keyword
https://read.qxmd.com/read/38535194/high-glucose-is-a-stimulation-signal-of-the-salt-tolerant-yeast-zygosaccharomyces-rouxii-on-thermoadaptive-growth
#1
JOURNAL ARTICLE
Zhenzhen Yan, Xiong Xiao, Quan Liu, Yangjian Wei, DongBo Cai, Xiong Chen, Xin Li
The salt-tolerant yeast Zygosaccharomyces rouxii is a typical aroma-producing yeast used in food brewing, but its mechanism of high temperature tolerance is still unclear. In this study, the response mechanism of Z. rouxii to glucose under high temperature stress at 40 °C was explored, based on the total synthetic lowest-nutrient medium. The results of the growth curves and scanning electron microscopy showed that high glucose was necessary for Z. rouxii to restore growth under high temperature stress, with the biomass at 300 g/L of glucose (OD600, 120h = 2...
February 28, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534128/high-throughput-profiling-of-metabolic-responses-to-exogenous-nutrients-in-synechocystis-sp-pcc-6803
#2
JOURNAL ARTICLE
Vilhelmiina Haavisto, Zachary Landry, Sammy Pontrelli
Cyanobacteria fix carbon dioxide and release carbon-containing compounds into the wider ecosystem, yet they are sensitive to small metabolites that may impact their growth and physiology. Several cyanobacteria can grow mixotrophically, but we currently lack a molecular understanding of how specific nutrients may alter the compounds they release, limiting our knowledge of how environmental factors might impact primary producers and the ecosystems they support. In this study, we develop a high-throughput phytoplankton culturing platform and identify how the model cyanobacterium Synechocystis sp...
March 27, 2024: MSystems
https://read.qxmd.com/read/38532480/dihydromyricetin-ameliorates-hepatic-steatosis-and-insulin-resistance-via-ampk-pgc-1%C3%AE-and-ppar%C3%AE-mediated-autophagy-pathway
#3
JOURNAL ARTICLE
Yan Yang, Wen Qiu, Jiyuan Xiao, Jie Sun, Xuan Ren, Luxia Jiang
BACKGROUND: Dihydromyricetin (DHM), a flavonoid compound of natural origin, has been identified in high concentrations in ampelopsis grossedentata and has a broad spectrum of biological and pharmacological functions, particularly in regulating glucose and lipid metabolism. The objective of this research was to examine how DHM affected nonalcoholic fatty liver disease (NAFLD) and its underlying mechanisms involved in the progression of NAFLD in a rat model subjected to a high-fat diet (HFD)...
March 26, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38532467/high-cell-density-sequential-batch-fermentation-for-enhanced-propionic-acid-production-from-glucose-and-glycerol-glucose-mixture-using-acidipropionibacterium-acidipropionici
#4
JOURNAL ARTICLE
Tarek Dishisha, Mridul Jain, Rajni Hatti-Kaul
BACKGROUND: Propionic acid fermentation from renewable feedstock suffers from low volumetric productivity and final product concentration, which limits the industrial feasibility of the microbial route. High cell density fermentation techniques overcome these limitations. Here, propionic acid (PA) production from glucose and a crude glycerol/glucose mixture was evaluated using Acidipropionibacterium acidipropionici, in high cell density (HCD) batch fermentations with cell recycle. The agro-industrial by-product, heat-treated potato juice, was used as N-source...
March 26, 2024: Microbial Cell Factories
https://read.qxmd.com/read/38529940/exosome-derived-microrna-221-3p-desensitizes-breast-cancer-cells-to-adriamycin-by-regulating-pik3r1-mediated-glycose-metabolism
#5
JOURNAL ARTICLE
Xiaolu Hong, Xiaoping Pan
Background: Cancer-derived exosomes facilitate chemoresistance by transferring RNAs, yet their role in exosomal microRNA-221-3p (miR-221-3p) regulation of Adriamycin resistance in breast cancer (BC) remains unclear. Methods: Adriamycin-resistant BC cells were developed from MCF-7 and MDA-MB-231 cells by incremental Adriamycin exposure. The miR-221-3p levels were quantified by quantitative reverse transcription-polymerase chain reaction. Subsequently, exosomes were isolated and incubated with BC cells, and exosome-mediated Adriamycin sensitivity was evaluated using Cell Counting Kit-8, colony formation, and flow cytometry assays...
