keyword
https://read.qxmd.com/read/38537209/enchondroma-on-bone-scan-and-psma-pet-ct-in-a-patient-with-prostate-cancer
#1
JOURNAL ARTICLE
Charisma DeSai, Lesley Flynt, Sanjit Om Tewari, Yang Lu
A 54-year-old man with Gleason 9 prostate cancer with reported nodal and skeletal metastases was referred to us. Outside hospital reports described abnormal left proximal humerus activity on bone scan concerning for metastasis; however, concurrent PSMA PET/CT did not show activity in this lesion. Further review of the PET/CT images revealed characteristic features of enchondroma in the left humeral lesion.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38534651/hyperbranched-polylysine-exhibits-a-collaborative-enhancement-of-the-antibiotic-capacity-to-kill-gram-negative-pathogens
#2
JOURNAL ARTICLE
Yuxin Gong, Qing Peng, Yu Qiao, Dandan Tian, Yuwei Zhang, Xiaoyan Xiong, Mengxin He, Xiaoqing Xu, Bo Shi
In recent years, traditional antibiotic efficacy outcomes have rapidly diminished due to the advent of drug resistance, and the dose limitation value has increased due to the severe side effect of globalized healthcare. Therefore, novel strategies are required to resensitize resistant pathogens to antibiotics existing in the field and prevent the emergence of drug resistance. In this study, cationic hyperbranched polylysine (HBPL-6) was synthesized using the one-pot polymerization method. HBPL-6 exhibited excellent non-cytotoxicity and bio-solubility properties...
February 26, 2024: Antibiotics
https://read.qxmd.com/read/38534107/signaling-through-the-salmonella-pbga-lapb-regulatory-complex-activates-lpxc-proteolysis-and-limits-lipopolysaccharide-biogenesis-during-stationary-phase-growth
#3
JOURNAL ARTICLE
Joshua A Mettlach, Melina B Cian, Medha Chakraborty, Zachary D Dalebroux
Salmonella enterica serovar Typhimurium ( S . Typhimurium) controls lipopolysaccharide (LPS) biosynthesis by regulating proteolysis of LpxC, the rate-limiting enzyme and target of preclinical antibiotics. PbgA/YejM/LapC regulates LpxC levels and controls outer membrane (OM) LPS composition at the log-to-stationary phase transition. Suppressor substitutions in <u>L</u>PS <u>a</u>ssembly <u>p</u>rotein <u>B</u> (LapB/YciM) rescue the LPS and OM integrity defects of pbgA -mutant S ...
March 27, 2024: Journal of Bacteriology
https://read.qxmd.com/read/38533487/pediatric-corneal-transplantation-techniques-challenges-and-outcomes
#4
REVIEW
Bharat Gurnani, Kirandeep Kaur, Sameer Chaudhary, Ruminder Preet Kaur, Swatishree Nayak, Deepak Mishra, Harinikrishna Balakrishnan, Rohit Om Parkash, Arvind Kumar Morya, Amit Porwal
Pediatric corneal transplant is a highly demanding and technically challenging procedure for the cornea surgeon in today's era. These cases pose unique challenges in clinical and surgical management. The indications of pediatric corneal transplant can be therapeutic, tectonic, optical, and cosmetic. Pediatric patients undergoing corneal transplants are at a high risk of graft infection, failure, rejection, dehiscence, and amblyopia due to young age, robust immune system, increased incidence of trauma, and compliance issues...
2024: Therapeutic Advances in Ophthalmology
https://read.qxmd.com/read/38533367/co-occurrence-of-otitis-media-with-effusion-and-another-environment-dependent-disease-selected-allergic-conditions
#5
JOURNAL ARTICLE
Oksana Wojas, Edyta Krzych-Fałta, Konrad Furmańczyk, Diana Dziewa-Dawidczyk, Bolesław Samoliński, Piotr Samel-Kowalik
INTRODUCTION: Otitis media eith effusion (OME) is an inflammatory condition of the middle ear that involves accumulation of sterile fluid or effusion in the tympanic cavity with the tympanic membrane intact. The pathophysiology of OME is undoubtedly multifactorial. AIM: To assess the co-occurrence of OME, allergic rhinitis, and asthma. MATERIAL AND METHODS: The study involved a group of 18,617 subjects aged 6-7 years, 13-14 years, or 20-44 years...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38532743/prevalence-of-prolonged-otitis-media-with-effusion-among-2-to-3-years-old-cameroonian-children-in-the-era-of-13-valent-pneumococcal-conjugate-vaccines
#6
JOURNAL ARTICLE
John Njuma Libwea, Viviane Armelle Ngomba, Nadesh Ashukem Taku, Chanceline Bilounga Ndongo, Bernadette Dorine Ngono Noah, Ninying Fointama, Marie Kobela, Heini Huhtala, Emilienne Epee, Sinata Koulla-Shiro, Paul Koki Ndombo
OBJECTIVES: There is data scarcity on the overall effects of pneumococcal conjugate vaccines (PCVs) on otitis media (OM) in low- and middle-income countries. The impact of the 13-valent PCV (PCV13) program on OM was evaluated in Cameroon where infant vaccination was implemented in July 2011 using a 3-dose primary series at 6, 10 and 14 weeks of age. METHODS: Through community-based surveillance, we used a retrospective cohort study design to assess OM prevalence among PCV13-vaccinated children aged 24 to 36 months in 2015...
