Philip C Haycock, Maria Carolina Borges, Kimberley Burrows, Rozenn N Lemaitre, Sean Harrison, Stephen Burgess, Xuling Chang, Jason Westra, Nikhil K Khankari, Kostas K Tsilidis, Tom Gaunt, Gibran Hemani, Jie Zheng, Therese Truong, Tracy A O'Mara, Amanda B Spurdle, Matthew H Law, Susan L Slager, Brenda M Birmann, Fatemeh Saberi Hosnijeh, Daniela Mariosa, Christopher I Amos, Rayjean J Hung, Wei Zheng, Marc J Gunter, George Davey Smith, Caroline Relton, Richard M Martin
BACKGROUND: Mendelian randomization (MR) studies are susceptible to metadata errors (e.g. incorrect specification of the effect allele column) and other analytical issues that can introduce substantial bias into analyses. We developed a quality control (QC) pipeline for the Fatty Acids in Cancer Mendelian Randomization Collaboration (FAMRC) that can be used to identify and correct for such errors. METHODS: We collated summary association statistics from fatty acid and cancer genome-wide association studies (GWAS) and subjected the collated data to a comprehensive QC pipeline...
October 2023: International Journal of Epidemiology