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Milk Protein

Ambika Gupta, Kirti M Naranje, Anita Singh, Aakash Pandita, Girish Gupta, Kaushik Mandal, Mandakini Pradhan
Congenital chylothorax is a relatively uncommon condition seen in newborn period. Treatment comprises of adequate pleural fluid drainage, octreotide infusion, total parenteral nutrition followed by medium chain triglyceride (MCT) based low fat milk preparations. The authors present a case of Cornelia de Lange syndrome with a rare presentation of antenatally diagnosed chlyothorax presenting at birth with respiratory distress. The baby was managed with skimmed milk formulation fortified with coconut oil providing low fat and high proteins...
March 16, 2019: Indian Journal of Pediatrics
Katharina May, Kerstin Brügemann, Sven König, Christina Strube
Infections with the liver fluke Fasciola hepatica may result in considerable economic losses in the dairy livestock industry worldwide. Infections have been associated with detrimental impacts on milk production and milk quality as well as reduced fertility. However, most related data rely on examinations on herd level and the rather few studies on individual cow level are based solely on antibodies as measure for F. hepatica infections. This entails the risk of including false-positives as anti-F. hepatica antibodies persist for months even if the infection is cleared...
March 2019: Veterinary Parasitology
Gian Carlo Tenore, Ester Pagano, Stefania Lama, Daniela Vanacore, Salvatore Di Maro, Maria Maisto, Raffaele Capasso, Francesco Merlino, Francesca Borrelli, Paola Stiuso, Ettore Novellino
Under physiological conditions, the small intestine represents a barrier against harmful antigens and pathogens. Maintaining of the intestinal barrier depends largely on cell⁻cell interactions (adherent-junctions) and cell⁻matrix interactions (tight-junctions). Inflammatory bowel disease is characterized by chronic inflammation, which induces a destructuring of the architecture junctional epithelial proteins with consequent rupture of the intestinal barrier. Recently, a peptide identified by Bubalus bubalis milk-derived products (MBCP) has been able to reduce oxidative stress in intestinal epithelial cells and erythrocytes...
March 13, 2019: Nutrients
Laura Elena Córdova-Dávalos, Mariela Jiménez, Eva Salinas
Food-derived bioactive peptides are reported as beneficial and safe for human health. Glycomacropeptide (GMP) is a milk-protein-derived peptide that, in addition to its nutritional value, retains many biological properties and has therapeutic effects in several inflammatory disorders. GMP was shown under in vitro and in vivo conditions to exert a number of activities that regulate the physiology of important body systems, namely the gastrointestinal, endocrine, and immune systems. This review represents a comprehensive compilation summarizing the current knowledge and updated information on the major biological properties associated with GMP...
March 12, 2019: Nutrients
Hongbo Li, Tianqi Zhang, Jin Li, Hongjuan Li, Youqiang Xu, Jinghua Yu
BACKGROUND: Transglutaminase catalyze posttranslational modification of proteins by γ-glutamyl-ε-lysine chain links, covalent conjugation of polyamines and deamidation. Zea mays transglutaminase (TGZ) is a plant TGase with potential application prospects in the food industry. In this study, two promoter types, PFLD1 and PTEF1 , were compared to improve the expression of TGZ, and cross-linking effect of recombinant TGZ on the properties of acid-induced milk protein concentrate (MPC) gel was assessed...
March 14, 2019: Journal of the Science of Food and Agriculture
Yong Yang, Jiebao Li, Qi Song, Kongjun Zhu, Xiaocheng Yu, Ye Tian, Jiaheng Zhang
Milk fat globule-EGF factor 8 (MFG-E8) has been demonstrated to be associated with the progression and metastasis of breast cancer, although the underlying mechanisms remain undefined. The aim of the present study was to explore the role of MFG-E8 in human breast cancer and examine the underlying molecular mechanisms. Reverse transcription-quantitative polymerase chain reaction analysis was used to evaluate the expression levels of MFG-E8 in human breast carcinoma cell lines. An MFG-E8 small interfering RNA lentiviral vector was constructed and transfected into MDA-MB-231 cells...
March 2019: Oncology Letters
Bo Lönnerdal
Human milk contains a wide variety of bioactive components, including long-chain fatty acids, complex oligosaccharides, and bioactive proteins. More recently, it was discovered that breast milk also contains exosomes, i.e., microvesicles containing microRNAs (miRNAs) with sizes of ∼22 nucleotides. Several of these miRNAs have been shown to originate from the mammary gland, and many of them are involved in cellular development and immune function. Exosome-mediated transfer of miRNAs is a novel mechanism of genetic exchange between cells...
