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Carolina Mazo-Molina, Samantha Mainiero, Sarah R Hind, Christine M Kraus, Mishi Vachev, Felicia Maviane-Macia, Magdalen Lindeberg, Surya Saha, Susan Strickler, Ari Feder, James Giovannoni, Christine Smart, Nemo Peeters, Gregory Martin
Race 1 strains of Pseudomonas syringae pv. tomato, which cause bacterial speck disease of tomato, are becoming increasingly common and no simply-inherited genetic resistance to such strains is known. We discovered that a locus in Solanum lycopersicoides, termed Pseudomonas tomato race 1 (Ptr1), confers resistance to race 1 Pst strains by detecting the activity of type III effector AvrRpt2. In Arabidopsis, AvrRpt2 degrades the RIN4 protein thereby activating RPS2-mediated immunity. Using site-directed mutagenesis of AvrRpt2 we found that, like RPS2, activation of Ptr1 requires AvrRpt2 proteolytic activity...
February 20, 2019: Molecular Plant-microbe Interactions: MPMI
Sanjay K Saha, Parthapratim Pradhan, Dibakar Haldar, Baisakhi Maji, Widhi Agarwal, Gautam N Sarkar
Background: Mental disorders cause considerable morbidity and disability, and there is ample evidence that mental disorders are positively associated with household food insecurity. Methods: A cross-sectional survey was conducted for a period of 2 months at Bakultala slum of Bankura town involving 152 people of ≥18 and ≤60 years of age selected using simple random sampling technique to estimate the prevalence of mental disorders and to find out its correlates...
January 2019: Indian Journal of Psychological Medicine
Nandadulal Bairagi, Suman Saha, Sanjay Chaudhuri, Syamal Kumar Dana
Mathematical modeling may be an excellent tool to analyze and explain complex biological phenomena. In this paper, we use a mathematical model to reveal various interesting dynamical features of phytoplankton-zooplankton interaction and attempt to explain the reason for contrasting dynamics shown by different laboratory and field experiments. Our study shows that the phytoplankton-zooplankton interaction in a pelagic system is very complex and the plankton dynamics, including the bloom phenomenon, strongly depends on the selective predation of zooplankton and the nutritional value of phytoplankton...
January 2019: Physical Review. E
Sayantan Mitra, Dipa Saha, Ankur Sensharma
This paper presents a Monte Carlo study of percolation in a distorted square lattice, in which the adjacent sites are not equidistant. Starting with an undistorted lattice, the position of the lattice sites are shifted through a tunable parameter α to create a distorted empty lattice. In this model, two occupied neighboring sites are considered to be connected to each other in order to belong to the same cluster, if the distance between them is less than or equal to a certain value, called connection threshold d...
January 2019: Physical Review. E
Shilpi Saha, Samir Kumar Sil
OBJECTIVE: To examine the body composition including fat patterning among 744 school going Chakma tribal and non- tribal Bengali girls (366 Chakma tribal and 378 Bengali girls), aged 6-12y from North, Unokoti, Dhalai and South District of Tripura. METHODS: The subjects were selected using cluster-random sampling method. The anthropometric measurements of height, weight, triceps and subscapular skinfold were recorded. The body mass index (BMI) was also calculated...
February 19, 2019: Indian Journal of Pediatrics
Kazunori Inoue, Geliang Gan, Maria Ciarleglio, Yan Zhang, Xuefei Tian, Christopher E Pedigo, Corey Cavanaugh, Janet Tate, Ying Wang, Elizabeth Cross, Marwin Groener, Nathan Chai, Zhen Wang, Amy Justice, Zhenhai Zhang, Chirag R Parikh, Francis P Wilson, Shuta Ishibe
We identified 2 genes, histone deacetylase 1 (HDAC1) and HDAC2, contributing to the pathogenesis of proteinuric kidney diseases, the leading cause of end-stage kidney disease. mRNA expression profiling from proteinuric mouse glomeruli was linked to Connectivity Map databases, identifying HDAC1 and HDAC2 with the differentially expressed gene set reversible by HDAC inhibitors. In numerous progressive glomerular disease models, treatment with valproic acid (a class I HDAC inhibitor) or SAHA (a pan-HDAC inhibitor) mitigated the degree of proteinuria and glomerulosclerosis, leading to a striking increase in survival...
February 18, 2019: Journal of Clinical Investigation
Amit Saha, Timothy J Poterucha, Sahil A Parikh, Ajay J Kirtane, Sanjum S Sethi, Philip Green
No abstract text is available yet for this article.
