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Mariann Bombicz, Daniel Priksz, Rudolf Gesztelyi, Rita Kiss, Nora Hollos, Balazs Varga, Jozsef Nemeth, Attila Toth, Zoltan Papp, Zoltan Szilvassy, Bela Juhasz
Background and Aims : Diabetic cardiomyopathy (DCM) is an emerging problem worldwide due to an increase in the incidence of type 2 diabetes. Animal studies have indicated that metformin and pioglitazone can prevent DCM partly by normalizing insulin resistance, and partly by other, pleiotropic mechanisms. One clinical study has evidenced the insulin-senzitizing effect of the drug candidate BGP-15, along with additional animal studies that have confirmed its beneficial effects in models of diabetes, muscular dystrophy and heart failure, with the drug affecting chaperones, contractile proteins and mitochondria...
February 7, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ioannis Vogiatzis, Nikolaos Chynkiamis, Matthew Armstrong, Nicholas D Lane, Tom Hartley, William K Gray, Stephen C Bourke
During exercise, non-invasive ventilation (NIV) prolongs endurance in chronic obstructive pulmonary disease (COPD), but routine use is impractical. The VitaBreath device provides portable NIV (pNIV); however, it can only be used during recovery. We assessed the effect of pNIV compared to pursed lip breathing (PLB) on exercise tolerance. Twenty-four COPD patients were randomised to a high-intensity (HI: 2-min at 80% peak work rate (WRpeak) alternated with 2-min recovery; n = 13), or a moderate-intensity (MOD: 6-min at 60% WRpeak alternated with 2-min recovery; n = 11) protocol, and within these groups two tests were performed using pNIV and PLB during recovery in balanced order...
January 15, 2019: Journal of Clinical Medicine
Stéfanie Parisien-La Salle, Ellie Abel Rivest, Vincent Gosselin Boucher, Mélina Lalande-Gauthier, Julie Morisset, Hélène Manganas, Claude Poirier, Alain-Steve Comtois, Bruno-Pierre Dubé
BACKGROUND: Although mainly described in patients with chronic obstructive pulmonary disease, pursed lip breathing (PLB) could prove useful in patients with interstitial lung disease (ILD) by improving exertional tachypnea and respiratory control. This prospective, randomized, crossover trial aimed at evaluating the impact of PLB on dyspnea and walking distance in ILD patients. METHODS: ILD patients with total lung capacity of <80% predicted were randomized to 6-min walk tests using either PLB or usual breathing...
January 7, 2019: Journal of Cardiopulmonary Rehabilitation and Prevention
Cosmo A Saunders, Ritankar Majumdar, Yaniris Molina, Bhagawat C Subramanian, Carole A Parent
Neutrophils are the most common leukocyte in human blood and are the first cells to respond to injury and infection. Improper neutrophil chemotaxis can have deleterious effects on human health, including autoimmune diseases, poor innate immune response, and cancer. Therefore, gaining a better understanding of the signaling pathways governing chemotactic responses in these cells is important. One of the main challenges of working with primary human neutrophils is their short lifespan (about 1 day), making genetic manipulations not feasible...
2019: Methods in Cell Biology
Kedong Xu, Yunxia Chang, Wei Wang, Ju Zhang, Bojin Feng, Cuicui Wang, Yan Liu, Qing Chen, Guangxuan Tan, Chengwei Li, Liangjun Zhao
The HAP3 subfamily gene RcLEC1-B, was isolated from protocorm-like body (PLB) of Rosa canina, encodes 213 amino acid residues. It was shown that RcLEC1-B was specifically expressed in PLB of R. canina and its subcellular localization is in the nucleus. Overexpression of RcLEC1-B in Arabidopsis resulted in a decrease in endogenous ABA level, an increase in GA, IAA and CTK contents, and an increased number of branches. RcLEC1-B promotes the formation of spontaneous embryoids, suggesting that it may be a homolog of the Arabidopsis LEC1 gene...
