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JOURNAL ARTICLE
Jasmine Singh, Pallavi Sharma, Shivani Randev, Narinder Kaur, Pankaj Kumar, Vishal Guglani
Tuberculosis is a leading cause of mortality in children worldwide. One of the greatest challenges in its management is the difficulty of diagnosis as the manifestations are non-specific and often mimic other illnesses. Neurological infection occurs in approximately 1% of patients diagnosed with tuberculosis, and usually takes the form of tuberculous meningitis or tuberculoma. An 11-year-old girl who was diagnosed with acute disseminated encephalomyelitis, a rare immunological manifestation of tuberculosis, is presented...
April 3, 2024: Paediatrics and International Child Health
#22
JOURNAL ARTICLE
Chen Li, Lisong Dong, Yayi Wei
The attenuated phase-shift mask (Att. PSM) is proven to be a promising resolution enhancement technology (RET) to improve the imaging performance in extreme ultraviolet (EUV) lithography. However, due to the reflective nature of the mask structure, the serious shadowing effect can affect the diffraction near field of the mask intensely and further impact the lithography imaging. With the purpose of improving the contrast of lithography imaging, a novel structure of the Att. PSM, to the best of our knowledge, is proposed in this paper...
March 20, 2024: Applied Optics
#23
JOURNAL ARTICLE
Ryan Meng, Mark van Ooij, Yali Li, Yunhai Zhang, Jianxun Xie
Accumulating evidence has shown that the abnormal toxicity test (ATT) is not suitable as a quality control batch release test for biologics and vaccines. The purpose of the current study was to explore the optimal ATT experimental design for an adenoviral vector-based vaccine product to avoid false positive results following the standard test conditions stipulated in the Pharmacopoeias. ATT studies were conducted in both mice and guinea pigs based on methods in Pharmacopeias, with modifications to assess effects of dose volume and amount of virus particles (VPs)...
March 30, 2024: Regulatory Toxicology and Pharmacology: RTP
#24
Furquan Ulhaque, Syed Hifzur Rahman, Abhishek Kumar Rai, Bhushan Sunil Hadole, K S Meghashyama, K G Geekesh Kumar
INTRODUCTION: Osteoarticular tuberculosis (OATB) contributes to around 10% of extrapulmonary tuberculosis of which the spine is the most common site. Isolated involvement of ulna diaphysis is extremely rare. We present a case of unifocal tuberculous osteomyelitis of ulna diaphysis in a 3 -year-old male child and highlight its resemblance with musculoskeletal tumors and stress the importance of GeneXpert mycobacterium tuberculosis (MTB)/resistance to rifampicin (RIF) in the diagnosis of OATB...
March 2024: Journal of Orthopaedic Case Reports
#25
Amartya Gain, Ish K Dhammi, Anil K Jain, Rajesh Arora, Shivam Saurav, Aayush Bhargava
INTRODUCTION: Tuberculosis (TB) is a global public health problem, endemic to India. Osteoarticular TB uncommonly presents in the foot, navicular osteomyelitis is an extremely rare entity. CASE REPORT: We report a rare case of navicular osteomyelitis caused by TB in a 37-year-old man who presented to OPD with swelling and dull aching pain over the dorsum of his left foot. A radiograph of the foot showed a lytic lesion in the navicular bone. Further investigations in the form of aspiration cytology, cartridge-based nucleic acid amplification test, and acid-fast bacilli culture confirmed TB...
March 2024: Journal of Orthopaedic Case Reports
#26
JOURNAL ARTICLE
Huihui Chen, Huiming Shen, Jiahao Han, Pingping Wang, Danlei Song, Hongyuan Shen, Xiaoying Wei, Bingjie Yang, Jia Li
OBJECTIVE: To establish a Bama minipigs model with Non-Alcoholic Fatty Liver (NAFL) induced by a high-fat diet and investigate the application of attenuation coefficient (ATT) and ultrasound-derived fat fraction (UDFF) in the diagnosis of NAFL. METHODS: Six-month-old male Bama minipigs were randomly divided into normal control and high-fat groups (n = 3 pigs per group), and fed with a control diet and high-fat diet for 32 weeks. Weight and body length were measured every four weeks, followed by quantitative ultrasound imaging (ATT and UDFF), blood biochemical markers, and liver biopsies on the same day...
