Zhenfei Wang, Weiyang Sun, Dongxu Li, Yue Sun, Menghan Zhu, Wenqi Wang, Yiming Zhang, Entao Li, Feihu Yan, Tiecheng Wang, Na Feng, Songtao Yang, Xianzhu Xia, Yuwei Gao
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant threat to human health globally. It is crucial to develop a vaccine to reduce the effect of the virus on public health, economy, and society and regulate the transmission of SARS-CoV-2. Influenza B virus (IBV) can be used as a vector that does not rely on the current circulating influenza A strains. In this study, we constructed an IBV-based vector vaccine by inserting a receptor-binding domain (RBD) into a non-structural protein 1 (NS1)-truncated gene (rIBV-NS110-RBD)...
April 19, 2024: Virus Research