keyword
https://read.qxmd.com/read/38545065/factors-influencing-the-accuracy-and-safety-of-preoperative-computed-tomography-ct-guided-soft-hook-wire-localization-for-pulmonary-nodules-a-comprehensive-analysis
#1
JOURNAL ARTICLE
Qianqian Feng, Jin Zhou, Ningyu Dong, Le Cheng, Weidong Kong, Ping Rong, Wenqian Chen, Yiming Ma, Xin Zhang, Xiaoyan Xin, Xiaowei Han, Bing Zhang
BACKGROUND: The necessity of localization of pulmonary nodules lies in ensuring the ability to locate the nodule quickly and accurately during surgery, thereby improving the success rate of the operation. The accuracy and risk of preoperative localization of pulmonary nodules need further exploration. Therefore, the purpose of this study was to investigate the factors of accuracy and safety of computed tomography (CT)-guided localization of pulmonary nodules using a flexible wire hook positioner...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38544902/exploration-of-novel-6-8-9-trisubstituted-purine-analogues-synthesis-in-vitro-biological-evaluation-and-their-effect-on-human-cancer-cells
#2
JOURNAL ARTICLE
Muhammed Fatih Polat, İrem Durmaz Şahin, Rengül Atalay, Meral Tunçbilek
Cancer, a leading global cause of mortality, demands continuous advancements in therapeutic strategies. This study focuses on the design and synthesis of a novel series of purine derivatives, specifically 6-(substituted phenyl piperazine)-8-(4-phenoxyphenyl)-9-cyclopentyl purine derivatives (5-11). The motivation behind this endeavor lies in addressing acquired resistance mechanisms in cancer cells, a significant hurdle in current treatment modalities. The synthesis, starting from 4,6-dichloro-5-nitropyrimidine, involves a multi-step process, resulting in seven new purine derivatives...
2024: Turkish Journal of Chemistry
https://read.qxmd.com/read/38543852/antigen-heterologous-vaccination-regimen-triggers-alternate-antibody-targeting-in-sars-cov-2-dna-vaccinated-mice
#3
JOURNAL ARTICLE
Anders Frische, Karen Angeliki Krogfelt, Anders Fomsgaard, Ria Lassaunière
An in-depth analysis of antibody epitopes following vaccination with different regimens provides important insight for developing future vaccine strategies. B-cell epitopes conserved across virus variants may be ideal targets for vaccine-induced antibodies and therapeutic drugs. However, challenges lie in identifying these key antigenic regions, and directing the immune system to target them. We previously evaluated the immunogenicity of two candidate DNA vaccines encoding the unmodified spike protein of either the SARS-CoV-2 Index strain or the Beta variant of concern (VOC)...
February 20, 2024: Vaccines
https://read.qxmd.com/read/38543297/drug-repurposing-of-metformin-for-the-treatment-of-haloperidol-related-behavior-disorders-and-oxidative-stress-a-preliminary-study
#4
JOURNAL ARTICLE
George Jîtcă, Zsolt Gáll, Carmen-Maria Jîtcă, Mădălina-Georgiana Buț, Erzsébet Májai
A particular attribute of the brain lies in the ability to learn, acquire information from the environment, and utilize the learned information. Previous research has noted that various factors (e.g., age, stress, anxiety, pathological issues), including antipsychotic medications, affect the brain and memory. The current study aimed to reveal the effects of chronic metformin treatment on the cognitive performance of rats and on commonly measured markers for oxidative stress. Wistar male rats (n = 40) were randomly divided into four groups: CTR (n = 10)-control group, METF (n = 10)-animals receiving metformin 500 mg/kg, HAL (n = 10)-animals receiving haloperidol 2 mg/kg, and HALMETF (n = 10)-animals receiving haloperidol 2 mg/kg and metformin 500 mg/kg...
March 15, 2024: Pharmaceutics
https://read.qxmd.com/read/38541037/changes-in-serum-il-12-levels-following-the-administration-of-h1-antihistamines-in-patients-with-chronic-spontaneous-urticaria
#5
JOURNAL ARTICLE
Corina Daniela Ene, Milena Tocut, Mircea Tampa, Simona Roxana Georgescu, Clara Matei, Iulia Maria Teodora Leulescu, Ilinca Nicolae, Cosmin Ene
INTRODUCTION: Research regarding the role of the IL-12 cytokine family in modulating immune and inflammatory responses is continuously evolving. In this study, the contribution of the p35 and p40 subunits as monomers (noted as IL-12p35 and IL-12p40) and heterodimers (noted as IL-12p70 or IL-12p35/p40) was analysed in the pathophysiology and progression of chronic spontaneous urticaria (CSU). MATERIALS AND METHODS: We conducted a longitudinal, case-control study involving 42 CSU cases and 40 control cases comprising adults without associated conditions...
