keyword
https://read.qxmd.com/read/38536934/attenuation-of-fibroblast-activation-and-fibrosis-by-adropin-in-systemic-sclerosis
#1
JOURNAL ARTICLE
Minrui Liang, Nicholas Dickel, Andrea-Hermina Györfi, Bilgesu SafakTümerdem, Yi-Nan Li, Aleix Rius Rigau, Chunguang Liang, Xuezhi Hong, Lichong Shen, Alexandru-Emil Matei, Thuong Trinh-Minh, Cuong Tran-Manh, Xiang Zhou, Ariella Zehender, Alexander Kreuter, Hejian Zou, Georg Schett, Meik Kunz, Jörg H W Distler
Fibrotic diseases impose a major socioeconomic challenge on modern societies and have limited treatment options. Adropin, a peptide hormone encoded by the energy homeostasis-associated ( ENHO ) gene, is implicated in metabolism and vascular homeostasis, but its role in the pathogenesis of fibrosis remains enigmatic. Here, we used machine learning approaches in combination with functional in vitro and in vivo experiments to characterize adropin as a potential regulator involved in fibroblast activation and tissue fibrosis in systemic sclerosis (SSc)...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536802/predicting-successful-weaning-from-mechanical-ventilation-by-reduction-in-positive-end-expiratory-pressure-level-using-machine-learning
#2
JOURNAL ARTICLE
Seyedmostafa Sheikhalishahi, Mathias Kaspar, Sarra Zaghdoudi, Julia Sander, Philipp Simon, Benjamin P Geisler, Dorothea Lange, Ludwig Christian Hinske
Weaning patients from mechanical ventilation (MV) is a critical and resource intensive process in the Intensive Care Unit (ICU) that impacts patient outcomes and healthcare expenses. Weaning methods vary widely among providers. Prolonged MV is associated with adverse events and higher healthcare expenses. Predicting weaning readiness is a non-trivial process in which the positive end-expiratory pressure (PEEP), a crucial component of MV, has potential to be indicative but has not yet been used as the target...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38536711/a-magnetic-resonance-conditional-robot-for-lumbar-spinal-injection-development-and-preliminary-validation
#3
JOURNAL ARTICLE
Depeng Liu, Gang Li, Shuyuan Wang, Zixuan Liu, Yanzhou Wang, Laura Connolly, David E Usevitch, Guofeng Shen, Kevin Cleary, Iulian Iordachita
PURPOSE: This work presents the design and preliminary validation of a Magnetic Resonance (MR) conditional robot for lumbar injection for the treatment of lower back pain. METHODS: This is a 4-degree-of-freedom (DOF) robot that is 200 × 230 × 130 mm3 in volume and has a mass of 0.8 kg. Its lightweight and compact features allow it to be directly affixed to patient's back, establishing a rigid connection, thus reducing positional errors caused by patient movements during treatment...
February 2024: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://read.qxmd.com/read/38536685/mcd-lightgbm-system-for-intelligent-analyzing-heterogeneous-clinical-drug-therapeutic-effects
#4
JOURNAL ARTICLE
Xiao-Hui Yang, Hao-Jie Liao, Pei- Yu Sun, Jing Ma, Bing Wang, Yan He, Liu-Gen Xue, Li-Min Su, Bin-Jie Wang
Causal effect estimation of individual heterogeneity is a core issue in the field of causal inference, and its application in medicine poses an active and challenging problem. In high-risk decision-making domain such as healthcare, inappropriate treatments can have serious negative impacts on patients. Recently, machine learning-based methods have been proposed to improve the accuracy of causal effect estimation results. However, many of these methods concentrate on estimating causal effects of continuous outcome variables under binary intervention conditions, and give less consideration to multivariate intervention conditions or discrete outcome variables, thus limiting their scope of application...
March 27, 2024: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/38536681/eisatc-fusion-inception-self-attention-temporal-convolutional-network-fusion-for-motor-imagery-eeg-decoding
#5
JOURNAL ARTICLE
Guangjin Liang, Dianguo Cao, Jinqiang Wang, Zhongcai Zhang, Yuqiang Wu
The motor imagery brain-computer interface (MI-BCI) based on electroencephalography (EEG) is a widely used human-machine interface paradigm. However, due to the non-stationarity and individual differences among subjects in EEG signals, the decoding accuracy is limited, affecting the application of the MI-BCI. In this paper, we propose the EISATC-Fusion model for MI EEG decoding, consisting of inception block, multi-head self-attention (MSA), temporal convolutional network (TCN), and layer fusion. Specifically, we design a DS Inception block to extract multi-scale frequency band information...
