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Manish Shukla, Koustav Roy, Charanjeet Kaur, Devasharma Nayak, K V Mani, Sangeeta Shukla, Neeru Kapoor
Hearing loss and cognitive decline are commonly associated with aging and morbidity. Present clinical interest lies in whether peripheral hearing loss promotes cognitive decline and if prophylaxis with selective adenosine receptor agonist CGS21680 effectively mitigates the adverse effects. In the current study, male Sprague Dawley rats weighing 200-250 gm were randomly allocated into three groups: Group 1) rats exposed to 100 dB SPL white noise, 2 hours a day for 15 consecutive days, 2) rats supplemented with an adenosine receptor agonist, CGS21680 at 100 μg/kg/day prior to noise exposure and 3) unexposed control rats...
February 13, 2019: Brain Research Bulletin
Anamarija Rogina, Andrea Lončarević, Maja Antunović, Inga Marijanović, Marica Ivanković, Hrvoje Ivanković
The synthesis of biologically active scaffolds is focused on the design of cell-sensitive surface by applying cell-adhesive proteins or bioceramic micro (nano) particles. The emerging new strategy for manipulating the biological properties lies in the modification by trace metals found in the living organism. In this work, we have prepared biocompatible chitosan hydrogels modified by copper (II) and zinc (II) ions through complexation interactions. Due to the strong affinity of metal ions towards amino groups of chitosan, we obtained defined and ordered structures of metal ion-chitosan hydrogel without the formation of additional metal species...
February 13, 2019: International Journal of Biological Macromolecules
Mitchell T Wallin, William J Culpepper, Jonathan D Campbell, Lorene M Nelson, Annette Langer-Gould, Ruth Ann Marrie, Gary R Cutter, Wendy E Kaye, Laurie Wagner, Helen Tremlett, Stephen L Buka, Piyameth Dilokthornsakul, Barbara Topol, Lie H Chen, Nicholas G LaRocca
OBJECTIVE: To generate a national multiple sclerosis (MS) prevalence estimate for the United States by applying a validated algorithm to multiple administrative health claims (AHC) datasets. METHODS: A validated algorithm was applied to private, military, and public AHC datasets to identify adult cases of MS between 2008 and 2010. In each dataset, we determined the 3-year cumulative prevalence overall and stratified by age, sex, and census region. We applied insurance-specific and stratum-specific estimates to the 2010 US Census data and pooled the findings to calculate the 2010 prevalence of MS in the United States cumulated over 3 years...
February 15, 2019: Neurology
Chao Zhu, Xu-Cheng Yin
Significant progress has been achieved in the past few years for the challenging task of pedestrian detection. Nevertheless, a major bottleneck of existing state-of-the-art approaches lies in a great drop in performance with reducing resolutions of the detected targets. For the boosting-based detectors which are popular in pedestrian detection literature, a possible cause for this drop is that in their boosting training process, low-resolution samples, which are usually more difficult to be detected due to the missing details, are still treated equally importantly as high-resolution samples, resulting in the false negatives since they are more easily rejected in the early stages and can hardly be recovered in the late stages...
February 14, 2019: Sensors
F Delduc, S Lacroix, M Magro, B Vicedo
A systematic procedure for constructing classical integrable field theories with arbitrarily many free parameters is outlined. It is based on the recent interpretation of integrable field theories as realizations of affine Gaudin models. In this language, one can associate integrable field theories with affine Gaudin models having arbitrarily many sites. We present the result of applying this general procedure to couple together an arbitrary number of principal chiral model fields on the same Lie group, each with a Wess-Zumino term...
February 1, 2019: Physical Review Letters
Yamin Li, Hailou Li, Jun Jiang, Lijuan Chen, Junwei Zhao
Three kinds of distinguishing ala-decorated RE-incorporated (ala = l-alanine, RE = rare-earth) polytungstoarsenate hybrids containing {As2 W19 O68 } building blocks [H2 N(CH3 )2 ]13 Na3 H2 [Eu4 W5 (H2 O)10 (ala)3 O14 (As2 W19 O68 )2 ]·35H2 O (1), [H2 N(CH3 )2 ]12 Na2 H2 [RE4 W6 (H2 O)8 (ala)4 O15 (OH)2 (As2 W19 O68 )2 ]·36H2 O [RE = Gd3+ (2), Tb3+ (3)], and [H2 N(CH3 )2 ]12 Na4 [RE4 W6 (H2 O)10 (ala)2 O15 (OH)2 (As2 W19 O68 )2 ]·40H2 O [RE = Dy3+ (4), Ho3+ (5), Er3+ (6), Yb3+ (7), Lu3+ (8)] were made in a facile one-step assembly strategy...
