keyword
https://read.qxmd.com/read/38547304/characterization-of-a-hemolytic-and-antibiotic-resistant-pseudomonas-aeruginosa-strain-s3-pathogenic-to-fish-isolated-from-mahananda-river-in-india
#1
JOURNAL ARTICLE
Dipanwita Ghosh, Preeti Mangar, Abhinandan Choudhury, Anoop Kumar, Aniruddha Saha, Protip Basu, Dipanwita Saha
Virulent strain Pseudomonas aeruginosa isolated from Mahananda River exhibited the highest hemolytic activity and virulence factors and was pathogenic to fish as clinical signs of hemorrhagic spots, loss of scales, and fin erosions were found. S3 was cytotoxic to the human liver cell line (WRL-68) in the trypan blue dye exclusion assay. Genotype characterization using whole genome analysis showed that S3 was similar to P. aeruginosa PAO1. The draft genome sequence had an estimated length of 62,69,783 bp, a GC content of 66...
2024: PloS One
https://read.qxmd.com/read/38546541/network-polymer-properties-engineered-through-polymer-backbone-dispersity-and-structure
#2
JOURNAL ARTICLE
Ibrahim O Raji, Obed J Dodo, Nirob K Saha, Mary Eisenhart, Kevin M Miller, Richard Whitfield, Athina Anastasaki, Dominik Konkolewicz
Dispersity (Ɖ or Mw/Mn) is an important parameter in material design and as such can significantly impact the properties of polymers. Here polymer networks with independent control over the molecular weight and dispersity of the linear chains that form the material are developed. Using a RAFT polymerization approach a library of polymers with dispersity ranging from 1.2-1.9 for backbone chain-length (DP) 100, and 1.4-3.1 for backbone chain-length 200 were developed and transformed to networks through post-polymerization crosslinking to form disulfide linkers...
March 28, 2024: Angewandte Chemie
https://read.qxmd.com/read/38545163/effect-of-silver-doping-on-the-band-gap-tuning-of-tungsten-oxide-thin-films-for-optoelectronic-applications
#3
JOURNAL ARTICLE
Md Arifuzzaman, Tusar Saha, Jiban Podder, Fahad Al-Bin, Hari Narayan Das
In the cutting-edge world, semiconductor metal oxides usually tend to have a high optical band gap (>3.0 eV), significantly acceptable for potential optoelectronic applications. The present study discusses the synthesize of pristine tungsten trioxide (WO3 ) and Silver (Ag) doped WO3 (Ag: WO3 ) thin films onto a glass substrate at 450 °C, with varying concentrations of Ag doping (2, 4, 6, 8 and 10 at.%) using a simple Spray Pyrolysis Technique. Field emission scanning electron microscopy (FESEM) analysis showed the presence of particles in the WO3 and Ag: WO3 materials...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38544133/multi-step-internet-traffic-forecasting-models-with-variable-forecast-horizons-for-proactive-network-management
#4
JOURNAL ARTICLE
Sajal Saha, Anwar Haque, Greg Sidebottom
The ISP (Internet Service Provider) industry relies heavily on internet traffic forecasting (ITF) for long-term business strategy planning and proactive network management. Effective ITF frameworks are necessary to manage these networks and prevent network congestion and over-provisioning. This study introduces an ITF model designed for proactive network management. It innovatively combines outlier detection and mitigation techniques with advanced gradient descent and boosting algorithms, including Gradient Boosting Regressor (GBR), Extreme Gradient Boosting (XGB), Light Gradient Boosting Machine (LGB), CatBoost Regressor (CBR), and Stochastic Gradient Descent (SGD)...