March 10, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38539974/effect-of-day-length-on-growth-and-gonadal-development-in-meishan-male-pigs
#6
JOURNAL ARTICLE
Naisheng Lu, Hao Yuan, Xueyuan Jiang, Hulong Lei, Wen Yao, Peng Jia, Dong Xia
Day length is a critical environmental factor for regulating animal growth and development. This study aimed to investigate the effects of different day lengths on the developmental changes of growth parameters, testicular sizes, testosterone secretion in Meishan male pigs, and steroidogenesis proteins and melatonin receptors. Fourteen Meishan male pigs (10 weeks (wks) of age) with the same parity, paired in litter and body weight (BW), were evenly allocated into a short-day-length group (SDL, 10 light/14 dark) and long-day-length group (LDL, 14 light/10 dark)...
March 13, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539945/effects-of-multistrain-probiotic-supplementation-on-sows-emotional-and-cognitive-states-and-progeny-welfare
#7
JOURNAL ARTICLE
Melody Martins Cavalcante Pereira, Ines Andretta, Carolina Haubert Franceschi, Marcos Kipper, Alexandre Mariani, Thais Stefanello, Camila Carvalho, Júlio Vieira, Luiene Moura Rocha, Andrea Machado Leal Ribeiro
The intensification of production systems has resulted in detrimental effects on sow welfare, which can have an adverse influence on their offspring. Considering the relevance of the microbiota-gut-brain axis, probiotics can mitigate such impacts. To investigate the effects of the dietary inclusion of probiotics on the welfare of sows and piglets, 147 multiparous sows were randomly assigned to two groups: a control group or a group supplemented with a multistrain probiotic from the beginning of pregnancy to the end of lactation...
March 9, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539850/strain-specific-benefits-of-bacillus-on-growth-intestinal-health-immune-modulation-and-ammonia-nitrogen-stress-resilience-in-hybrid-grouper
#8
JOURNAL ARTICLE
Congjie Han, Huizhong Shi, Congcong Cui, Jiawen Wang, Ling Li, Weilie Bei, Yan Cai, Shifeng Wang
In the dynamic field of intensive aquaculture, the strategic application of probiotics has become increasingly crucial, particularly for enhancing resistance to environmental stressors such as ammonia-nitrogen. Over a 42-day period, this study investigated the effects of different probiotic strains- Bacillus subtilis (BS, 6-3-1, and HAINUP40)-on the health and resilience of hybrid groupers. Each strain, distinct in its origin, was assessed for its influence on growth performance, antioxidant capacity, immune gene expressions, and ammonia-nitrogen stress response in the hybrid grouper...
March 6, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38538660/phylogenomics-of-tetraopes-longhorn-beetles-unravels-their-evolutionary-history-and-biogeographic-origins
#9
JOURNAL ARTICLE
Nayeli Gutiérrez-Trejo, Matthew H Van Dam, Athena W Lam, Gonzalo Martínez-Herrera, Felipe A Noguera, Thomas Weissling, Jessica L Ware, Víctor H Toledo-Hernández, Frederick W Skillman, Brian D Farrell, Oscar Pérez-Flores, Lorenzo Prendini, James M Carpenter
Tetraopes longhorn beetles are known for their resistance to milkweed plant toxins and their coevolutionary dynamics with milkweed plants (Asclepias). This association is considered a textbook example of coevolution, in which each species of Tetraopes is specialized to feed on one or a few species of Asclepias. A major challenge to investigating coevolutionary hypotheses and conducting molecular ecology studies lies in the limited understanding of the evolutionary history and biogeographical patterns of Tetraopes...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38538469/risk-factors-for-unexpected-infant-death-among-very-premature-infants-in-france
#10
JOURNAL ARTICLE
Anne-Laure Bourneuf, Estelle Le Pabic, Sophie de Visme, Karine Levieux, Patrick Pladys
BACKGROUND: Prematurity is one of the risk factors for sudden unexpected infant death (SUID), a phenomenon that remains poorly explained. MATERIALS AND METHODS: The analysis of specific factors associated with SUID among very premature infants (VPI) was performed through a retrospective review of data collected in the French SUID registry from May 2015 to December 2018. The factors associated with SUID among VPI were compared with those observed among full-term infants (FTI)...
