keyword
https://read.qxmd.com/read/38535095/exploring-the-correlation-between-systemic-inflammatory-markers-and-carotid-atherosclerosis-indices-in-middle-aged-adults-a-cross-sectional-study
#1
JOURNAL ARTICLE
Ji-Eun Song, Ji-In Hwang, Hae-Jin Ko, Ji-Yeon Park, Hee-Eun Hong, A-Sol Kim
BACKGROUND: This study investigated the association between atherosclerosis and systemic inflammation markers, specifically the C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), in healthy middle-aged adults. METHODS: A retrospective cross-sectional study was conducted on a total of 1264 Korean adults aged 40-65. We assessed these inflammatory markers and carotid metrics, such as carotid intima-media thickness (cIMT), plaque number (PN), plaque stenosis score (PSS), and plaque score (PS), using linear regression, logistic regression, and receiver operating characteristic analysis...
February 21, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38533913/case-report-systemic-lupus-erythematosus-combined-with-myocardial-hypertrophy
#2
JOURNAL ARTICLE
Shanshan Wang, Xinfeng Wei, Wenqing Yang, Dan Zhang
OBJECTIVE: Systemic lupus erythematosus (SLE) is a multisystem-involved, highly heterogeneous autoimmune disease with diverse clinical manifestations. We report an extremely rare case of SLE with severe diffuse myocardial hypertrophy. METHODS: The patient's echocardiography and cardiac magnetic resonance imaging (CMR) results indicated diffuse myocardial hypertrophy. After excluding coronary atherosclerosis, hypertensive cardiomyopathy, drug toxicity, and other causes, the patient was diagnosed with SLE-specific cardiomyopathy...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38533842/more-than-just-a-simple-barrier
#3
EDITORIAL
Erandi Velazquez-Miranda, Ming He
Endothelial cell subpopulations are characterized by unique gene expression profiles, epigenetic landscapes and functional properties.
March 27, 2024: ELife
https://read.qxmd.com/read/38533317/evaluation-of-peri-plaque-pericoronary-adipose-tissue-attenuation-in-coronary-atherosclerosis-using-a-dual-layer-spectral-detector-ct
#4
JOURNAL ARTICLE
Yulin Jia, Lei Zou, Ming Xue, Xiaoyu Zhang, Xigang Xiao
PURPOSE: This study aimed to evaluate the differences between pericoronary adipose tissue (PCAT) attenuation at different measured locations in evaluating coronary atherosclerosis using spectral computed tomography (CT) and to explore valuable imaging indicators. METHODS: A total of 330 patients with suspicious coronary atherosclerosis were enrolled and underwent coronary CT angiography with dual-layer spectral detector CT (SDCT). Proximal and peri-plaque fat attenuation index (FAI) of stenosis coronary arteries were measured using both conventional images (CIs) and virtual monoenergetic images (VMIs) ranging from 40 keV to 100 keV...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38532042/a-parametric-study-of-the-effect-of-3d-plaque-shape-on-local-hemodynamics-and-implications-for-plaque-instability
#5
JOURNAL ARTICLE
Shaolie S Hossain, Michael J Johnson, Thomas J R Hughes
The vast majority of heart attacks occur when vulnerable plaques rupture, releasing their lipid content into the blood stream leading to thrombus formation and blockage of a coronary artery. Detection of these unstable plaques before they rupture remains a challenge. Hemodynamic features including wall shear stress (WSS) and wall shear stress gradient (WSSG) near the vulnerable plaque and local inflammation are known to affect plaque instability. In this work, a computational workflow has been developed to enable a comprehensive parametric study detailing the effects of 3D plaque shape on local hemodynamics and their implications for plaque instability...
March 26, 2024: Biomechanics and Modeling in Mechanobiology
https://read.qxmd.com/read/38529605/role-of-abca1-in-atherosclerosis-novel-mutations-and-potential-plant-derived-therapies
#6
JOURNAL ARTICLE
Siarhei A Dabravolski, Nikolay A Orekhov, Victor Y Glanz, Vasily N Sukhorukov, Elizaveta M Pleshko, Alexander N Orekhov
ATP-binding cassette transporter A1 (ABCA1) is one of the key proteins regulating cholesterol homeostasis and playing a crucial role in atherosclerosis development. ABCA1 regulates the rate-limiting step of reverse cholesterol transport, facilitates the efflux of surplus intracellular cholesterol and phospholipids, and suppresses inflammation through several signalling pathways. At the same time, many mutations and Single Nucleotide Polymorphisms (SNPs) have been identified in the ABCA1 gene, which affects its biological function and is associated with several hereditary diseases (such as familial hypo-alpha-lipoproteinaemia and Tangier disease) and increased risk of cardiovascular diseases (CVDs)...
