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Michael Bauer, Tasha Glenn, Martin Alda, Ole A Andreassen, Elias Angelopoulos, Raffaella Ardau, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T Baune, Claudia Becerra-Palars, Frank Bellivier, Robert H Belmaker, Michael Berk, Yuly Bersudsky, Şule Bicakci, Harriet Birabwa-Oketcho, Thomas D Bjella, Jorge Cabrera, Eric Y Wo Cheung, Maria Del Zompo, Seetal Dodd, Markus Donix, Bruno Etain, Andrea Fagiolini, Kostas N Fountoulakis, Mark A Frye, Ana Gonzalez-Pinto, John F Gottlieb, Paul Grof, Hirohiko Harima, Chantal Henry, Erkki T Isometsä, Sven Janno, Flávio Kapczinski, Mathias Kardell, Slim Khaldi, Sebastian Kliwicki, Barbara König, Timur L Kot, Rikke Krogh, Mauricio Kunz, Beny Lafer, Mikael Landén, Erik R Larsen, Ute Lewitzka, Rasmus W Licht, Carlos Lopez-Jaramillo, Glenda MacQueen, Mirko Manchia, Wendy Marsh, Mónica Martinez-Cengotitabengoa, Ingrid Melle, Fátima Meza-Urzúa, Mok Yee Ming, Scott Monteith, Gunnar Morken, Enrica Mosca, Anton A Mozzhegorov, Rodrigo Munoz, Starlin V Mythri, Fethi Nacef, Ravi K Nadella, Fabiano G Nery, René E Nielsen, Claire O'Donovan, Adel Omrani, Yamima Osher, Helle Østermark Sørensen, Uta Ouali, Yolanda Pica Ruiz, Maximilian Pilhatsch, Marco Pinna, Francisco D R da Ponte, Danilo Quiroz, Raj Ramesar, Natalie Rasgon, M S Reddy, Andreas Reif, Philipp Ritter, Janusz K Rybakowski, Kemal Sagduyu, Bharathram Sathur Raghuraman, Ângela M Scippa, Emanuel Severus, Christian Simhandl, Paul W Stackhouse, Dan J Stein, Sergio Strejilevich, Mythily Subramaniam, Ahmad Hatim Sulaiman, Kirsi Suominen, Hiromi Tagata, Yoshitaka Tatebayashi, Leonardo Tondo, Carla Torrent, Arne E Vaaler, Edgar Vares, Julia Veeh, Eduard Vieta, Biju Viswanath, Maria Yoldi-Negrete, Mark Zetin, Yosra Zgueb, Peter C Whybrow
In many international studies, rates of completed suicide and suicide attempts have a seasonal pattern that peaks in spring or summer. This exploratory study investigated the association between solar insolation and a history of suicide attempt in patients with bipolar I disorder. Solar insolation is the amount of electromagnetic energy from the Sun striking a surface area on Earth. Data were collected previously from 5536 patients with bipolar I disorder at 50 collection sites in 32 countries at a wide range of latitudes in both hemispheres...
March 8, 2019: Journal of Psychiatric Research
Mauricio Macossay-Castillo, Giulio Marvelli, Mainak Guharoy, Aashish Jain, Daisuke Kihara, Peter Tompa, Shoshana J Wodak
Intrinsically disordered proteins (IDPs) or regions (IDRs) perform diverse cellular functions, but are also prone to forming promiscuous and potentially deleterious interactions. We investigate the extent to which the properties of, and content in, IDRs have adapted to enable functional diversity while limiting interference from promiscuous interactions in the crowded cellular environment. Information on protein sequences, their predicted intrinsic disorder and 3D structure contents, is related to data on protein cellular concentrations, gene co-expression, and protein-protein interactions (PPI) in the well-studied yeast S...
March 13, 2019: Journal of Molecular Biology
Kainan S Wang, Mauricio R Delgado
The ability to perceive and exercise control over an outcome is both desirable and beneficial to our well-being. It has been shown that animals and humans alike exhibit behavioral bias towards seeking control and that such bias recruits the ventromedial prefrontal cortex (vmPFC) and striatum. Yet, this bias remains to be quantitatively captured and studied neurally. Here, we employed a behavioral task to measure the preference for control and characterize its neural underpinnings. Participants made a series of binary choices between having control and no-control over a game for monetary reward...
