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JOURNAL ARTICLE
Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A DiCorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, JoAnn E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S de Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs
OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18...
April 23, 2024: Diabetes Care
#2
JOURNAL ARTICLE
Yuzhu Zhu, Dong Wang, Shaobo Zhou, Tao Zhou
Aiming to provide a basis for the application of Gynura divaricata (L.) DC polysaccharide (GDP) in functional foods, the hypoglycemic effects of GDP, and action mechanisms, were investigated. Results showed that GDP effectively inhibited α-glucosidase and remarkably increased the glucose absorption, glycogen content, and pyruvate kinase and hexokinase activities of insulin-resistant HepG2 cells, indicating its potent in vitro hypoglycemic effect. In streptozotocin-induced type 2 diabetes mice, GDP significantly improved various glycolipid metabolism-related indices in serum and liver, e...
April 23, 2024: Journal of Agricultural and Food Chemistry
#3
Leo Meller, Vasan Jagadeesh, Katherine Wilson, Michael C Oca, Timothy Sestak, Nathan Scott
Cytomegalovirus (CMV) retinitis is commonly associated with immunosuppression and can cause irreversible vision loss. Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as an effective cancer treatment option but requires immunosuppression, thereby increasing the possibility of acquiring opportunistic infections such as CMV. We present the case of a 76-year-old female with a history of hypertension and type 2 diabetes mellitus who initially presented with shortness of breath and was diagnosed with the activated B-cell subset of diffuse large B-cell lymphoma (DLBCL)...
March 2024: Curēus
#4
JOURNAL ARTICLE
Lina Chang, Xiaohui Ma, Menghua Yuan, Li Ding, Yian Gu, Lili Liu, Yan Li, Hua Shu, Ming Liu, Qing He
PURPOSE: Understanding factors that influence blood glucose levels in patients with type 2 diabetes mellitus (T2DM) is crucial for managing hyperglycemia. Currently, there is no standardized interpretation method for glucagon levels in oral glucose tolerance test (OGTT). This study aims to assess the relationship between the lowest glucagon/highest C-peptide ratio (Lglc/Hcp) in OGTT and glucose control levels in T2DM. PATIENTS AND METHODS: Clinical data from 120 patients with T2DM were examined to compare the correlations of Lglc/Hcp and other pancreatic islet function-associated indices with fasting blood glucose (G0), glucose at 120 minutes in OGTT (G120), hemoglobin A1c (HbA1c), and the area under the glucose curve in OGTT (AUCglu)...
2024: Diabetes, Metabolic Syndrome and Obesity
#5
JOURNAL ARTICLE
Yuhan Qin, Yong Qiao, Gaoliang Yan, Dong Wang, Chengchun Tang
BACKGROUND: Insulin resistance (IR) is a pivotal pathogenesis characteristic of type 2 diabetes mellitus (T2DM). The current study aimed to explore the association between triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-c), triglyceride-glucose (TyG), and triglyceride glucose-body mass index (TyG-BMI), and T2DM incidence. METHODS: A total of 116,855 Chinese adults aged over 20 without diabetes were included. Multivariate Cox regression analysis and restricted cubic spine were utilized to investigate the association between IR indicators and T2DM...
April 20, 2024: Endocrine
#6
JOURNAL ARTICLE
Hannah C Coulson, Miriam Brown, Kyle Burke, Emma Griffith, Victoria Shadiack, Harold R Garner, Jaime A Foushee
CONTEXT: Clinical clerkships provide osteopathic medical students the opportunity to participate in the diagnosis and treatment of commonly encountered medical conditions. Appropriate management of these conditions may include pharmacotherapy and/or nonpharmacologic interventions, such as osteopathic manipulative treatment (OMT). Opportunities may exist to expand the utilization of OMT in the management of common conditions, particularly for geriatric patients, who are at increased risk for adverse outcomes from pharmacologic treatments...
