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Type 3 C Diabetes

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https://read.qxmd.com/read/30900662/oral-health-status-and-knowledge-among-10-15years-old-type-1-diabetes-mellitus-children-and-adolescents-in-bengaluru
#1
S Geetha, M Pramila, Kittu Jain, C M Suresh
Context: Type 1 diabetes mellitus (T1DM) is a chronic systemic metabolic disease. This disorder affects mainly children and adolescents. The main complications of diabetes mellitus affect the organs and tissues rich in capillary vessels such as kidney, retina, and nerves. These complications are secondary to the development of microangiopathy. Similar changes in small vessels can be found in the oral tissues. There is a significant increase in gingival inflammation and plaque seen in children with T1DM...
January 2019: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://read.qxmd.com/read/30900413/end-of-trial-health-outcomes-in-look-ahead-participants-who-elected-to-have-bariatric-surgery
#2
Thomas A Wadden, Ariana M Chao, Judy L Bahnson, John P Bantle, Jeanne M Clark, Sarah A Gaussoin, John M Jakicic, Karen C Johnson, Gary D Miller, Jessica L Unick, Susan Z Yanovski
OBJECTIVE: This study examined end-of-trial health outcomes in participants in the Action for Health in Diabetes (Look AHEAD) trial who had bariatric surgery during the approximately 10-year randomized intervention. METHODS: Data were obtained from the Look AHEAD public access database of 4,901 individuals with type 2 diabetes and overweight/obesity who were assigned to intensive lifestyle intervention (ILI) or a diabetes support and education (DSE) control group...
April 2019: Obesity
https://read.qxmd.com/read/30900372/the-association-of-calcium-channel-blockers-with-%C3%AE-cell-function-in-type-2-diabetic-patients-a-cross-sectional-study
#3
Dong Zhao, Yu Cao, Cai-Guo Yu, Sha-Sha Yuan, Ning Zhang, Yuan-Yuan Zhang, Jan A Staessen, Ying-Mei Feng
Type 2 diabetes mellitus (T2DM) patients are often accompanied with hypertension. However, the association of antihypertensive drugs with β-cell function has not been well studied. To investigate this question, the authors performed a cross-sectional study involving 882 hypertensive T2DM patients. To assess β-cell function, patients were given 75g glucose orally and C-peptide levels before and 1, 2, and 3 hours after glucose intake were measured. Homa-β was computed by Homeostasis Model Assessment model to evaluate β-cell function using fasting C-peptide and glucose levels in the plasma...
March 22, 2019: Journal of Clinical Hypertension
https://read.qxmd.com/read/30899846/choroidal-thickness-changes-following-cataract-surgery-in-patients-with-type-2-diabetes-mellitus
#4
Hamidreza Torabi, Mohammad Sadraei, Khosrow Jadidi, Ali-Agha Alishiri
Purpose: To evaluate the choroidal thickness changes after cataract surgery in type 2 diabetic patients. Methods: Three groups of patients were enrolled into this prospective study. Group A included diabetic patients without diabetic retinopathy (DR) or with mild non-proliferative diabetic retinopathy (NPDR) who underwent phacoemulsification, Group B included non-diabetic patients with significant cataract who underwent phacoemulsification, and Group C included diabetic patients without DR or with mild NPDR who followed up without surgical procedure...
March 2019: Journal of Current Ophthalmology
https://read.qxmd.com/read/30896215/increasing-the-impact-of-behavior-change-intervention-research-is-there-a-role-for-stakeholder-engagement
#5
Molly Byrne
OBJECTIVE: There is powerful evidence that changing people's health-related behavior can impact the leading causes of mortality and morbidity. However, despite the significant potential to improve health and clinical outcomes, behavior change interventions frequently fall short of expected reach or impact. METHOD: Stakeholder engagement, which refers to the active involvement of public, patients, health professionals, and other decision makers throughout the research process, has been proposed as a strategy to improve the quality, reach, and impact of research...
April 2019: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://read.qxmd.com/read/30891858/associations-of-hba1c-with-the-timing-of-c-peptide-responses-during-the-oral-glucose-tolerance-test-at-the-diagnosis-of-type-1-diabetes
#6
Heba M Ismail, Carmella Evans-Molina, Linda A DiMeglio, Dorothy J Becker, Ingrid Libman, Emily K Sims, David Boulware, Kevan C Herold, Lisa Rafkin, Jay Skyler, Mario A Cleves, Jerry Palmer, Jay Sosenko
BACKGROUND: In new onset type 1 diabetes (T1D), overall C-peptide measures such as area under the curve (AUC) C-peptide and peak C-peptide are useful for estimating the extent of β-cell dysfunction, and for assessing responses to intervention therapy. However, measures of the timing of C-peptide responsiveness could have additional value. OBJECTIVES: We assessed the contribution of the timing of C-peptide responsiveness during oral glucose tolerance tests (OGTTs) to HbA1c variation at T1D diagnosis...
