keyword
https://read.qxmd.com/read/37602925/hydrogen-rich-saline-alleviates-cardiomyocyte-apoptosis-by-reducing-expression-of-calpain1-via-mir-124-3p
#1
JOURNAL ARTICLE
Xiaofei Xue, Wang Xi, Wei Li, Jian Xiao, Zhinong Wang, Yufeng Zhang
AIMS: Molecular hydrogen has been exhibited a protective function in heart diseases. Our previous study demonstrated that hydrogen-rich saline (HRS) could scavenge free radicals selectively and alleviate the inflammatory response in the myocardial ischaemia/reperfusion (I/R) injury, but the underlying mechanism has not been fully clarified. METHODS AND RESULTS: Adult (10 weeks) C57BL/6 male mice and neonatal rat cardiomyocytes were used to establish I/R and hypoxia/reoxygenation (H/R) injury models...
August 21, 2023: ESC Heart Failure
https://read.qxmd.com/read/37326122/mir%C3%A2-124-inhibits-cardiomyocyte-apoptosis-in-myocardial-ischaemia%C3%A2-reperfusion-injury-by-activating-mitochondrial-calcium-uniporter-regulator-1
#2
JOURNAL ARTICLE
Linlin Guo, Chaoying Liu, Chunyan Jiang, Yanhan Dong, Lynn Htet Htet Aung, Han Ding, Yanyan Gao
Mitochondria‑mediated apoptosis is the primary cause of cardiomyocyte death. Therefore, mitochondria are a key target for treating myocardial injury. Mitochondrial calcium uniporter regulator 1 (MCUR1)‑mediated mitochondrial calcium homeostasis markedly promotes cell proliferation and resistance to apoptosis. However, whether MCUR1 is involved in regulation of cardiomyocyte apoptosis during myocardial ischaemia‑reperfusion remains unknown. microRNA‑124 (miR‑124) is upregulated in cardiovascular disease, suggesting a key role for miR‑124 in the cardiovascular system...
August 2023: Molecular Medicine Reports
https://read.qxmd.com/read/36800233/circ_0001052-promotes-cardiac-hypertrophy-via-elevating-hipk3
#3
JOURNAL ARTICLE
Mengyue Yang, Weichen Wang, Longlong Wang, Yuze Li
Cardiac hypertrophy (CH) is a crucial risk factor for sudden death. Circular RNAs (circRNAs) exert significant effects in various biological and pathological processes. Circ_0001052 is sourced from Hipk3 (homeodomain-interacting protein kinase 3) and is reported to aggravate myocardial fibrosis. The purpose of the current study was to clarify the role and mechanism of circ-Hipk3 in CH. Transverse aortic constriction (TAC) was used to create an in vivo CH model, and angiotensin II (Ang II) therapy was used to create an in vitro CH model in cardiomyocytes (CMs)...
February 14, 2023: Aging
https://read.qxmd.com/read/36609501/alkbh5-alleviates-hypoxia-postconditioning-injury-in-d-galactose-induced-senescent-cardiomyocytes-by-regulating-stat3
#4
JOURNAL ARTICLE
Xuan Zhang, Feixiang Li, Ji Ma, Xiaobei Zhang, Yiqing Yin
Ischemic postconditioning (I/Post) reduces ischemia/reperfusion (I/R) injury by activating endogenous cardioprotection mechanisms, such as the JAK/STAT3 and PI3K/Akt pathways, which offer a traditional approach to myocardial protection. According to the previous study, cardioprotection by I/Post may lost in aged mice, and in our previous research, hypoxic postconditioning (H/Post) lacked a protective effect in senescent cardiomyocytes, which was associated with low expression of long noncoding RNA (lncRNA) H19...