March 27, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/38536680/lower-limb-exoskeletons-appeal-to-both-clinicians-and-older-adults-especially-for-fall-prevention-and-joint-pain-reduction
#6
JOURNAL ARTICLE
Michael Raitor, Sandra Ruggles, Scott L Delp, C Karen Liu, Steven H Collins
Exoskeletons are a burgeoning technology with many possible applications to improve human life; focusing the effort of exoskeleton research and development on the most important features is essential for facilitating adoption and maximizing positive societal impact. To identify important focus areas for exoskeleton research and development, we conducted a survey with 154 potential users (older adults) and another survey with 152 clinicians. The surveys were conducted online and to ensure a consistent concept of an exoskeleton across respondents, an image of a hip exoskeleton was shown during exoskeleton-related prompts...
March 27, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/38536679/multi-path-fusion-in-sfcf-net-for-enhanced-multi-frequency-electrical-impedance-tomography
#7
JOURNAL ARTICLE
Xiang Tian, Jian'an Ye, Tao Zhang, Liangliang Zhang, Xuechao Liu, Feng Fu, Xuetao Shi, Canhua Xu
Multi-frequency electrical impedance tomography (mfEIT) offers a nondestructive imaging technology that reconstructs the distribution of electrical characteristics within a subject based on the impedance spectral differences among biological tissues. However, the technology faces challenges in imaging multi-class lesion targets when the conductivity of background tissues is frequency-dependent. To address these issues, we propose a spatial-frequency cross-fusion network (SFCF-Net) imaging algorithm, built on a multi-path fusion structure...
March 27, 2024: IEEE Transactions on Medical Imaging
https://read.qxmd.com/read/38536670/tyrosinase-modified-uhmw-selp-polymers-as-wet-and-underwater-adhesives-to-achieve-multi-interface-adhesion
#8
JOURNAL ARTICLE
Wenxin Huang, Sijia Wang, Zhaoxuan Feng, Dasen Zhou, Wenqin Bai
The presence of a hydration layer in humid and underwater environments challenges adhesive-substrate interactions and prevents effective bonding, which has become a significant obstacle to the development of adhesives in the industrial and biomedical fields. In this study, ultrahigh-molecular-weight (UHMW) silk-elastin-like proteins (SELP) with 3,4-dihydroxyphenylalanine (DOPA) converted from tyrosine residues by tyrosinase exhibited excellent adhesive properties on different interfaces, such as glass, aluminum, wood, polypropylene sheets, and pigskin, under both dry and wet conditions...
March 27, 2024: ACS Synthetic Biology
https://read.qxmd.com/read/38536507/oxaloacetate-as-new-inducer-for-osteogenic-differentiation-of-human-adipose-tissue-derived-mesenchymal-stem-cells-in-vitro
#9
JOURNAL ARTICLE
Fatemeh Jamali Shirkoohi, Marzieh Ghollasi, Raheleh Halabian, Elahe Eftekhari, Mohsen Ghiasi
BACKGROUND: Mitochondrial organelles play a crucial role in cellular metabolism so different cell types exhibit diverse metabolic and energy demands. Therefore, alternations in the intracellular distribution, quantity, function, and structure of mitochondria are required for stem cell differentiation. Finding an effective inducer capable of modulating mitochondrial activity is critical for the differentiation of specific stem cells into osteo-like cells for addressing issues related to osteogenic disorders...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536235/decentralizing-health-care-history-and-opportunities-of-web3
#10
JOURNAL ARTICLE
Aditya Narayan, Kydo Weng, Nirav Shah
This paper explores the relationship between the development of the internet and health care, highlighting their parallel growth and mutual influence. It delves into the transition from the early, static days of Web 1.0, akin to siloed physician expertise in health care, to the more interactive and patient-centric era of Web 2.0, which was accompanied by advancements in medical technologies and patient engagement. This paper then focuses on the emerging era of Web3-the decentralized web-which promises a transformative shift in health care, particularly in how patient data are managed, accessed, and used...