February 7, 2019: JACC. Cardiovascular Interventions
Abhijit Saha, Suman Neogy, Dumpala Rama Mohana Rao, Sadhan Bijoy Deb, Manoj Kumar Saxena, Bhupendra Singh Tomar
The authors describe the synthesis and characterization of 3-mercaptopropionylamidoxime functionalized gold nanoparticles (AuNPs) for visual detection of uranium (U) by cloud point extraction. The method is capable of quantifying U at the concentration limits set by the World Health Organization in drinking water i.e., 30.0 ng mL-1 . The method is based on the gradual color change from red to blue that occurs as a result of the interaction between uranyl ion and the modified AuNPs leading to particle aggregation...
February 15, 2019: Mikrochimica Acta
Sushweta Mahalanobish, Sukanya Saha, Sayanta Dutta, Parames C Sil
Arsenic contaminated drinking water consumption is a serious health issue around the world. Chronic inorganic arsenic exposure has been associated with respiratory dysfunctions. It exerts various detrimental effects, disrupting normal cellular homeostasis and turning on severe pulmonary complications. This study elucidated the role of mangiferin, a natural xanthone, against arsenic induced lung toxicity. Chronic exposure of sodium arsenite (NaAsO2 ) at 10 mg/kg bw for 3 months abruptly increased the LDH release in broncho-alveolar lavage fluid, generated reactive oxygen species (ROS), impaired the antioxidant defense and distorted the alveoli architecture...
February 12, 2019: Food and Chemical Toxicology
Ellin-Kristina Hillert, Slavica Brnjic, Xiaonan Zhang, Magdalena Mazurkiewicz, Amir Ata Saei, Arjan Mofers, Karthik Selvaraju, Roman Zubarev, Stig Linder, Padraig D'Arcy
Proteasome inhibitors have been shown to induce cell death in cancer cells by triggering an acute proteotoxic stress response characterized by accumulation of poly-ubiquitinated proteins, ER stress and the production of reactive oxygen species. The aggresome pathway has been described as an escape mechanism from proteotoxicity by sequestering toxic cellular aggregates. Here we show that b-AP15, a small-molecule inhibitor of proteasomal deubiquitinase activity, induces poly-ubiquitin accumulation in absence of aggresome formation...
February 12, 2019: Cancer Letters
Simona Citro, Alice Bellini, Claudia Miccolo, Lavinia Ghiani, Thomas E Carey, Susanna Chiocca
BACKGROUND: Epidermal growth factor receptor (EGFR) overexpression is associated with the development of head and neck cancer (HNC) and represents one of the main therapeutic targets for this disease. The use of EGFR inhibitors has limited efficacy due to their primary and acquired resistance, partially because of increased epithelial to mesenchymal transition (EMT). The HDAC inhibitor SAHA has been shown to revert EMT in different tumours, including HNC. In this study, we investigated the cooperative role of SAHA and the EGFR tyrosine kinase inhibitor gefitinib in both HPV-positive and HPV-negative HNC cell lines...
February 15, 2019: British Journal of Cancer
Iqbal Ansary Khan, Ashraful Islam Khan, Anisur Rahman, Shah Alam Siddique, Md Taufiqul Islam, Md Amirul Islam Bhuiyan, Atique Iqbal Chowdhury, Nirod Chandra Saha, Prasanta Kumar Biswas, Amit Saha, Fahima Chowdhury, John D Clemens, Firdausi Qadri
Bangladesh has historically been cholera endemic, with seasonal cholera outbreaks occurring each year. In collaboration with the government of Bangladesh, the Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) initiated operational research to test strategies to reach the high-risk urban population with an affordable oral cholera vaccine (OCV) "ShancholTM" and examine its effectiveness in reducing diarrhea due to cholera. Here we report a sub-analysis focusing on the organization, implementation and effectiveness of different oral cholera vaccine delivery strategies in the endemic urban setting in Bangladesh...
2019: Global Health Action
Minu Bharati, Priyanka Rai, Dhiraj Saha
Dengue is one of the most rapidly spreading infectious diseases prevalent throughout the tropical and sub-tropical regions of the world. In absence of specific medications and vaccines, the sole method of disease prevention relies on vector control mainly using insecticides. But with the advent of Insecticide resistance, worldwide vector control programs are facing failure. In this study, eleven different Ae. albopictus population from sub-Himalayan districts of West Bengal, India were investigated as per WHO protocols to find out the current status of insecticide susceptibility against DDT, permethrin and propoxur...
February 11, 2019: Acta Tropica
Shanthi Saha, Claire McCarthy, Rohan Dhillon
OBJECTIVES: This paper outlines the use of psychodynamic psychotherapy as an adjunct to treatment as usual for addressing challenging behaviours in a patient with schizophrenia under the care of a community mental health team (CMHT) in South Australia. METHODS: Ms P suffered from schizophrenia and demonstrated challenging behaviours in the context of being administered depot medication under a community treatment order (CTO). Multiple attempts at addressing non-compliance and consistently disruptive behaviour through conventional methods had failed...
