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Joseph Jacob, Michael Pienn, Christian Payer, Martin Urschler, Maria Kokosi, Anand Devaraj, Athol U Wells, Horst Olschewski
BACKGROUND AND OBJECTIVE: This study aimed to investigate whether quantitative lung vessel morphology determined by a new fully automated algorithm is associated with functional indices in idiopathic pulmonary fibrosis (IPF). METHODS: A total of 152 IPF patients had vessel volume, density, tortuosity and heterogeneity quantified from computed tomography (CT) images by a fully automated algorithm. Separate quantitation of vessel metrics in pulmonary arteries and veins was performed in 106 patients...
February 20, 2019: Respirology: Official Journal of the Asian Pacific Society of Respirology
Yong Hu, Guohua Zhong, Ying-Shi Guan, Jason N Armstrong, Changning Li, Changjiang Liu, Alpha N'Diaye, Anand Bhattacharya, Shenqiang Ren
Strongly correlated electronic molecules open the way for strong coupling between charge, spin, and lattice degrees of freedom to enable interdisciplinary fields, such as molecular electronic switches and plasmonics, spintronics, information storage, and superconducting circuits. However, despite exciting computational predictions and promising advantages to prepare flexible geometries, the electron correlation effect in molecules has been elusive. Here, the electron correlation effects of molecular plasmonic films are reported to uncover their coupling of charge, spin, lattice, and orbital for the switchable metal-to-insulator transition under external stimuli, at which the simultaneous transition occurs from the paramagnetic, electrical, and thermal conducting state to the diamagnetic, electrical, and thermal insulating state...
February 20, 2019: Small
Mark Hayter, Anand Ahankari, Khurshid Jamadar, Anita Nawale, Pravina Mahadalkar
In India, nurses and midwives make up more than 30% of the national healthcare workforce (World Health Organisation, 2016). The country has also witnessed a phenomenal growth in the uptake of nursing education with an increase during the last eight years of Graduate nursing schools; 285 to 3215, BSc colleges; 30 to 1936, and MSc nursing colleges; 10 to 643 (Indian Nursing Council, 2019). Many of the BSc and MSc colleges are now moving to health universities and deemed institutes. Academic nursing is also developing apace and the University Grant Commission (UGC) of India now requires that university lecturers must hold, as a minimum, a master's degree in their subject and preferable a PhD...
February 20, 2019: Journal of Advanced Nursing
Andreas Charidimou, Gregoire Boulouis, Duangnapa Roongpiboonsopit, Li Xiong, Marco Pasi, Kristin M Schwab, Jonathan Rosand, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
BACKGROUND: To obtain more precise estimates on cortical superficial siderosis as an MRI predictor of lobar intracerebral hemorrhage (ICH) recurrence risk in cerebral amyloid angiopathy (CAA) from a large prospective MRI cohort and a systematic review. METHODS: We analyzed a single-center MRI prospective cohort of consecutive CAA-related ICH survivors. Using Kaplan-Meier and Cox regression analyses, we investigated cortical superficial siderosis and ICH risk, adjusting for known confounders...
February 20, 2019: International Journal of Stroke: Official Journal of the International Stroke Society
Deepika Anand, Catherine Paquette, Anna Bartuska, Stacey B Daughters
BACKGROUND: Research examining directionality of the relationship between depressive symptoms and substance use following treatment entry is limited. Furthermore, substances differ in their neurobiological effects on mood. The relationship between depression and substance use following treatment entry may be moderated by dependence on specific substances. The study tested (a) lagged effects between depressive symptoms and substance use frequency following substance use treatment entry through a 1-year post-treatment follow-up and (b) if substance dependence type moderates these effects...
February 5, 2019: Drug and Alcohol Dependence
Shilpa Anand, Susan Thomas, Mahesh Jayachandra, Tinku Thomas, Tor Arne Strand, Anura V Kurpad, Christopher P Duggan, Krishnamachari Srinivasan
INTRODUCTION: Vitamin B12 deficiency is highly prevalent in pregnant Indian women. Neuropsychological tests have shown an association between low maternal vitamin B12 status and poorer cognitive performances in the offspring, although findings from these studies have been inconsistent. Vitamin B12 has an important role in the formation of myelin which is important for the transmission speed of neural impulses and myelination in the central nervous system has been linked to cognition. Assessing neurophysiological measures using event-related potentials (ERPs) in children may provide additional information on the effect of maternal vitamin B12 supplementation on offspring brain function...