March 14, 2024: Sensors
https://read.qxmd.com/read/38539849/exosomal-dynamics-and-brain-redox-imbalance-implications-in-alzheimer-s-disease-pathology-and-diagnosis
#5
REVIEW
Aritri Bir, Arindam Ghosh, Aman Chauhan, Sarama Saha, Adesh K Saini, Marco Bisaglia, Sasanka Chakrabarti
Oxidative burden plays a central role in Alzheimer's disease (AD) pathology, fostering protein aggregation, inflammation, mitochondrial impairment, and cellular dysfunction that collectively lead to neuronal injury. The role of exosomes in propagating the pathology of neurodegenerative diseases including AD is now well established. However, recent studies have also shown that exosomes are crucial responders to oxidative stress in different tissues. Thus, this offers new insights and mechanistic links within the complex pathogenesis of AD through the involvement of oxidative stress and exosomes...
March 5, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539615/can-brain-volume-driven-characteristic-features-predict-the-response-of-alzheimer-s-patients-to-repetitive-transcranial-magnetic-stimulation-a-pilot-study
#6
JOURNAL ARTICLE
Chandan Saha, Chase R Figley, Brian Lithgow, Paul B Fitzgerald, Lisa Koski, Behzad Mansouri, Neda Anssari, Xikui Wang, Zahra Moussavi
This study is a post-hoc examination of baseline MRI data from a clinical trial investigating the efficacy of repetitive transcranial magnetic stimulation (rTMS) as a treatment for patients with mild-moderate Alzheimer's disease (AD). Herein, we investigated whether the analysis of baseline MRI data could predict the response of patients to rTMS treatment. Whole-brain T1-weighted MRI scans of 75 participants collected at baseline were analyzed. The analyses were run on the gray matter (GM) and white matter (WM) of the left and right dorsolateral prefrontal cortex (DLPFC), as that was the rTMS application site...
February 28, 2024: Brain Sciences
https://read.qxmd.com/read/38539029/evaluation-of-in-feed-supplementation-of-formic-acid-and-thymol-as-non-antibiotic-growth-promoters-and-assessing-their-effect-on-antimicrobial-resistant-e-coli-isolated-in-turkey
#7
JOURNAL ARTICLE
Abhijeet Champati, Subrat Kumar Bhanja, Jaydip Jaywant Rokade, Nibedita Nayak, Ajit Singh Yadav, Avishek Biswas, Divya Sharma, Juli Chakma, Sky, Jyotiprabha Mishra, Subodh Kumar Saha, Ravi Kant Agrawal, Mukesh Singh
With the rampant usage of antibiotics as growth promoters (AGPs) in poultry sector, there has been alarming concerns of antimicrobial resistant microbes such as Escherichia coli. Diversification of poultry farming due to consumer demand for safer products with higher protein content, turkey production is gaining popularity. Feed additives such as formic acid (FA) and thymol (TH) are effectively replacing AGPs due to their antimicrobial action. This directed the researchers to find alternatives to antibiotics such as thymol and formic acid because of their strong antimicrobial, anti-oxidative, digestive-stimulating properties...
March 28, 2024: Veterinary Research Communications
https://read.qxmd.com/read/38537316/which-clinician-responses-to-emotion-are-associated-with-more-positive-patient-experiences-of-communication
#8
JOURNAL ARTICLE
Kamini Kuchinad, Jenny Rose Park, Dingfen Han, Somnath Saha, Richard Moore, Mary Catherine Beach
OBJECTIVES: To identify communication strategies that may improve clinician-patient interactions, we assessed the association between clinician response to emotion and patient ratings of communication. METHODS: From a cohort of 1817 clinician-patient encounters, we designed a retrospective case-control study by identifying 69 patients who rated their interpersonal care as low-quality and 69 patients who rated their care as high-quality. We used the Verona Coding Definitions of Emotional Sequences (VR-CoDES) to identify patient emotional expressions and clinician responses...
March 8, 2024: Patient Education and Counseling
https://read.qxmd.com/read/38537279/optical-and-dielectric-properties-of-divalent-copper-based-double-perovskite-compound-gd-2-cutio-6
#9
JOURNAL ARTICLE
Papiya Saha, Nithya R, R M Sarguna, Sujoy Sen
In this work, we have investigated high temperature dielectric properties and room temperature optical properties on rare earth ion based orthorhombic Gd2CuTiO6. Optical properties like reflectance and band gap were determined from UV-visible diffuse reflectance spectroscopy technique and photoluminescence spectrum. The compound exhibited substantial optical absorption and emission in the visible region. Our findings reveal the presence of an intermediate band, as evidenced by the difference between the band gap values obtained from the Tauc plot using the diffuse reflectance spectrum (3...