April 22, 2024: Journal of osteopathic medicine
#7
JOURNAL ARTICLE
Xin Xiao, Lie Zhang, Mingjie Ni, Xi Liu, Liyun Xing, Licheng Wu, Zhou Zhou, Lian Li, Jingyuan Wen, Yuan Huang
Ligand-modified nanocarriers can promote oral or inhalative administration of macromolecular drugs across the intestinal or pulmonary mucosa. However, enhancing the unidirectional transport of the nanocarriers through "apical uptake→intracellular transport→basolateral exocytosis" route remains a hot topic and challenge in current research. Forskolin is a naturally occurring diterpenoid compound extracted from the roots of C. forskohlii. In our studies, we found that forskolin could increase the transcellular transport of butyrate-modified nanoparticles by 1...
April 17, 2024: Journal of Controlled Release
#8
JOURNAL ARTICLE
Melanie B Gillingham, Martin Chase Marak, Michael C Riddell, Peter Calhoun, Robin L Gal, Susana R Patton, Peter G Jacobs, Jessica R Castle, Mark A Clements, Francis J Doyle, Michael R Rickels, Corby K Martin
BACKGROUND: The amount and type of food consumed impacts the glycemic response and insulin needs of people with type 1 diabetes mellitus (T1DM). Daily variability in consumption, reflected in diet quality, may acutely impact glycemic levels and insulin needs. OBJECTIVE: Type 1 Diabetes Exercise Initiative (T1DEXI) data were examined to evaluate the impact of daily diet quality on near-term glycemic control and interaction with exercise. METHODS: Using the Remote Food Photography Method, ≤8 d of dietary intake data were analyzed per participant...
April 2024: Current Developments in Nutrition
#9
JOURNAL ARTICLE
Kang-Su Shin, Min-Seung Park, Mi Yeon Lee, Eun Hye Cho, Hee-Yeon Woo, Hyosoon Park, Min-Jung Kwon
Glycated albumin (GA) reflects glycemic status for the past three weeks. GA level demonstrates a strong correlation with HbA1c level and is used as an adjunctive biomarker for diagnosis and monitoring of type 2 diabetes mellitus (T2DM). In this study, we validated the predictive performance of baseline GA for development of T2DM in healthy individuals in Korea. From August 2013 to September 2014, the medical records of 3,771 healthy Koreans were retrospectively reviewed. Each participant was categorized into tertiles based on initial GA level...
April 18, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
#10
JOURNAL ARTICLE
Jeffrey Neuman, Emily A Ina, Shakil O Huq, Alex Blanca, Stephanie N Petrosky
BACKGROUND: Unhealthy dietary habits, decreased physical activity, poor sleep quality, and increasing levels of stress and burnout have all been identified as major concerns of medical students. Due to the rigorous environment of medical school, maintaining a well-balanced and nutritious diet is often replaced by more convenient and nutrient-poor options. Improper dietary habits and a sedentary lifestyle both play an essential role in the development of type II diabetes, obesity, hypertension, and hyperlipidemia...
March 2024: Curēus
#11
JOURNAL ARTICLE
Srikanth Gadicherla, Kirti Manglani, Kalyana C Pentapati, Adarsh Kudva, Chithra Aramanadka, Rajaji Chandravel
OBJECTIVE: To evaluate the profile of patients operated for maxillofacial space infections and associated risk factors for the length of hospital stay. MATERIALS AND METHODS: We conducted a retrospective study among patients operated for maxillofacial infections at our center from 2010 to 2020. Information collected from the records were age, sex, type and number of spaces involved, clinical signs and symptoms (pain, swelling, toothache, sore throat, otalgia, hoarseness, headache, cough, neck swelling, rancid breath, sialorrhea, gingival swelling, muffled voice, trismus, fever, dysphagia, odynophagia, malaise, lymphadenopathy, dyspnoea, pus discharge), treatment modality, total leukocyte count, evidence of bacterial growth, comorbidities, complications if any and length of hospital stay...