January 9, 2023: Shock
https://read.qxmd.com/read/36299891/stem-cell-derived-extracellular-vesicles-reduce-the-expression-of-molecules-involved-in-cardiac-hypertrophy-in-a-model-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#5
JOURNAL ARTICLE
Alina Constantin, Ioana Karla Comarița, Nicoleta Alexandru, Alexandru Filippi, Florina Bojin, Mihaela Gherghiceanu, Alexandra Vîlcu, Miruna Nemecz, Loredan Stefan Niculescu, Virgil Păunescu, Adriana Georgescu
Cardiac pathological hypertrophy is the major risk factor that usually progresses to heart failure. We hypothesized that extracellular vesicles (EVs), known to act as important mediators in regulating physiological and pathological functions, could have the potential to reduce the cardiac hypertrophy and the ensuing cardiovascular diseases. Herein, the effects of mesenchymal stem cell-derived extracellular vesicles (EV-MSCs) on cardiac hypertrophy were investigated. EVs were isolated from the secretome of human adipose tissue-derived stem cells (EV-ADSCs) or bone marrow-derived stem cells (EV-BMMSCs)...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/36267811/activation-of-pten-p13k-akt-signaling-pathway-by-mirna-124-3p-loaded-nanoparticles-to-regulate-oxidative-stress-attenuates-cardiomyocyte-regulation-and-myocardial-injury
#6
JOURNAL ARTICLE
Yuan Cheng, Qing He, Na Li, Mengdi Luo
As a common cardiovascular disease, acute myocardial infarction seriously affects the health and life of patients. miRNAs play an important role in acute myocardial infarction. Based on miRNA obtained from the previous sequencing, this study investigated whether miRNA (miR)-124-3p-loaded nanoparticles (NPs) affect the phenotype of the acute myocardial infarction (AMI) rat. Nano-miR-124-3p decreased the myocardial infarction area, improved the myocardial tissue structure, and increased the degree of fibrosis...
2022: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/36056380/time-regulated-transcripts-with-the-potential-to-modulate-human-pluripotent-stem-cell-derived-cardiomyocyte-differentiation
#7
JOURNAL ARTICLE
Juan J A M Muñoz, Rafael Dariolli, Caio Mateus da Silva, Elida A Neri, Iuri C Valadão, Lauro Thiago Turaça, Vanessa M Lima, Mariana Lombardi Peres de Carvalho, Mariliza R Velho, Eric A Sobie, Jose E Krieger
BACKGROUND: Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising disease model, even though hiPSC-CMs cultured for extended periods display an undifferentiated transcriptional landscape. MiRNA-target gene interactions contribute to fine-tuning the genetic program governing cardiac maturation and may uncover critical pathways to be targeted. METHODS: We analyzed a hiPSC-CM public dataset to identify time-regulated miRNA-target gene interactions based on three logical steps of filtering...
September 2, 2022: Stem Cell Research & Therapy
https://read.qxmd.com/read/35091534/microrna-124-3p-attenuates-myocardial-injury-in-sepsis-via-modulating-sp1-hdac4-hif-1%C3%AE-axis
#8
JOURNAL ARTICLE
Mei Wu, Zehong Huang, Wenfang Huang, Mengyu Lin, Weifeng Liu, Kexuan Liu, Cai Li
Sepsis-induced cardiac dysfunction can lead to death in sepsis. In this case, we targeted to explore in detail the relative mechanism of microRNA (miR)-124-3p in sepsis-induced myocardial injury via the specific protein 1/histone deacetylase 4/hypoxia-inducing factor 1α (SP1/HDAC4/HIF-1α) axis. Septic rats were modeled by cecal ligation puncture while in vitro septic cardiomyocyte H9C2 were induced by lipopolysaccharide (LPS). miR-124-3p/SP1/HDAC4/HIF-1α expression levels in myocardial tissues of septic rats and LPS-treated H9C2 cells were measured...
January 28, 2022: Cell Death Discovery
https://read.qxmd.com/read/34732131/weighted-gene-co-expression-network-based-approach-to-identify-key-genes-associated-with-anthracycline-induced-cardiotoxicity-and-construction-of-mirna-transcription-factor-gene-regulatory-network
#9
JOURNAL ARTICLE
Guoxing Wan, Peinan Chen, Xue Sun, Xiaojun Cai, Xiongjie Yu, Xianhe Wang, Fengjun Cao
BACKGROUND: Cardiotoxicity is a common complication following anthracycline chemotherapy and represents one of the serious adverse reactions affecting life, which severely limits the effective use of anthracyclines in cancer therapy. Although some genes have been investigated by individual studies, the comprehensive analysis of key genes and molecular regulatory network in anthracyclines-induced cardiotoxicity (AIC) is lacking but urgently needed. METHODS: The present study integrating several transcription profiling datasets aimed to identify key genes associated with AIC by weighted correlation network analysis (WGCNA) and differentially expressed analysis (DEA) and also constructed miRNA-transcription factor-gene regulatory network...
November 3, 2021: Molecular Medicine
https://read.qxmd.com/read/34666672/long-noncoding-rna-mapkapk5-as1-promoted-lipopolysaccharide-induced-inflammatory-damage-in-the-myocardium-by-sponging-microrna-124-3p-e2f3
#10
JOURNAL ARTICLE
Weiwei Chen, Guangyuan Gao, Mengjie Yan, Ming Yu, Kaiyao Shi, Ping Yang
BACKGROUND: Myocardial dysfunction caused by sepsis (SIMD) leads to high mortality in critically ill patients. We investigated the function and mechanism of long non-coding RNA MAPKAPK5-AS1 (lncRNA MAPKAPK-AS1) on lipopolysaccharide (LPS)-induced inflammation response in vivo and in vitro. METHOD: Male SD rats were utilized for in vivo experiments. Rat cardiomyocytes (H9C2) were employed for in vitro experiments. Western blotting was employed to measure protein expression, and RT-PCR was performed to measure mRNA expression of inflammation factors...