March 26, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38529630/systematic-engineering-of-escherichia-coli-for-efficient-production-of-pseudouridine-from-glucose-and-uracil
#6
JOURNAL ARTICLE
Chi Zhang, Guoguang Wei, Ning Zhou, Yingying Wang, Jia Feng, Xin Wang, Alei Zhang, Kequan Chen
In this study, we proposed a biological approach to efficiently produce pseudouridine (Ψ) from glucose and uracil in vivo using engineered Escherichia coli . By screening host strains and core enzymes, E. coli MG1655 overexpressing Ψ monophosphate (ΨMP) glycosidase and ΨMP phosphatase was obtained, which displayed the highest Ψ concentration. Then, optimization of the RBS sequences, enhancement of ribose 5-phosphate supply in the cells, and overexpression of the membrane transport protein UraA were investigated...
March 26, 2024: ACS Synthetic Biology
https://read.qxmd.com/read/38529464/can-currently-available-non-invasive-continuous-blood-pressure-monitors-replace-invasive-measurement-with-an-arterial-catheter
#7
REVIEW
Payton Gore, Hong Liu, Christian Bohringer
Deviations from normal blood pressure (BP) during general anesthesia have been clearly linked to several adverse outcomes. Measuring BP accurately is therefore critically important for producing excellent outcomes in health care. Normal BP does not necessarily guarantee adequate organ perfusion however and adverse events have occurred even when BP seemed adequate. Invasive blood pressure monitoring has recently evolved beyond merely measuring BP. Arterial line-derived pulse contour analysis is used now to assess both cardiac output and stroke volume variation as indices of adequate intravascular volume...
February 2024: Curēus
https://read.qxmd.com/read/38526589/pomelo-citrus-grandis-l-osbeck-sponge-layers-as-a-potential-source-of-soluble-dietary-fiber-evaluation-of-its-physicochemical-structural-and-functional-properties
#8
JOURNAL ARTICLE
Xiaowei Chen, Jiajia Chen, Jian Peng, Yuanshan Yu, Jijun Wu, Jing Wen, Zhiying Kang, Yanhui Wang, Yujuan Xu, Lu Li
Pomelo sponge layer (PSL) had been considered as a potential source of soluble dietary fiber (SDF), while they were mostly disposed of as waste. To promote high-value utilization of pomelo wastes, this study extracted SDF from PSL of six varieties of pomelo, and their physicochemical, structural and functional properties were investigated. Results indicated that all PSL-SDFs showed good physicochemical and functional properties. Among them, PSL-SDF from grapefruit (GRSDF) showed better water holding capacity and swelling capacity, whereas Shatian pomelo PSL-SDF and Guanxi pomelo PSL-SDF had the highest thermal stability and oil holding capacity, respectively...
March 15, 2024: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38525944/advanced-glycation-endproducts-a-marker-of-long-term-exposure-to-glycemia
#9
JOURNAL ARTICLE
David C Klonoff, Rachel E Aaron, Tiffany Tian, Ashley Y DuNova, Ambarish Pandey, Connie Rhee, G Alexander Fleming, David B Sacks, Rodica Pop-Busui, David Kerr
This article examines the importance of advanced glycation endproducts (AGEs) and summarizes the structure of AGEs, pathological changes associated with AGEs, the contribution of AGEs to metabolic memory, and the value of AGEs as a predictor of diabetic complications and cardiovascular disease in people with and without diabetes. As a practical focus, skin autofluorescence (SAF) is examined as an attractive approach for estimating AGE burden. The measurement of AGEs may be of significant value to specific individuals and groups, including Black and Hispanic/Latino Americans, as they appear to have higher concentrations of hemoglobin A1c (HbA1c ) than would be predicted by other metrics of mean glycemia...
March 25, 2024: Journal of Diabetes Science and Technology
https://read.qxmd.com/read/38525542/apelin-regulates-skeletal-muscle-adaptation-to-exercise-in-a-high-intensity-interval-training-hiit-model
#10
JOURNAL ARTICLE
Teemu Kilpiö, Sini Skarp, Abel Perjes, Julia Swan, Leena Kaikkonen, Samu Saarimaki, Istvan Szokodi, Josef M Penninger, Zoltan Szabo, Johanna Magga, Risto Kerkela
Plasma apelin levels are reduced in aging and muscle wasting conditions. We aimed to investigate the significance of apelin signaling in cardiac and skeletal muscle responses to physiological stress. Apelin knockout (KO) and wild type (WT) mice were subjected to high intensity interval training (HIIT) by treadmill running. The effects of apelin on energy metabolism were studied in primary mouse skeletal muscle myotubes and cardiomyocytes. Apelin increased mitochondrial ATP production and mitochondrial coupling efficiency in myotubes and promoted the expression of mitochondrial genes both in primary myotubes and cardiomyocytes...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38522677/enhancing-simultaneous-saccharification-and-co-fermentation-of-corncob-by-kluyveromyces-marxianus-through-overexpression-of-putative-transcription-regulator
#11
JOURNAL ARTICLE
Kehui Zhang, Ziyun Jiang, Xingjiang Li, Dongmei Wang, Jiong Hong
Overexpression of a gene with unknown function in Kluyveromyces marxianus markedly improved tolerance to lignocellulosic biomass-derived inhibitors. This overexpression also enhanced tolerance to elevated temperatures, ethanol, and high concentrations of NaCl and glucose. Inhibitor degradation and transcriptome analyses related this K. marxianusMultiple Stress Resistance (KmMSR) gene to the robustness of yeast cells. Nuclear localization and DNA-binding domain analyses indicate that KmMsr is a putative transcriptional regulator...
