keyword
https://read.qxmd.com/read/38503845/no-adverse-association-between-exercise-exposure-and-diffuse-myocardial-fibrosis-in-male-endurance-athletes
#1
JOURNAL ARTICLE
Kristoffer Andresen, Lars Gunnar Klæboe, Øyvind Haugen Lie, Kaspar Broch, Anette Borger Kvaslerud, Gerhard Bosse, Einar Hopp, Charlotte de Lange, Kristina Hermann Haugaa, Thor Edvardsen
The potential association between endurance exercise and myocardial fibrosis is controversial. Data on exercise exposure and diffuse myocardial fibrosis in endurance athletes are scarce and conflicting. We aimed to investigate the association between exercise exposure and markers of diffuse myocardial fibrosis by cardiovascular magnetic resonance imaging (CMR) in endurance athletes. We examined 27 healthy adult male competitive endurance athletes aged 41 ± 9 years and 16 healthy controls in a cross sectional study using 3 Tesla CMR including late gadolinium enhancement and T1 mapping...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38325343/pre-participation-screenings-frequently-miss-occult-cardiovascular-conditions-in-apparently-healthy-male-middle-aged-first-time-marathon-runners
#2
Inarota Laily, Tom G H Wiggers, Niels van Steijn, Nick Bijsterveld, Adrianus J Bakermans, Martijn Froeling, Sandra van den Berg-Faay, Ferdinand H de Haan, Rianne H A C M de Bruin-Bon, S Matthijs Boekholdt, R Nils Planken, Evert Verhagen, Harald T Jorstad
INTRODUCTION: The optimal pre-participation screening strategy to identify athletes at risk for exercise-induced cardiovascular events is unknown. We therefore aimed to compare the American College of Sports Medicine (ACSM) and European Society of Cardiology (ESC) pre-participation screening strategies against extensive cardiovascular evaluations in identifying high-risk individuals among 35-50-year-old apparently healthy men. METHODS: We applied ACSM and ESC pre-participation screenings to 25 men participating in a study on first-time marathon running...
February 7, 2024: Cardiology
https://read.qxmd.com/read/38319954/the-effects-of-daily-dose-of-intense-exercise-on-cardiac-responses-and-atrial-fibrillation
#3
JOURNAL ARTICLE
Renée A Gorman, Simona Yakobov, Nazari Polidovitch, Ryan Debi, Victoria C Sanfrancesco, David A Hood, Robert Lakin, Peter H Backx
Atrial fibrillation (AF) is a supraventricular tachyarrhythmia that is strongly associated with cardiovascular (CV) disease and sedentary lifestyles. Despite the benefits of exercise on overall health, AF incidence in high-level endurance athletes rivals that of CV disease patients, suggesting a J-shaped relationship with AF. To investigate the dependence of AF vulnerability on exercise, we varied daily swim durations (120, 180 or 240 min day-1 ) in 7-week-old male CD1 mice. We assessed mice after performing equivalent amounts of cumulative work during swimming (i...
February 6, 2024: Journal of Physiology
https://read.qxmd.com/read/38282168/prognostic-relevance-of-ischemic-late-gadolinium-enhancement-in-apparently-healthy-endurance-athletes-a-follow-up-study-over-5%C3%A2-years
#4
JOURNAL ARTICLE
Gunnar K Lund, Sharon Leptin, Haissam Ragab, Martin R Sinn, Alexander Fierenz, Ersin Cavus, Kai Muellerleile, Hang Chen, Jennifer Erley, Phillip Harms, Anna Kisters, Jitka Starekova, Gerhard Adam, Enver Tahir
BACKGROUND: In many cardiac diseases, myocardial scar tissue detected by late gadolinium enhancement (LGE) is a risk factor for cardiac arrhythmia and sudden cardiac death. Previous studies in athletes reported an increased risk for cardiac events in this group of ostensibly healthy subjects. However, the currently available longitudinal studies on this topic included fairly old marathon runners with a mean age of 57 ± 6 years or represent a case-control study in athletes with preexisting ventricular arrhythmia...