March 20, 2019: Pediatric Diabetes
https://read.qxmd.com/read/30890479/a-polymorphism-rs6815464-in-the-macrophage-erythroblast-attacher-gene-is-associated-with-low-bone-mineral-density-in-postmenopausal-japanese-women
#7
Yulan Che, Noriko Sugita, Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura, Hiromasa Yoshie
BACKGROUND AND PURPOSES: Osteoporosis and osteopenia are multifactorial diseases characterized by low bone mineral density (BMD) and are susceptible to genetic and environmental risk factors. The macrophage erythroblast attacher (MAEA) was discovered as a protein to mediate the attachment of erythroid cells to macrophages and is essential for bone marrow hematopoiesis. MAEA is expressed in a wide range of cells and tissues including osteoblasts and osteoclasts. Recent studies have shown that a single nucleotide polymorphism (SNP) rs6815464 (C/G) in the MAEA gene increases the susceptibility of type 2 diabetes mellitus...
March 16, 2019: Gene
https://read.qxmd.com/read/30890475/%C3%AE%C2%B53-4-genotype-of-the-apolipoprotein-e-is-associated-with-higher-risk-of-alzheimer-s-disease-in-patients-with-type-2-diabetes-mellitus
#8
Yi Tang, Ya-Mei Li, Ming Zhang, Yan-Qiu Chen, Qin Sun
As a progressive and chronic disease, type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia with rising prevalence worldwide. The ε4 allele of the apolipoprotein E (ApoE) gene may be risk factor of severe peripheral neuropathy in T2DM patients. The association of ApoE polymorphism and Alzheimer's disease (AD) in T2DM patients remains largely unknown. Totally 156 T2DM patients with AD and 145 T2DM patients were included. The genotypes and allele frequency of ApoE were analyzed to explore the role of ApoE in AD in T2DM patients...
March 16, 2019: Gene
https://read.qxmd.com/read/30889297/%C3%AE-2-adrenoceptors-indirectly-support-impaired-%C3%AE-1-adrenoceptor-responsiveness-in-the-isolated-type-2-diabetic-rat-heart
#9
Rosalind F Cook, Carol T Bussey, Ingrid C Fomison-Nurse, Gillian Hughes, Andrew Bahn, Patricia A Cragg, Regis R Lamberts
NEW FINDINGS: What is the central question of this study? Are there specific contributions of β1 - and β2 -adrenoceptor subtypes to the impaired β-adrenoceptor responsiveness of the type 2 diabetic heart. What is the main finding and its importance? In hearts, isolated from the Zucker Diabetic Fatty rat model of type 2 diabetes, we showed that the β1 - adrenoceptors are the main subtype to regulate heart rate, contraction and relaxation. Notably, the β2 - adrenoceptor subtype actions seem to indirectly support function in the diabetic heart...
March 19, 2019: Experimental Physiology
https://read.qxmd.com/read/30887650/what-s-new-in-lipid-lowering-therapies-in-diabetes
#10
REVIEW
Yee-Ming Cheung, Richard O'Brien, Elif I Ekinci
Diabetes can lead to myriad of microvascular and macrovascular complications - with the leading cause of mortality in diabetes being cardiovascular disease (CVD). Low-density lipoprotein cholesterol (LDL-C), along with non-high-density lipoprotein cholesterol (non-HDL-C) and triglycerides (TGs) are proven, modifiable risk factors for CVD. This article will focus on lipid lowering agents in individuals with diabetes. It will summarise relevant changes in the latest guidelines for dyslipidemia, and will also review the mechanisms of action of lipid lowering agents along with the latest cardiovascular outcomes data specific to individuals with diabetes...
March 19, 2019: Internal Medicine Journal
https://read.qxmd.com/read/30885955/the-sglt2-inhibitor-dapagliflozin-reduces-liver-fat-but-does-not-affect-tissue-insulin-sensitivity-a-randomized-double-blind-placebo-controlled-study-with-8-week-treatment-in-type-2-diabetes-patients
#11
Aino Latva-Rasku, Miikka-Juhani Honka, Joel Kullberg, Nina Mononen, Terho Lehtimäki, Juha Saltevo, Anna K Kirjavainen, Virva Saunavaara, Patricia Iozzo, Lars Johansson, Jan Oscarsson, Jarna C Hannukainen, Pirjo Nuutila
OBJECTIVE: The aim of this study was to investigate tissue-specific effects of dapagliflozin on insulin sensitivity and liver and body fat in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: This randomized, double-blind, parallel group, placebo-controlled study recruited 32 patients with type 2 diabetes. Enrolled patients were to have HbA1c 6.5-10.5% (48-91 mmol/mol) and ≥3 months of stable treatment with metformin, dipeptidyl peptidase 4 inhibitor, or their combination...
