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Alicja Puszkiel, Cécile Arellano, Christelle Vachoux, Alexandre Evrard, Valérie Le Morvan, Jean-Christophe Boyer, Jacques Robert, Caroline Delmas, Florence Dalenc, Marc Debled, Laurence Venat-Bouvet, William Jacot, Etienne Suc, Isabelle Sillet Bach, Thomas Filleron, Henri Roché, Etienne Chatelut, Melanie White-Koning, Fabienne Thomas
In addition to the effect of CYP2D6 genetic polymorphisms, the metabolism of tamoxifen may be impacted by other factors with possible consequences on therapeutic outcome (efficacy, toxicity). This analysis focused on the pharmacokinetic-pharmacogenetic evaluation of tamoxifen in 730 adjuvant breast cancer patients included in a prospective multicenter study. Plasma concentrations of tamoxifen and six major metabolites, the genotype for 63 single nucleotide polymorphisms and co-medications were obtained 6 months after treatment initiation...
February 20, 2019: Clinical Pharmacology and Therapeutics
J F M Scheerman
The primary aim of the dissertation was to develop and evaluate a smartphone app, the WhiteTeeth app, designed to promote good oral health behaviour and oral hygiene among adolescent orthodontic patients between the ages of 12 and 16. The app's development and evaluation was guided methodically by intervention mapping (IM). Development thus starts with an analysis of the health problem and the identification of the psychosocial factors and health behaviour related to it. To identify the psychosocial factors underlying oral health behaviour in our target group, a systematic literature review with meta-analysis was conducted,a cross-sectional clinical study and semi-structured interviews...
February 2019: Nederlands Tijdschrift Voor Tandheelkunde
Kimberly J Hassett, Kerry E Benenato, Eric Jacquinet, Aisha Lee, Angela Woods, Olga Yuzhakov, Sunny Himansu, Jessica Deterling, Benjamin M Geilich, Tatiana Ketova, Cosmin Mihai, Andy Lynn, Iain McFadyen, Melissa J Moore, Joseph J Senn, Matthew G Stanton, Örn Almarsson, Giuseppe Ciaramella, Luis A Brito
mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and well-tolerated delivery technology is integral to fully realizing the potential of mRNA vaccines. Pre-clinical and clinical studies have demonstrated that mRNA delivered intramuscularly (IM) with first-generation lipid nanoparticles (LNPs) generates robust immune responses. Despite progress made over the past several years, there remains significant opportunity for improvement, as the most advanced LNPs were designed for intravenous (IV) delivery of siRNA to the liver...
February 7, 2019: Molecular Therapy. Nucleic Acids
Mohsen Keshavarz, Haideh Namdari, Yaser Arjeini, Hamed Mirzaei, Vahid Salimi, Ahmadreza Sadeghi, Talat Mokhtari-Azad, Farhad Rezaei
Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remains a nonignorable serious concern for public health worldwide. To combat the surge of viral outbreaks, new treatments are urgently needed. Here, we design a new vaccine based on virus-like particles (VLPs) and show how intranasal administration of this vaccine triggers protective immunity, which can be exploited for the development of new therapies. H1N1 VLPs were produced in baculovirus vectors and were injected into BALB/c mice by the intramuscular (IM) or intranasal (IN) route...
February 19, 2019: Journal of Cellular Physiology
Ji Hye Han, Yong Sun Lee, Jun Hyung Im, Young Wan Ham, Hee Pom Lee, Sang Bae Han, Jin Tae Hong
Astaxanthin (AXT), a xanthophyll carotenoid compound, has potent antioxidant, anti-inflammatory and neuroprotective properties. Neuroinflammation and oxidative stress are significant in the pathogenesis and development of Alzheimer's disease (AD). Here, we studied whether AXT could alleviate neuroinflammation, oxidative stress and memory loss in lipopolysaccharide (LPS) administered mice model. Additionally, we investigated the anti-oxidant activity and the anti-neuroinflammatory response of AXT in LPS-treated BV-2 microglial cells...
February 18, 2019: Marine Drugs
Katrina N Glazebrook, Stefan Doerge, Shuai Leng, Tammy A Drees, Katie N Hunt, Shannon N Zingula, Sandhya Pruthi, Jennifer R Geske, Rickey E Carter, Cynthia H McCollough, Joel G Fletcher
OBJECTIVE: The purpose of this study is to compare the performance of dual-energy CT (DECT) with that of breast MRI for detection of silicone gel breast implant rupture and nodal spread of silicone. SUBJECTS AND METHODS: This prospective study enrolled consecutive patients with current or prior silicone gel implants and clinical suspicion of implant rupture or extra-capsular silicone. All patients underwent MRI followed by unenhanced DECT. A breast radiologist not participating in image evaluation established reference standards for implant rupture (intra- or extracapsular) and regional nodal silicone spread (to axillary nodes and internal mammary [IM] and mediastinal nodes) using MRI, surgical findings, and medical records...