March 16, 2019: Cerebral Cortex
Mauricio La Rosa, Victoria Jauk, George R Saade, Kim Boggess, Sherri Longo, Erin A S Clark, Sean Esplin, Kirsten Cleary, Ronald Wapner, Kellet Letson, Michelle Y Owens, Sean Blackwell, Jeff M Szychowski, William Andrews, Alan T Tita
OBJECTIVE:  Hospital readmissions are increasingly tracked and assessed for value-based compensation. Our objective was to determine the incidence and risk factors associated with post-cesarean delivery (CD) readmissions or unexpected visits, defined as unexpected office or emergency room visits. STUDY DESIGN:  This is a secondary analysis of a multicenter randomized controlled trial of adjunctive azithromycin prophylaxis for CD performed in laboring patients with viable pregnancies...
March 15, 2019: American Journal of Perinatology
Alexandre Peixoto de Mello, Glaucus Cajaty Dos Santos Martins, André Raposo Heringer, Raphael Barbosa Gamallo, Luiz Felippe Dos Santos Martins Filho, Antônio Vítor de Abreu, Antonio Carlos Pires Carvalho, Maurício de Pinho Gama
OBJECTIVE: The objective of this research was to evaluate the prevalence of cervical and lumbar pain in obese patients eligible for bariatric surgery and to investigate possible changes in sagittal spine alignment in these patients. METHODS: The following parameters were compared in 30 obese patients and a control group of 25 non-obese volunteers: body mass index, prevalence of cervical and lumbar pain assessed by visual analog scale (VAS), Neck Disability Index [NDI] and Oswestry Disability Index [ODI], as well as radiographic parameters of the spine and pelvis measured with Surgimap software...
March 15, 2019: European Spine Journal
Kafui Adjaye-Gbewonyo, Sebastian Vollmer, Mauricio Avendano, Kenneth Harttgen
BACKGROUND: There has been growing interest in understanding the role of agricultural trade policies in diet and nutrition. This cross-country study examines associations between government policies on agricultural trade prices and child nutrition outcomes, particularly undernutrition. METHODS: This study links panel data on government distortions to agricultural incentives to data from 212,258 children aged 6 to 35 months participating in Demographic and Health Surveys from 22 countries between 1991 and 2010...
March 15, 2019: Globalization and Health
Nancy Carolina Corredor, Carolina López, Paula Andrea Aguilera, Lina María Prieto, Giovanni Rodríguez-Leguizamón, Aura Lucía Leal, María Victoria Ovalle-Guerro, Juan Mauricio Pardo-Oviedo, Claudia Elena Chica, Manuel Alfonso Patarroyo
BACKGROUND: Enterococcus faecium is ranked worldwide as one of the top ten pathogens identified in healthcare-associated infections (HAI) and is classified as one of the high priority pathogens for research and development of new antibiotics worldwide. Due to molecular biology techniques' higher costs, the approach for identifying and controlling infectious diseases in developing countries has been based on clinical and epidemiological perspectives. Nevertheless, after an abrupt vancomycin-resistant Enterococcus faecium dissemination in the Méderi teaching hospital, ending up in an outbreak, further measures needed to be taken into consideration...
March 15, 2019: BMC Infectious Diseases
Gastón Siano, Stefano Crespi, Mariella Mella, Sergio Mauricio Bonesi
Irradiation of a series of p-substituted aryl benzoates under N2 atmosphere in homogeneous and micellar media was investigated by means of both steady-state and laser flash photolysis. A notable selectivity in favor of the 2-hydroxybenzophenone derivatives was observed when the photoreaction was carried out in micellar media. The benzophenone derivatives were the main photoproduct. On the other hand, in homogeneous media (cyclohexane, acetonitrile and methanol) the observed product distribution was quite different, viz...
March 15, 2019: Journal of Organic Chemistry
Danielle Ruiz Lima, Priscila Dib Gonçalves, Mariella Ometto, Andre Malbergier, Ricardo Abrantes Amaral, Bernardo Dos Santos, Mikael Cavallet, Tiffany Chaim-Avancini, Mauricio Henriques Serpa, Luiz Roberto Kobuti Ferreira, Fabio Luis de Souza Duran, Marcus Vinicius Zanetti, Sergio Nicastri, Geraldo Filho Busatto, Arthur Guerra Andrade, Paulo Jannuzzi Cunha
BACKGROUND: The severity of substance use disorder (SUD) is currently defined by the sum of DSM-5 criteria. However, little is known about the validity of this framework or the role of additional severity indicators in relapse prediction. This study aimed to investigate the relationship between DSM-5 criteria, neurocognitive functioning, substance use variables and cocaine relapse among inpatients with cocaine use disorder (CUD). METHODS: 128 adults aged between 18 and 45 years were evaluated; 68 (59 males, 9 females) had CUD and 60 (52 males, 8 females) were healthy controls...
