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Yuji Suzuki, Keisuke Kakisaka, Akiko Suzuki, Takeshi Takahara, Tokio Sasaki, Takuro Sato, Takehiro Yonezawa, Hiroyuki Nitta, Yasuhiro Takikawa
AIM: Corticosteroids are the most widely used agents for the treatment of severe alcoholic hepatitis (SAH). The therapeutic effectiveness of corticosteroids is assessed by the Lille model, which has been validated well in Western countries; however, its usefulness has not yet been confirmed independently in Japanese patients. The present study aimed to determine whether the Lille model could predict the prognosis of SAH in Japanese patients. METHODS: This was a retrospective cohort study including 32 SAH patients who were admitted to our institute from April 2011 to February 2018...
March 22, 2019: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Kyosuke Kaji, Atsushi Hashiba, Chika Uotani, Yasushi Yamaguchi, Toshio Ueno, Kenji Ohno, Ichiro Takabatake, Tokio Wakabayashi, Hisashi Doyama, Itasu Ninomiya, Masato Kiriyama, Shigekazu Ohyama, Manabu Yoneshima, Nobu Koyama, Yasuo Takeda, Kenji Yasuda
No abstract text is available yet for this article.
March 6, 2019: American Journal of Gastroenterology
Sven P Hoekstra, Christof A Leicht, Yoshi-Ichiro Kamijo, Tokio Kinoshita, Ben T Stephenson, Victoria L Goosey-Tolfrey, Nicolette C Bishop, Fumihiro Tajima
This study investigates the relationship between autonomic function and the inflammatory response to a wheelchair half-marathon in people with a spinal cord injury (SCI). Seventeen wheelchair athletes with a cervical SCI (CSCI, N = 7) and without CSCI (NON-CSCI, N = 10) participated in a wheelchair half-marathon. Blood was taken prior, post and 1 h post-race to determine the concentrations of adrenaline, noradrenaline, extracellular heat shock protein 72 (eHsp72) and interleukin-6 (IL-6). A sit-up tilt test was performed to assess autonomic function at rest...
March 5, 2019: Journal of Sports Sciences
Daichi Wada, Hirotaka Igawa, Masato Tamayama, Tokio Kasai, Hitoshi Arizono, Hideaki Murayama, Natsumi Isoda, Masafumi Katsuta
We applied a fiber optic distributed simultaneous strain and temperature measurement technique to the structural monitoring of the main wing of a middle-sized passenger jet aircraft during flight. We used 40 10 cm long fiber Bragg gratings (FBGs), inscribed in a highly birefringent polarization-maintaining fiber. The FBGs were interrogated by optical frequency domain reflectometry, which could measure Bragg wavelength distributions at a sampling rate of 151 Hz. The simultaneous measurement technique could detect structural behaviors of the wing during flight under temperature-changing conditions...
December 20, 2018: Applied Optics
Hironori Kumagai, Kosuke Yamada, Kanako Nakai, Tokio Kitamura, Kohta Mohri, Masami Ukawa, Takumi Tomono, Takaaki Eguchi, Testuya Yoshizaki, Takumi Fukuchi, Takuya Yoshino, Minoru Matsuura, Etsuo Tobita, Wellington Pham, Hiroshi Nakase, Shinji Sakuma
We are investigating an imaging agent for early detection of colorectal cancer. The agent, named the nanobeacon, is coumarin 6-encapsulated polystyrene nanospheres whose surfaces are covered with poly(N-vinylacetamide) and peanut agglutinin that reduces non-specific interactions with the normal mucosa and exhibits high affinity for terminal sugars of the Thomsen-Friedenreich antigen, which is expressed cancer-specifically on the mucosa, respectively. We expect that cancer can be diagnosed by detecting illumination of intracolonically administered nanobeacon on the mucosal surface...
January 9, 2019: European Journal of Pharmaceutics and Biopharmaceutics
Yuko Murata, Yoshiki Kadoya, Shoichi Yamada, Tokio Sanke
Aims: Sarcopenia, which shortens healthy life expectancy, has recently been attracting attention because the Japanese population is rapidly aging. In this preliminary study, we estimated the prevalence of elderly diabetic patients who were complicated with sarcopenia and searched for any related clinical factors. Methods: Elderly (≥65 years of age) Japanese patients with type 2 diabetes mellitus were recruited by asking doctors to supply candidates for the study...
May 2018: Diabetology International
Tsuyoshi Suda, Yuji Hodo, Yukihiro Shirota, Haruhiko Ogawa, Katsuaki Sato, Tokio Wakabayashi
The high mortality rate due to severe herpes simplex viral (HSV) hepatitis is associated with it being difficult to diagnose. We describe the extremely rapid disease course of a patient who died of severe HSV hepatitis. A 73-year-old woman was admitted for a bronchial asthma attack. Her symptoms improved with steroid administration, but she developed a sore throat and painful swallowing. On day 12 after admission, she suddenly went into shock. Blood test results showed a significant increase in the liver enzyme levels, with remarkable disseminated intravascular coagulation...