February 19, 2019: BMJ Open
Monalisa Jena, Rajeev Ranjan, Biswa Ranjan Mishra, Archana Mishra, Shantanu Nath, Pallabi Sahu, Bikash Ranjan Meher, Anand Srinivasan, Rituparna Maiti
Neurotrophic factors like Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin 3 (NT3) and Nerve Growth Factor (NGF), play a role in neuroplasticity and neurogenesis contributing to the pathogenesis of schizophrenia. The objective of the present study was to investigate and compare the effect of olanzapine and lurasidone on the change in serum neurotrophins in patients with schizophrenia. The present study was a randomized, open-label, active-controlled, parallel design clinical trial. After randomization baseline evaluations of serum BDNF, NGF, NT3, Positive and Negative Syndrome Scale (PANSS) scoring, Social and Occupational Functioning Assessment Scale (SOFAS) scoring of 101 unmedicated schizophrenia patients were done...
February 12, 2019: Journal of Psychiatric Research
Anand S Iyer, Kristen E Holm, Surya P Bhatt, Victor Kim, Gregory L Kinney, Frederick S Wamboldt, Michael R Jacobs, Elizabeth A Regan, Hilary F Armstrong, Katherine E Lowe, Carlos H Martinez, Mark T Dransfield, Marilyn G Foreman, Gen Shinozaki, Nicola A Hanania, Robert A Wise, Barry J Make, Karin F Hoth
OBJECTIVES: To compare the frequency of anxiety/depressive symptoms and use of anxiolytic-hypnotics/antidepressants in smokers with and without COPD and to identify characteristics associated with having unmedicated symptoms. METHODS: Cross-sectional analysis of ambulatory, current/former smokers ≥10 pack years enrolled in the COPDGene study. We measured anxiety/depressive symptoms using the Hospital Anxiety and Depression Scale (subscales ≥8), recorded anxiolytic-hypnotic/antidepressant use, and defined unmedicated symptoms as elevated anxiety/depressive symptoms and not on medications...
March 2019: Journal of Psychosomatic Research
Alan Hsieh, Charles Murchison, Anand Devaiah
BACKGROUND: We sought to understand thyroid cancer study modalities, publications, and grants. This provides scope, resources, and dissemination patterns to inform future directions for research and policy. METHODS: A retrospective study of thyroid cancer trials using was performed. Publication and grant awards were sourced using and NIH RePORTER, respectively. RESULTS: Seventy-three thyroid cancer trials were identified out of 217 000 from 1998 to 2015...
February 18, 2019: Head & Neck
Venkatraman Radhakrishnan, Anand Raja, Manikandan Dhanushkodi, T S Ganesan, G Selvaluxmy, T G Sagar
OBJECTIVES: Management of neuroblastoma, especially high-risk (HR) disease is difficult in a resource-limited setting. There is a paucity of literature on outcomes of patients treated in India. The present study was conducted to analyse the clinical profile, treatment, and outcomes of patients with neuroblastoma treated at authors' centre. METHODS: The study was a retrospective analysis of newly diagnosed patients with neuroblastoma treated at authors' centre between 2000 to 2017...
February 18, 2019: Indian Journal of Pediatrics
Anand Narain Srivastava, Jata Shankar Misra, Shruti Srivastava, Bhudav C Das, Shilpi Gupta
Cervical carcinoma is one of the most common and dreaded diseases of women, and in India, it accounts for 16 per cent of total cervical cancer cases occurring globally. The situation is more alarming in the rural areas where the majority of women are illiterate and ignorant about the hazards of cervical cancer. Different screening strategies such as rural cancer registries and camp approach for cancer detection have been found useful in minimizing the problem of cervical cancer in the villages. Various screening techniques such as visual inspection with acetic acid, visual inspection with Lugol's iodine, visual inspection with magnification devices-magnavisualizer, Pap smear and HPV-DNA testing have been suggested and tried under low-resource settings of our country, and cervical cytology screening has been found effective in reducing incidence of the disease...