March 22, 2024: Bioresource Technology
https://read.qxmd.com/read/38518862/modelling-remission-from-overweight-type-2-diabetes-reveals-how-altering-advice-may-counter-relapse
#12
JOURNAL ARTICLE
Catherine Z W Hassell Sweatman
The development or remission of diet-induced overweight type 2 diabetes involves many biological changes which occur over very different timescales. Remission, defined by HbA1c <6.5%, or fasting plasma glucose concentration G<126 mg/dl, may be achieved rapidly by following weight loss guidelines. However, remission is often short-term, followed by relapse. Mathematical modelling provides a way of investigating a typical situation, in which patients are advised to lose weight and then maintain fat mass, a slow variable...
March 20, 2024: Mathematical Biosciences
https://read.qxmd.com/read/38518263/greater-glycemic-control-following-low-load-high-repetition-resistance-exercise-compared-with-moderate-intensity-continuous-exercise-in-males-and-females-a-randomized-control-trial
#13
JOURNAL ARTICLE
Kayleigh M Beaudry, Julian C Surdi, Kristian Pancevski, Cory Tremblay, Michaela Devries-Aboud
Exercise has long been known for its beneficial effects on insulin sensitivity (IS) and glucose handling with both moderate-intensity continuous (MIC) exercise and resistance exercise (RE) inducing beneficial effects. In recent years, low-load high repetition (LLHR) RE has emerged as a strategy to increase muscle mass and strength to levels similar to traditional RE, however the effects of LLHR RE on glucose handling has yet to be investigated. The purpose of this trial was to compare the acute effects of LLHR RE to MIC exercise on post-exercise glycemic control and insulin sensitivity in males and females...
March 22, 2024: Applied Physiology Nutrition and Metabolism
https://read.qxmd.com/read/38518039/the-effect-of-hyperbaric-oxygen-therapy-on-hematological-indices-and-biochemical-parameters-in-patients-with-diabetic-foot
#14
JOURNAL ARTICLE
Erdinç Ercan, Gamze Aydin, Bülent Erdoğan, Fatih Özçelik
BACKGROUND: Diabetes Mellitus (DM) is a metabolic disease with a high morbidity and mortality and increasing in prevalence all over the world. Due to the hypoxic, ischemic, inflammatory, and infective environment in DM, diabetic foot ulcers have been treated with medico-surgical interventions and adjuvant hyperbaric oxygen Therapy (HBOT). The purpose of this study was to evaluate the effects of HBOT on hematological indices and biochemical parameters in patients with diabetic foot. METHODS: The study group was formed from the file records of 103 male patients who applied to Yunus Emre State Hospital HBOT Center between September 1, 2016 and December 31, 2020, and were treated HBOT with a multidisciplinary approach...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38516776/circular-rnas-and-the-regulation-of-gene-expression-in-diabetic-nephropathy-review
#15
JOURNAL ARTICLE
Maximo Berto Martinez Benitez, Yussel Pérez Navarro, Elisa Azuara-Liceaga, Angeles Tecalco Cruz, Jesús Valdés Flores, Lilia Lopez-Canovas
Circular RNAs (circRNAs) are non‑coding single‑stranded covalently closed RNA molecules that are considered important as regulators of gene expression at the transcriptional and post‑transcriptional levels. These molecules have been implicated in the initiation and progression of multiple human diseases, ranging from cancer to inflammatory and metabolic diseases, including diabetes mellitus and its vascular complications. The present article aimed to review the current knowledge on the biogenesis and functions of circRNAs, as well as their role in cell processes associated with diabetic nephropathy...
