Jian-Rong He, Yongfu Yu, Fang Fang, Mika Gissler, Per Magnus, Krisztina D László, Mary H Ward, Ora Paltiel, Gabriella Tikellis, Milena Maria Maule, Xiu Qiu, Jiangbo Du, Unnur Anna Valdimarsdóttir, Kazem Rahimi, Joseph L Wiemels, Martha S Linet, Jane E Hirst, Jiong Li, Terence Dwyer
IMPORTANCE: Maternal infection is common during pregnancy and is an important potential cause of fetal genetic and immunological abnormalities. Maternal infection has been reported to be associated with childhood leukemia in previous case-control or small cohort studies. OBJECTIVE: To evaluate the association of maternal infection during pregnancy with childhood leukemia among offspring in a large study. DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study used data from 7 Danish national registries (including the Danish Medical Birth Register, the Danish National Patient Registry, the Danish National Cancer Registry, and others) for all live births in Denmark between 1978 and 2015...
February 1, 2023: JAMA Network Open