January 29, 2024: Sports Medicine—Open
https://read.qxmd.com/read/38109351/reduced-ejection-fraction-in-elite-endurance-athletes-clinical-and-genetic-overlap-with-dilated-cardiomyopathy
#5
JOURNAL ARTICLE
Guido Claessen, Ruben De Bosscher, Kristel Janssens, Paul Young, Christophe Dausin, Mathias Claeys, Piet Claus, Kaatje Goetschalckx, Jan Bogaert, Amy M Mitchell, Michael D Flannery, Adrian D Elliott, Chenglong Yu, Olivier Ghekiere, Tomas Robyns, Caroline M Van De Heyning, Prashanthan Sanders, Jonathan M Kalman, Monique Ohanian, Magdalena Soka, Emma Rath, Eleni Giannoulatou, Renee Johnson, Paul Lacaze, Lieven Herbots, Rik Willems, Diane Fatkin, Hein Heidbuchel, André La Gerche
BACKGROUND: Exercise-induced cardiac remodeling can be profound, resulting in clinical overlap with dilated cardiomyopathy, yet the significance of reduced ejection fraction (EF) in athletes is unclear. The aim is to assess the prevalence, clinical consequences, and genetic predisposition of reduced EF in athletes. METHODS: Young endurance athletes were recruited from elite training programs and underwent cardiac phenotyping, genetic analyses and clinical events were recorded over a mean of 4...
December 18, 2023: Circulation
https://read.qxmd.com/read/37741350/cardiac-magnetic-resonance-assessment-of-athletic-myocardial-fibrosis-benign-bystander-or-malignant-marker
#6
REVIEW
Wasim Javed, Aneil Malhotra, Peter Swoboda
The benefits of exercise are irrefutable with a well-established dose-dependent relationship between exercise intensity and reduction in cardiovascular disease. Differentiating the physiological adaptation to exercise, termed the "athlete's heart" from cardiomyopathies, has been advanced by the advent of more sophisticated imaging modalities such as cardiac magnetic resonance imaging (CMR). Myocardial fibrosis on CMR is a mutual finding amongst seemingly healthy endurance athletes and individuals with cardiomyopathy...
September 22, 2023: International Journal of Cardiology
https://read.qxmd.com/read/37705566/external-iliac-artery-endofibrosis-a-discussion-on-two-unique-cases
#7
Vincent F Carfagno, Justin Rouintan, Michael A Rucker, David Carfagno
Iliac artery endofibrosis (IAE), as the name suggests, involves subintimal fibrosis of the iliac artery. IAE is most commonly associated with competitive athletics, particularly cycling, and remains a rather underappreciated diagnosis in the clinical setting. We present two unique and distinct presentations of IAE in competitive athletes. The first case involves a 38-year-old male cyclist who initially presented with complaints of a bulge at the right groin and acute onset monoplegia and paresthesia associated with exertion of the right lower extremity...
September 2023: Curēus
https://read.qxmd.com/read/37669972/identification-of-non-ischaemic-fibrosis-in-male-veteran-endurance-athletes-mechanisms-and-association-with-premature-ventricular-beats
#8
JOURNAL ARTICLE
Maryum Farooq, Louise A E Brown, Andrew Fitzpatrick, David A Broadbent, Ali Wahab, Joel R L Klassen, Jonathan Farley, Christopher E D Saunderson, Arka Das, Thomas Craven, Erica Dall'Armellina, Eylem Levelt, Hui Xue, Peter Kellman, John P Greenwood, Sven Plein, Peter P Swoboda
Left ventricular fibrosis can be identified by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) in some veteran athletes. We aimed to investigate prevalence of ventricular fibrosis in veteran athletes and associations with cardiac arrhythmia. 50 asymptomatic male endurance athletes were recruited. They underwent CMR imaging including volumetric analysis, bright blood (BB) and dark blood (DB) LGE, motion corrected (MOCO) quantitative stress and rest perfusion and T1/T2/extracellular volume mapping...