December 21, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Shunsuke Yamagishi, Yutaka Midorikawa, Hisashi Nakayama, Tokio Higaki, Masamichi Moriguchi, Osamu Aramaki, Shintaro Yamazaki, Shingo Tsuji, Tadatoshi Takayama
AIM: Although radiofrequency ablation (RFA) is an effective local treatment of hepatocellular carcinoma (HCC), local recurrence is relatively frequent. We aimed to elucidate the validity of salvage liver resection for recurrent HCC after RFA. METHODS: Patients who underwent liver resection for recurrent HCC after RFA (LR after RFA) and those who underwent second liver resection for recurrent HCC (second LR) were included. The short-term outcomes were compared between the two groups...
November 29, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Nobuaki Ochi, Tokio Wakabayashi, Atsushi Urakami, Tomoki Yamatsuji, Naoto Ikemoto, Yasunari Nagasaki, Nozomu Nakagawa, Yoshihiro Honda, Hidekazu Nakanishi, Hiromichi Yamane, Yasumasa Monobe, Takeshi Akisada, Hiroshi Katayama, Yoshio Naomoto, Nagio Takigawa
A 26-year-old man with right lower mandibular and chest pain, fever, and respiratory distress was urgently transported to our hospital. CT images revealed gas collection and an abscess from the neck to the mediastinum with bilateral pleural effusion. Descending necrotizing mediastinitis (DNM) induced by an odontogenic infection of a right mandibular molar abscess was diagnosed. The cervical and mediastinal areas were drained, extensive debridement was performed, necrotic tissue was excised, and broad-spectrum antibiotics were administered immediately...
2018: Therapeutics and Clinical Risk Management
Davide La Regina, Matteo Di Giuseppe, Stefano Cafarotti, Andrea Saporito, Marcello Ceppi, Francesco Mongelli, Florian Bihl, Ruben Carlo Balzarotti Canger, Antonjacopo Ferrario di Tor Vajana
INTRODUCTION: Acute cholecystitis is a common disease and a frequent cause of emergency admission to surgical wards. Evidence regarding antibiotic administration in urgent procedures is limited and remains a contentious issue. According to the Tokyo guidelines, the antibiotic administration should be guided by the severity of cholecystitis, but internationally accepted guidelines are lacking. In particular, the need to perform antibiotic therapy after laparoscopic cholecystectomy is controversial for mild and moderate acute calculous cholecystitis (Tokio I and II)...
February 2019: Surgical Endoscopy
Kyosuke Kaji, Atsushi Hashiba, Chika Uotani, Yasushi Yamaguchi, Toshio Ueno, Kenji Ohno, Ichiro Takabatake, Tokio Wakabayashi, Hisashi Doyama, Itasu Ninomiya, Masato Kiriyama, Shigekazu Ohyama, Manabu Yoneshima, Nobu Koyama, Yasuo Takeda, Kenji Yasuda
OBJECTIVES: In order to screen for gastric cancer effectively, its interval should be set according to the risk. This study aimed to determine whether risk stratification is possible using the data obtained from medical examination or endoscopic findings. METHODS: First, subjects who underwent both cancer screening and medical examination from 2009 to 2015 and underwent cancer screening once more by 2016 were studied. Data such as the lipid profile and history of smoking obtained during the medical examination, and the grade of atrophy and presence of peptic ulcers were studied using multivariate analysis...
October 12, 2018: American Journal of Gastroenterology
Miho Yamada, Kiyoshi Minoura, Takashi Mizoguchi, Kenichiro Nakamatsu, Tokio Taguchi, Takuya Kameda, Miho Sekiguchi, Tatsuo Suzutani, Shinichi Konno
BACKGROUND: Recent studies report that surfaces displaying micrometer- or nanometer-sized undulating structures exhibit antibacterial effects. In previous work, we described the use of an advanced nanofabrication technique to generate an artificial biomimetic Moth-eye film by coating a polyethylene terephthalate (PET) film with nanoscale moth-eye protrusions made from a hydrophilic resin. This moth-eye film exhibited enhanced antibacterial effects in in vitro experiments. The aim of the present study was to verify the antibacterial efficacy of the Moth-eye film in practical environments...
2018: PloS One
Yuji Hodo, Yukihiro Shirota, Tsuyoshi Suda, Tokio Wakabayashi
No abstract text is available yet for this article.