February 14, 2019: Inorganic Chemistry
Kehinde O Okonjo, Adedayo A Fodeke, Orighomisan B Atolaiye, Abimbola M Olatunde, Chijioke J Ajaelu, Oluwatoyin Ajelabi, Abisola T Adediji, Ayorinde M Adebayo, Onyinyechi V Uhuo, Oyebamiji J Babalola
The reaction of 5,5'-dithiobis(2-nitrobenzoate), DTNB, with hemoglobin sulfhydryl groups is linked to three negatively contributing Bohr effect groups: His2β is present in all avian hemoglobins but absent in some mammalian hemoglobins; His77β and His143β are absent in avian but present in nearly all mammalian hemoglobins. To probe the consequences of these differences, we determined the influence of inositol hexakisphosphate (inositol-P6 ) on the DTNB affinities of avian and mammalian carbonmonoxyhemoglobins...
February 6, 2019: Biophysical Chemistry
Stine Emilie Junker Udesen, Trine Lenskjold, Birgit Niclasen
Gambling has never been investigated in Greenlandic adolescents. High prevalence of gambling problems and a relation to other addictive behaviours has been found in adult Greenlanders. Greenlandic adolescents are daily exposed to gambling, for example, by selling lottery tickets, through advertises and electronic devices. The aim of this study is to investigate how Greenlandic adolescents perceive gambling, and to pilot test the Lie/Bet screening-instrument.Ten semi-structured focus group interviews were conducted for 31 adolescents, aged 12-16, from 3 schools in Nuuk, Greenland...
December 2019: International Journal of Circumpolar Health
Thasleem Moolakkadath, Mohd Aqil, Abdul Ahad, Syed Sarim Imam, Arshiya Praveen, Yasmin Sultana, Mohd Mujeeb, Zeenat Iqbal
Fisetin loaded binary ethosomes were prepared and optimized using Box-Behnken design for dermal application to alleviate skin cancer. The prepared formulations were evaluated for vesicle size, entrapment efficiency and flux of fisetin. Additionally, the optimized formulation was further evaluated by transmission electron microscopy, confocal laser microscopy, vesicles-skin interaction, dermatokinetic study and DPPH (2, 2-diphenyl-1-picryl-hydrazyl) assay. The in vivo study was carried out for the evaluation of tumor incidence, pro-inflammatory cytokines such as TNF-α and IL-1α, lipid peroxidation values, glutathione content and catalase activity in mice...
February 8, 2019: International Journal of Pharmaceutics
Alyssa S Ball, Julia C van Kessel
In Vibrio species, quorum sensing controls gene expression for numerous group behaviors, including bioluminescence production, biofilm formation, virulence factor secretion systems, and competence. The LuxR/HapR master quorum sensing regulators activate expression of hundreds of genes in response to changes in population densities. The mechanism of transcription activation by these TetR-type transcription factors is unknown, though LuxR DNA binding sites that lie in close proximity to the -35 region of the promoter are required for activation at some promoters...
February 11, 2019: Molecular Microbiology
Elena Lalinde, Teresa Moreno, Nora Giménez, Rebeca Lara
Pentafluorophenyl benzoquinolinyl PtII [Pt(bzq)(HC^N-κN)(C6F5)] (1a-g) complexes, bearing non-metalated N-heterocyclic HC^N ligands (HC^N = Hoxd a, dfppy b, pbt c, Br-pbt d, pq e, thpy f, pypy g), and heteroleptic bis(cyclometalated) PtIV fac-[Pt(bzq)(C^N)(C6F5)Cl] (2b-g) derivatives, generated by oxidation of 1b-g with PhICl2, are reported. The oxidation reaction of 1a evolves with formation of the bimetallic PtIV complex syn-[Pt(bzq)(C6F5)Cl(µ-OH)]2 3. The crystal structures of 1a,d,f, 2b,d,e and 3 have been corroborated by X-ray crystallography...
February 11, 2019: Chemistry: a European Journal
Bibek Laha, Rimpa Goswami, Sabyasachi Maiti, Kalyan Kumar Sen
This investigation was undertaken to unveil the controlled drug delivery and preclinical anti-hypertensive potential of a novel interpenetrating biopolymer-based network of karaya gum and carboxymethyl locust bean gum (CLBG). The Williamson synthesis of CLBG was confirmed after analyzing FTIR spectra, degree of O-carboxymethyl group substitution and viscosity. The hydrogel particles (HPs) were developed using aluminium chloride solution as cross-linker. A full 32 factorial design approach was adopted for the optimization of two responses: drug entrapment efficiency and drug release (%) in simulated gastrointestinal conditions at 10 h...
April 15, 2019: Carbohydrate Polymers
Maria Soonberg, Tanel Kaart, David Richard Arney
In a system in which cows are grouped and given differential access to feeding bins with different rations, and where these groups change over time, it is important to find out how a change in the ration (and hence feeding bin) affects the cow's feeding behaviour. Monitoring the locomotion of cows can be used to predict oestrus and improve health (lameness diagnosis), but activity monitors can also be used to estimate both activity and numbers of feeding visits by cows. Ice tag activity monitors were attached to the right hind legs of ten cows...