December 7, 2018: Gene
Chintan N Koyani, Christopher Trummer, Niroj Shrestha, Susanne Scheruebel, Benjamin Bourgeois, Ioanna Plastira, Sandra Kickmaier, Harald Sourij, Peter P Rainer, Tobias Madl, Wolfgang Sattler, Brigitte Pelzmann, Ernst Malle, Dirk von Lewinski
Some oral anti-hyperglycemic drugs, including gliptins that inhibit dipeptidyl peptidase 4 (DPP4), have been linked to the increased risk of heart failure (HF) in type-2 diabetic patients. While the cardiovascular safety trial, TECOS, revealed no link between sitagliptin and the risk of HF, a substantial 27% increase in the hospitalization for HF was observed in type-2 diabetic patients treated with saxagliptin within the SAVOR-TIMI 53 trial. A previous in vitro study revealed that saxagliptin impairs the Ca2+ /calmodulin-dependent protein kinase II (CaMKII)-phospholamban (PLB)-sarcoplasmic reticulum Ca2+ -ATPase 2a axis and protein kinase C (PKC) activity in cardiomyocytes leading to impaired cardiac contractility and electrophysiological function...
2018: Frontiers in Physiology
Dan Wu, Xin Wang, Junjie Bai, Xiaoyang Xu, Bin Ouyang, Yuwei Li, Heye Zhang, Qi Song, Kunlin Cao, Youbing Yin
PURPOSE: Automated anatomical labeling facilitates the diagnostic process for physicians and radiologists. One of the challenges in automated anatomical labeling problems is the robustness to handle the large individual variability inherited in human anatomy. A novel deep neural network framework, referred to Tree Labeling Network (TreeLab-Net), is proposed to resolve this problem in this work. METHODS: A multi-layer perceptron (MLP) encoder network and a bidirectional tree-structural long short-term memory (Bi-TreeLSTM) are combined to construct the TreeLab-Net...
November 27, 2018: International Journal of Computer Assisted Radiology and Surgery
Yanggan Wang, Thitima Keskanokwong, Jun Cheng
BACKGROUND: Down-regulation of Kv4.3 protein is a general feature of cardiac hypertrophy. Based on our recent studies, we propose that Kv4.3 reduction may be a hypertrophic stimulator. OBJECTIVE: We tested whether Kv4.3 expression can prevent or reverse cardiac hypertrophy induced by norepinephrine (NE). METHODS AND RESULTS: Incubation of 20 μM NE in cultured neonatal rat ventricular myocytes (NRVMs) for 48 h and 96 h induced myocyte hypertrophy in a time-dependent manner, characterized by progressive increase in cell size, protein/DNA ratio, ANP and BNP, along with an progressive increase in the activity of CaMKII and calcineurin and reduction of Kv4...
November 18, 2018: Journal of Molecular and Cellular Cardiology
Shahriar Sakhaei, Hassan Ebrahimpour Sadagheyani, Soryya Zinalpoor, Abdolah Khorami Markani, Hossein Motaarefi
BACKGROUND: Respiratory system, together with the cardiovascular and central nervous system, is responsible for all processes related to oxygenation and hemodynamics and the defect in the functioning of each of these systems, along with ageing, can have mutual effects on their performance and physiological symptoms. The use of Pursed-lips Breathing (PLB) training is an essential part of the treatment of patients with the obstructive pulmonary disease, PLB stimulates the autonomic nervous system and causes relaxation and improvement of physiological parameters...
October 25, 2018: Open Access Macedonian Journal of Medical Sciences
Cécile Low-Kam, David Rhainds, Ken Sin Lo, Amina Barhdadi, Marie Boulé, Sonia Alem, Valérie Pedneault-Gagnon, Eric Rhéaume, Marie-Pierre Dubé, David Busseuil, Robert A Hegele, Guillaume Lettre, Jean-Claude Tardif
Background Macrophage cholesterol efflux to high-density lipoproteins ( HDLs ) is the first step of reverse cholesterol transport. The cholesterol efflux capacity ( CEC ) of HDL particles is a protective risk factor for coronary artery disease independent of HDL cholesterol levels. Using a genome-wide association study approach, we aimed to identify pathways that regulate CEC in humans. Methods and Results We measured CEC in 5293 French Canadians. We tested the genetic association between 4 CEC measures and genotypes at >9 million common autosomal DNA sequence variants...