October 19, 2021: Molecular Medicine
https://read.qxmd.com/read/34336120/lncrna-nonhsat069381-and-nonhsat140844-increase-in-aging-human-blood-regulating-cardiomyocyte-apoptosis
#11
JOURNAL ARTICLE
Jinyang Zhao, Xiaolong Lin, Haoxuan Sun, Donghui Zhao, Qin Ma, Wayne Bond Lau, Zichao Cheng, Fanqi Li, Jinghua Liu, Qian Fan
Aging augments postischemic apoptosis via incomplete mechanisms. Our previous animal study suggests that in addition to proapoptotic effects, lncRNAs also exert antiapoptotic effects in cardiomyocytes. However, whether this unexpected phenomenon exists in humans is unknown. In the present study, we investigated the relationship between aging and apoptosis regulation in human blood samples and confirmed their role by utilizing the cardiomyocyte lines (AC16 cells). Human blood samples were collected from 20 pairs of older adult and young volunteers...
2021: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/33233425/ace2-interaction-networks-in-covid-19-a-physiological-framework-for-prediction-of-outcome-in-patients-with-cardiovascular-risk-factors
#12
JOURNAL ARTICLE
Zofia Wicik, Ceren Eyileten, Daniel Jakubik, Sérgio N Simões, David C Martins, Rodrigo Pavão, Jolanta M Siller-Matula, Marek Postula
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019; COVID-19) is associated with adverse outcomes in patients with cardiovascular disease (CVD). The aim of the study was to characterize the interaction between SARS-CoV-2 and Angiotensin-Converting Enzyme 2 (ACE2) functional networks with a focus on CVD. METHODS: Using the network medicine approach and publicly available datasets, we investigated ACE2 tissue expression and described ACE2 interaction networks that could be affected by SARS-CoV-2 infection in the heart, lungs and nervous system...
November 21, 2020: Journal of Clinical Medicine
https://read.qxmd.com/read/32689640/mir-134-5p-inhibition-reduces-infarct-induced-cardiomyocyte-apoptosis-via-creb1-upregulation
#13
JOURNAL ARTICLE
Jibin Yang, Shiwen Liu, Hao Wang, Ying Liu, Yong Liu
BACKGROUND: Following the recent discovery that microRNA-134-5p (miR-134-5p) is elevated in the early stages of acute myocardial infarction (AMI), we examined the specific role of miR-134-5p in cardiomyocytes during AMI. METHODS: To study miR-134-5p's role in the context of AMI, we used a combination of in vitro experiments in H2 O2 -treated or hypoxic cardiomyocyte cell cultures as well as in vivo experiments in a murine model of AMI. RESULTS: H2 O2 - and hypoxia-induced cardiomyocyte injury upregulated miR-134-5p expression...
August 2020: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/32551941/lncrna-gas5-upregulates-mir-214-through-methylation-to-participate-in-cell-apoptosis-of-sepsis
#14
JOURNAL ARTICLE
Min Li, Zhimin Zhang, Boyi Liu, Li Chen, Menghe Wang
It has been reported that lncRNA GAS5 can inhibit LPS-induced inflammation, indicating its involvement in sepsis. We observed the downregulation of GAS5 in plasma of sepsis patients. In addition, expression levels of GAS5 were positively correlated with the expression levels of miR-214. In cardiomyocytes, overexpression of GAS5 upregulated the expression of miR-214, while its knockdown resulted in decreased expression levels of miR-124. Methylation-specific PCR (MSP) revealed that GAS5 negatively regulated the methylation of miR-124...
June 19, 2020: Archives of Physiology and Biochemistry
https://read.qxmd.com/read/32220226/tanshinone-iia-alleviates-hypoxia-reoxygenation-induced-cardiomyocyte-injury-via-lncrna-ak003290-mir-124-5p-signaling
#15
JOURNAL ARTICLE
Liye Chen, Lili Wei, Qiongyang Yu, Haozhe Shi, George Liu
BACKGROUND: Acute myocardial infarction (AMI) is the leading cause of death globally and has thus placed a heavy burden on healthcare. Tanshinone IIA (TSA) is a major active compound, extracted from Salvia miltiorrhiza Bunge, that possesses various pharmacological activities. The aim of the present study was to investigate the role of TSA in AMI and its underlying mechanism of action. RESULTS: We have shown that TSA decreased the apoptosis rate, the amount of LDH, MDA as well as ROS of cardiomyocytes...