June 2018: VideoGIE
Tokio Sasaki, Yuji Suzuki, Kazuyuki Ishida, Keisuke Kakisaka, Hiroaki Abe, Tamotsu Sugai, Yasuhiro Takikawa
RATIONALE: Although immunization could possibly cause autoimmune hepatitis (AIH), to date, no cases of AIH have been reported secondary to influenza virus vaccination. This paper describes 2 women who developed AIH after receiving influenza virus vaccination. PATIENT CONCERNS AND DIAGNOSES: Two women presented with elevation of liver enzymes after receiving influenza virus vaccination. Both patients were diagnosed with AIH using the International Autoimmune Hepatitis Group criteria...
July 2018: Medicine (Baltimore)
Oscar Alvarez-Garcia, Tokio Matsuzaki, Merissa Olmer, Kohei Miyata, Sho Mokuda, Daisuke Sakai, Koichi Masuda, Hiroshi Asahara, Martin K Lotz
Intervertebral disk (IVD) degeneration is a prevalent age-associated musculoskeletal disorder and a major cause of chronic low back pain. Aging is the main risk factor for the disease, but the molecular mechanisms regulating IVD homeostasis during aging are unknown. The aim of this study was to investigate the function of FOXO, a family of transcription factors linked to aging and longevity, in IVD aging and age-related degeneration. Conditional deletion of all FOXO isoforms (FOXO1, 3, and 4) in IVD using the Col2a1Cre and AcanCreER mouse resulted in spontaneous development of IVD degeneration that was driven by severe cell loss in the nucleus pulposus (NP) and cartilaginous endplates (EP)...
October 2018: Aging Cell
Tsuyoshi Suda, Yukihiro Shirota, Tokio Wakabayashi
No abstract text is available yet for this article.
May 17, 2018: Clinical Gastroenterology and Hepatology
Yuji Taniguchi, Cornelia Appiah-Kwarteng, Mami Murakami, Junpei Fukumoto, Kisaburo Nagamune, Tomohide Matsuo, Tatsunori Masatani, Hirotaka Kanuka, Tokio Hoshina, Katsuya Kitoh, Yasuhiro Takashima
The virulence of a type III Toxoplasma gondii strain isolated in Japan and designated here as TgCatJpGi1/TaJ was examined in mice and micro minipigs in this study. Despite its type III genotype, oral or intraperitoneal inoculation of cysts from it resulted in severe virulence in C57BL/6J and BALB/c mice. In contrast, mice inoculated with a high dose of TgCatJpGi1/TaJ tachyzoites showed no obvious clinical signs of infection, and all of them survived for >21 days post-inoculation. Furthermore, no clinical signs of infection were seen when micro minipigs were inoculated with 900 cysts...
May 22, 2018: Parasitology International
Tokio Higaki, Osamu Aramaki, Masamichi Moriguchi, Hisashi Nakayama, Yutaka Midorikawa, Tadatoshi Takayama
Conventional regimens for unresectable intrahepatic cholangiocarcinoma are considered of limited effectiveness. To evaluate the efficacy and toxicity of combination chemotherapy with hepatic arterial infusion of IA-call (a fine-powder formulation of cisplatin) plus oral S-1 in patients with unresectable intrahepatic cholangiocarcinoma. The clinicopathological data and long-term outcome of 12 patients who were received with IA-call plus S-1 were compared with those of 16 patients who were received other treatments, such as radiation therapy, trans-arterial chemoembolization, and systemic chemotherapy...
2018: Bioscience Trends
Tokio Higaki, Shintaro Yamazaki, Yusuke Mitsuka, Masaru Aoki, Nao Yoshida, Yutaka Midorikawa, Hisashi Nakayama, Tadatoshi Takayama
To clarify whether high transient elevation of serum transaminase predicts severe complications and is related to the ischemic area on CT. Postoperative laboratory data and ischemia area on CT were analyzed on the basis of the presence of high transaminase elevation (aspartate aminotransferase (AST) > 1,000 IU/L within postoperative day (POD) 2 after liver resection. In the high elevation group, volume of ischemic areas was assessed by CT on POD2. The 538 patients were divided into a high transaminase group (n = 51) and a control group (n = 487)...
2018: Bioscience Trends
Takao Togawa, Tatsuki Mizuochi, Tokio Sugiura, Hironori Kusano, Ken Tanikawa, Takato Sasaki, Fumio Ichinose, Seiichi Kagimoto, Takahisa Tainaka, Hiroo Uchida, Shinji Saitoh
OBJECTIVE: To clarify the clinical, pathologic, and genetic features of neonatal Dubin-Johnson syndrome. STUDY DESIGN: Ten patients with neonatal Dubin-Johnson syndrome were recruited from 6 pediatric centers in Japan between September 2013 and October 2016. Clinical and laboratory course, macroscopic and microscopic liver findings, and molecular genetic findings concerning ATP-binding cassette subfamily C member 2 (ABCC2) were retrospectively and prospectively examined...
May 2018: Journal of Pediatrics
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