March 27, 2024: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://read.qxmd.com/read/38534787/unveiling-the-molecular-mechanism-of-trastuzumab-resistance-in-skbr3-and-bt474-cell-lines-for-her2-positive-breast-cancer
#10
JOURNAL ARTICLE
Anna Kokot, Sachin Gadakh, Indrajit Saha, Ewa Gajda, Michał Łaźniewski, Somnath Rakshit, Kaustav Sengupta, Ayatullah Faruk Mollah, Michał Denkiewicz, Katarzyna Górczak, Jürgen Claesen, Tomasz Burzykowski, Dariusz Plewczynski
HER2-positive breast cancer is one of the most prevalent forms of cancer among women worldwide. Generally, the molecular characteristics of this breast cancer include activation of human epidermal growth factor receptor-2 (HER2) and hormone receptor activation. HER2-positive is associated with a higher death rate, which led to the development of a monoclonal antibody called trastuzumab, specifically targeting HER2. The success rate of HER2-positive breast cancer treatment has been increased; however, drug resistance remains a challenge...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533117/the-first-complete-mitochondrial-genome-data-of-the-afghan-pika-ochotona-rufescens-lagomorpha-ochotonidae-near-the-type-locality
#11
JOURNAL ARTICLE
Anwesha Saha, Mateusz Baca, Danijela Popović, Zeinolabedin Mohammadi, Urban Olsson, Emily Roycroft, Łucja Fostowicz-Frelik
The Afghan pika Ochotona rufescens (Gray, 1842) is widely distributed across the mountains of Afghanistan, Iran, Pakistan, and southwestern Turkmenistan, most often at elevations between 2,000 and 3,000 m. Here we present, for the first time, the complete mitochondrial genomes of two specimens of the nominotypical subspecies Ochotona rufescens rufescens , de novo assembled from Illumina short reads of fragmented probe-enriched DNA. The lengths of the circular mitogenomes are 16,408 bp and 16,407 bp, respectively...
April 2024: Data in Brief
https://read.qxmd.com/read/38532414/combining-public-datasets-for-automated-tooth-assessment-in-panoramic-radiographs
#12
JOURNAL ARTICLE
Niels van Nistelrooij, Khalid El Ghoul, Tong Xi, Anindo Saha, Steven Kempers, Max Cenci, Bas Loomans, Tabea Flügge, Bram van Ginneken, Shankeeth Vinayahalingam
OBJECTIVE: Panoramic radiographs (PRs) provide a comprehensive view of the oral and maxillofacial region and are used routinely to assess dental and osseous pathologies. Artificial intelligence (AI) can be used to improve the diagnostic accuracy of PRs compared to bitewings and periapical radiographs. This study aimed to evaluate the advantages and challenges of using publicly available datasets in dental AI research, focusing on solving the novel task of predicting tooth segmentations, FDI numbers, and tooth diagnoses, simultaneously...
March 26, 2024: BMC Oral Health
https://read.qxmd.com/read/38531727/cost-effectiveness-and-public-health-impact-of-typhoid-conjugate-vaccine-introduction-strategies-in-bangladesh
#13
JOURNAL ARTICLE
Christopher Weyant, Yogesh Hooda, Sira Jam Munira, Nathan C Lo, Theresa Ryckman, Arif M Tanmoy, Naito Kanon, Jessica C Seidman, Denise Garrett, Samir K Saha, Jeremy D Goldhaber-Fiebert, Senjuti Saha, Jason R Andrews
PURPOSE: Typhoid fever causes substantial morbidity and mortality in Bangladesh. The government of Bangladesh plans to introduce typhoid conjugate vaccines (TCV) in its expanded program on immunization (EPI) schedule. However, the optimal introduction strategy in addition to the costs and benefits of such a program are unclear. METHODS: We extended an existing mathematical model of typhoid transmission to integrate cost data, clinical incidence data, and recently conducted serosurveys in urban, semi-urban, and rural areas...