2019: Nestlé Nutrition Institute Workshop Series
J Bruce German, Nurit Argov-Argaman, Ben J Boyd
The evolution of lactation and the composition, structures, and functions of milk's biopolymers illustrates that the Darwinian pressure on lactation selected for gene products with considerable structural complexity and diverse functions within the digestive system. For example, complex sugar polymers - oligosaccharides - possess unique properties in guiding the growth of intestinal bacteria that are not possible by feeding their simple sugars. The proteins of milk are diverse with some exhibiting enzymatic activities towards other milk components rendering those components both more digestible but also releasing biologically active products...
2019: Nestlé Nutrition Institute Workshop Series
Kevin R Nicholas, Vengama Modepalli, Ashalyn P Watt, Lyn A Hinds, Amit Kumar, Christophe Lefevre, Julie A Sharp
Significantly preterm and low-birthweight (LBW) babies have diminished lung and gut development, generally fail to thrive, have increased mortality and higher frequency of mature-onset disease. Mothers often cannot breastfeed, and babies receive either formula or pasteurized donor milk, which may further limit the baby's recovery. New approaches are required to manage the early stages of neonatal development. The tammar wallaby, an Australian marsupial, has a short gestation and a simple placenta, and gives birth to an altricial young equivalent to a final trimester human embryo...
2019: Nestlé Nutrition Institute Workshop Series
Ferdinand Haschke, Christoph Binder, Mercedes Huber-Dangl, Nadja Haiden
It is well established that nutrition during the first 1,000 days of life can have a long-term effect on growth, metabolic outcome, and long-term health. We review the long-term anthropometric follow-ups of children with risk of later morbidity: (a) very-low-birth-weight (VLBW) infants who have birth weights <10th percentile of weight and receive fortified breast milk, (b) infants from developing countries who are breastfed according to the present recommendations but have low birth weight and length, and (c) children from developed countries who were enrolled in randomized controlled trials (RCTs) to test if breastfeeding and low-protein formulas can prevent from rapid weight gain and childhood obesity...
2019: Nestlé Nutrition Institute Workshop Series
Sharon M Donovan
Human milk (HM) contains hundreds of proteins with very diverse functions that likely contribute to the short- and long-term beneficial effects of breastfeeding. These functions include serving as a source of amino acids, improving the bioavailability of micronutrients, including vitamins, minerals, and trace elements, providing immunologic defense, stimulating intestinal growth and maturation, shaping the microbiome, and enhancing learning and memory. Human milk proteins can be broadly classified into 3 categories: caseins, whey proteins, and mucins, which are present in the milk fat globule membrane...
2019: Nestlé Nutrition Institute Workshop Series
Norimah A Karim, Nurliyana Abdul Razak
Two nationwide studies, namely the South East Asian Nutrition Survey (SEANUTS Malaysia) and MyBreakfast study showed that 13-17% of children aged between 6 and 12 years were either overweight or obese. From dietary assessment, the majority of children achieved the Malaysian recommended nutrient intake (RNI) for energy and protein, but more than 50% did not fulfill the RNI for calcium and vitamin D. The majority of children consumed breakfast regularly; however, 20-30% of children skipped breakfast. The MyBreakfast study showed that 17...
2019: Nestlé Nutrition Institute Workshop Series
Christiani Jeyakumar Henry
We live in a world of paradoxes: one half of the world is overweight or obese with abundant access to food and the other half undernourished due to poor food access. It has been estimated that nearly 36% of children in Asia are stunted. Worldwide, approximately 1 in 4 children under the age of 5 years shows stunted growth, making the number of stunted children to 155 million; 52 million children under 5 years are wasted, of which 17 million are severely wasted. Given the wide-scale nature of global malnutrition and its long-term consequences, why has this scar in our consciousness not being addressed systematically? The Asian enigma underscores the observation that unlike other regions of the world, economic growth does not appear to keep pace with the eradication of undernutrition...
2019: Nestlé Nutrition Institute Workshop Series
Ankita Sharma, Umesh K Shandilya, Monika Sodhi, Pradeep Jatav, Ashok Mohanty, Pranay Jain, Preeti Verma, R S Kataria, Parvesh Kumari, Manishi Mukesh
The molecular physiology of milk production of two important dairy species; Sahiwal cows ( Bos indicus ) and Murrah buffaloes ( Bubalus bubalis ) are not fully understood due to constraints in obtaining mammary tissue samples because of sacred and ethical reasons. The present study suggests the use of milk-derived mammary epithelial cells (MECs) as a non-invasive method to understand molecular aspects of lactation biology in dairy animals. A total of 76 MECs were collected from five different lactation periods viz...