March 25, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38528718/the-cytoplasmic-sensor-the-aim2-inflammasome-a-precise-therapeutic-target-in-vascular-and-metabolic-diseases
#7
REVIEW
Jiuguo Lin, Jiaojiao Wang, Jian Fang, Meihang Li, Suowen Xu, Peter J Little, Dongmei Zhang, Zhiping Liu
Cardio-cerebrovascular diseases encompass pathological changes in the heart, brain and vascular system, which pose a great threat to health and well-being worldwide. Moreover, metabolic diseases contribute to and exacerbate the impact of vascular diseases. Inflammation is a complex process that protects against noxious stimuli but is also dysregulated in numerous so-called inflammatory diseases, one of which is atherosclerosis. Inflammation involves multiple organ systems and a complex cascade of molecular and cellular events...
March 25, 2024: British Journal of Pharmacology
https://read.qxmd.com/read/38528580/fibrinogen-to-hdl-cholesterol-ratio-as-a-predictor-of-mortality-risk-in-patients-with-acute-myocardial-infarction
#8
JOURNAL ARTICLE
Congzhuo Jia, Wanying Wu, Huan Lu, Jin Liu, Shiqun Chen, Guoxiao Liang, Yang Zhou, Sijia Yu, Linfang Qiao, Jinming Chen, Ning Tan, Yong Liu, Jiyan Chen
BACKGROUND: Acute myocardial infarction (AMI) is characterized by inflammation, oxidative stress, and atherosclerosis, contributing to increased mortality risk. High-density lipoprotein (HDL) takes a crucial part in mitigating atherosclerosis and inflammation through its diverse functionalities. Conversely, fibrinogen is implicated in the development of atherosclerotic plaques. However, the mortality risk predictive capacity of fibrinogen to HDL-cholesterol ratio (FHR) in AMI patients remains unexplored...
March 25, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38526285/atherosis-associated-lnc_000048-activates-pkr-to-enhance-stat1-mediated-polarization-of-thp-1-macrophages-to-m1-phenotype
#9
JOURNAL ARTICLE
Yuanyuan Ding, Yu Sun, Hongyan Wang, Hongqin Zhao, Ruihua Yin, Meng Zhang, Xudong Pan, Xiaoyan Zhu
JOURNAL/nrgr/04.03/01300535-202419110-00029/figure1/v/2024-03-08T184507Z/r/image-tiff Our previous study has demonstrated that lnc_000048 is upregulated in large-artery atherosclerotic stroke and promotes atherosclerosis in ApoE-/- mice. However, little is known about the role of lnc_000048 in classically activated macrophage (M1) polarization. In this study, we established THP-1-derived testing state macrophages (M0), M1 macrophages, and alternately activated macrophages (M2). Real-time fluorescence quantitative PCR was used to verify the expression of marker genes and the expression of lnc_000048 in macrophages...
November 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38523705/aiming-at-early-stage-vulnerable-plaques-a-nanoplatform-with-dual-mode-imaging-and-lipid-inflammation-integrated-regulation-for-atherosclerotic-theranostics
#10
JOURNAL ARTICLE
Yao Wang, Zhebin Chen, Qiongjun Zhu, Zhezhe Chen, Guosheng Fu, Boxuan Ma, Wenbin Zhang
The vulnerable plaques in atherosclerosis can cause severe outcome with great danger of acute cardiovascular events. Thus, timely diagnosis and treatment of vulnerable plaques in early stage can effectively benefit the clinical management of atherosclerosis. In this work, a targeting theranostic strategy on early-stage vulnerable plaques in atherosclerosis is realized by a LAID nanoplatform with X-CT and fluorescent dual-mode imaging and lipid-inflammation integrated regulation abilities. The iodinated contrast agents (ICA), phenylboronic acid modified astaxanthin and oxidized-dextran (oxDEX) jointly construct the nanoparticles loaded with the lipid-specific probe LFP...