September 5, 2023: Scientific Reports
https://read.qxmd.com/read/37572028/circulating-gal-3-and-sst2-are-associated-with-acute-exercise-induced-sustained-endothelial-activation-possible-relevance-for-fibrosis-development
#9
JOURNAL ARTICLE
Julia M Kröpfl, Fernando G Beltrami, Hans-Jürgen Gruber, Arno Schmidt-Trucksäss, Thomas Dieterle, Christina M Spengler
Long-term, intense endurance exercise training can occasionally induce endothelial micro-damage and cardiac fibrosis. The underlying mechanisms are incompletely understood. Twenty healthy, well-trained male participants (10 runners and 10 cyclists) performed a strenuous high-intensity interval training (HIIT) session matched by age, height, weight and maximal oxygen consumption. We assessed the acute exercise response of novel cardiac biomarkers of fibrosis [e.g., galectin-3 (Gal-3) and soluble suppression of tumorigenicity 2 (sST2)] per exercise modality and their relationship with haemodynamic contributors, such as preload, afterload and cardiac contractility index (CTi), in addition to endothelial damage by sustained activation and shedding of endothelial cells (ECs)...
August 12, 2023: Experimental Physiology
https://read.qxmd.com/read/37367420/the-complex-but-fascinating-relationship-between-sport-and-atrial-fibrillation-from-pathophysiology-to-the-clinical-scenario
#10
REVIEW
Mario Tatangelo, Marco Rebecchi, Marianna Sgueglia, Alessandra Colella, Cinzia Crescenzi, Germana Panattoni, Pellegrino Ciampi, Oreste Lanza, Emanuele Canali, Leonardo Calò
Atrial fibrillation (AF) is the most common cause of hospital admission among all arrhythmias in the general population. Moreover, AF represents the most common arrhythmia in the athletic population as well. The complex but fascinating relationship between sport and atrial fibrillation has not yet been fully clarified. Although the benefits of moderate physical activity in controlling cardiovascular risk factors and in reducing the risk of atrial fibrillation have been widely demonstrated, some concerns have been raised about the potential adverse effects of physical activity...
June 11, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/37040062/role-of-echocardiography-on-early-diagnosis-of-atrial-remodelling-and-fibrosis-in-elite-athletes
#11
JOURNAL ARTICLE
Arzu Yıldırım, Sadberk Lale Tokgözoğlu, Murat Yıldırım, Yusuf Ziya Şener, Metin Okşul, Duygu Akçay, Çetin Kocaefe, Gürhan Dönmez, Hikmet Yorgun, Necla Özer
There is emerging data indicating that long-standing vigorous exercise may be associated with atrial structural remodelling. This remodelling process is may be the cause of the increasing frequency of atrial arrythmias in athletes. Early diagnosis of atrial remodelling by atrial imaging could have a role in management of atrial arrythmias in elite athletes. In this study we aimed to diagnose early phases of atrial remodelling in elite athletes. Two groups of athletes including professional weight lifters (n = 33), professional marathoners (n = 32) and sedentary participants (n = 30) were enrolled...
April 11, 2023: International Journal of Cardiovascular Imaging
https://read.qxmd.com/read/36965010/asthma-and-exercise-induced-bronchoconstriction-in-athletes-diagnosis-treatment-and-anti-doping-challenges
#12
JOURNAL ARTICLE
Morten Hostrup, Erik S H Hansen, Søren M Rasmussen, Søren Jessen, Vibeke Backer
Athletes often experience lower airway dysfunction, such as asthma and exercise-induced bronchoconstriction (EIB), which affects more than half the athletes in some sports, not least in endurance sports. Symptoms include coughing, wheezing, and breathlessness, alongside airway narrowing, hyperresponsiveness, and inflammation. Early diagnosis and management are essential. Not only because untreated or poorly managed asthma and EIB potentially affects competition performance and training, but also because untreated airway inflammation can result in airway epithelial damage, remodeling, and fibrosis...