February 14, 2019: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Bernard Freudenthal, Samiksha Shetty, Natalie C Butterfield, John G Logan, Cho Rong Han, Xu-Guang Zhu, Inna Astapova, Anthony N Hollenberg, Sheue-Yann Cheng, J H Duncan Bassett, Graham Williams
Background Thyroid hormones act in bone and cartilage via thyroid hormone receptor α (TRα). In the absence of T3, TRα interacts with co-repressors, including nuclear receptor co-repressor-1 (NCoR1), which recruit histone deacetylases (HDACs) and mediate transcriptional repression. Dominant-negative mutations of TRα cause resistance to thyroid hormone α (RTHα; OMIM 614450), characterized by excessive repression of T3 target genes leading to delayed skeletal development, growth retardation and bone dysplasia...
February 14, 2019: Thyroid: Official Journal of the American Thyroid Association
Parisa Yousefpour, Lucie Ahn, Joel Tewksbury, Soumen Saha, Simone A Costa, Joseph J Bellucci, Xinghai Li, Ashutosh Chilkoti
Short circulation time and off-target toxicity are the main challenges faced by small-molecule chemotherapeutics. To overcome these shortcomings, an albumin-binding peptide conjugate of chemotherapeutics is developed that binds specifically to endogenous albumin and harnesses its favorable pharmacokinetics and pharmacodynamics for drug delivery to tumors. A protein-G-derived albumin-binding domain (ABD) is conjugated with doxorubicin (Dox) via a pH-sensitive linker. One to two Dox molecules are conjugated to ABD without loss of aqueous solubility...
February 13, 2019: Small
Kausik Ganguly, Tania Saha, Arpan Saha, Tithi Dutta, Souradeep Banerjee, Debmalya Sengupta, Sreyashi Bhattacharya, Sampurna Ghosh, Mainak Sengupta
Skin pigmentation in human is a complex trait, which varies widely, both within and between human populations. The exact players governing the trait of skin pigmentation remain elusive till date. Various Genome Wide Association Studies (GWAS) have shown the association of different genomic variants with normal human skin pigmentation, often indicating genes with no direct implications in melanin biosynthesis or distribution. Little has been explained in terms of the functionality of the associated Single-Nucleotide Polymorphisms (SNPs) with respect to modulating the skin pigmentation phenotype...
February 13, 2019: Archives of Dermatological Research
M F Sazzad, M A Uddin, M A Imran, A M Ansary, S A Musa, H Saha, M M Rahman, M R Hoque, M N Islam, S Sarkar, G Tanchangya, A K Pal, I Alam, M S Ershad, M Kamruzzaman, S Sultana
We examined the hypothesis that the cross mattress for chest drain insertion site security is better than that of polypropylene horizontal mattress in chest trauma patient required tube thoracostomy at the Department of Casualty Surgery, Dhaka Medical College Hospital, Dhaka, Bangladesh from January 2016 to June 2016. Accordingly we prospectively studied 50 consecutive patients who needed chest tube insertion. In 25 consecutive cases chest drain insertion site was secured with polypropylene horizontal mattress technique (Control- Group A) and another 25 consecutive patients had a cross-mattress with non-absorbable suture materials (Experimental- Group B)...
January 2019: Mymensingh Medical Journal: MMJ
J Chowdhury, M S Islam, A R Miah, A Saha, P Pal, A A Siddique, M S Alam, M A Raihan
Dyspepsia is a symptom complex that includes epigastric pain, post-prandial fullness, bloating, early satiety, belching, nausea, vomiting, heartburn, acid regurgitations and anorexia. The most widely applied definition of dyspepsia is the Rome working team formulation namely chronic or recurrent pain or discomfort centered in the upper abdomen. Till date the prevalence of dyspepsia in Bangladesh has not been studied much. The last study was done in 1987 in a rural community and the prevalence of dyspepsia was found to be 41...
January 2019: Mymensingh Medical Journal: MMJ
A M Sarkar, S Akhter, M R Khan, M Saha, M R Alam, C K Ghosh, D S Ahmed, A R Miah, P K Roy
Several mechanisms have been proposed to explain the symptoms of functional dyspepsia but actual pathogenesis is still poorly understood. Recent studies support duodenal abnormality to be the most important causal link to explain symptoms and to understand abnormal pathophysiology of functional dyspepsia. The aim of this prospective observational study is to compare eosinophil count in duodenal mucosa between patients with functional dyspepsia and control subjects without dyspepsia and was done at the department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from December 2015 to December 2016...
January 2019: Mymensingh Medical Journal: MMJ
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