March 2019: 3 Biotech
Xiao Yu Liu, Dongyang Li, Tong Li, Haitao Liu, Dan Cui, Yang Liu, Shuwei Jia, Xiaoran Wang, Runsheng Jiao, Hui Zhu, Fengmin Zhang, Danian Qin, Yu-Feng Wang
Oxytocin (OT), a hypothalamic neuropeptide, applied through nasal approach (IAO), could improve maternal health during lactation that is disrupted by mother-baby separation; however, the regulation of IAO effects on maternal behaviors and lactation as well as the underlying mechanisms remain unclear. Using lactating rats, we observed effects of intermittent pup deprivation (PD) with and without IAO on maternal behaviors and lactation as well as the activity of OT neurons in the supraoptic nucleus (SON) and the activity of hypothalamic pituitary-adrenal axis, key factors determining the milk-letdown reflex during lactation and maternal behaviors...
2019: Frontiers in Neuroscience
Cinderella A Fahmy, Amira M Gamal-Eldeen, Enas A El-Hussieny, Bassem M Raafat, Nayra S Mehanna, Roba M Talaat, Mohamed T Shaaban
The modulatory role of the Bifidobacterium longum (BL), isolated from women breast milk, on some oncogenic and tumor suppressor miRNAs as well as IL-1β and IL6 targeted-miRNAs was investigated using murine colorectal cancer (CRC) induced on the top of inflammatory ulcerative colitis model. The investigation of the oncomiRs miR-21a and miR-155, which regulate IL-6 and IL-1β expression, indicated that both was depressed by BL-administration in healthy and in CRC-mice. BL-administration induced the tumor suppressor miRNAs (miR-145 and miR-15a) expression in both of the healthy and in CRC-mice...
March 12, 2019: Nutrition and Cancer
Harald Zänker, Katja Heine, Stephan Weiss, Vinzenz Brendler, Richard Husar, Gert Bernhard, Karsten Gloe, Thomas Henle, Astrid Barkleit
Hexavalent uranium is ubiquitous in the environment. In view of the chemical and radiochemical toxicity of uranium(VI), a good knowledge of its possible interactions in the environment is crucial. The aim of this work was to identify typical binding and sorption characteristics of uranium(VI) with both the pure bovine milk protein β-casein and diverse related protein mixtures (caseins, whey proteins). For comparison, selected model peptides representing the amino acid sequence 13-16 of β-casein and dephosphorylated β-casein were also studied...
March 12, 2019: Inorganic Chemistry
Makoto Irahara, Wakako Shinahara, Mayumi Sugimoto, Yukiko Ogawa, Keiji Shitsukawa, Kenji Kubota, Limin Yang, Yukihiro Ohya, Hirohisa Saito, Shoji Kagami, Kokichi Arisawa, Hiroshi Kido
INTRODUCTION: Allergen-specific immunoglobulin isotype formation associated with immunoglobulin class-switching during the lactation period is the immunological background for food allergy in infants. We analyzed the serial changes in the production of feeding type-related egg- and milk-specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants. METHODS: Allergen-specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen's egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray...
March 11, 2019: Immunity, Inflammation and Disease
Tian-Xin Cong, Dan Hao, Xiang Wen, Xiao-Hua Li, Gu He, Xian Jiang
Acne vulgaris is a cutaneous chronic inflammatory disorder with complex pathogenesis. Four factors play vital roles in acne pathophysiology: hyperseborrhea and dysseborrhea, altered keratinization of the pilosebaceous duct, Cutibacterium acnes (C. acnes) and inflammation. The main hormones responsible for the development of acne vulgaris include androgens, insulin and insulin-like growth factor-1. Other factors involved in this process are corticotropin-releasing hormone, α-melanocyte-stimulating hormone and substance P...
March 11, 2019: Archives of Dermatological Research
Wenjin Guo, Bingrun Liu, Yunhou Yin, Xingchi Kan, Qian Gong, Yanwei Li, Yu Cao, Jianfa Wang, Dianwen Xu, He Ma, Shoupeng Fu, Juxiong Liu
Background/Aims: Mastitis is an acute clinical inflammatory response. The occurrence and development of mastitis seriously disturb women's physical and mental health. Licochalcone A, a phenolic compound in Glycyrrhiza uralensis , has anti-inflammatory properties. Here, we examined the effect of licochalcone A on blood-milk barrier and inflammatory response in LPS-induced mice mastitis. Methods: In vivo , we firstly established mice models of mastitis by canal injection of LPS to mammary gland, and then detected the effect of licochalcone A on pathological indexes, inflammatory responses and blood-milk barrier in this model...
2019: Frontiers in Immunology
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