March 27, 2024: JMIR Formative Research
https://read.qxmd.com/read/38536171/a-revised-definition-of-left-bundle-branch-block-using-time-to-notch-in-lead-i
#11
JOURNAL ARTICLE
Jeremy S Treger, Ahmad B Allaw, Pouyan Razminia, Dipayon Roy, Amulya Gampa, Swati Rao, Andrew D Beaser, Srinath Yeshwant, Zaid Aziz, Cevher Ozcan, Gaurav A Upadhyay
IMPORTANCE: Current left bundle branch block (LBBB) criteria are based on animal experiments or mathematical models of cardiac tissue conduction and may misclassify patients. Improved criteria would impact referral decisions and device type for cardiac resynchronization therapy. OBJECTIVE: To develop a simple new criterion for LBBB based on electrophysiological studies of human patients, and then to validate this criterion in an independent population. DESIGN, SETTING, AND PARTICIPANTS: In this diagnostic study, the derivation cohort was from a single-center, prospective study of patients undergoing electrophysiological study from March 2016 through November 2019...
March 27, 2024: JAMA Cardiology
https://read.qxmd.com/read/38536107/benchmarking-machine-learning-based-real-time-respiratory-signal-predictors-in-4d-sbrt
#12
JOURNAL ARTICLE
Lukas Wimmert, Maximilian Nielsen, Frederic Madesta, Tobias Gauer, Christian Hofmann, Rene Werner
BACKGROUND: Stereotactic body radiotherapy of thoracic and abdominal tumors has to account for respiratory intrafractional tumor motion. Commonly, an external breathing signal is continuously acquired that serves as a surrogate of the tumor motion and forms the basis of strategies like breathing-guided imaging and gated dose delivery. However, due to inherent system latencies, there exists a temporal lag between the acquired respiratory signal and the system response. Respiratory signal prediction models aim to compensate for the time delays and to improve imaging and dose delivery...
March 27, 2024: Medical Physics
https://read.qxmd.com/read/38535862/surgical-outcomes-of-laminectomy-durotomy-and-a-non-synthetic-dura-substitute-application-in-ten-dogs-with-a-spinal-subarachnoid-diverticulum
#13
JOURNAL ARTICLE
Michał Mól, Ricardo Fernandes, Simon Wheeler, Massimo Mariscoli
This retrospective study aimed to report the surgical treatment and outcomes of laminectomies followed by durotomy and the application of a non-synthetic collagen matrix dura substitute (DurepairTM ) in ten dogs with a spinal subarachnoid diverticulum (SAD). The medical records of these ten client-owned dogs with SAD diagnosed by magnetic resonance imaging (MRI) were reviewed. All patients had chronic and progressive deficits. At presentation, common neurological signs were proprioceptive ataxia, ambulatory spastic paraparesis or tetraparesis, and faecal incontinence...
March 14, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535808/potential-biotechnological-applications-of-venoms-from-the-viperidae-family-in-central-america-for-thrombosis
#14
REVIEW
Jorge Eduardo Chang Estrada, Taissa Nunes Guerrero, Daniel Fernando Reyes-Enríquez, Erica Santos Nardy, Roseane Guimarães Ferreira, Cristian José Ruiz Calderón, Irmgardt A Wellmann, Kaio Murilo Monteiro Espíndola, Alejandro Ferraz do Prado, Andreimar Martins Soares, Marcos Roberto de Mattos Fontes, Marta Chagas Monteiro, Russolina Benedeta Zingali
Central America is home to one of the most abundant herpetofauna in the Americas, occupying only 7% of the continent's total area. Vipers and lizards are among the most relevant venomous animals in medical practice due to the consequences of envenomation from the bite of these animals. A great diversity of biomolecules with immense therapeutic and biotechnological value is contained in their venom. This paper describes the prominent leading representatives of the family Viperidae , emphasizing their morphology, distribution, habitat, feeding, and venom composition, as well as the biotechnological application of some isolated components from the venom of the animals from these families, focusing on molecules with potential anti-thrombotic action...
