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renal failure acute

Thomas Oliver, Brandon Ciaudelli, David A Cohen
Anticoagulation-related nephropathy might just be the most common diagnosis you've never heard of. Formerly known as warfarin-induced nephropathy, until it was observed with numerous other anticoagulants and broadened to anticoagulation-related nephropathy. It is a potentially devastating disorder with serious and life-changing consequences if not recognized and diagnosed swiftly. As the clinician is faced with new acute renal failure, it is important to appreciate those factors that place patients at greater risk of anticoagulation-related nephropathy...
March 13, 2019: American Journal of Medicine
Yuki Kotani, Tomoko Fujii, Shigehiko Uchino, Kent Doi
PURPOSE: To assess the predictive validity of a modified Sequential Organ Failure Assessment (SOFA) score, of which the renal component was replaced with Kidney Disease Improving Global Outcomes (KDIGO) classification of Acute Kidney Injury (AKI). MATERIALS AND METHODS: Using a prospective cohort study on AKI in Japan, we replaced the renal component of SOFA score with AKI stages according to the KDIGO criteria except that initiation of renal replacement therapy was assigned four points...
February 26, 2019: Journal of Critical Care
Tobias Täger, Hanna Fröhlich, Mirjam Seiz, Hugo A Katus, Lutz Frankenstein
The majority of patients with chronic heart failure (HF) receive long-term treatment with loop diuretics. The comparative effectiveness of different loop diuretics is unknown. We searched PubMed, , the Cochrane Central Register of Controlled Trials and the European Union Clinical Trials Register for randomised clinical trials exploring the efficacy of the loop diuretics azosemide, bumetanide, furosemide or torasemide in patients with HF. Comparators included placebo, standard medical care or any other active treatment...
March 14, 2019: Heart Failure Reviews
Agnès Esiéné, Paul Owono Etoundi, Joel Noutakdie Tochie, Arlette Junette Mbengono Metogo, Jacqueline Ze Minkande
BACKGROUND: Snake envenomation is an underestimated pathology in sub-Saharan Africa associated with severe emergencies, and even death in case of late presentation. We herein present a case of severe envenomation managed at the surgical emergency department of the Yaoundé Central Hospital. CASE PRESENTATION: We report a case of a 47-year-old female farmer with no relevant past history who sustained a snakebite by an Echis occellatus viper during an agricultural activity...
March 12, 2019: BMC Emergency Medicine
Manas Kinra, Devinder Arora, Jayesh Mudgal, K S R Pai, Chamallamudi Mallikarjuna Rao, Madhavan Nampoothiri
BACKGROUND: Cyclooxygenase (COX)-lipooxygenase (LOX) pathway plays a key role in the pathogenesis of renal ischemia/reperfusion (IR). OBJECTIVE: This study was aimed to evaluate the role of dietary phenol caffeic acid (CA), alone and in combination with selective COX-2 inhibitor celecoxib (CEL) in IR-induced acute renal failure (ARF) in rats. MATERIALS AND METHODS: Renal IR was induced by bilateral occlusion of renal pedicels for 90 min followed by reperfusion for 24 h...
March 14, 2019: Pharmacology
Chan Myae Thein, Roger W Byard
Clinical and pathological case files of lethal snakebites were reviewed from the XXXX, Magway, Myanmar, over a five-year period (January 2013 December 2017). A total of 2069 postmortem examinations were performed which included 84 cases of lethal snake bite (4.1%). The annual numbers ranged from 10 out of a total of 268 autopsies in 2013 (3.7%), to 31 out of a total of 501 autopsies in 2016 (6.2%). There were 54 males (64%) and 30 females (36%) (M:F = 1.9:1; age range 5-75yrs, mean 33yrs). The most common time for lethal envenomation was August (16/84-19%), the middle of the monsoon season...
March 5, 2019: Journal of Forensic and Legal Medicine
Ying Chen, Suhua Zhang, Shanshan Wei, Yao Li, Wenqun Li, Miao Yan, Yang Deng, Bikui Zhang, Hualin Cai
BACKGROUND AND OBJECTIVES: Shen-Fu-Shu granule is traditional Chinese herb formula for acute and chronic renal failure. This work was aimed to identify the compounds in Shen-Fu-Shu granule extract and absorbed compounds in rat plasma following oral administration of Shen-Fu-Shu granule. METHODS: A high-resolution and high-sensitivity ultra-performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry in positive and negative ion mode were established...