December 2018: Indian Journal of Medical Research
Awanish Kumar, Ajay Kumar Pal, Anuraag Choudhary, Akshay Anand, Abhinav Arun Sonkar, Harvinder Singh Pahwa
Purpose: Among laparoscopic surgeries in inguinal hernias, totally extraperitoneal (TEP) repair has demonstrated favourable results in reduction of post-operative pain and mean operative times with early return to physical activity. We have done a prospective comparative study on two different techniques of mesh fixation, i.e., transfascial suture and tack fixation. Materials and Methods: It was a prospective, non-randomised comparative study done on inguinal hernia patients operated by TEP repair from October 2014 to September 2016...
February 18, 2019: Journal of Minimal Access Surgery
Christoph F Dietrich, Paolo Giorgio Arcidiacono, Barbara Braden, Sean Burmeister, Silvia Carrara, Xinwu Cui, Milena Di Leo, Yi Dong, Pietro Fusaroli, Odd Helge Gilja, Andrew J Healey, Michael Hocke, Stephan Hollerbach, Julio Iglesias Garcia, André Ignee, Christian Jürgensen, Michel Kahaleh, Masayuki Kitano, Rastislav Kunda, Alberto Larghi, Kathleen Möller, Bertrand Napoleon, Kofi W Oppong, Maria Chiara Petrone, Adrian Saftoiu, Rajesh Puri, Anand V Sahai, Erwin Santo, Malay Sharma, Assaad Soweid, Siyu Sun, Anthony Yuen Bun Teoh, Peter Vilmann, Christian Jenssen
Direct referral of patients for EUS - instead of preprocedural consultation with the endosonographer - has become standard practice (like for other endoscopic procedures) as it is time- and cost-effective. To ensure appropriate indications and safe examinations, the endosonographer should carefully consider what information is needed before accepting the referral. This includes important clinical data regarding relevant comorbidities, the fitness of the patient to consent and undergo the procedure, and the anticoagulation status...
January 2019: Endoscopic Ultrasound
Ángel Chamorro, Scott Brown, Sergio Amaro, Michael D Hill, Keith W Muir, Diederik W J Dippel, Wim van Zwam, Ken Butcher, Gary A Ford, Heleen M den Hertog, Peter J Mitchell, Andrew M Demchuk, Charles B L M Majoie, Serge Bracard, Igor Sibon, Ashutosh P Jadhav, Blanca Lara-Rodriguez, Aad van der Lugt, Elizabeth Osei, Arturo Renú, Sébastien Richard, David Rodriguez-Luna, Geoffrey A Donnan, Anand Dixit, Mohammed Almekhlafi, Sandrine Deltour, Jonathan Epstein, Benoit Guillon, Serge Bakchine, Meritxell Gomis, Richard du Mesnil de Rochemont, Demetrius Lopes, Vivek Reddy, Gernot Rudel, Yvo B W E M Roos, Alain Bonafe, Hans-Christoph Diener, Olvert A Berkhemer, Geoffrey C Cloud, Stephen M Davis, Robert van Oostenbrugge, Francis Guillemin, Mayank Goyal, Bruce C V Campbell, Bijoy K Menon
Background and Purpose- Hyperglycemia is a negative prognostic factor after acute ischemic stroke but is not known whether glucose is associated with the effects of endovascular thrombectomy (EVT) in patients with large-vessel stroke. In a pooled-data meta-analysis, we analyzed whether serum glucose is a treatment modifier of the efficacy of EVT in acute stroke. Methods- Seven randomized trials compared EVT with standard care between 2010 and 2017 (HERMES Collaboration [highly effective reperfusion using multiple endovascular devices])...
February 19, 2019: Stroke; a Journal of Cerebral Circulation
Srikanth Katla, Bappa Karmakar, Subbi Rami Reddy Tadi, Naresh Mohan, B Anand, Uttariya Pal, Senthilkumar Sivaprakasam
AIMS: The present study was aimed at design of experiments (DoE) and artificial intelligence based culture medium optimization for high level extracellular production of a novel recombinant human interferon alpha 2b (huIFNα2b) in glycoengineered Pichia pastoris and its characterization. METHODS AND RESULTS: Artificial neural network- Genetic algorithm (ANN-GA) model exhibited improved huIFNα2b production and better predictability compared to RSM. The optimized medium exhibited 5-fold increase in huIFNα2b titer compared to the complex medium...