March 18, 2019: Diabetes Care
https://read.qxmd.com/read/30885951/variation-in-the-plasma-membrane-monoamine-transporter-pmat-encoded-in-slc29a4-and-organic-cation-transporter-1-oct1-encoded-in-slc22a1-and-gastrointestinal-intolerance-to-metformin-in-type-2-diabetes-an-imi-direct-study
#12
Adem Y Dawed, Kaixin Zhou, Nienke van Leeuwen, Anubha Mahajan, Neil Robertson, Robert Koivula, Petra J M Elders, Simone P Rauh, Angus G Jones, Reinhard W Holl, Julia C Stingl, Paul W Franks, Mark I McCarthy, Leen 't Hart, Ewan R Pearson
OBJECTIVE: Gastrointestinal adverse effects occur in 20-30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5-10% of the cases. Gastrointestinal intolerance may reflect localized high concentrations of metformin in the gut. We hypothesized that reduced transport of metformin via the plasma membrane monoamine transporter (PMAT) and organic cation transporter 1 (OCT1) could increase the risk of severe gastrointestinal adverse effects. RESEARCH DESIGN AND METHODS: The study included 286 severe metformin-intolerant and 1,128 metformin-tolerant individuals from the IMI DIRECT (Innovative Medicines Initiative: DIabetes REsearCh on patient straTification) consortium...
March 18, 2019: Diabetes Care
https://read.qxmd.com/read/30885233/lower-hdl-cholesterol-a-known-marker-of-cardiovascular-risk-was-associated-with-depression-in-type-1-diabetes-a-cross-sectional-study
#13
Eva Olga Melin, Hans Olav Thulesius, Magnus Hillman, Ralph Svensson, Mona Landin-Olsson, Maria Thunander
BACKGROUND: Depression, metabolic disturbances and inflammation have been linked to cardiovascular disease and mortality. Low levels of high-density lipoprotein cholesterol (HDL-cholesterol), a known marker of cardiovascular risk, have been observed in patients with major depression in psychiatric populations. Our main aim was to explore associations between depression, antidepressants, and metabolic and inflammatory variables in patients with type 1 diabetes (T1D). A secondary aim was to explore variables associated with HDL-cholesterol...
March 18, 2019: Lipids in Health and Disease
https://read.qxmd.com/read/30884990/perspectives-of-pain-in-patients-with-type-2-diabetes
#14
Julienne K Kirk, Jaimie C Hunter, Shannon L Mihalko, Suzanne C Danhauer, Sally A Shumaker
Reducing symptom burden is often secondary to risk factor control in diabetes. Symptom burden with comorbid medical conditions and the need for symptom palliation are not well defined. Although neuropathy is one of the most frequent occurring comorbidities of diabetes, patient experience is inconsistent. Using in-depth interview, we assessed patients' perspectives of pain experienced through neuropathy and the impact on type 2 diabetes management. Areas covered: Participants completed a structured telephone interview during which perspectives on diabetes and its management occurred...
March 19, 2019: Expert Review of Endocrinology & Metabolism
https://read.qxmd.com/read/30878435/the-association-of-coronary-artery-calcification-with-subsequent-incidence-of-cardiovascular-disease-in-type-1-diabetes-the-dcct-edic-trials
#15
Matthew Budoff, Jye-Yu C Backlund, David A Bluemke, Joseph Polak, Ionut Bebu, David Schade, Suzanne Strowig, Philip Raskin, John M Lachin
OBJECTIVES: This study sought to determine the relationship between coronary artery calcium (CAC) scores and subsequent cardiovascular disease (CVD) events in DCCT (Diabetes Control and Complications Trial)/EDIC (Epidemiology of Diabetes Interventions and Complications) participants. BACKGROUND: The CAC score has been validated for improved risk stratification in general populations; however, this association has not been well studied in type 1 diabetes (T1DM). METHODS: Computed tomography (CT) to measure CAC was performed in 1,205 DCCT/EDIC participants at a mean of 42...