March 6, 2019: Journal of Pharmaceutical and Biomedical Analysis
Muhammad Shoaib, Syed Nayer Mahmud, Muhammad Safdar
BACKGROUND: Acute kidney injury (AKI) is a major cause of mortality and morbidity in the hospitalized patients. It is also a risk factor for chronic kidney disease and advance renal failure. Early diagnosis with new biomarkers for AKI can prevent and/or reverse the process before rise in serum creatinine and symptomatic renal failure. This study is aimed at the accuracy of Urine neutrophil gelatinase associated lipocalin (NGAL) for detection of AKI at an early stage. METHODS: It is a descriptive, cross sectional study conducted in the Medical Intensive Care Unit of Shifa International Hospital, Islamabad...
January 2019: Journal of Ayub Medical College, Abbottabad: JAMC
Alberto Santagostino, Laura Lombardi, Gerard Dine, Pierre Hirsch, Srimanta Chandra Misra
Paroxysmal nocturnal hemoglobinurea (PNH) is a rare disorder of complement regulation due to somatic mutation of PIGA (phosphatidylinositol glycan anchor) gene. We herewith report a case who developed a symptomatic PNH long after an allogenic marrow transplant. Some reasonable arguments concerning the origin of PNH clone have been discussed. The molecular studies revealed presence of JAK2 and TET2 mutations without a BCOR mutation. The literature review has been performed to probe into the complex interplay of autoimmunity and clonal selection and expansion of PNH cells, which occurs early in hematopoietic differentiation...
2019: Case Reports in Hematology
Andrew Mitchell, Alexandre Dugas
BACKGROUND: Malakoplakia is a chronic inflammatory disease characterized by tissue infiltrates of large granular macrophages containing distinctive intracytoplasmic inclusions termed Michaelis-Gutmann (MG) bodies. The genitourinary system is the most commonly involved site, followed by the gastrointestinal tract. Malakoplakia may occur as a complication of primary or secondary immunosuppression and, therefore, renal transplant recipients are at risk. The graft itself or extra-renal sites may be involved...
March 13, 2019: Diagnostic Pathology
Brett Rollins, Samira Farouk, Graciela DeBoccardo, Susan Lerner, Meenakshi Rana, Shirish Huprikar, Leandra Miko, Veronica Delaney, Sander Florman, Ron Shapiro
Rejection rates in HIV-infected kidney transplant (KTx) recipients are higher than HIV-negative recipients. Immunosuppression and highly active antiretroviral therapy (HAART) protocols vary with potentially significant drug-drug interactions, likely influencing outcomes. This is an IRB-approved, single-center, retrospective study of adult HIV infected KTx patients between 5/2009-12/2014 with three-year follow-up, excluding antibody-depleting induction. 42 patients were included; median age was 52 years, 81% male, 50% African American, 29% Hispanic, 17% Caucasian...
March 12, 2019: Clinical Transplantation
Julie C Fitzgerald, Nicole R Zane, Adam S Himebauch, Michael D Reedy, Kevin J Downes, Alexis A Topjian, Susan L Furth, Neal J Thomas, Marc H Scheetz, Athena F Zuppa
BACKGROUND: Acute kidney injury (AKI) commonly occurs after cardiac arrest. Those subsequently treated with vancomycin are at additional risk for drug-induced kidney injury. OBJECTIVE: We aimed to determine whether opportunities exist for improved drug monitoring after cardiac arrest. METHODS: This was a retrospective cohort study of children aged 30 days-17 years treated after cardiac arrest in an intensive care unit from January 2010 to September 2014 who received vancomycin within 24 h of arrest...
March 12, 2019: Paediatric Drugs
J-P Martellosio, X Leleu, P Roblot, M Martin, M Puyade
Serum free light chains (sFLC) assay is an important marker in plasma cell dyscrasia. It is thus recommended for the diagnosis of monoclonal gammopathy, together with serum protein electrophoresis and immunofixation. sFLC assay has also a prognostic value and is a criterion for treatment response and relapse of some monoclonal gammopathies. Three assays are currently available in France, the gold standard being the Freelite® assay, the two others requiring further validation. These three assays are not interchangeable during patient's follow-up...
March 9, 2019: La Revue de Médecine Interne
Page Axley, Zunirah Ahmed, Sumant Arora, Allen Haas, Yong-Fang Kuo, Patrick S Kamath, Ashwani K Singal
BACKGROUND & AIMS: Acute on chronic liver failure (ACLF) among patients with cirrhosis is characterized by multiple organ failure (OF) with high short-term mortality. There is lack of population based data on trends on ACLF related morbidity and disease burden based on liver disease etiology. METHODS: National Inpatient Sample (2006-2014) was queried using the ICD-09 codes for admissions with cirrhosis and ACLF (defined with ≥2 extrahepatic organ failures)...
