies were subsumed under a single feature. The pooled diagnostic accuracies, including the diagnostic odds ratios (DORs) and 95% confidence intervals (CIs) of the identified features, were calculated using a bivariate random-effects model...
January 28, 2019: Clinical Radiology
F F Liu, D H Shen, H L Wang, Y T Ma, F Yuan, J Liu, L Chen, Q J Song, Y Y Zhang
Objective: To investigate the expression of immunomarkers CK7, CK20, CK17, CDX2, MUC1 and MUC2 in primary adenocarcinoma of the ampulla of Vater, to explore the role of these markers in the histopathologic subclassification of ampullary carcinoma; and to provide biologic basis for precision treatment of patients with different types of ampullary carcinoma. Methods: Forty-two cases of primary ampullary carcinoma were collected at Peking University People's Hospital, from 2012 to 2018 year. There were 22 males and 20 females...
February 8, 2019: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Akihiro Tokuhisa, Kazuhiko Sakamoto, Kenyu Nishimura, Ryoji Kamei, Yoshinori Kitamura, Tatsuhito Yamamoto, Seiichiro Ando
A 76-year-old woman with lower bile duct carcinoma underwent subtotal stomach-preserving pancreaticoduodenectomy (SSPPD)after percutaneous transhepatic biliary drainages(PTBD). Nine months after the operation, chest computed tomography revealed a mass in the subcutis of the right chest wall, which was a different lesion from that in the PTBD site. The aspiration biopsy cytology and needle biopsy indicated no malignant findings. However, the mass was growing and was suspected to be a metastasis of bile duct cancer...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Yuichiro Watanabe, Noriaki Nakamura, Takeshi Ishii, Taku Sato, Takahiro Sanada, Hiroshi Kuwabara, Narihide Goseki, Morio Koike
A 60-year-old male undergoing pelvic evisceration with D3 lymph node dissection for pR0 in 2006f or carcinoma of the rectum was diagnosed pathologically with moderately differentiated adenocarcinoma, fStage ⅡA(UICC pT3, pN0, M0). Follow-up CT revealed hypovascular liver tumors with intrahepatic bile duct dilation in the right lobe 8 years after the pelvic evisceration. We conducted right lobe hepatectomy. The resected specimens showed that the tumor extended predominantly along the right intrahepatic bile duct...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Masahiro Shiihara, Ryota Higuchi, Satoru Morita, Toru Furukawa, Takehisa Yazawa, Shuichiro Uemura, Wataru Izumo, Masakazu Yamamoto
BACKGROUND: This study aimed to demonstrate the diagnostic ability of 64-row multidetector computed tomography (64-row MDCT) for longitudinal superficial extension of distal cholangiocarcinoma (LSEDC). METHODS: Twenty-seven patients with distal cholangiocarcinoma (DC) underwent preoperative 64-row MDCT without drainage tubes. LSEDC was diagnosed using curved planar reconstruction images reconstructed from 64-row MDCT, which were compared with pathologic findings...
March 2019: Journal of Surgical Research
Daisuke Uehara, Hitoshi Takagi, Takashi Hoshino, Yuhei Suzuki, Satoshi Takakusagi, Kyoko Maruhashi, Kazuko Kizawa, Takashi Kosone, Atsushi Naganuma, Etsuko Hisanaga, Junko Hirato, Satoru Kakizaki, Toshio Uraoka
The patient was an 86-year-old man who was admitted with obstructive jaundice. Computed tomography revealed a tumor in the hilar choledochus with peripheral hepatic duct dilatation. Endoscopic cholangiography (ERC) demonstrated the defect in the choledochus. Brushing cytology during ERC showed Orange-G-philic keratinized atypical cells, which led to a diagnosis of squamous cell carcinoma. Chemotherapy with tegafur-gimeracil-oteracil potassium was ineffective and was discontinued due to adverse effects. The patient died 5 months after the diagnosis and autopsy revealed tubular adenocarcinoma of the hilar bile duct with squamous cell carcinoma component...
September 2018: Case Reports in Gastroenterology
Ahmad F Soliman, Mahmoud M Abouelkhair, Maha S Hasab Allah, Nabil M El-Kady, Wafaa M Ezzat, Haitham A Gabr, Ehab H Elsayed, Ahmed I Saleh, Amira Kamel
Background and aim: Imaging guided microwave ablation (MWA) for hepatocellular carcinoma (HCC) has become a widely used method over recent years. Tumors close to the diaphragm, gastrointestinal tract, gallbladder, pancreas, hepatic hilum and major bile duct or vessels are generally considered relative contraindications for microwave ablation. This study was conducted to assess the effectiveness and safety of ultrasonography-guided MWA in treating patients with HCC in difficult anatomical sites in comparison to those in conventional sites...
January 25, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Hideki Iwamoto, Mika Nomiyama, Takashi Niizeki, Shigeo Shimose, Tomotake Shirono, Masahito Nakano, Manabu Satani, Syusuke Okamura, Yu Noda, Naoki Kamachi, Miwa Sakai, Hiroyuki Suzuki, Ryoko Kuromatsu, Etsuyo Ogo, Toshi Abe, Masatoshi Tanaka, Hironori Koga, Takuji Torimura
AIM: Prognosis of hepatocellular carcinoma (HCC) with macrovascular invasion (MVI) is extremely poor. However, proper therapeutic strategies have not been established yet. The purpose of this study is to identify the effects of external beam radiation therapy (EBRT) for MVI of HCC. METHODS: We have analyzed and evaluated 80 consecutive patients with HCC with MVI who underwent EBRT, and factors associated with enhanced survival in EBRT were evaluated by univariate and multivariate analysis...
January 16, 2019: Oncology
Ji Young Park, Tae Joo Jeon
Primary neuroendocrine tumors originating from the extrahepatic bile duct are rare. Among these tumors, large cell neuroendocrine carcinomas (NECs) are extremely rare. A 59-year-old man was admitted to Sanggye Paik Hospital with jaundice that started 10 days previously. He had a history of laparoscopic cholecystectomy, which he had undergone 12 years previously due to chronic calculous cholecystitis. Laboratory data showed abnormally elevated levels of total bilirubin 15.3 mg/dL (normal 0.2-1.2 mg/dL), AST 200 IU (normal 0-40 IU), ALT 390 IU (normal 0-40 IU), and gamma-glutamyl transferase 1,288 U/L (normal 0-60 U/L)...
December 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
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