March 25, 2024: Vaccine
https://read.qxmd.com/read/38531498/efficacy-of-exopolysaccharide-in-dye-laden-wastewater-treatment-a-comprehensive-review
#14
REVIEW
Sumona Show, Ramisa Akhter, Indrani Paul, Payal Das, Manisha Bal, Riya Bhattacharya, Debajyoti Bose, Amita Mondal, Shouvik Saha, Gopinath Halder
The discharge of dye-laden wastewater into the water streams causes severe water and soil pollution, which poses a global threat to aquatic ecosystems and humans. A diverse array of microorganisms such as bacteria, fungi, and algae produce exopolysaccharides (EPS) of different compositions and exhibit great bioflocculation potency to sustainably eradicate dyes from water bodies. Nanomodified chemical composites of EPS enable their recyclability during dye-laden wastewater treatment. Nevertheless, the selection of potent EPS-producing strains and physiological parameters of microbial growth and the remediation process could influence the removal efficiency of EPS...
March 24, 2024: Chemosphere
https://read.qxmd.com/read/38530845/differential-carbonic-anhydrase-activities-control-ebv-induced-b-cell-transformation-and-lytic-cycle-reactivation
#15
JOURNAL ARTICLE
Samaresh Malik, Joyanta Biswas, Purandar Sarkar, Subhadeep Nag, Chandrima Gain, Shatadru Ghosh Roy, Bireswar Bhattacharya, Dipanjan Ghosh, Abhik Saha
Epstein-Barr virus (EBV) contributes to ~1% of all human cancers including several B-cell neoplasms. A characteristic feature of EBV life cycle is its ability to transform metabolically quiescent B-lymphocytes into hyperproliferating B-cell blasts with the establishment of viral latency, while intermittent lytic cycle induction is necessary for the production of progeny virus. Our RNA-Seq analyses of both latently infected naïve B-lymphocytes and transformed B-lymphocytes upon lytic cycle replication indicate a contrasting expression pattern of a membrane-associated carbonic anhydrase isoform CA9, an essential component for maintaining cell acid-base homeostasis...
March 26, 2024: PLoS Pathogens
https://read.qxmd.com/read/38530661/first-principles-predictions-of-structural-electronic-and-topological-properties-of-two-dimensional-janus-ti-2-n-2-xi-x-br-cl-structures
#16
JOURNAL ARTICLE
Shiladitya Karmakar, Soumendu Datta, Tanusri Saha-Dasgupta
Motivated by the report of the giant Rashba effect in ternary layered compounds BiTeX, we consider two Janus structured compounds Ti2 N2 XI (X = Br, Cl) of the same ternary family exhibiting a 1 : 1 : 1 stoichiometric ratio. Broken inversion symmetry in the Janus structure, together with its unique electronic structure exhibiting anti-crossing states formed between Ti-d states and strong spin-orbit coupled I-p states, generates large Rashba cofficients of 2-3 eV Å for these compounds, classifying them as strong Rashba compounds...
March 26, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38530563/exploring-the-gamma-ray-enhanced-nir-luminescence-and-cytotoxic-potential-of-lanthanide-naphthalene-dicarboxylate-based-metal-organic-frameworks
#17
JOURNAL ARTICLE
Podilapu Atchutha Rao, Harihara Padhy, Krishanu Bandyopadhyay, Adapaka Venkateswara Rao, Ravikumar Ganta, Samatha Bevara, Bheeshma Pratap Singh, Bhavani Kundrapu, Satyen Saha, RamaRao Malla, Saratchandra Babu Mukkamala
In this investigation, we explore the integration of lanthanides into Metal-Organic Frameworks (MOFs) to enable Near-Infrared (NIR) emission. Specifically, we focus on Lanthanide-Naphthalene Dicarboxylate based MOFs (Ln-MOFs), incorporating elements such as Praseodymium (Pr), Samarium (Sm), Dysprosium (Dy), and Erbium (Er). The synthesis of Ln-MOFs is achieved via the hydrothermal method. The structure, morphology, thermal stability, and luminescence properties of synthesized Ln-MOFs have been evaluated through different characterization techniques...