February 18, 2019: Journal of Applied Microbiology
N Ahuja, J Kathiresan, T Anand, P Isaakidis, D Bajaj
Setting and Objetives: Police personnel, alongside other key stakeholders, are responsible for implementing the Cigarettes and Other Tobacco Products Act (COTPA) in India. This study aimed to assess knowledge and attitudes about COTPA among police personnel and explore enablers and barriers in implementing it. Design: This convergent parallel mixed-methods study used a self-administered questionnaire (quantitative) and key informant interviews (qualitative). Of 300 police personnel across all eight police stations in Daman, 155 participated...
December 21, 2018: Public Health Action
Aakash Agarwal, Boren Lin, Jeffrey C Wang, Christian Schultz, Steve R Garfin, Vijay K Goel, Neel Anand, Anand K Agarwal
Study Design: A prospective single-center study. Objectives: Assess to what degree contamination of pedicle screws occur in standard intraoperative practice and if use of an impermeable guard could mitigate or reduce such an occurrence. Methods: Two groups of sterile prepackaged pedicle screws, one with an intraoperative guard (group 1) and the other without such a guard (group 2), each consisting of 5 samples distributed over 3 time points, were loaded onto the insertion device by the scrub tech and left on the sterile table...
February 2019: Global Spine Journal
Robert K Eastlack, Ravi Srinivas, Gregory M Mundis, Stacie Nguyen, Praveen V Mummaneni, David O Okonkwo, Adam S Kanter, Neel Anand, Paul Park, Pierce Nunley, Juan S Uribe, Behrooz A Akbarnia, Dean Chou, Vedat Deviren
Study Design: A multicenter retrospective review of an adult spinal deformity database. Objective: We aimed to characterize reoperation rates and etiologies of adult spinal deformity surgery with circumferential minimally invasive surgery (cMIS) and hybrid (HYB) techniques. Methods: Inclusion criteria were age ≥18 years, and one of the following: coronal Cobb >20°, sagittal vertical axis >5 cm, pelvic tilt >20°, and pelvic incidence-lumbar lordosis >10°...
February 2019: Global Spine Journal
Anu Rani, Amit Anand, Kewal Kumar, Vipan Kumar
Chalcones are attractive to synthetic chemists because they are easy to prepare, have a large number of replaceable hydrogens, thereby having significant biological potential. Chalcones and their derivatives (carbocyclic as well as heterocyclic) exhibit a range of biological properties including anticancer, antimalarial, antioxidant, anti-inflammatory and anti-tubercular activities. Their promising biological profile, along with their ease of synthetic manipulations, have triggered the design and development of new chalcone derivatives as well as their conjugates with active pharmacophores affording therapeutic templates targeting various diseases...
March 2019: Expert Opinion on Drug Discovery
Dian A Munawar, Rajiv Mahajan, Thomas A Agbaedeng, Anand Thiyagarajah, Darragh J Twomey, Kashif Khokar, Catherine O'Shea, Glenn D Young, Kurt C Roberts-Thomson, Muhammad Munawar, Dennis H Lau, Prashanthan Sanders
BACKGROUND: Atrial fibrillation (AF) is common after pacemaker implantation. Nevertheless, the impact of pacemaker algorithms in AF prevention is not well understood. OBJECTIVES: To evaluate the role of pacing algorithms in preventing AF progression. METHODS: A systematic search of articles using PUBMED and EMBASE database resulted in a total of 754 references. After exclusions, 21 randomized controlled trials (8,336 patients) were analysed, comprising studies reporting ventricular pacing percentage (VP%) (AAI vs DDD, n=1; and reducing ventricular pacing (RedVP) algorithms, n=2), atrial pacing therapies (atrial preference pacing (APP), n=14; antitachycardia pacing (aATP)+APP,n=3; and RedVP+APP+aATP,n=1)...
February 14, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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