March 27, 2020: BMC molecular and cell biology
https://read.qxmd.com/read/32096187/overexpression-of-the-long-noncoding-rna-neat1-protects-against-as2o3-induced-injury-of-cardiomyocyte-by-inhibiting-the-mir-124-nf-%C3%AE%C2%BAb-signaling-pathway
#16
JOURNAL ARTICLE
X-X Chen, Y-J Jiang, T Zeng, J-J Li
OBJECTIVE: Arsenic trioxide (As2O3) an evident effect in the treatment of acute promyelocytic leukemia and other malignant tumors in recent years. However, more and more studies have found that the cardiac toxicity of As2O3 was increased, limiting its wide clinical application. This study aims to explore the molecule mechanisms of As2O3 on cardiomyocyte injury. MATERIALS AND METHODS: The cardiomyocyte injury under As2O3 was detected by MTT assay. The levels of NEAT1 and miR-124 were examined by RT-PCR...
February 2020: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/31672275/mir-124-attenuates-doxorubicin-induced-cardiac-injury-via-inhibiting-p66shc-mediated-oxidative-stress
#17
JOURNAL ARTICLE
Yihai Liu, Yue Li, Jie Ni, Yimei Shu, Hongye Wang, Tingting Hu
Previous studies showed that miR-124 had a protective role by reducing oxidant stress and preventing cell apoptosis and autophagy. However, its role in doxorubicin-induced cardiomyopathy was less known. In our study, we confirmed increased ROS and decreased expression of miR-124 in doxorubicin-treated heart tissues and primary cardiomyocytes. The oxidative stress and cell apoptosis were alleviated by overexpressing miR-124, characterized by decreased activity of MDA and increased activity of SOD. While inhibiting miR-124 generated opposed effects...
October 28, 2019: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/31486506/mir-124-promotes-ischemia-reperfusion-induced-cardiomyocyte-apoptosis-by-targeting-sphingosine-kinase-1
#18
JOURNAL ARTICLE
B-F Liu, Q Chen, M Zhang, Y-K Zhu
OBJECTIVE: Ischemia-reperfusion (IR) injury of cardiomyocyte contributes to the cardiac dysfunction following myocardial infarction (MI). MiRNAs have been found to play a vital role in the pathogenesis of myocardial IR injury. In this study, the role of miR-124 in the myocardial IR injury was examined. MATERIALS AND METHODS: Myocardial ischemia rats' model was established to examine the expression level of miR-124. The primary rat cardiomyocytes were isolated to determine in vitro oxygen-glucose deprivation and reoxygenation model...
August 2019: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/31432169/inhibition-of-microrna%C3%A2-124%C3%A2-3p-protects-against-acute-myocardial-infarction-by-suppressing-the-apoptosis-of-cardiomyocytes
#19
JOURNAL ARTICLE
Guangrong Hu, Lingbo Ma, Fei Dong, Xiao Hu, Sida Liu, Hui Sun
The aims of the present study were to investigate the roles and underlying mechanisms of microRNA‑124‑3p (miR‑124‑3p) in the progression of acute myocardial infarction (AMI). The expression of miR‑124‑3p was determined via reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). TargetScan analysis and a luciferase reporter assay were conducted to reveal the association between miR‑124‑3p and nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB) repressing factor (NKRF)...
October 2019: Molecular Medicine Reports
https://read.qxmd.com/read/31144180/correlation-between-pri-mir-124-rs531564-polymorphism-and-congenital-heart-disease-susceptibility-in-chinese-population-at-two-different-altitudes-a-case-control-and-in-silico-study
#20
JOURNAL ARTICLE
Wenke Yang, Kang Yi, Hongmiao Yu, Yunhan Ding, Dehong Li, Yuping Wei, Tao You, Xiaodong Xie
The development of congenital heart disease (CHD) is a complicated process and affected by multiple environmental factors, as genetic factors, and the interactions among those factors. Previous studies have shown that intrauterine hypoxic environment exposure is a risk factor of CHD, but the genetic factors involved in the process are not clear. In this study, given that tetralogy of Fallot (TOF) is a CHD with hypoxemia as its primary pathophysiological manifestation, an in silico analysis was performed to reveal the relationship between potential target genes (miR-124) with the energy metabolism in non-syndromic TOF patients' cardiomyocyte...
May 29, 2019: Environmental Science and Pollution Research International
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