March 25, 2023: Scandinavian Journal of Medicine & Science in Sports
https://read.qxmd.com/read/36815557/cardiac-electrophysiological-remodeling-associated-with-enhanced-arrhythmia-susceptibility-in-a-canine-model-of-elite-exercise
#13
JOURNAL ARTICLE
Alexandra Polyák, Leila Topal, Noémi Zombori-Tóth, Noémi Tóth, János Prorok, Zsófia Kohajda, Szilvia Déri, Vivien Demeter-Haludka, Péter Hegyi, Viktória Venglovecz, Gergely Ágoston, Zoltán Husti, Péter Gazdag, Jozefina Szlovák, Tamás Árpádffy-Lovas, Muhammad Naveed, Annamária Sarusi, Norbert Jost, László Virág, Norbert Nagy, István Baczkó, Attila S Farkas, András Varró
The health benefits of regular physical exercise are well known. Even so, there is increasing evidence that the exercise regimes of elite athletes can evoke cardiac arrhythmias including ventricular fibrillation and even sudden cardiac death (SCD). The mechanism of exercise-induced arrhythmia and SCD is poorly understood. Here, we show that chronic training in a canine model (12 sedentary and 12 trained dogs) that mimics the regime of elite athletes induces electrophysiological remodeling (measured by ECG, patch-clamp, and immunocytochemical techniques) resulting in increases of both the trigger and the substrate for ventricular arrhythmias...
February 23, 2023: ELife
https://read.qxmd.com/read/36286299/may-strenuous-endurance-sports-activity-damage-the-cardiovascular-system-of-healthy-athletes-a-narrative-review
#14
REVIEW
Francesca Graziano, Vencel Juhasz, Giulia Brunetti, Alberto Cipriani, Liliana Szabo, Béla Merkely, Domenico Corrado, Flavio D'Ascenzi, Hajnalka Vago, Alessandro Zorzi
The positive effects of physical activity are countless, not only on the cardiovascular system but on health in general. However, some studies suggest a U-shape relationship between exercise volume and effects on the cardiovascular system. On the basis of this perspective, moderate-dose exercise would be beneficial compared to a sedentary lifestyle, while very high-dose physical activity would paradoxically be detrimental. We reviewed the available evidence on the potential adverse effects of very intense, prolonged exercise on the cardiovascular system, both acute and chronic, in healthy athletes without pre-existing cardiovascular conditions...
October 10, 2022: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/36196004/voltage-mapping-and-pulmonary-vein-isolation-in-master-athletes-with-atrial-fibrillation
#15
JOURNAL ARTICLE
Brian Liu, Eric Pagan, Nicholas Beccarino, David Chang, Eric Dulmovits, Stuart Beldner
BACKGROUND: Master athletes encompass a wide range of exercise enthusiasts. At the extreme, there is an increased risk of atrial fibrillation (AF). Therapies aimed at rate or rhythm control are often limited given unfavorable side effects. Although studies suggest an increase in left atrial (LA) fibrosis in this population, minimal electrophysiologic data exist regarding the LA voltage mapping and the efficacy of AF ablation with pulmonary vein isolation (PVI). METHODS: In a retrospective single-center study, we reviewed AF ablations (pulmonary vein isolation and assessment/ablation of non-pulmonary vein triggers) performed in extreme master athletes with AF...
October 4, 2022: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/35950659/strenuous-endurance-exercise-and-the-heart-physiological-versus-pathological-adaptations
#16
JOURNAL ARTICLE
Pedro L Valenzuela, Aaron Baggish, Adrián Castillo-García, Alejandro Santos-Lozano, Araceli Boraita, Alejandro Lucia
Although the benefits of regular physical activity on cardiovascular health are well established, the effects of strenuous endurance exercise (SEE) have been a matter of debate since ancient times. In this article, we aim to provide a balanced overview of what is known about SEE and the heart-from epidemiological evidence to recent cardiac imaging findings. Lifelong SEE is overall cardioprotective, with endurance master athletes showing in fact a youthful heart. Yet, some lines of research remain open, such as the need to elucidate the time-course and potential relevance of transient declines in heart function (or increases in biomarkers of cardiac injury) with SEE...