August 21, 2018: Journal of the American Heart Association
Rita S Costa, Ana F Cardoso, Anibal Ferreira, Juliana Costa, Dalila Costa, Dália Fernandes, Ana C Caetano
INTRODUCTION: Percutaneous liver biopsy (PLB) is an invasive procedure used for the assessment of liver diseases. The patient's recovery position after the PLB differs among hospitals and departments. This study aims to evaluate adverse events and patient acceptability according to the recovery position adopted after the PLB. PATIENTS AND METHODS: From September 2014 to March 2017, patients submitted to PLB were randomly assigned to a recovery position arm: right-side position (RRP), dorsal position (DRP), or combined position...
October 24, 2018: European Journal of Gastroenterology & Hepatology
Huimin Hu, Quanhua Mu, Zhaoshi Bao, Yiyun Chen, Yanwei Liu, Jing Chen, Kuanyu Wang, Zheng Wang, Yoonhee Nam, Biaobin Jiang, Jason K Sa, Hee-Jin Cho, Nam-Gu Her, Chuanbao Zhang, Zheng Zhao, Ying Zhang, Fan Zeng, Fan Wu, Xun Kang, Yuqing Liu, Zenghui Qian, Zhiliang Wang, Ruoyu Huang, Qiangwei Wang, Wei Zhang, Xiaoguang Qiu, Wenbin Li, Do-Hyun Nam, Xiaolong Fan, Jiguang Wang, Tao Jiang
Low-grade gliomas almost invariably progress into secondary glioblastoma (sGBM) with limited therapeutic option and poorly understood mechanism. By studying the mutational landscape of 188 sGBMs, we find significant enrichment of TP53 mutations, somatic hypermutation, MET-exon-14-skipping (METex14), PTPRZ1-MET (ZM) fusions, and MET amplification. Strikingly, METex14 frequently co-occurs with ZM fusion and is present in ∼14% of cases with significantly worse prognosis. Subsequent studies show that METex14 promotes glioma progression by prolonging MET activity...
October 12, 2018: Cell
King-Wah Chiu, Ting-Lung Lin, Chee-Chien Yong, Chih-Che Lin, Yu-Fan Cheng, Chao-Long Chen
RATIONALE: According to previously published studies, major complications arising from a percutaneous liver biopsy are rare and occur in less than 0.1% of cases. This report describes an approach to percutaneous liver biopsy that can help avoid damage to the liver in a living donor liver transplantation (LDLT) setting. PATIENT CONCERNS: Case 1: In the first case a donor percutaneous liver biopsy (PLB) of both lobes of the liver was performed for pre-LDLT evaluation...
October 2018: Medicine (Baltimore)
Ben Fm Wijnen, Ruben Plb Van Engelen, Jan Ostermann, Axel Muhlbacher, Arnolf Fw Hendriks, Rafael Conde, Javier Gr Gonzalez, Mark Jg Govers, Silvia Maa Evers, Mickaël Hiligsmann
BACKGROUND: To assess patients' preferences for HIV testing in Colombia. METHODS: A discrete-choice experiment was used to assess preferences of patients diagnosed with HIV, for HIV testing in two HIV clinics in Bogotá, Colombia. Patients were asked to choose repeatedly between two hypothetical HIV testing options that varied with respect to five attributes: distance to testing site, confidentiality, testing days, sample collection method and the services if HIV positive...
October 3, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
Anna Del Poggio, Luca Facchetti, Alessandra Ranza, Fabio Facchetti, Ugo Pazzaglia, Maria Pia Bondioni
Primary lymphoma of bone (PLB) is a rare entity, defined as a lymphoma confined to the bone without evidence of systemic involvement. The disease commonly affects middle-aged to elderly population and it accounts for less than 1% of all malignant lymphomas. We present a case of a 10-year-old child affected by PLB of the forearm and the frontal bone. Characteristic imaging features of PLB and the main differential diagnosis were discussed.