March 8, 2019: JACC. Cardiovascular Imaging
https://read.qxmd.com/read/30878389/c-peptide-predicts-all-cause-and-cardiovascular-death-in-a-cohort-of-individuals-with-newly-diagnosed-type-2-diabetes-the-skaraborg-diabetes-register
#16
Miriam Pikkemaat, Tobias Andersson, Olle Melander, John Chalmers, Karin Rådholm, Kristina Bengtsson Boström
AIMS: To study the association between baseline level of C-peptide and all-cause death, cardiovascular death and cardiovascular complications among persons with newly diagnosed type 2 diabetes. METHODS: The Skaraborg Diabetes Register contains data on baseline C-peptide concentrations among 398 persons <65 years with newly diagnosed type 2 diabetes 1996-1998. National registries were used to determine all-cause death, cardiovascular death and incidence of myocardial infarction and ischemic stroke until 31 December 2014...
March 13, 2019: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/30878037/patient-and-disease-characteristics-of-type-2-diabetes-patients-with-or-without-chronic-kidney-disease-an-analysis-of-the-german-dpv-and-dive-databases
#17
Peter Bramlage, Stefanie Lanzinger, Gesine van Mark, Eva Hess, Simon Fahrner, Christoph H J Heyer, Mathias Friebe, Jochen Seufert, Thomas Danne, Reinhard W Holl
BACKGROUND: To evaluate the characteristics of type 2 diabetes (T2DM) patients with or without chronic kidney disease (CKD) in Germany. METHODS: Using combined DPV/DIVE registry data, the analysis included patients with T2DM at least ≥ 18 years old who had an estimated glomerular filtration rate (eGFR) value available. CKD was defined as an eGFR < 60 mL/min/1.73 m2 or eGFR ≥ 60 mL/min/1.73 m2 and albuminuria (≥ 30 mg/g). Median values of the most recent treatment year per patient are reported...
March 16, 2019: Cardiovascular Diabetology
https://read.qxmd.com/read/30876826/healthy-dietary-pattern-and-their-corresponding-gut-microbiota-profile-are-linked-to-a-lower-risk-of-type-2-diabetes-independent-of-the-presence-of-obesity
#18
D A Díaz-Rizzolo, B Kostov, M López-Siles, A Serra, C Colungo, L González-de-Paz, M Martinez-Medina, A Sisó-Almirall, R Gomis
BACKGROUND: Prediabetes and old age are both high risk factors for developing Type 2 Diabetes (T2D), while obesity is one of the most important factors triggering the disease. Nutritional interventions are the most effective tool for preventing T2D, as they improve different biochemical and anthropometric outcomes and growth-promoting/inhibiting gut microbiota populations. However, to date there are no specific dietary recommendations to stop the development of T2D in elderly groups, for whom hypocaloric diets and other commonly used weight-loss programs could be considered dangerous...
March 4, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/30874782/effectiveness-of-targeted-insulin-adherence-interventions-for-glycemic-control-using-predictive-analytics-among-patients-with-type-2-diabetes-a-randomized-clinical-trial
#19
Julie C Lauffenburger, Jennifer Lewey, Saira Jan, Sagar Makanji, Christina A Ferro, Alexis A Krumme, Jessica Lee, Roya Ghazinouri, Nancy Haff, Niteesh K Choudhry
Importance: Patient adherence to antidiabetic medications, especially insulin, remains poor, leading to adverse outcomes and increased costs. Most adherence interventions have only been modestly effective, partly because they are not targeted to patients who could benefit most. Objective: To evaluate whether delivering more intensive insulin-adherence interventions only to individuals with type 2 diabetes predicted to benefit most was more effective than delivering a lower-intensity intervention to a larger group of unselected individuals...
March 1, 2019: JAMA Network Open
https://read.qxmd.com/read/30873823/a-novel-role-for-somatostatin-in-the-survival-of-mouse-pancreatic-beta-cells
#20
Erin L Damsteegt, Zoheb Hassan, Nirun V Hewawasam, Kittiwadee Sarnsamak, Peter M Jones, Astrid C Hauge-Evans
BACKGROUND/AIMS: Cross-talk between different pancreatic islet cell types regulates islet function and somatostatin (SST) released from pancreatic delta cells inhibits insulin secretion from pancreatic beta cells. In other tissues SST exhibits both protective and pro-apoptotic properties in a tissue-specific manner, but little is known about the impact of the peptide on beta cell survival. Here we investigate the specific role of SST in the regulation of beta cell survival in response to physiologically relevant inducers of cellular stress including palmitate, cytokines and glucose...
2019: Cellular Physiology and Biochemistry
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