May 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38516166/dual-active-pyrimidine-based-carbocyclic-nucleoside-derivatives-synthesis-and-in-silico-and-in-vitro-anti-diabetic-and-anti-microbial-studies
#16
JOURNAL ARTICLE
Kalyani Mallidi, Rambabu Gundla, Parameshwar Makam, Naresh Kumar Katari, Sreekantha Babu Jonnalagadda
Diabetes mellitus (DM) is a chronic metabolic disorder marked by high blood glucose levels, impairing glucose production in the body. Its prevalence has steadily risen over the past decades, leading to compromised immunity and heightened susceptibility to microbial infections. Immune dysfunction associated with diabetes raises vulnerability, while neuropathy dulls sensation in the extremities, reducing injury awareness. Hence, the development of novel chemical compounds for anti-diabetic and anti-infective treatments is imperative to mitigate adverse effects...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38516160/probing-the-influence-of-crosslinkers-on-the-properties-response-and-degradation-of-enzymatic-hydrogels-for-electrochemical-glucose-biosensing-through-fluorescence-analysis
#17
JOURNAL ARTICLE
Jancarlo Diaz-Gonzalez, L G Arriaga, Jannu R Casanova-Moreno
Drop-cast crosslinked hydrogels are a common platform for enzymatic electrochemical biosensors. Despite the widespread use of these complex systems, there are still several questions about how their physicochemical properties affect their performance, stability, and reproducibility. In this work, first-generation faradaic biosensors composed of glucose oxidase and branched polyethyleneimine (BPEI) are prepared using either glutaraldehyde (GA) or ethylene glycol diglycidyl ether (EGDGE) as crosslinkers. While EGDGE gels present an increasing electrochemical response with increasing crosslinker concentration, the current of GA gels decreases at high crosslinker concentration probably due to the hampered diffusion on tightly networked gels...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38515569/cytotoxic-response-of-tumor-infiltrating-lymphocytes-of-head-and-neck-cancer-slice-cultures-under-mitochondrial-dysfunction
#18
JOURNAL ARTICLE
Maria do Carmo Greier, Annette Runge, Jozsef Dudas, Roland Hartl, Matthias Santer, Daniel Dejaco, Teresa Bernadette Steinbichler, Julia Federspiel, Christof Seifarth, Marko Konschake, Susanne Sprung, Sieghart Sopper, Avneet Randhawa, Melissa Mayr, Benedikt Gabriel Hofauer, Herbert Riechelmann
BACKGROUND: Head and neck squamous cell carcinomas (HNSCC) are highly heterogeneous tumors. In the harsh tumor microenvironment (TME), metabolic reprogramming and mitochondrial dysfunction may lead to immunosuppressive phenotypes. Aerobic glycolysis is needed for the activation of cytotoxic T-cells and the absence of glucose may hamper the full effector functions of cytotoxic T-cells. To test the effect of mitochondrial dysfunction on cytotoxic T cell function, slice cultures (SC) of HNSCC cancer were cultivated under different metabolic conditions...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38515139/hypochlorous-acid-derived-from-microglial-myeloperoxidase-could-mediate-high-mobility-group-box-1-release-from-neurons-to-amplify-brain-damage-in-cerebral-ischemia-reperfusion-injury
#19
JOURNAL ARTICLE
Shuang Chen, Jingrui Pan, Zhe Gong, Meiling Wu, Xiaoni Zhang, Hansen Chen, Dan Yang, Suhua Qi, Ying Peng, Jiangang Shen
Myeloperoxidase (MPO) plays critical role in the pathology of cerebral ischemia-reperfusion (I/R) injury via producing hypochlorous acid (HOCl) and inducing oxidative modification of proteins. High-mobility group box 1 (HMGB1) oxidation, particularly disulfide HMGB1 formation, facilitates the secretion and release of HMGB1 and activates neuroinflammation, aggravating cerebral I/R injury. However, the cellular sources of MPO/HOCl in ischemic brain injury are unclear yet. Whether HOCl could promote HMGB1 secretion and release remains unknown...
March 21, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38514991/some-pyrroles-as-inhibitors-of-the-pentose-phosphate-pathways-enzymes-an-in-vitro-and-molecular-docking-study
#20
JOURNAL ARTICLE
Muhammet Serhat Özaslan
Glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) are pentose phosphate pathway enzymes. Compounds with a heterocyclic pyrrole ring system containing this atom can be derivatized with various functional groups into highly effective bioactive agents. In this study, pyrrole derivatives on these enzyme's activity were investigated. The IC50 values of different concentrations of pyrrole derivatives for G6PD were found in the range of 0.022-0.221 mM Ki values 0.021 ± 0...
March 21, 2024: Journal of Molecular Recognition: JMR
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