February 16, 2019: Drug and Alcohol Dependence
Aman Anand, Martin Bues, Mauricio E Gamez, Corbin Stefan, Samir H Patel
In order to better spare organs at risk in the head and neck, the application of proton beam therapy is of great interest. In this study we report the clinical utilization of a novel and robust scanning proton beam therapy treatment planning method called Individual Field Simultaneous Optimization (IFSO) that incorporates the advantages of field patching technique integrated with simultaneous optimization of multiple fields. A treatment planning intercomparison between a conventional Intensity Modulated Proton Therapy Treatment Plan with single target volume vs a split target volume utilizing IFSO method demonstrates superiority of IFSO with regards to sparing of organs at risk and plan robustness...
March 12, 2019: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Carlos Schmidt, Gabriel Reyes, Mauricio Barrientos, Álvaro I Langer, Jérôme Sackur
In the last decade of research on metacognition, the literature has been focused on understanding its mechanism, function and scope; however, little is known about whether metacognitive capacity can be trained. The specificity of the potential training procedure is in particular still largely unknown. In this study, we evaluate whether metacognition is trainable through generic meditation training, and if so, which component of meditation would be instrumental in this improvement. To this end, we evaluated participants' metacognitive efficiency before and after two types of meditation training protocols: the first focused on mental cues (Mental Monitoring [MM] training), whereas the second focused on body cues (Self-observation of the Body [SoB] training)...
March 11, 2019: Consciousness and Cognition
Mauricio Comas-Garcia
The packaging of genomic RNA in positive-sense single-stranded RNA viruses is a key part of the viral infectious cycle, yet this step is not fully understood. Unlike double-stranded DNA and RNA viruses, this process is coupled with nucleocapsid assembly. The specificity of RNA packaging depends on multiple factors: (i) one or more packaging signals, (ii) RNA replication, (iii) translation, (iv) viral factories, and (v) the physical properties of the RNA. The relative contribution of each of these factors to packaging specificity is different for every virus...
March 13, 2019: Viruses
Tomotaroh Granzier-Nakajima, Kazunori Fujisawa, Vivek Anil, Mauricio Terrones, Yin-Ting Yeh
Graphene provides a unique platform for the detailed study of its dopants at the atomic level. Previously, doped materials including Si, and 0D-1D carbon nanomaterials presented difficulties in the characterization of their dopants due to gradients in their dopant concentration and agglomeration of the material itself. Graphene's two-dimensional nature allows for the detailed characterization of these dopants via spectroscopic and atomic resolution imaging techniques. Nitrogen doping of graphene has been well studied, providing insights into the dopant bonding structure, dopant-dopant interaction, and spatial segregation within a single crystal...
March 12, 2019: Nanomaterials
Mercedes García-Roche, Alberto Casal, Diego A Mattiauda, Mateo Ceriani, Alejra Jasinsky, Mauricio Mastrogiovanni, Andrés Trostchansky, Mariana Carriquiry, Adriana Cassina, Celia Quijano
Early lactation is an energy-deming period for dairy cows which may lead to negative energy balance, threatening animal health consequently productivity. Herein we studied hepatic mitochondrial function in Holstein-Friesian multiparous dairy cows during lactation, under two different feeding strategies. During the first 180 days postpartum the cows were fed a total mixed ration (70% forage: 30% concentrate) ad libitum (non-grazing group, G0) or grazed Festuca arundinacea or Mendicago sativa plus supplementation (grazing group, G1)...
2019: PloS One
Silvia López-Argüello, Verónica Rincón, Alicia Rodríguez-Huete, Encarnación Martínez-Salas, Graham J Belsham, Alejandro Valbuena, Mauricio G Mateu
Infection by viruses depends on a balance between capsid stability and dynamics. This study has investigated biologically and biotechnologically relevant aspects of the relationship in foot-and-mouth disease virus (FMDV) between capsid structure and thermostability, and between thermostability and infectivity. In the FMDV capsid a substantial number of amino acid side chains at the interfaces between pentameric subunits are charged at neutral pH. Here a mutational analysis revealed that the essential role for virus infection of most of the 8 tested charged groups is not related to substantial changes in capsid protein expression or processing, or in capsid assembly or stability against thermally-induced dissociation into pentamers...