August 11, 2022: Comprehensive Physiology
https://read.qxmd.com/read/35834825/endurance-training-induced-cardiac-remodeling-in-a-guinea-pig-athlete-s-heart-model
#17
JOURNAL ARTICLE
Leila Topal, Alexandra Polyák, Noémi Tóth, Gergely Ágoston, Péter Bencsik, Zsófia Kohajda, Janos Prorok, Szilvia Déri, Norbert Nagy, Norbert Jost, László Virág, Attila Sándor Farkas, András Varró, István Baczkó
Besides the health benefits of regular exercise, high-level training - above an optimal level -may have adverse effects. In this study, we investigated the effects of long-term vigorous training and its potentially detrimental structural-functional changes in a small animal athlete's heart model. Thirty-eight 4-month-old male guinea pigs were randomised into sedentary and exercised groups. The latter underwent a 15-week-long endurance-training program. To investigate the effects of the intense long-term exercise, in vivo (echocardiography, electrocardiography), ex vivo and in vitro (histopathology, patch-clamp) measurements were performed...
July 14, 2022: Canadian Journal of Physiology and Pharmacology
https://read.qxmd.com/read/35734145/arrhythmogenesis-of-sports-myth-or-reality
#18
REVIEW
Saad Fyyaz, Michael Papadakis
Regular exercise confers health benefits with cardiovascular mortality risk reduction through a variety of mechanisms. At a population level, evidence suggests that undertaking more exercise has greater benefits. In the modern era of sport, there has been an exponential rise in professional and amateur athletes participating in endurance events, with a progressively better understanding of the associated cardiac adaptations, collectively termed 'athletes heart'. However, emerging data raise questions regarding the risk of potential harm from endurance exercise, with an increased risk of arrhythmia from adverse cardiac remodelling...
April 2022: Arrhythmia & Electrophysiology Review
https://read.qxmd.com/read/34902061/acute-impact-of-an-endurance-race-on-biventricular-and-biatrial-myocardial-strain-in-competitive-male-and-female-triathletes-evaluated-by-feature-tracking-cmr
#19
JOURNAL ARTICLE
Hang Chen, Malte L Warncke, Kai Muellerleile, Dennis Saering, Antonia Beitzen-Heineke, Anna Kisters, Monika Swiderska, Ersin Cavus, Charlotte M Jahnke, Gerhard Adam, Gunnar K Lund, Enver Tahir
OBJECTIVES: Cardiac adaptation in endurance athletes is a well-known phenomenon, but the acute impact of strenuous exercise is rarely reported on. The aim of this study was to analyze the alterations in biventricular and biatrial function in triathletes after an endurance race using novel feature-tracking cardiac magnetic resonance (FT-CMR). METHODS: Fifty consecutive triathletes (45 ± 10 years; 80% men) and twenty-eight controls were prospectively recruited, and underwent 1...
December 13, 2021: European Radiology
https://read.qxmd.com/read/34611636/absence-of-cardiac-damage-induced-by-long-term-intensive-endurance-exercise-training-a-cardiac-magnetic-resonance-and-exercise-echocardiography-analysis-in-masters-athletes
#20
JOURNAL ARTICLE
Olivier Missenard, Charline Gabaudan, Helene Astier, Florian Desmots, Eric Garnotel, Pierre-Laurent Massoure
Objectives: It is under debate whether the long-term practice of intensive endurance exercise induces chronic cardiac damage such as myocardial fibrosis and ventricle contractile dysfunction. Multimodality analysis was performed to evaluate myocardial damage induced by long term intensive endurance training in master athletes. Methods: Thirty-three asymptomatic endurance master athletes (47 ± 6 year-old, 9,6 ± 1,7 h training/week for 26 ± 6 years), were compared to 18 sedentary controls (49 ± 7 year-old)...
September 2021: American journal of preventive cardiology
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