July 2024: Bioactive Materials
https://read.qxmd.com/read/38523689/fto-stabilizes-mis12-to-inhibit-vascular-smooth-muscle-cell-senescence-in-atherosclerotic-plaque
#11
JOURNAL ARTICLE
Jingzhao Sun, Mengqi Wang, Fengming Jia, Jiantao Song, Jinlin Ren, Bo Hu
PURPOSE: Atherosclerosis is the main cause of atherosclerotic cardiovascular disease (CVD). Here, we aimed to uncover the role and mechanisms of fat mass and obesity-associated genes (FTO) in the regulation of vascular smooth muscle cell (VSMC) senescence in atherosclerotic plaques. METHODS: ApoE-/- mice fed a high-fat diet (HFD) were used to establish an atherosclerotic animal model. Immunohistochemistry, and the staining of hematoxylin-eosin, Oil Red O, Sirius red, and Masson were performed to confirm the role of FTO in atherosclerosis in vivo...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38523002/low-level-ambient-ozone-exposure-associated-with-neutrophil-extracellular-traps-and-pro-atherothrombotic-biomarkers-in-healthy-adults
#12
JOURNAL ARTICLE
Hongbing Xu, Xinghou He, Bin Zhang, Mengyao Li, Yutong Zhu, Tong Wang, Shengcong Liu, Mushui Shu, Ding Ding, Yu Wang, Qian Zhao, Jianping Li, Xiaoming Song, Wei Huang
BACKGROUND AND AIMS: Uncertainty of the causality determinations for ambient ozone (O3 ) on cardiovascular events is heightened by the limited understanding of the mechanisms involved in humans. We aimed to examine the pro-atherothrombotic impacts of O3 exposure and to explore the potential mediating roles of dysfunctional neutrophils, focusing on neutrophil extracellular traps (NETs). METHODS: A longitudinal panel study of 152 healthy adults was conducted in the cool to cold months with relatively low levels of O3 between September 2019 and January 2020 in Beijing, China...
March 7, 2024: Atherosclerosis
https://read.qxmd.com/read/38522762/blockade-of-endothelial-adenosine-receptor-2a-suppresses-atherosclerosis-in-vivo-through-inhibiting-creb-alk5-mediated-endothelial-to-mesenchymal-transition
#13
JOURNAL ARTICLE
Yongfeng Cai, Yaqi Zhou, Qiuhua Yang, Jiean Xu, Qingen Da, Qian Ma, Dingwei Zhao, Tammy Lu, Ha Won Kim, David Fulton, Xuejun Jiang, Neal L Weintraub, Kunzhe Dong, Suowen Xu, Mei Hong, Zhiping Liu, Yuqing Huo
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and morbidity and mortality rates continue to rise. Atherosclerosis constitutes the principal etiology of CVDs. Endothelial injury, inflammation, and dysfunction are the initiating factors of atherosclerosis. Recently, we reported that endothelial adenosine receptor 2A (ADORA2A), a G protein-coupled receptor (GPCR), plays critical roles in neovascularization disease and cerebrovascular disease. However, the precise role of endothelial ADORA2A in atherosclerosis is still not fully understood...
March 22, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38522315/polyphenols-from-hickory-nut-reduce-the-occurrence-of-atherosclerosis-in-mice-by-improving-intestinal-microbiota-and-inhibiting-trimethylamine-n-oxide-production
#14
JOURNAL ARTICLE
Chenyu Jiang, Song Wang, Yihan Wang, Ketao Wang, Chunying Huang, Fei Gao, Huang Peng Hu, Yangyong Deng, Wen Zhang, Jian Zheng, Jianqin Huang, Yan Li
BACKGROUND: Trimethylamine N-oxide (TMAO), a metabolite produced by intestinal microbiota through metabolizing phosphatidylcholine, choline, l-carnitine and betaine in the diet, has been implicated in the pathogenesis of atherosclerosis (AS). Concurrently, dietary polyphenols have garnered attention for their potential to ameliorate obesity, diabetes and atherosclerosis primarily by modulating the intestinal microbial structure. Hickory (Carya cathayensis) nut, a polyphenol-rich food product favored for its palatability, emerges as a candidate for exploration...
January 9, 2024: Phytomedicine
https://read.qxmd.com/read/38522236/growth-and-differentiation-factor-15-a-link-between-inflammaging-and-cardiovascular-disease
#15
REVIEW
Balázs Bence Nyárády, Loretta Zsuzsa Kiss, Zsolt Bagyura, Béla Merkely, Edit Dósa, Orsolya Láng, László Kőhidai, Éva Pállinger
Age-related disorders are closely linked to the accumulation of senescent cells. The senescence-associated secretory phenotype (SASP) sustains and progresses chronic inflammation, which is involved in cellular and tissue dysfunction. SASP-related growth and differentiation factor-15 (GDF-15) is an immunoregulatory cytokine that is coupled to aging and thus may have a regulatory role in the development and maintenance of atherosclerosis, a major cause of cardiovascular disease (CVD). Although the effects of GDF-15 are tissue-specific and dependent on microenvironmental changes such as inflammation, available data suggest that GDF-15 has a significant role in CVD...