March 26, 2024: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://read.qxmd.com/read/38537867/oxytocin-and-social-learning-in-socially-anxious-men-and-women
#11
JOURNAL ARTICLE
Aleya Flechsenhar, Seth M Levine, Laura E Müller, Sabine C Herpertz, Katja Bertsch
OBJECTIVE: This study extended a classic self-referential learning paradigm by investigating the effects of intranasally-administered oxytocin in high and low socially anxious participants during social learning, as a function of social anxiety levels and sex. METHODS: In a randomized double-blinded design, 160 participants were either given intranasal oxytocin (24 I·U.) or placebo. Subsequently, while lying in an MR scanner, participants were shown neutral faces that were paired with positively, neutrally, or negatively valenced self-referential sentences, during which we measured self-reported arousal and sympathy of the facial stimuli, pupil dilation, and changes in the brain-oxygen-level dependent signal...
March 25, 2024: Neuropharmacology
https://read.qxmd.com/read/38537247/enhanced-piezoelectricity-of-mapbi-3-by-the-introduction-of-mxene-and-its-utilization-in-boosting-high-performance-photodetectors
#12
JOURNAL ARTICLE
Gaosi Han, Xiao-Fen Li, Andy Berbille, Yueming Zhang, Xiongxin Luo, Lindong Liu, Longyi Li, Zhong Lin Wang, Laipan Zhu
Recently, perovskite photodetectors (PDs) have been risen to prominence due to substantial research interest. Beyond merely tweaking the composition of materials, a cutting-edge advancement lies in leveraging the innate piezoelectric polarization properties of perovskites themselves. Here, the investigation shows utilizing Ti3 C2 Tx , a typical MXene, as an intermediate layer for significantly boosting the piezoelectric property of MAPbI3 thin films. This improvement is primarily attributed to the enhanced polarization of the methylammonium (MA+ ) groups within MAPbI3 , induced by the OH groups present in Ti3 C2 Tx ...
March 27, 2024: Advanced Materials
https://read.qxmd.com/read/38536029/a-vaginal-birth-is-a-cost-reduction-strategy-for-women-with-a-low-lying-placenta
#13
JOURNAL ARTICLE
Elisabetta Colciago, Pietro Ferrara, Isadora Vaglio Tessitore, Lorenzo G Mantovani, Patrizia Vergani, Sara Ornaghi
BACKGROUND: Alongside health consequences, cesarean delivery (CD) has been associated with increased healthcare resource utilization (HCRU). A CD should be performed in case of placenta previa; in turn, the most appropriate mode of birth in women with a low-lying placenta (LLP) is still controversial. Since no previous data are available on the topic, the aim of this study was to evaluate the HCRU and economic impact on the Italian HC system of vaginal birth (VB) and CD in women with a LLP...
March 27, 2024: Minerva obstetrics and gynecology
https://read.qxmd.com/read/38533467/the-automated-greulich-and-pyle-a-coming-of-age-for-segmental-methods
#14
JOURNAL ARTICLE
Rashmi Chapke, Shruti Mondkar, Chirantap Oza, Vaman Khadilkar, Tim R J Aeppli, Lars Sävendahl, Neha Kajale, Dipali Ladkat, Anuradha Khadilkar, Pranay Goel
The well-known Greulich and Pyle (GP) method of bone age assessment (BAA) relies on comparing a hand X-ray against templates of discrete maturity classes collected in an atlas. Automated methods have recently shown great success with BAA, especially using deep learning. In this perspective, we first review the success and limitations of various automated BAA methods. We then offer a novel hypothesis: When networks predict bone age that is not aligned with a GP reference class, it is not simply statistical error (although there is that as well); they are picking up nuances in the hand X-ray that lie "outside that class...
2024: Frontiers in artificial intelligence
https://read.qxmd.com/read/38532375/the-effect-of-typical-case-discussion-and-scenario-simulation-on-the-critical-thinking-of-midwifery-students-evidence-from-china
#15
JOURNAL ARTICLE
Yuji Wang, Yijuan Peng, Yan Huang
BACKGROUND: Assessment ability lies at the core of midwives' capacity to judge and treat clinical problems effectively. Influenced by the traditional teaching method of "teacher-led and content-based", that teachers involve imparting a large amount of knowledge to students and students lack active thinking and active practice, the clinical assessment ability of midwifery students in China is mostly at a medium or low level. Improving clinical assessment ability of midwifery students, especially critical thinking, is highly important in practical midwifery education...