December 2018: Radiology Case Reports
Mu Chen, Dongzhu Xu, Adonis Z Wu, Evangelia Kranias, Shien-Fong Lin, Peng-Sheng Chen, Zhenhui Chen
AIMS: Phospholamban (PLB) is the key regulator of the cardiac Ca2+ pump (SERCA2a)-mediated sarcoplasmic reticulum Ca2+ stores. We recently reported that PLB is highly concentrated in the nuclear envelope (NE) from where it can modulate perinuclear Ca2+ handling of the cardiomyocytes (CMs). Since inositol 1,4,5-trisphosphate (IP3 ) receptor (IP3 R) mediates nuclear Ca2+ release, we examined whether the nuclear pool of PLB regulates IP3 -induced nuclear Ca2+ handling. METHODS AND RESULTS: Fluo-4 based confocal Ca2+ imaging was performed to measure Ca2+ dynamics across both nucleus and cytosol in saponin-permeabilized CMs isolated from wild-type (WT) or PLB-knockout (PLB-KO) mice...
October 2018: Journal of Molecular and Cellular Cardiology
Hideaki Fukuda, Shigehiro Asai, Izumi Kanisawa, Tatsuya Takahashi, Takahiro Ogura, Hiroki Sakai, Kenji Takahashi, Akihiro Tsuchiya
PURPOSE: The purpose of this study was to evaluate the signal/noise quotient (SNQ) for graft maturation and the serial changes observed in the magnetic resonance imaging (MRI) findings after double-bundle (DB) anterior cruciate ligament (ACL) reconstruction using a hamstring tendon autograft at a minimum of 5 years after surgery. METHODS: Forty-five patients who underwent DB ACL reconstruction between 2007 and 2010 were included in this prospective study. All participants underwent postoperative MRI at 3 weeks and 3, 6, 9 and 12, 18, 24, 36, 48 and 50 months...
September 8, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Emily Chen, Bruna Benso, Dalia Seleem, Luiz Eduardo Nunes Ferreira, Silvana Pasetto, Vanessa Pardi, Ramiro Mendonça Murata
Current treatments for Candida albicans infection are limited due to the limited number of antifungal drugs available and the increase in antifungal resistance. Curcumin is used as a spice, food preservative, flavoring, and coloring agent that has been shown to have many pharmacological activities. Thus, this study evaluated the modulatory effects of curcumin on major virulence factors associated with the pathogenicity of C. albicans . The minimum inhibitory concentration (MIC) of curcumin against C. albicans (SC5314) was determined...
2018: International Journal of Dentistry
Daniel R Stroik, Samantha L Yuen, Kevyn A Janicek, Tory M Schaaf, Ji Li, Delaine K Ceholski, Roger J Hajjar, Razvan L Cornea, David D Thomas
We have developed a structure-based high-throughput screening (HTS) method, using time-resolved fluorescence resonance energy transfer (TR-FRET) that is sensitive to protein-protein interactions in living cells. The membrane protein complex between the cardiac sarcoplasmic reticulum Ca-ATPase (SERCA2a) and phospholamban (PLB), its Ca-dependent regulator, is a validated therapeutic target for reversing cardiac contractile dysfunction caused by aberrant calcium handling. However, efforts to develop compounds with SERCA2a-PLB specificity have yet to yield an effective drug...
August 22, 2018: Scientific Reports
Baisen Li, Xiuhui Gu, Mingbo Wu, Ye Zhao, Jie Yang, Li Feng, Junjie Gou, Linyi Chen, Ting Li, Linpeng Li, Lan Wang, Li Zhu, Kun Zhang
Plumbagin (PLB) is the primary component of the traditional Chinese medicine Baihua Dan, and possesses anti-infection and anticancer effects, with the ability to enhance the sensitivity of tumor cells to radiation therapy. However, the anticancer effect of PLB on nasopharyngeal carcinoma and the underlying mechanisms remain unclear. In this study, we investigated the anticancer effects of PLB on nasopharyngeal carcinoma 6-10B cells and clarified its molecular mechanisms in vitro. The results showed that PLB was effective against 6-10B cells proliferation in a dose-dependent manner by inducing G2/M phase cell cycle arrest...
October 2018: Anti-cancer Drugs
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