March 8, 2024: Toxins
https://read.qxmd.com/read/38535786/bee-venom-composition-and-anticancer-properties
#15
REVIEW
Goran Gajski, Elina Leonova, Nikolajs Sjakste
Among the various natural compounds used in alternative and Oriental medicine, toxins isolated from different organisms have had their application for many years, and Apis mellifera venom has been studied the most extensively. Numerous studies dealing with the positive assets of bee venom (BV) indicated its beneficial properties. The usage of bee products to prevent the occurrence of diseases and for their treatment is often referred to as apitherapy and is based mainly on the experience of the traditional system of medical practice in diverse ethnic communities...
February 29, 2024: Toxins
https://read.qxmd.com/read/38535492/iron-oxide-magnetite-based-nanobiomaterial-with-medical-applications-environmental-hazard-assessment-using-terrestrial-model-species
#16
JOURNAL ARTICLE
Susana I L Gomes, Janeck J Scott-Fordsmand, Mónica J B Amorim
Nanobiomaterials (NBMs) have tremendous potential applications including in cancer diagnosis and treatment. However, the health and environmental effects of NBMs must be thoroughly assessed to ensure safety. Fe3 O4 (magnetite) nanoparticles coated with polyethylene glycol (PEG) and poly (lactic-co-glycolic acid) (PLGA) were one of the focus NBMs within the EU project BIORIMA. Fe3 O4 PEG-PLGA has been proposed to be used as a contrast agent in magnetic resonance imaging for the identification of solid tumors and has revealed low cytotoxicity in several cell lines...
February 22, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535289/an-untargeted-metabolomics-strategy-to-identify-substrates-of-known-and-orphan-e-coli-transporters
#17
JOURNAL ARTICLE
Mohammad S Radi, Lachlan J Munro, Daniela Rago, Douglas B Kell
Transport systems play a pivotal role in bacterial physiology and represent potential targets for medical and biotechnological applications. However, even in well-studied organisms like Escherichia coli , a notable proportion of transporters, exceeding as many as 30%, remain classified as orphans due to their lack of known substrates. This study leveraged high-resolution LC-MS-based untargeted metabolomics to identify candidate substrates for these orphan transporters. Human serum, including a diverse array of biologically relevant molecules, served as an unbiased source for substrate exposure...
March 20, 2024: Membranes
https://read.qxmd.com/read/38535093/cardiopulmonary-exercise-testing-in-heart-failure
#18
REVIEW
Michel Juarez, Cristian Castillo-Rodriguez, Dina Soliman, Gaspar Del Rio-Pertuz, Kenneth Nugent
Cardiopulmonary exercise testing (CPET) provides important information for the assessment and management of patients with heart failure. This testing measures the respiratory and cardiac responses to exercise and allows measurement of the oxygen uptake (V˙O2 ) max and the relationship between minute ventilation (V˙E) and carbon dioxide excretion (V˙CO2 ). These two parameters help classify patients into categories that help predict prognosis, and patients with a V˙O2 < 14 mL/kg/min and V˙E/V˙CO2 slope >35 have a poor prognosis...
February 20, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38534906/artificial-intelligence-based-clinical-decision-support-systems-in-primary-care-a-scoping-review-of-current-clinical-implementations
#19
REVIEW
Cesar A Gomez-Cabello, Sahar Borna, Sophia Pressman, Syed Ali Haider, Clifton R Haider, Antonio J Forte
Primary Care Physicians (PCPs) are the first point of contact in healthcare. Because PCPs face the challenge of managing diverse patient populations while maintaining up-to-date medical knowledge and updated health records, this study explores the current outcomes and effectiveness of implementing Artificial Intelligence-based Clinical Decision Support Systems (AI-CDSSs) in Primary Healthcare (PHC). Following the PRISMA-ScR guidelines, we systematically searched five databases, PubMed, Scopus, CINAHL, IEEE, and Google Scholar, and manually searched related articles...
March 13, 2024: European journal of investigation in health, psychology and education
https://read.qxmd.com/read/38534854/review-of-spider-silk-applications-in-biomedical-and-tissue-engineering
#20
REVIEW
Marija Branković, Fatima Zivic, Nenad Grujovic, Ivan Stojadinovic, Strahinja Milenkovic, Nikola Kotorcevic
This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems...
March 11, 2024: Biomimetics
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