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Pluronic f 127

Tao Wang, Li-Ni Zeng, Zhe Zhu, Yu-Hui Wang, Lu Ding, Wei-Bin Luo, Xiao-Min Zhang, Zhi-Wei He, Hong-Fu Wu
Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles. However, no satisfactory treatment is currently available. Hypoxia-inducible factor 1α is a critical molecule targeting several genes associated with ischemia-hypoxia damage and angiogenesis. In this study, a rat model of brachial plexus avulsion-reimplantation was established, in which C5-7 ventral nerve roots were avulsed and only the C6 root reimplanted. Different implants were immediately injected using a microsyringe into the avulsion-reimplantation site of the C6 root post-brachial plexus avulsion...
June 2019: Neural Regeneration Research
Hee Chul Yang, Hye Young Chang
Background: Prolonged air leak is the most common complication after pulmonary resection surgery. Water submersion test (WST) has been used to check for air leak. However, it is cumbersome under the circumstances of video-assisted thoracic surgery (VATS). This study aimed to devise a new air leak detection method that is suitable for the VATS. Methods: We decided to utilize the properties of the surfactants to overcome the disadvantages of WST. To find the optimal surfactant, ex-vivo porcine lung experiments were prepared with a custom-made large glass vessel mimicking a human thoracic cavity...
December 2018: Journal of Thoracic Disease
Nadia M Morsi, Rehab Nabil Shamma, Nouran Osama Eladawy, Abdelfattah A Abdelkhalek
The application of minimally invasive surgical techniques in the field of orthopedic surgery has created a growing need for new injectable synthetic materials that can be used for bone grafting. In this work, novel injectable thermosensitive foam was developed by mixing nHAP powder with a thermosensitive polymer with foaming power (Pluronic F-127) and loaded with a water-soluble bisphosphonate drug (risedronate) to promote osteogenesis. The foam was able to retain the porous structure after injection and set through temperature change of PF-127 solution to form gel inside the body...
February 8, 2019: AAPS PharmSciTech
Lupe Carolina Espinoza, Marcelle Silva-Abreu, Beatriz Clares, María José Rodríguez-Lagunas, Lyda Halbaut, María-Alexandra Cañas, Ana Cristina Calpena
Donepezil (DPZ) is widely used in the treatment of Alzheimer's disease in tablet form for oral administration. The pharmacological efficacy of this drug can be enhanced by the use of intranasal administration because this route makes bypassing the blood⁻brain barrier (BBB) possible. The aim of this study was to develop a nanoemulsion (NE) as well as a nanoemulsion with a combination of bioadhesion and penetration enhancing properties (PNE) in order to facilitate the transport of DPZ from nose-to-brain. Composition of NE was established using three pseudo-ternary diagrams and PNE was developed by incorporating Pluronic F-127 to the aqueous phase...
February 1, 2019: Pharmaceutics
Chunjie Li, Xianhong Zhou, Edwin E Lewis, Yi Yu, Congli Wang
Pluronic F-127 gel (PF127) has proven to be a powerful medium in which to study host-finding behavior and chemotaxis for plant-parasitic nematodes. Pluronic gel can also be used to study host-habitat seeking behavior of entomopathogenic nematodes (EPN), which are natural enemies of root-feeding insect pests. In this study, PF127 was used to study tritrophic interactions among EPNs, host-habitat roots and insects. We also tested whether EPN aggregated to acetic acid (pH gradient) which mimicked the conditions near the roots...
January 29, 2019: Journal of Invertebrate Pathology
Prashant Sahu, Sushil K Kashaw, Samaresh Sau, Varun Kushwah, Sanyog Jain, Ram K Agrawal, Arun K Iyer
The current research is focused to develop and investigate the toxicity and penetration potential of biocompatible chitosan nanogel encapsulating capecitabine by ionic interaction mechanism exhibiting pH triggered transdermal targeting. The nanogel (CPNL) was synthesized by ion gelation mechanism using Pluronic F 127 and surface decoration by Transcutol as non-ionic penetration enhancer. The CPNL possesses fine morphology and nano size range when evaluated by TEM, SEM and DLS analysis with cationic charge and slightly acidic pH assayed by zeta potential and pH analysis...
January 27, 2019: International Journal of Biological Macromolecules
Alexander P Haring, Emily G Thompson, Yuxin Tong, Sahil Laheri, Ellen Cesewski, Harald Sontheimer, Blake N Johnson
A bio-inspired hydrogel for 3D bioprinting of soft free-standing neural tissues is presented. The novel filler-free bioinks were designed by combining natural polymers for extracellular matrix biomimicry with synthetic polymers that endow desirable rheological properties for 3D bioprinting. Crosslinking of thiolated Pluronic F-127 with dopamine-conjugated (DC) gelatin and DC hyaluronic acid through a thiol - catechol reaction resulted in thermally gelling bioinks with Herschel-Bulkley fluid rheological behavior...