March 12, 2019: Liver Transplantation
Erik L Lum, Andres Cardenas, Paul Martin, Suphamai Bunnapradist
Liver transplantation (LT) is definitive therapy for individuals with end stage liver disease and acute liver failure. Pre-transplant renal dysfunction is common in patients with advanced decompensated cirrhosis and increases mortality in wait-listed LT candidates. Chronic kidney disease (CKD) in LT recipients is a common complication, and is associated with reduced survival, especially if a LT recipient requires long-term dialysis following transplantation (1-6). Kidney transplantation (KT) following LT improves survival in LT recipients with kidney disease; however, a LT recipient may wait years before receiving a deceased donor KT, mitigating its benefit in LT...
March 12, 2019: Liver Transplantation
Yüksel Çavuşoğlu, Ahmet Taha Alper, Hakan Altay, Ahmet Çelik, Burcu Demirkan, Tolga Sinan Güvenç, Mehmet Serdar Küçükoğlu, Sanem Nalbantgil, Murat Özdemir, Bülent Özin, Tamer Sayın, Özlem Yıldırımtürk, Mehmet Birhan Yılmaz, Cafer Zorkun
Natriuretic peptides have long been introduced into clinical practice. These biomarkers have certainly been shown to provide useful information in the diagnosis, prognosis and risk stratification in heart failure and also may have a role in the guidance of heart failure therapy. Although, there are some limitations in using of these markers such as lack of specificity, aging, renal dysfunction or obesity, among the huge number of candidates for heart failure biomarkers, only natriuretic peptides are currently widely used in daily clinical practice in heart failure...
March 2019: Anatolian Journal of Cardiology
Rosângela L Pinheiro, Regielly C R Cognialli, Rodolfo C Barros, Tyane de A Pinto, Mariana F M Cunha, Tony T Tahan, Morgana F Voidaleski, Renata R Gomes, Guilherme N Becker, Lucas V Andrade, Flavio Queiroz-Telles, G Sybren de Hoog, Renata R Sakiyama, Vânia A Vicente
Fungal peritonitis is frequent on peritoneal dialysis, with rare cases by Exophiala dermatitidis . A 25-month-old female admitted to the pediatric ICU with acute renal failure was submitted to peritoneal dialysis. After 10 days patient presented fever. Peritoneal fluid culture showed yeast colonies molecularly identified as E. dermatitidis . Patient was treated with voriconazole and hemodialysis. The literature was reviewed. Disseminated infections are frequently fatal, but appropriate diagnose and therapeutic led to cure in this case...
June 2019: Medical Mycology Case Reports
Magdy Mohamed El-Sayed Ahmed, Mathew Thomas, Samuel Jacob, Ian A Makey, Kevin P Landolfo, Si M Pham, Erol V Belli
A 60-year-old male patient presented to an outside hospital with severe cardiogenic shock. A triple bridge of mechanical circulatory support was utilized to transition him to heart transplantation listing. Initially, coronary artery disease was percutaneously treated and Impella 2.5 was used as mechanical circulatory support for 5 days followed by the second Impella 2.5 for 4 days. Veno-arterial extracorporeal membrane oxygenation support was deployed for 16 days. This was exchanged for HeartWare ventricular assist device support as the third stage of mechanical circulatory support to heart transplantation listing...
2019: SAGE open medical case reports
Christoph Fisser, Christoph Reichenbächer, Thomas Müller, Roland Schneckenpointner, Maximilian V Malfertheiner, Alois Philipp, Maik Foltan, Dirk Lunz, Florian Zeman, Matthias Lubnow
OBJECTIVES: Venovenous extracorporeal membrane oxygenation is indicated in patients with severe refractory acute respiratory failure. Venous thrombosis due to indwelling catheters is a frequent complication. The aim of this study was to analyze the incidence of cannula-related thrombosis and its risk factors after venovenous extracorporeal membrane oxygenation. DESIGN: Retrospective observational study. SETTING: A medical ICU at the University Hospital Regensburg...
January 11, 2019: Critical Care Medicine
Kamolwich Income, Nalin Ratnarathorn, Napassawan Khamchaiyo, Chanut Srisuvo, Leela Ruckthong, Wijitar Dungchai
Uric acid (UA) and creatinine are the imperative biological substance for clinical monitoring and diagnosis. Measuring the ratio between uric acid and creatinine in urine helps differentiate acute uric acid nephropathy from the hyperuricemia that secondarily occurs to renal failure. In general, the ratio is greater than 0.9 in acute uric acid nephropathy and less than 0.7 in hyperuricemia. In this work, disposable nonenzymatic screen-printed reduced graphene oxide-gold nanocomposites electrodes were firstly developed for the quantitative analysis of uric acid...
2019: International Journal of Analytical Chemistry
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