March 26, 2024: BMC Medical Education
https://read.qxmd.com/read/38530568/efficacy-safety-and-immunogenicity-of-sun-s-ranibizumab-biosimilar-in-neovascular-age-related-macular-degeneration-a-phase-3-double-blind-comparative-study
#16
JOURNAL ARTICLE
Asim K Ghosh, Usha S Nikumbh, Chaitanya K Shukla, Rohit S Laul, Abhishek Dixit, Santosh K Mahapatra, Sameera Nayak, Urmil M Shah, Sandeep Parwal, Narendran Venkatapathy, Natasha Radhakrishnan, Anup Kelgaonkar, Sandeep Saxena, Divyansh Mishra, Vivek Pravin Dave, Perwez Khan, Manojkumar R Saswade, Malli S Shantilal, Kim Ramasamy, Smitha Sreekanta, Mandodari Rajurkar, Maulik Doshi, Sapan Behera, Piyush Patel, Shilpi Dhawan, Lalit Lakhwani
INTRODUCTION: The study aimed to evaluate comparability in terms of efficacy, safety and immunogenicity of Sun's ranibizumab biosimilar with reference ranibizumab in patients with neovascular age-related macular degeneration (nAMD). METHODS: This prospective, randomised, double-blind, two-group, parallel-arm, multicentre, phase 3 comparative study included patients with nAMD ≥ 50 years, randomised (in a 2:1 ratio) in a double-blind manner to receive 0...
March 26, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38529388/cost-effective-prognostic-evaluation-of-breast-cancer-using-a-star-nomogram-model-based-on-routine-blood-tests
#17
JOURNAL ARTICLE
Caibiao Wei, Yihua Liang, Dan Mo, Qiumei Lin, Zhimin Liu, Meiqin Li, Yuling Qin, Min Fang
BACKGROUND: Breast cancer (BC) is the most common and prominent deadly disease among women. Predicting BC survival mainly relies on TNM staging, molecular profiling and imaging, hampered by subjectivity and expenses. This study aimed to establish an economical and reliable model using the most common preoperative routine blood tests (RT) data for survival and surveillance strategy management. METHODS: We examined 2863 BC patients, dividing them into training and validation cohorts (7:3)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38524823/contemporary-practices-of-portuguese-and-brazilian-soccer-coaches-in-designing-and-applying-small-sided-games
#18
JOURNAL ARTICLE
Filipe Manuel Clemente, José Afonso, Rui Miguel Silva, Rodrigo Aquino, Luiz Palucci Vieira, Fernando Santos, Israel Teoldo, Rafael Oliveira, Gibson Praça, Hugo Sarmento
This descriptive study aimed to investigate the current practices of Portuguese and Brazilian soccer coaches in the design and implementation of small-sided games (SSGs) in soccer. A total of 187 male coaches participated in the online survey, consisting of 82 Portuguese and 105 Brazilian individuals. These coaches held various positions within the technical staff, with 63 serving as head coaches, 38 as assistant coaches, 38 as physical trainers, and 48 in other roles related to the technical staff. Additionally, the participants represented both youth (n = 102) and adult competitive levels (n = 59), along with some who were not currently associated with a specific group...
March 2024: Biology of Sport
https://read.qxmd.com/read/38524487/disruptive-model-that-explains-for-the-long-lived-triplet-states-observed-for-2-thiocytosine-upon-uva-radiation
#19
JOURNAL ARTICLE
Jorge Baños, Alejandro Avilés, Fernando Colmenares
The possible role of radical species in the formation of the long-lived triplet states observed for 2-thiocytosine upon UV irradiation was theoretically investigated. It is predicted that the radical fragments arising from the homolytic rupture of the NH group of the thiobase can be yielded upon ultraviolet-A radiation. Recombination of the radicals through the most favorable singlet channel yields the lowest-lying tautomer of the 2-thiocytosine (the amino-thiol form) through a barrierless pathway. The rebounding of the radical fragments along the triplet channels that emerge from the attack of the hydrogen to the nitrogen atoms next to the C-S bond leads to stable structures for the amino-thion-N1 H and amino-thion-N3 H tautomers...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38522411/bacillus-cereus-sensu-lato-antimicrobial-arsenal-an-overview
#20
REVIEW
Louis Morandini, Simon Caulier, Claude Bragard, Jacques Mahillon
The Bacillus cereus group contains genetically closed bacteria displaying a variety of phenotypic features and lifestyles. The group is mainly known through the properties of three major species: the entomopathogen Bacillus thuringiensis, the animal and human pathogen Bacillus anthracis and the foodborne opportunistic strains of B. cereus sensu stricto. Yet, the actual diversity of the group is far broader and includes multiple lifestyles. Another less-appreciated aspect of B. cereus members lies within their antimicrobial potential which deserves consideration in the context of growing emergence of resistance to antibiotics and pesticides, and makes it crucial to find new sources of antimicrobial molecules...
March 18, 2024: Microbiological Research
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