April 15, 2024: Heliyon
#27
JOURNAL ARTICLE
Atte Junnila, Laurence Mortier, Alba Arbiol, Elina Harju, Teemu Tomberg, Jouni Hirvonen, Tapani Viitala, Anssi-Pekka Karttunen, Leena Peltonen
The importance of ink rheology to the outcome of 3D printing is well recognized. However, rheological properties of printing inks containing drug nanocrystals have not been widely investigated. Therefore, the objective of this study was to establish a correlation between the composition of nanocrystal printing ink, the ink rheology, and the entire printing process. Indomethacin was used as a model poorly soluble drug to produce nanosuspensions with improved solubility properties through particle size reduction...
March 28, 2024: International Journal of Pharmaceutics
#28
JOURNAL ARTICLE
Elisa M Molanes-López, José M Ferrer, Abdias Ogobara Dougnon, Abdoul Aziz Gado, Atté Sanoussi, Nassirou Ousmane, Ramatoulaye Hamidou Lazoumar, Pilar Charle-Cuéllar
BACKGROUND: A non-randomized controlled trial, conducted from June 2018 to March 2019 in two rural communes in the health district of Mayahi in Niger, showed that including community health workers (CHWs) in the treatment of severe acute malnutrition (SAM) resulted in a better recovery rate (77.2% vs. 72.1%) compared with the standard treatment provided solely at the health centers. The present study aims to assess the cost and cost-effectiveness of the CHWs led treatment of uncomplicated SAM in children 6-59 months compared to the standard national protocol...
March 29, 2024: Human Resources for Health
#29
JOURNAL ARTICLE
Jobe Shatrov, Petra Bonacic Bartolin, Sander R Holthof, Simon Ball, Andy Williams, Andrew A Amis
BACKGROUND: There is little evidence of the biomechanical performance of medial collateral ligament (MCL) reconstructions for restoring stability to the MCL-deficient knee regarding valgus, external rotation (ER), and anteromedial rotatory instability (AMRI). HYPOTHESIS: A short isometric reconstruction will better restore stability than a longer superficial MCL (sMCL) reconstruction, and an additional deep MCL (dMCL) graft will better control ER and AMRI than single-strand reconstructions...
March 29, 2024: American Journal of Sports Medicine
#30
JOURNAL ARTICLE
Youhua Wang, Chunhong Xiao, Di Wu, Yue Li
BACKGROUND: In the context of the global aging challenge, an increasing number of middle-aged and older adults (MAOAs) are engaging in grandparenting. However, the effect of grandparenting on the mental health of caregivers has shown inconsistent findings. To effectively promote healthy aging, it is imperative to adopt a comprehensive perspective and employ a rigorous approach to further investigate the relationship between these two social phenomena. METHODS: The data from the Harmonized China Health and Retirement Longitudinal Study were analyzed, focusing on MAOAs with at least one grandchild...
April 2024: International Journal of Geriatric Psychiatry
#31
JOURNAL ARTICLE
Du Chen, Mei-Qi Yu, Qi-Jing Li, Xiang He, Fei Liu, Jie-Fei Shen
OBJECTIVES: In many prosthodontic procedures, traditional computer-aided design (CAD) is often time-consuming and lacks accuracy in shape restoration. In this study, we innovatively combined implicit template and deep learning (DL) to construct a precise neural network for personalized tooth defect restoration. METHODS: Ninety models of right maxillary central incisor (80 for training, 10 for validation) were collected. A DL model named ToothDIT was trained to establish an implicit template and a neural network capable of predicting unique identifications...
