Yoko Urashima, Tatsuya Ueno, Chiyuki Takeda, Hiroshi Kusaba, Rina Tanaka, Karin Noda, Kanako Kawakami, Takuo Murakami, Aoi Kawaguchi, Yuka Suemitsu, Kazuya Urashima, Kaoru Suzuki, Kazumi Kurachi, Masami Nishihara, Masashi Neo, Michiaki Myotoku, Takuro Kobori, Tokio Obata
BACKGROUND: Previously, we revealed that co-administration of particular enteral nutrients (ENs) decreases plasma concentrations and gastric absorption of phenytoin (PHT), an antiepileptic drug, in rats; however, the mechanism has not been clarified. METHODS: We measured the permeability rate of PHT using a Caco-2 cell monolayer as a human intestinal absorption model, with casein, soy protein, simulated gastrointestinal digested casein or soy protein, dextrin, sucrose, degraded guar-gum, indigestible dextrin, calcium, and magnesium, which are abundant in the ENs, and also measured the solution's properties...
June 27, 2023: JPEN. Journal of Parenteral and Enteral Nutrition