Juan J A M Muñoz, Rafael Dariolli, Caio Mateus da Silva, Elida A Neri, Iuri C Valadão, Lauro Thiago Turaça, Vanessa M Lima, Mariana Lombardi Peres de Carvalho, Mariliza R Velho, Eric A Sobie, Jose E Krieger
BACKGROUND: Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising disease model, even though hiPSC-CMs cultured for extended periods display an undifferentiated transcriptional landscape. MiRNA-target gene interactions contribute to fine-tuning the genetic program governing cardiac maturation and may uncover critical pathways to be targeted. METHODS: We analyzed a hiPSC-CM public dataset to identify time-regulated miRNA-target gene interactions based on three logical steps of filtering...
September 2, 2022: Stem Cell Research & Therapy