2024: TheScientificWorldJournal
#12
JOURNAL ARTICLE
Mustafa Tosur, Xiaofan Huang, Audrey S Inglis, Rebecca Schneider Aguirre, Maria J Redondo
Classifying diabetes at diagnosis is crucial for disease management but increasingly difficult due to overlaps in characteristics between the commonly encountered diabetes types. We evaluated the prevalence and characteristics of youth with diabetes type that was unknown at diagnosis or was revised over time. We studied 2073 youth with new-onset diabetes (median age [IQR] = 11.4 [6.2] years; 50% male; 75% White, 21% Black, 4% other race; overall, 37% Hispanic) and compared youth with unknown versus known diabetes type, per pediatric endocrinologist diagnosis...
April 17, 2024: Scientific Reports
#13
JOURNAL ARTICLE
Liang Shu-Jie, Peng Yi-Hua, Lei Jia-Hong, Jia Ai-Min, Jiang Hong, Cai Yan
Hepatocyte nuclear factor 1α (HNF1α) is a transcription factor that is crucial for the regulation to maintain the function of pancreatic β-cell, hepatic lipid metabolism, and other processes. Mature-onset diabetes of the young type 3 is a monogenic form of diabetes caused by HNF1α mutations. Although several mutation sites have been reported, the specific mechanisms remain unclear, such hot-spot mutation as the P291fsinsC mutation and the P112L mutation and so on. In preliminary studies, we discovered one MODY3 patient carrying a mutation at the c...
March 20, 2024: Yi Chuan, Hereditas
#14
JOURNAL ARTICLE
Aybike Sena Ozuynuk-Ertugrul, Cemre Buse Kirsan, Aycan Fahri Erkan, Berkay Ekici, Evrim Komurcu-Bayrak, Neslihan Coban
BACKGROUND AND AIM: Coronary artery disease (CAD) remains a leading cause of morbidity and mortality globally despite advancements in treatment. Long non-coding RNAs (lncRNAs) play crucial roles in the atherosclerotic process, with ANRIL being one such lncRNA. This study explored the association between ANRIL polymorphisms (rs1333049:C > G, rs564398:T > C, and rs10757274:A > G) and CAD along with CAD risk factors in a Turkish patient group. METHODS: The study included 1285 participants, consisting of 736 patients diagnosed with CAD (mean age = 63...
April 16, 2024: Gene
#15
JOURNAL ARTICLE
Vaios Amountzias, Dennis Abatis, Antonios Drakopoulos, Grigoris Zoidis, Nektarios Aligiannis
A new cyclopeptide alkaloid, spinachristene A ( 1 ), along with two previously described, sanjoinenine ( 2 ) and oxyphylline C ( 3 ), were isolated from the fruits of Paliurus spina-christi Mill. All three metabolites are being isolated for the first time from the genus Paliurus . A model for the in silico binding affinity of compounds 1 - 3 to Dipeptidyl Peptidase IV (DPP4), which is related to type 2 diabetes (T2D), was developed. According to our model, compounds 1-3 were ranked in positions 9/12, 11/12 and 8/12, respectively and are predicted to exhibit significant affinity to DPP4, in the range of low 2-digit μΜ...
April 17, 2024: Natural Product Research
#16
JOURNAL ARTICLE
Ali Es-Haghi, Mozhgan Soltani, Masoud Homayouni Tabrizi, Maryam Karimi Noghondar, Nilofar Khatamian, Niloofar Barati Naeeni, Matin Kharaghani
We aimed to study the potential of epigallocatechin-3-gallate/tyrosol-loaded chitosan/lecithin nanoparticles (EGCG/tyrosol-loaded C/L NPs) in streptozotocin-induced type 2 diabetes mellitus (T2DM) mice. The EGCG/tyrosol-loaded C/L NPs were created using the self-assembly method. Dynamic light scattering, Field Emission Scanning Electron Microscopy, and Fourier transform infrared spectroscopy were utilized to characterize the nanoparticle. Furthermore, in streptozotocin-induced T2DM mice, treatment with EGCG/tyrosol-loaded C/L NPs on fasting blood sugar levels, the expression of PCK1 and G6Pase, and IL-1β in the liver, liver glutathione content, nanoparticle toxicity on liver cells, and liver reactive oxygen species were measured...