March 26, 2024: Journal of Dentistry
#32
Maulin Shah, Godhasiri Ponugoti, Santosh Raibhagkar, Nitingiri Goswami, Joyance James, Meet Jain
Tuberculous dactylitis is infrequently seen after the age of 6 years. The index and middle fingers are the most common sites. Early diagnosis is essential to eradicate the infection. Delay in diagnosis and management leads to extensive involvement which may require surgical intervention. The current literature reveals conservative management gives satisfactory results in early stages. Though surgical intervention in Tuberculous dactylitis is seldom required, delay in diagnosis and management leads to extensive involvement of the bone and sequestration which does not respond to Anti Tubercular Therapy and needs staged surgical interventions...
April 2024: Indian Journal of Orthopaedics
#33
JOURNAL ARTICLE
Himanshu Gupta, Rajesh Arora, Manish Chadha, I K Dhammi, Anil K Jain
BACKGROUND: Management outcomes of drug-resistant (DR) osteoarticular tuberculosis (OATB) is dismal as in pre-ATT era (1905). The studies documenting treatment outcome of DR-OATB are scarce; hence, present retrospective analysis was conducted to evaluate outcome of consecutive cases of DR-OATB. METHODS: 45 consecutive patients of suspected DR-OATB were treated from 2010 onwards. Tissue samples were submitted for AFB smear, cytology/histology, liquid culture, CBNAAT/LPA besides gram's staining and aerobic/anaerobic culture...
April 2024: Indian Journal of Orthopaedics
#34
JOURNAL ARTICLE
Iulia Minciuna, Madalina Taru, Andreea Fodor, Oana Nicoara Farcau, Petra Fischer, Corina Radu, Monica Lupsor-Platon, Horia Stefanescu, Bogdan Procopet
AIMS: This study assessed the effectiveness of three ultrasound-based techniques (2D-SWE.PLUS, Att.PLUS, Vi.PLUS) for non-invasive evaluation of liver fibrosis, steatosis, and inflammation in chronic liver disease (CLD) patients.Materials and methods: Involving 209 consecutive compensated CLD patients, the study compared these ultrasound methods from Aixplorerwith standard Vibration-controlled Transient Elastography (VCTE) and Controlled Attenuation Parameter (CAP) from Fibroscan, alongside non-invasive serological markers...
February 7, 2024: Medical Ultrasonography
#35
JOURNAL ARTICLE
Atte Somero, Auli Suominen, Vesa Pohjola, Mika Ogawa, Kirsi Sipilä, Niklas Kakko, Mikko Tulppo, Satu Lahti
Autonomic nervous system (ANS) activity may be associated with dental anxiety; however, no studies exist on the topic. The aim of this study was to assess if ANS activity and dental anxiety are associated. Data were collected as part of a Northern Finland Birth Cohort Study, NFBC1966, at the age of 46 years with eligible data on 1905 participants. Dental anxiety was measured using the Modified Dental Anxiety Scale (MDAS) categorized as follows: 19-25 = high, 10-18 = moderate, 5-9 = no to low dental anxiety...
March 21, 2024: Dentistry Journal
#36
JOURNAL ARTICLE
Kinga Pajdzik, Ruitu Lyu, Xiaoyang Dou, Chang Ye, Li-Sheng Zhang, Qing Dai, Chuan He
N 1 -methyl adenosine (m1 A) is a wide-spread RNA modification present in tRNA, rRNA and mRNA. m1 A modification sites in tRNAs are evolutionary conserved and its formation on tRNA is catalyzed by methyltransferase TRMT61A and TRMT6 complex. m1 A promotes translation initiation and elongation. Due to its positive charge under physiological conditions, m1 A can notably modulate RNA structure. It also blocks Watson-Crick-Franklin base pairing and causes mutation and truncation during reverse transcription. Several misincorporation-based high throughput sequencing methods have been developed to sequence m1 A...