February 19, 2019: AJR. American Journal of Roentgenology
Nataliia Chemer, Volodymyr Bilanovskyi
INTRODUCTION: Recent studies show that spasticity occurs in 20-30% of all stroke victims, especially in younger patients. Botulinum toxin is a very effective treatment; however, it is not reimbursed in the Ukraine, thus leaving patients untreated and unable to use the paralyzed limb. Finally, this might result in long-term disability with economic consequences and negative impact on the psychological state of patients. Therefore, alternative and affordable treatment options are of high interest...
February 18, 2019: Neurology and Therapy
Valeria Caramello, Giulia Marulli, Giuseppe Reimondo, Fausto Fanto', Adriana Boccuzzi
Resource allocation in our overcrowded hospitals would require classification of inpatients according to the severity of illness, the evolving risk and the clinical complexity. Reverse triage (RT) is a method used in disasters to identify inpatients according to their use of hospital resources. The aim of this observational prospective study is to evaluate the use of RT in medical inpatients of an Italian Hospital and to compare the RT score with National Early Warning Score, Sequential Organ Failure Assessment and Charlson Comorbidity Index...
February 18, 2019: Internal and Emergency Medicine
Kay Tanita, Akihiro Hoshino, Ken-Ichi Imadome, Takahiro Kamiya, Kento Inoue, Tsubasa Okano, Tzu-Wen Yeh, Masakatsu Yanagimachi, Akira Shiraishi, Masataka Ishimura, Tilmann Schober, Meino Rohlfs, Masatoshi Takagi, Kohsuke Imai, Hidetoshi Takada, Shouichi Ohga, Christoph Klein, Tomohiro Morio, Hirokazu Kanegane
Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is an EBV-associated lymphoproliferative disease characterized by repeated or sustainable infectious mononucleosis (IM)-like symptoms. EBV is usually detected in B cells in patients who have IM or Burkitt's lymphoma and even in patients with X-linked lymphoproliferative syndrome, which is confirmed to have vulnerability to EBV infection. In contrast, EBV infects T cells (CD4+ T, CD8+ T, and γδT) or NK cells mono- or oligoclonally in CAEBV patients...
2019: Frontiers in Pediatrics
Jee-Soo Lee, Mihye Yoon, Man Jin Kim, Sung Im Cho, Moon-Woo Seong, Sung Sup Park, Ji Yeon Kim
The accurate measurement of the Epstein-Barr virus (EBV) DNA level in the blood is required for managing EBV-associated diseases. A new commercial Abbott Real-Time EBV assay, which targets the BLLF1 gene, was evaluated on 120 clinical whole blood samples and the Qnostics EBV analytical panel. The limit of detection of the assay was 48.9 IU/mL (95% confidence interval, 48.1-49.8 IU/mL). The assay was linear from 2 to 5 log10 IU/mL (R2  = 0.997). The within-run coefficients of variation (CVs) ranged from 1...
January 3, 2019: Diagnostic Microbiology and Infectious Disease
Matthew C Morris, Miriam Marco, Kathryn Maguire-Jack, Chrystyna D Kouros, Wansoo Im, Codi White, Brooklynn Bailey, Uma Rao, Judy Garber
Rates of substantiated child abuse and neglect vary significantly across counties. Despite strong cross-sectional support for links between social-contextual characteristics and abuse and neglect, few longitudinal studies have tested relations between these risk factors and substantiated rates of abuse/neglect. The goal of this study was to identify county-level socioeconomic and crime factors associated with substantiated abuse/neglect rates over 13 years (2004-2016). Annual county-level data for Tennessee, obtained from the KIDS COUNT Data Center, included rates of substantiated child abuse and neglect, children's race and ethnicity, births to unmarried women, teen birth rate, children in families receiving Supplemental Nutrition Assistance Program (SNAP) benefits, and children in families receiving Temporary Assistance for Needy Families...
February 15, 2019: Child Abuse & Neglect
Jaqueline A Picache, Bailey S Rose, Andrzej Balinski, Katrina L Leaptrot, Stacy D Sherrod, Jody C May, John A McLean
Ion mobility mass spectrometry (IM-MS) expands the analyte coverage of existing multi-omic workflows by providing an additional separation dimension as well as a parameter for characterization and identification of molecules - the collision cross section (CCS). This work presents a large, Unified CCS compendium of >3800 experimentally acquired CCS values obtained from traceable molecular standards and measured with drift tube ion mobility-mass spectrometers. An interactive visualization of this compendium along with data analytic tools have been made openly accessible...
January 28, 2019: Chemical Science
Sholhui Park, Tae Dong Jeong, Yeung Chul Mun, Dongchun Seo, Jisu Im, Jungwon Huh
Loss or decrease in expression of human leukocyte antigen (HLA) caused by somatic mutations of HLA genes has been reported in various malignancies. However, mutations in the HLA-DR gene have been rarely noted in hematologic malignancies. Here, we report a case of myelodysplastic syndrome (MDS) with a novel point mutation in exon 2 of the HLA-DRB1*04:03 gene pertaining to a silent mutation (c.357A>T(p.Thr=)). When compared before and after anticancer drug treatment and to the results from the full HLA-matching sibling donor, mutation of the HLA-DRB1 gene suggests clonal evolution...