February 8, 2019: Journal of Dairy Research
Hyun Deok Lee, Hyunsoo Chung, Sang Gyun Kim, Jung Kim, Jue Lie Kim, Eunwoo Lee, Hyun Chae Jung
BACKGROUND: The current standard treatment modality for clinical submucosal invasive (cT1b) early gastric cancer (EGC) is surgery. However, there are discrepancies in T staging between pre- and post-operative findings, and in cases of overestimation, patients may lose the opportunity to preserve the stomach. The aim of this study was to analyze surgical outcomes of cT1b EGC and determine the pre-treatment factors favoring ESD. METHODS: Patients who underwent gastrectomy for cT1b EGC with a tumor size of 30 mm or less in diameter and differentiated-type histology were retrospectively reviewed from January 2010 to December 2014...
February 6, 2019: Surgical Endoscopy
Daniel Zaborski, Teresa Rzepa, Maciej Pastucha, Andrzej Modrzejewski, Wilhelm Grzesiak
BACKGROUND: The aim of the present study was to verify the relationship between the level of neuroticism and selected aspects of life satisfaction in women undergoing breast augmentation surgery. METHODS: The study group included 109 women, aged 18-46 years, who completed the self-developed survey measuring selected psychological traits before and after (1 year) surgery. Four questions in this survey were related to the level of neuroticism and two pertained to the self-assessment of leading character traits and the level of life satisfaction...
February 6, 2019: Aesthetic Plastic Surgery
Barbara Gandek, Ewa M Roos, Patricia D Franklin, John E Ware
OBJECTIVE: To evaluate reliability, validity and responsiveness of KOOS-12, a 12-item short form of the 42-item Knee injury and Osteoarthritis Outcome Score (KOOS) that provides Pain, Function and Quality of Life (QOL) scale scores and a summary knee impact score. DESIGN: Data from 1,392 knee osteoarthritis (OA) patients from the FORCE-TJR research cohort who completed KOOS before and 6 and 12 months after total knee replacement (TKR) were analyzed. KOOS-12 includes a pain frequency item and three items measuring pain during increasingly difficult (sitting/lying, walking, stairs) activities; function items about standing, rising from sitting, getting in/out of a car, and twisting/pivoting; and the 4-item KOOS QOL scale...
February 1, 2019: Osteoarthritis and Cartilage
Selma Øverland Lie, Øyvind Rø, Lasse Bang
OBJECTIVE: Involvement in bullying and teasing has been associated with adverse health outcomes, including eating disorders (EDs). The purpose of this systematic review and meta-analysis was to examine the association between bullying/teasing and EDs. METHOD: A systematic search was conducted. We included research articles that examined the association between bullying/teasing (victimization and perpetration) and EDs. Studies were required to compare ED cases with a reference group...
February 1, 2019: International Journal of Eating Disorders
Débora M A Costa, Stefanya V Gómez, Simara S de Araújo, Mozart S Pereira, Rosemeire B Alves, Denize C Favaro, Alvan C Hengge, Ronaldo A P Nagem, Tiago A S Brandão
Salicylate hydroxylase (NahG) is a flavin-dependent monooxygenase that catalyzes the decarboxylative hydroxylation of salicylate into catechol in the naphthalene degradation pathway in Pseudomonas putida G7. We explored the mechanism of action of this enzyme in detail using a combination of structural and methods. NahG shares many structural and mechanistic features with other versatile flavin-dependent monooxygenases, with potential biocatalytic applications. The crystal structure at 2.0 Å resolution for the apo form of NahG adds a new snapshot preceding the FAD binding in flavin-dependent monooxygenases...
January 28, 2019: International Journal of Biological Macromolecules
Weihong Zhu, Chao Shen, Yongzhen Wu, Hao Zhang, Erpeng Li, Weiwei Zhang, Xiaojia Xu, Wenjun Wu, He Tian
The construction of state-of-the-art hole transporting materials (HTMs) always meets a dilemma in modulating the molecular configuration for simultaneously achieving high morphology uniformity and charge mobility, especially in due to the lack of appropriate building blocks. Herein a semi-locked tetrathienylethene (TTE) as promising building block is reported for HTMs via fine tuning molecular planarity. Upon incorporation of four triphenylamine groups in the resulting TTE-2, we have for the first time realized a specific hybridization of orthogonal and planar conformation, thus leading to the desirable electronic and morphological properties in perovskite solar cells (PSCs)...
January 30, 2019: Angewandte Chemie
Carlos Sirvent, Juan Herrero, María de la Villa Moral, Francisco Javier Rodríguez
We all need to resort to deception, either with ourselves (denial, self-deception, mystification) or with others (with modalities, such as impression management, social desirability), to a greater or lesser extent. Lies, in their broader meaning, are interpreted as something rather adaptive, useful, and necessary in our socioaffective world. In particular, self-deception is a highly interesting psychological concept in the clinical population, namely, in drug dependents, as it serves as a mechanism for maintaining addiction...
2019: PloS One
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