March 26, 2024: RNA
#37
JOURNAL ARTICLE
Nikolaos Mouchtouris, Isaiah Ailes, Reid Gooch, Christian Raimondo, Yazan Shamli Oghli, Stavropoula Tjoumakaris, Pascal Jabbour, Robert Rosenwasser, Mahdi Alizadeh
Increased blood-brain barrier permeability (BBBP) after ischemic stroke predisposes patients to hemorrhagic conversion. While altered BBBP can impact patient recovery, it is not routinely assessed during the workup of acute ischemic stroke (AIS). We study the effectiveness of the non-contrast MRI sequences diffusion-prepared pseudocontinuous arterial spin labeling (DP-pCASL) and Neurite Orientation Dispersion and Density Imaging (NODDI) in assessing BBBP and correlating to tissue microstructure after ischemic insult...
March 19, 2024: Magnetic Resonance Imaging
#38
JOURNAL ARTICLE
Olaf E M G Schijns, Daniel Delev, Marec von Lehe, Dirk van Roost, Karl Rössler, Tom Theys, Christian Auer, Thomas Blauwblomme, Marcelo Budke, Alexandre Rainha Campos, Santiago Candela Canto, Hans Clusmann, Christian Dorfer, Georg Dorfmüller, Arild Egge, Lorand Eröss, Sarah Ferrand-Sorbets, Flavio Giordano, Jürgen Honegger, Cihan Isler, Jugoslav Ivanovic, Thilo Kalbhenn, Atte Karppinen, Niklaus Krayenbühl, Rick H G J van Lanen, Carlo E Marras, Ioannis Mavridis, Daniel Nilsson, Julia Onken, Christian Raftopoulos, Jonathan Roth, Jordi Rumia, Thomas Sauvigny, Didier Scavarda, Karl Schaller, Christian Scheiwe, Sophie Schuind, Alexandra Seromenho-Santos, Kostas Fountas
INTRODUCTION: The surgical procedure for severe, drug-resistant, unilateral hemispheric epilepsy is challenging. Over the last decades the surgical landscape for hemispheric disconnection procedures changed from anatomical hemispherectomy to functional hemispherotomy with a reduction of complications and stable good seizure outcome. Here, a task force of European epilepsy surgeons prepared, on behalf of the EANS Section for Functional Neurosurgery, a consensus statement on different aspects of the hemispheric disconnection procedure...
2024: Brain Spine
#39
JOURNAL ARTICLE
Citra Cesilia, Harry Galuh Nugraha, Safendra Siregar, Heda Melinda Nataprawira
BACKGROUND: Genitourinary tuberculosis (GUTB) is a common form of extrapulmonary TB (EPTB) in children. An example of GUTB is epididymal TB, which usually presents unspecific chronic clinical manifestations. Definitive diagnosis can be conducted based on bacteriologic confirmation and histopathologic results, but this is challenging due to the paucibacillary nature of EPTB. Therefore, we reported the challenges in diagnosing isolated epididymal TB in an adolescent male. CASE PRESENTATION: A 16-year-old male presented to respirology clinic with painful swelling of the left scrotum for 3 months before visiting to the hospital...
March 19, 2024: BMC Urology
#40
JOURNAL ARTICLE
Hemant K Mishra
ELISpot (enzyme-linked immunospot) is a powerful immunological tool for the detection of cytokine-secreting cells at a single-cell resolution. It is widely used for the diagnosis of various infectious diseases, e.g., tuberculosis and sarcoidosis, and it is also widely used in cancer immunotherapy research. Its ability to distinguish between active and latent forms of tuberculosis makes it an extremely powerful tool for epidemiological studies and contact tracing. In addition to that, it is a very useful tool for the research and development of cancer immunotherapies...
2024: Methods in Molecular Biology
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