January 29, 2019: Biofabrication
Jully Oyama, Daniele Stéfanie Sara Lopes Lera-Nonose, Áquila Carolina Fernandes Herculano Ramos-Milaré, Fabiana Borges Padilha Ferreira, Camila Fabiano de Freitas, Wilker Caetano, Noboru Hioka, Thaís Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni
Leishmaniasis is a neglected disease and drugs approved for its treatment often lead to abandonment, failure of therapy and even death. Photodynamic therapy (PDT) has been shown to be a promising, non-invasive and selective for a target region without requiring high-cost technology. Usually, it is employed a photosensitizing agent (PS) incorporated into nanoparticles (NP). Pluronics® P-123 and F-127 micelles are very interesting aqueous NP promoting efficient and selective delivery and less adverse effects...
January 16, 2019: Acta Tropica
Maysoon Saleh, Ihor Panas, Florian Frenzel, Christian Wuerth, Bastian Rühle, Yuri L Slominskii, Alexander Demchenko, Ute Resch-Genger
Photon upconversion nanomaterials have a wide range of applications, including biosensing and deep-tissue imaging. Their typically very weak and narrow absorption bands together with their size dependent luminescence efficiency can limit their application potential. This has been addressed by increasingly sophisticated core-shell particle architectures including the sensitization with organic dyes that strongly absorb in the near infrared (NIR). In this work, we present a simple water-dispersible micellar system that features energy transfer from the novel NIR excitable dye, 1859 SL with a high molar absorption coefficient and a moderate fluorescence quantum yield to oleate-capped NaYF<sub>4</sub>:20%Yb(III),2%Er(III) upconversion nanoparticles (UCNP) upon 808 nm excitation...
January 14, 2019: Methods and Applications in Fluorescence
Adriana Trapani, Alessia Catalano, Alessia Carocci, Antonio Carrieri, Annalisa Mercurio, Antonio Rosato, Delia Mandracchia, Giuseppe Tripodo, Brigida Immacolata Pia Schiavone, Carlo Franchini, Ernesto Mesto, Emanuela Schingaro, Filomena Corbo
The antibacterial activity of the S-unsubstituted- and S-benzyl-substituted-2-mercapto-benzothiazoles 1-4 has been evaluated after complexation with Methyl-β-Cyclodextrin (Me-β-CD) or incorporation in solid dispersions based on Pluronic® F-127 and compared with that of the pure compounds. This with the aim to gain further insights on the possible mechanism(s) involved in the CD-mediated enhancement of antimicrobial effectiveness, a promising methodology to overcome the microbial resistance issue. Together with Differential Scanning Calorimetry, FT-IR spectroscopy and X-ray Powder Diffraction investigations, a molecular modeling study focused on compounds 2 and 4 showed that the S-unsubstituted compound 2/Me-β-CD complex should be more stable than S-benzyl-substituted 4/Me-β-CD...
March 1, 2019: Carbohydrate Polymers
Phillip L Lewis, Ming Yan, Jimmy Su, Ramille N Shah
Three-dimensional (3D) printing of decellularized extracellular matrix (dECM) hydrogels is a promising technique for regenerative engineering. 3D-printing enables the reproducible and precise patterning of multiple cells and biomaterials in 3D, while dECM has high organ-specific bioactivity. However, dECM hydrogels often display poor printability on their own and necessitate additives or support materials to enable true 3D structures. In this study, we used a sacrificial material, 3D-printed Pluronic F-127, to serve as a platform into which dECM hydrogel can be incorporated to create specifically designed structures made entirely up of dECM...
December 24, 2018: Acta Biomaterialia
Cameron S Giglio, Osayuki Osazuwa, Marianna Kontopoulou, Aristides Docoslis
The role of surfactant (Pluronic® F 127) concentration on the yield and morphological characteristics of graphene nanoplatelets (GNPs) produced from the sonication of aqueous graphene suspensions is investigated in this work. By employing a wide surfactant concentration range (0.1-15 wt%) and sonication power densities up to 420 W L-1 we identify two graphene exfoliation regimes: the first occurs at low sonication power densities (<340 W L-1 ) and produces GNPs with sizes 200-300 nm, aspect ratios between 70 and 100, and concentrations up 1 mg mL-1 ...
December 10, 2018: Journal of Colloid and Interface Science
Flávia Amanda Pedroso de Morais, Adalberto Enumo, Renato Sonchini Gonçalves, Gabriel Batista Cesar, Nathielle Miranda, Bruno Henrique Vilsinski, Ranulfo Combuca da Silva, Celso Vataru Nakamura, Noboru Hioka, Wilker Caetano
Chagas is a parasitic endemic disease caused by the protozoan Trypanosoma cruzi. It represents a strong threat to public health due to its strong resistance against commonly available drugs. We studied the in vitro ability to inactivate the trypomastigote form of this parasite using photodynamic inactivation of microorganisms (or antimicrobial Photodynamic Therapy, aPDT). For this, we chose to use the photosensitizer hypericin (Hyp) formulated in ethanol/water (1% v/v) and Hyp loaded in the dispersion of different aqueous nanocarrier systems...