March 23, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38519881/vascular-smooth-muscle-cells-in-response-to-cholesterol-crystals-modulates-inflammatory-cytokines-release-and-promotes-neutrophil-extracellular-trap-formation
#16
JOURNAL ARTICLE
Jishamol Thazhathveettil, Ashok Kumar Kumawat, Isak Demirel, Allan Sirsjö, Geena Varghese Paramel
BACKGROUND: The formation and accumulation of cholesterol crystals (CC) at the lesion site is a hallmark of atherosclerosis. Although studies have shown the importance of vascular smooth muscle cells (VSMCs) in the disease atherosclerosis, little is known about the molecular mechanism behind the uptake of CC in VSMCs and their role in modulating immune response. METHODS: Human aortic smooth muscle cells were cultured and treated with CC. CC uptake and CC mediated signaling pathway and protein induction were studied using flow cytometry, confocal microscopy, western blot and Olink proteomics...
March 22, 2024: Molecular Medicine
https://read.qxmd.com/read/38516841/naringenin-inhibits-acid-sphingomyelinase-mediated-membrane-raft-clustering-to-reduce-nadph-oxidase-activation-and-vascular-inflammation
#17
JOURNAL ARTICLE
Meng Ding, Yuan Zhu, Xiaoting Xu, Hui He, Tianyu Jiang, Xiaochuan Mo, Zhuting Wang, Wenfeng Yu, Hailong Ou
Macrophage inflammation and oxidative stress promote atherosclerosis progression. Naringenin is a naturally occurring flavonoid with antiatherosclerotic properties. Here, we elucidated the effects of naringenin on monocyte/macrophage endothelial infiltration and vascular inflammation. We found naringenin inhibited oxidized low-density lipoprotein (oxLDL)-induced pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α toward an M2 macrophage phenotype and inhibited oxLDL-induced TLR4 (Toll-like receptor 4) membrane translocation and downstream NF-κB transcriptional activity...
March 22, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38515522/-trans-isomeric-fatty-acids-in-human-milk-and-their-role-in-infant-health-and-development
#18
REVIEW
Okba Hatem, Ömer Furkan Kaçar, Hüsna Kaya Kaçar, József L Szentpéteri, Tamás Marosvölgyi, Éva Szabó
It is well known that long chain polyunsaturated fatty acids (LCPUFAs) play an important role in neurodevelopment in the perinatal life. The most important source of these fatty acids is the diet, however, they can also be formed in the human body from their shorter chain precursors, the essential fatty acids. Since the WHO recommends exclusive breastfeeding for the first six months after birth, the exclusive source of these fatty acids for breastfed infants is human milk, which can be influenced by the mother's diet...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38514208/extracellular-vesicles-in-heart-failure
#19
JOURNAL ARTICLE
Alexander E Berezin, Alexander A Berezin
Physiologically, extracellular vesicles (EVs) have been implicated as crucial mediators of immune response, cell homeostasis, angiogenesis, cell differentiation and growth, and tissue repair. In heart failure (HF) they may act as regulators of cardiac remodeling, microvascular inflammation, micro environmental changes, tissue fibrosis, atherosclerosis, neovascularization of plaques, endothelial dysfunction, thrombosis, and reciprocal heart-remote organ interaction. The chapter summaries the nomenclature, isolation, detection of EVs, their biologic role and function physiologically as well as in the pathogenesis of HF...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38511327/virus-associated-cd8-t-cells-are-not-activated-through-antigen-mediated-interaction-inside-atherosclerotic-lesions
#20
JOURNAL ARTICLE
Maaike J M de Jong, Frank H Schaftenaar, Marie A C Depuydt, Fernando Lozano Vigario, George M C Janssen, Judith A H M Peeters, Lauren Goncalves, Anouk Wezel, Harm J Smeets, Johan Kuiper, Ilze Bot, Peter van Veelen, Bram Slütter
INTRODUCTION: Viral infections have been associated with the progression of atherosclerosis and CD8+ T-cells directed against common viruses, such as influenza, Epstein-Barr virus, and cytomegalovirus, have been detected inside human atherosclerotic lesions. These virus-specific CD8+ T-cells have been hypothesized to contribute to the development of atherosclerosis; however, whether they affect disease progression directly remains unclear. In this study, we aimed to characterize the activation status of virus-specific CD8+ T-cells in the atherosclerotic lesion...
March 21, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
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