April 14, 2024: International Journal of Biological Macromolecules
#17
JOURNAL ARTICLE
Xinyu Li, Louise A Donnelly, Roderick C Slieker, Joline W J Beulens, Leen M 't Hart, Petra J M Elders, Ewan R Pearson, Anoukh van Giessen, Jose Leal, Talitha Feenstra
AIMS/HYPOTHESIS: This study aimed to explore the added value of subgroups that categorise individuals with type 2 diabetes by k-means clustering for two primary care registries (the Netherlands and Scotland), inspired by Ahlqvist's novel diabetes subgroups and previously analysed by Slieker et al. METHODS: We used two Dutch and Scottish diabetes cohorts (N=3054 and 6145; median follow-up=11.2 and 12.3 years, respectively) and defined five subgroups by k-means clustering with age at baseline, BMI, HbA1c , HDL-cholesterol and C-peptide...
April 16, 2024: Diabetologia
#18
JOURNAL ARTICLE
Wei Liu, Ying Gao, Rui Zhang, Siqian Gong, Xiangqing Wang, Yanai Wang, Xiaoling Cai, Xiuying Zhang, Xiaoqi Xie, Xueyao Han, Linong Ji
PURPOSE: Multiple daily injection (MDI) insulin therapy is an effective method of glycemic control and appropriate assignment to MDI therapy could minimize the risks of hypoglycemia and weight gain. The aim of the present study was to identify factors associated with indication for MDI therapy in type 2 diabetes (T2DM). METHODS: We recruited 360 participants with T2DM that were admitted to the Endocrinology Department of Peking University People's Hospital between August 2017 and July 2018...
April 15, 2024: Endocrine
#19
JOURNAL ARTICLE
Laura M Jacobsen, David Cuthbertson, Brian N Bundy, Mark A Atkinson, Wayne Moore, Michael J Haller, William E Russell, Stephen E Gitelman, Kevan C Herold, Maria J Redondo, Emily K Sims, Diane K Wherrett, Antoinette Moran, Alberto Pugliese, Peter A Gottlieb, Jay M Sosenko, Heba M Ismail
OBJECTIVE: Mixed-meal tolerance test-stimulated area under the curve (AUC) C-peptide at 12-24 months represents the primary end point for nearly all intervention trials seeking to preserve β-cell function in recent-onset type 1 diabetes. We hypothesized that participant benefit might be detected earlier and predict outcomes at 12 months posttherapy. Such findings would support shorter trials to establish initial efficacy. RESEARCH DESIGN AND METHODS: We examined data from six Type 1 Diabetes TrialNet immunotherapy randomized controlled trials in a post hoc analysis and included additional stimulated metabolic indices beyond C-peptide AUC...
April 15, 2024: Diabetes Care
#20
JOURNAL ARTICLE
Meriem Chayah, Angélica Luque-González, Verónica Gómez-Pérez, Diego Salagre, Amjad Al-Shdaifat, Joaquín María Campos, Ana Conejo-García, Ahmad Agil
Type 2 diabetes mellitus (T2DM) is one of the world's principal metabolic diseases characterized by chronic hyperglycemia. The gut incretin hormones, glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP), which has been proposed as a new treatment for T2DM, are extensively metabolized by Dipeptidyl peptidase 4 (DPP-4). Inhibitors of DPP-4 block the degradation of GLP-1 and GIP and may increase their natural circulating levels, favoring glycemic control in T2DM. A novel and potent selective inhibitor of DPP-4 with an 8-purine derived structure ( 1 ) has been developed and tested in vitro and in vivo in Zücker obese diabetic fatty (ZDF) rats, an experimental model of the metabolic syndrome and T2DM to assess the inhibitory activity using vildagliptin as reference standard...
2024: Drug Design, Development and Therapy
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