February 17, 2019: HLA
Takamasa Ishii, Yosuke Sasaki, Tadashi Maeda, Fumiya Komatsu, Takeshi Suzuki, Yoshihisa Urita
INTRODUCTION: Infectious mononucleosis (IM) is a common viral infection that typically causes fever, pharyngitis, and lymphadenopathy in young patients. The Epstein-Barr virus (EBV) is the most common cause of IM, followed by cytomegalovirus (CMV). Given that serological testing is associated with limitations regarding its accuracy, availability, and time to receive results, clinical differentiation based on symptoms, signs, and basic tests would be useful. We evaluated whether clinical findings could be used to differentiate EBV-IM from CMV-IM...
February 15, 2019: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Changgui Shi, Lecheng Wu, Wenbo Lin, Yuanqi Cai, Ying Zhang, Bo Hu, Rui Gao, Andre J van Wijnen, Wen Yuan, Xiaojian Ye, Hee-Jeong Im
No abstract text is available yet for this article.
February 13, 2019: Gene
Jun Wang, Yi Yang, Rongli Yang, Xiaodong Tang, Wei Guo
INTRODUCTION: This is a retrospective study that evaluate the outcome of patients with extremity sarcoma between extramedullary plate and intramedullary nailing for the biological reconstruction after tumor resection. METHODS: 58 patients (40 treated with plate fixation and 18 with intramedullary nailing, IM group) with sarcomas of the lower and upper extremity who received biological reconstruction at our bone tumor center from November 2003 to November 2015 were reviewed for the study...
February 6, 2019: Injury
Liliane Simpson-Lourêdo, Cecília M F Silva, Elena Hacker, Nadjla F Souza, Milena M Santana, Camila A Antunes, Prescilla E Nagao, Raphael Hirata, Andreas Burkovski, Maria Helena S Villas Bôas, Ana Luíza Mattos-Guaraldi
Diphtheria by Corynebacterium ulcerans is increasingly occurring in children, adolescents and adults. In addition to diphtheria toxin (DT), phospholipase D (PLD) is considered a virulence factor of C. ulcerans. In the present study, a first case of concurrent diphtheria by a PLD-negative C. ulcerans and infectious mononucleosis (IM) was verified. Clinical and microbiological profiles and binding properties to human Fibrinogen (Fbg), Fibronectin (Fn) and type I collagen (col I) biotinylated proteins and virulence to Caenorhabditis elegans were investigated for C...
February 15, 2019: Antonie Van Leeuwenhoek
Se-Hee Min, Hyunjae Im, Bo Rim Kim, Susie Yoon, Jae-Hyon Bahk, Jeong-Hwa Seo
BACKGROUND: During induction of general anesthesia, it is common practice to delay neuromuscular blockade until the ability to deliver mask ventilation has been confirmed. However, the benefits of this approach have never been scientifically validated. We thus compared the early and late administration of rocuronium before and after checking mask ventilation to investigate the efficiency of mask ventilation and the time to tracheal intubation in patients with normal airways. METHODS: Patients (n = 114) were randomized to receive IV rocuronium either before (early rocuronium group, n = 58) or after (late rocuronium group, n = 56) checking mask ventilation...
February 12, 2019: Anesthesia and Analgesia
Wenshan Ren, Shaohui Zhang, Ziyi Xu, Xuebing Ma
The reactivity of the magnesium alkyl {[HC(C(Me)N-2,6-iPr2C6H3)2]Mg(nBu)}2 (1) toward various small molecules provides access to a variety of magnesium derivatives. For example, the insertion of elemental chalcogens (S8 and Se8) into the Mg-C bond of complex 1 gives the dimeric magnesium thiolate {[HC(C(Me)N-2,6-iPr2C6H3)2]Mg(μ-SnBu)}2 (2), magnesium selenolate [HC(C(Me)N-2,6-iPr2C6H3)2]Mg(SenBu)(THF) (3), and magnesium diselenolate [HC(C(Me)N-2,6-iPr2C6H3)2]Mg(Se2nBu)(THF) (4). Meanwhile, compound 4 can be readily obtained by further insertion of one selenium atom into complex 3...
February 15, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Vlad Mihai Voiculescu, Cristina Victoria Lisievici, Mihai Lupu, Cristina Vajaitu, Carmen Cristina Draghici, Alexandra Victoria Popa, Iulia Solomon, Teona Ioana Sebe, Maria Magdalena Constantin, Constantin Caruntu
Taking into consideration that the immune system plays a very important role in the development of melanoma and non-melanoma skin cancers, which have a high prevalence in immunosuppressed patients and after prolonged ultraviolet radiation, the interest in developing novel therapies, in particular targeting the inflammation in cancer, has increased in the past years. The latest data suggest that therapies such as imiquimod (IMQ), ingenol mebutate (IM), 5-fluorouracil (5-FU), retinoids, and nonsteroidal anti-inflammatory drugs (NSAIDs) have been used with success in the topical treatment of some cancers...
2019: Mediators of Inflammation
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