March 13, 2019: Journal of Virology
Mauricio P Lima, Denise Yamamoto, Ana Carolina de Mello Santos, Tadasuke Ooka, Rodrigo T Hernandes, Mônica A M Vieira, Fernanda Fernandes Dos Santos, Rosa Maria Silva, Tetsuya Hayashi, Tânia A T Gomes
Escherichia albertii are emerging enteropathogens, whose identification is difficult, as they share biochemical characteristics and some virulence-related genes with diarrheagenic Escherichia coli (DEC). Studies on phylogeny, phenotypic characteristics and potential virulence factors of human E. albertii strains are scarce. In this study, we identified by multiplex PCR five E. albertii among 106 strains isolated from diarrheic children in São Paulo, Brazil, which were previously classified as atypical enteropathogenic E...
March 13, 2019: Pathogens and Disease
Gabriela Molinari Roberto, Regia Caroline Lira, Lara Elis Delsin, Gabriela Maciel Vieira, Marcela Oliveira Silva, Rodrigo Guedes Hakime, Mauricio Eiji Yamashita, Edgard Eduard Engel, Carlos Alberto Scrideli, Luiz Gonzaga Tone, María Sol Brassesco
Osteosarcoma (OS) is the most common primary malignant bone tumor with two peaks of incidence, in early adolescence and the elderly. Patients affected with this malignancy often present metastatic disease at diagnosis, and despite multimodality therapy, survival has not improved substantially over the past 3 decades. Recently, miR-138-5p, proposed as a crucial intracellular mediator of invasion, has been recognized to target the Rho-associated coiled-coil containing protein kinase 2 (ROCK2). Dysregulation of ROCK1 and ROCK2 was also described in OS, being associated to higher metastasis incidence and worse prognosis...
March 12, 2019: Pathology Oncology Research: POR
Deborah Antunes, Natasha Andressa Nogueira Jorge, Mauricio Garcia de Souza Costa, Fabio Passetti, Ernesto Raul Caffarena
Riboswitches are RNA sensors that affect post-transcriptional processes through their ability to bind to small molecules. Thiamine pyrophosphate (TPP) riboswitch class is the most widespread riboswitch occurring in all three domains of life. Even though it controls different genes involved in the synthesis or transport of thiamine and its phosphorylated derivatives in bacteria, archaea, fungi, and plants, the TPP aptamer has a conserved structure. In this study, we aimed at understanding differences in the structural dynamics of TPP riboswitches from Escherichia coli and Arabidopsis thaliana, based on their crystallographic structures (TPPswec and TPPswat , respectively) and dynamics in aqueous solution, both in apo and holo states...
March 12, 2019: Scientific Reports
Daniel Pfeiffer, Mauricio Toro-Nahuelpan, Marc Bramkamp, Jürgen M Plitzko, Dirk Schüler
Magnetotactic bacteria (MTB) are of special scientific interest due to the formation of magnetosomes, intracellular membrane-enveloped magnetite crystals arranged into a linear chain by a dedicated cytoskeleton. Magnetotaxis relies on the formation and proper inheritance of these unique magnetic organelles, both of which need to be coordinated with the segregation of other cellular content such as chromosomes or motility and chemotaxis related structures. Thus, elaborated mechanisms are required in MTB to coordinate and maintain a high level of spatial and temporal subcellular organization during cytokinesis...
March 12, 2019: MBio
Jeann L Sabino-Carvalho, Milena Samora, André L Teixeira, Mauricio Daher, Lauro C Vianna
NEW FINDINGS: What is the central question of this study? The initial circulatory response to isometric exercise in young healthy subjects is thought to be cholinergic-mediated. Do patients with Parkinson Disease (PD), a specific population known to present cholinergic dysfunction, present impairment in these initial circulatory responses? What is the main finding and its importance? The initial fall in total peripheral resistance was absent in patients with PD, as well as in older subjects, which augmented the pressor response at the onset of isometric handgrip exercise...
March 12, 2019: Experimental Physiology
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