Matthew J Yousefzadeh, Ana P Huerta Guevara, Andrea C Postmus, Rafael R Flores, Tokio Sano, Angelika Jurdzinski, Luise Angelini, Sara J McGowan, Ryan D O'Kelly, Erin A Wade, Lisa V Gonzalez-Espada, Danielle Henessy-Wack, Shannon Howard, Tania A Rozgaja, Christy E Trussoni, Nicholas F LaRusso, Bart J L Eggen, Johan W Jonker, Paul D Robbins, Laura J Niedernhofer, Janine K Kruit
Age is the greatest risk factor for the development of type 2 diabetes mellitus (T2DM). Age-related decline in organ function is attributed to the accumulation of stochastic damage, including damage to the nuclear genome. Islets of T2DM patients display increased levels of DNA damage. However, whether this is a cause or consequence of the disease has not been elucidated. Here, we asked if spontaneous, endogenous DNA damage in β-cells can drive β-cell dysfunction and diabetes, via deletion of Ercc1 , a key DNA repair gene, in β-cells...
2023: Aging Biol