March 26, 2024: Journal of Fluorescence
https://read.qxmd.com/read/38530051/vessel-and-airway-characteristics-in-one-year-ct-defined-rapid-emphysema-progression-spiromics
#18
JOURNAL ARTICLE
Sarah E Gerard, Timothy M Dougherty, Prashant Nagpal, Dakai Jin, MeiLan K Han, John D Newell, Punam K Saha, Alejandro P Comellas, Christopher B Cooper, David Couper, Spyridon Fortis, Junfeng Guo, Nadia N Hansel, Richard E Kanner, Ella A Kazeroni, Fernando J Martinez, Amin Motahari, Robert Paine Iii, Stephen Rennard, Joyce D Schroeder, Prescott G Woodruff, R Graham Barr, Benjamin M Smith, Eric A Hoffman
Rationale: Rates of emphysema progression vary in chronic obstructive pulmonary disease (COPD), and the relationship with vascular and airway pathophysiology remain unclear. Objective: We sought to determine if indices of peripheral (segmental and beyond) pulmonary arterial (PA) dilation measured via computed tomography (CT) are associated with a 1-year index of emphysema (EI: %voxels<-950HU) progression. Methods: 599 GOLD 0-3 former and never-smokers were evaluated from the SubPopulations and InterMediate Outcome Measures in COPD Study (SPIROMICS) cohort: rapid-emphysema-progressors (RP, n=188; 1-year ΔEI>1%), non-progressors (NP, n=301; 1-year ΔEI±0...
March 26, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38529661/uracil-and-pyridine-containing-hdac-inhibitors-displayed-cytotoxicity-in-colorectal-and-glioblastoma-cancer-stem-cells
#19
JOURNAL ARTICLE
Francesco Fiorentino, Emanuele Fabbrizi, Alessia Raucci, Beatrice Noce, Rossella Fioravanti, Sergio Valente, Chantal Paolini, Ruggero De Maria, Christian Steinkühler, Paola Gallinari, Dante Rotili, Antonello Mai
Cancer stem cells (CSCs) are a niche of highly tumorigenic cells featuring self-renewal, activation of pluripotency genes, multidrug resistance, and ability to cause cancer relapse. Seven HDACi (1-7), showing either hydroxamate or 2'-aminoanilide function, were tested in colorectal cancer (CRC) and glioblastoma multiforme (GBM) CSCs to determine their effects on cell proliferation, H3 acetylation levels and in-cell HDAC activity. Two uracil-based hydroxamates, 5 and 6, which differ in substitution at C5 and C6 positions of the pyrimidine ring, exhibited the greatest cytotoxicity in GBM (5) and CRC (6) CSCs, followed by the pyridine-hydroxamate 2, with 2- to 6-fold higher potency than the positive control SAHA...
March 26, 2024: ChemMedChem
https://read.qxmd.com/read/38528774/are-oral-cancers-effectively-palliated-with-radiotherapy-outcomes-of-treatment-with-a-modified-quad-shot-regimen
#20
JOURNAL ARTICLE
Saheli Saha, Indranil Mallick, Prattusha Mukherjee, Santam Chakraborty, Tapesh Bhattacharyya, Moses Arunsingh S, Rimpa Basu Achari, Sanjoy Chatterjee
BACKGROUND: This study assessed a palliative radiotherapy regimen using daily radiation over 4 days for three courses in inoperable head and neck cancers, emphasizing oral primary cancers. METHODS: Retrospective data of 116 patients treated with a daily dose of 3.6-3.7 Gy in four fractions over 4 days to a total of three courses, with a 2-week gap after every course, were analyzed for survival outcomes. A subgroup analysis was done for oral cancer...
March 25, 2024: Head & Neck
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