December 10, 2018: Photochemical & Photobiological Sciences
Manar M Obiedallah, A M Abdel-Mageed, Tahani H Elfaham
In the present work, the antiglaucoma drug, acetazolamide, was formulated as microsponges in situ gel for ocular drug delivery aiming an improved therapeutic efficacy and reduction in the systemic side effects of oral acetazolamide. The microsponges were prepared by the quasi emulsion solvent diffusion method and were incorporated into 25% pluronic F-127 in situ gel. Ethyl cellulose polymer in different proportions with drug was used to prepare the microsponges. Different parameters were evaluated to select the best formulation...
November 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
V Naumenko, A Garanina, A Nikitin, S Vodopyanov, N Vorobyeva, Y Tsareva, M Kunin, A Ilyasov, A Semkina, V Chekhonin, M Abakumov, A Majouga
Magnetic resonance imaging (MRI) is a powerful technique for tumor diagnostics. Iron oxide nanoparticles (IONPs) are safe and biocompatible tools that can be used for further enhancing MR tumor contrasting. Although numerous IONPs have been proposed as MRI contrast agents, low delivery rates to tumor site limit its application. IONPs accumulation in malignancies depends on both IONPs characteristics and tumor properties. In the current paper, three differently shaped Pluronic F-127-modified IONPs (nanocubes, nanoclusters, and nanorods) were compared side by side in three murine tumor models (4T1 breast cancer, B16 melanoma, and CT26 colon cancer)...
2018: Contrast Media & Molecular Imaging
Soraya Hosseini, Woranunt Lao-Atiman, Siow Jing Han, Amornchai Arpornwichanop, Tetsu Yonezawa, Soorathep Kheawhom
Zinc-air batteries are a promising technology for large-scale electricity storage. However, their practical deployment has been hindered by some issues related to corrosion and passivation of the zinc anode in an alkaline electrolyte. In this work, anionic surfactant sodium dodecyl sulfate (SDS) and nonionic surfactant Pluronic F-127 (P127) are examined their applicability to enhance the battery performances. Pristine zinc granules in 7 M KOH, pristine zinc granules in 0-8 mM SDS/7 M KOH, pristine zinc granules in 0-1000 ppm P127/7 M KOH, and SDS coated zinc granules in 7 M KOH were examined...
October 8, 2018: Scientific Reports
Jie Liang Phua, Aihua Hou, Yuan Siang Lui, Tanima Bose, George Kanianthara Chandy, Louis Tong, Subbu Venkatraman, Yingying Huang
Topical ophthalmologic treatments have been facing great challenges with main limitations of low drug bioavailability, due to highly integrative defense mechanisms of the eye. This study rationally devised strategies to increase drug bioavailability by increasing ocular surface residence time of drug-loaded nanoliposomes dispersed within thermo-sensitive hydrogels (Pluronic F-127). Alternatively, we utilized sub-conjunctival injections as a depot technique to localize nanoliposomes. Senicapoc was encapsulated and sustainably released from free nanoliposomes and hydrogels formulations in vitro...
September 29, 2018: International Journal of Molecular Sciences
Raquel O Rodrigues, Giovanni Baldi, Saer Doumett, Lorena Garcia-Hevia, Juan Gallo, Manuel Bañobre-López, Goran Dražić, Ricardo C Calhelha, Isabel C F R Ferreira, Rui Lima, Helder T Gomes, Adrián M T Silva
The synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform for cancer therapy, exhibiting (i) an outstanding loading capacity of 91% (w/w, representing 910 μg mg-1 ) of the chemotherapeutic drug doxorubicin, (ii) a high heating efficiency under an alternating (AC) magnetic field (intrinsic power loss ranging from 2...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
JiUn Lee, GeunHyung Kim
It is well known that a nanoscale fibrous structure can provide a unique stage for encouraging reasonable cell activities including attachment and proliferation owing to its similar topological structure to the extracellular matrix. Hence, the structure has been widely applied in tissue regeneration. Type-I collagen has been typically used as a typical tissue regenerative material owing to its biocompatibility and abundance, although it has potential for antigenicity. In particular, collagen has been fabricated in two different forms, porous spongy and nanofibers...
October 24, 2018: ACS Applied Materials & Interfaces
Aylin M Deliormanlı, Mert Türk, Harika Atmaca
In the study, three-dimensional, grid-like silicate-based bioactive glass scaffolds were manufactured using a robotic deposition technique. Inks were prepared by mixing 13-93 bioactive glass particles in Pluronic® F-127 solution. After deposition, scaffolds were dried at room temperature and sintered at 690°C for 1 h. The surface of the sintered scaffolds was coated with graphene nanopowder (1, 3, 5, 10 wt%) containing poly(ε-caprolactone) solution. The in vitro mineralization ability of the prepared composite scaffolds was investigated in simulated body fluid...
September 24, 2018: Journal of Biomaterials Applications
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