March 2024: IJID Reg
https://read.qxmd.com/read/38532027/diagnostic-imaging-of-the-diabetic-foot-an-eanm-evidence-based-guidance
#7
JOURNAL ARTICLE
Chiara Lauri, Edel Noriega-Álvarez, Riddhika M Chakravartty, Olivier Gheysens, Andor W J M Glaudemans, Riemer H J A Slart, Thomas C Kwee, Frédéric Lecouvet, Emmanouil Panagiotidis, Jules Zhang-Yin, Jose Luis Lazaro Martinez, Benjamin A Lipsky, Luigi Uccioli, Alberto Signore
PURPOSE: Consensus on the choice of the most accurate imaging strategy in diabetic foot infective and non-infective complications is still lacking. This document provides evidence-based recommendations, aiming at defining which imaging modality should be preferred in different clinical settings. METHODS: This working group includes 8 nuclear medicine physicians appointed by the European Association of Nuclear Medicine (EANM), 3 radiologists and 3 clinicians (one diabetologist, one podiatrist and one infectious diseases specialist) selected for their expertise in diabetic foot...
March 27, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38531819/a-mechanistic-and-preclinical-assessment-of-biorestore-bioactive-glass-as-a-synthetic-bone-graft-extender-and-substitute-for-osteoinduction-and-spine-fusion
#8
JOURNAL ARTICLE
Elianna J Fred, Silvia Minardi, Alyssa M Goodwin, Tejas S Nandurkar, Mark A Plantz, Joseph G Lyons, Jonathan T Paul, James P Foley, Allison J Wintring, Andrew A Furman, Soyeon Jeong, Chawon Yun, Stuart R Stock, Wellington K Hsu, Erin L Hsu
STUDY DESIGN: Preclinical animal study. OBJECTIVE: Evaluate the osteoinductivity and bone regenerative capacity of BioRestore bioactive glass. SUMMARY OF BACKGROUND DATA: BioRestore is a Food and Drug Administration (FDA)-approved bone void filler that has not yet been evaluated as a bone graft extender or substitute for spine fusion. METHODS: In vitro and in vivo methods were used to compare BioRestore with other biomaterials for the capacity to promote osteodifferentiation and spinal fusion...
March 22, 2024: Clinical Spine Surgery
https://read.qxmd.com/read/38530671/what-is-the-efficacy-of-antibiotic-treatment-for-children-diagnosed-with-acute-otitis-media
#9
EDITORIAL
Brooke Lajeunesse, Michael Gottlieb, Brit Long
No abstract text is available yet for this article.
March 25, 2024: Annals of Emergency Medicine
https://read.qxmd.com/read/38530610/omentopexy-versus-no-omentopexy-in-sleeve-gastrectomy-an-updated-systematic-review-and-meta-analysis
#10
JOURNAL ARTICLE
Mohamed Ali Chaouch, Mehdi Khalfallah, Sadok Ben Jabra, Mariem Jouilli, Om Kalthoum Sallem, Ramzi Nouira, Faouzi Noomen
Laparoscopic sleeve gastrectomy with omentopexy (O-LSG) has been compared to laparoscopic sleeve gastrectomy with no-omentopexy (NO-LSG) in terms of postoperative outcomes and one-year anthropometric results. This systematic review with meta-analysis aimed to compare the utility of omentopexy in sleeve gastrectomy. We performed a systematic review with meta-analysis according to PRISMA 2020 and AMSTAR 2 guidelines. We included studies that systematically searched electronic databases and compared the O-LSG with the NO-LSG conducted through 1st March 2023...
March 26, 2024: Updates in Surgery
https://read.qxmd.com/read/38530520/an-experimental-and-prediction-modeling-study-on-water-lettuce-pistia-stratiotes-l-assisted-heavy-metals-removal-from-glass-industry-effluent
#11
JOURNAL ARTICLE
Jogendra Singh, Sadeq K Alhag, Eman A Al-Shahari, Laila A Al-Shuraym, Ibtisam M Alsudays, Mohamed T Ahmed, Ebrahem M Eid, Sami Abou Fayssal, Pankaj Kumar, Sandeep Kumar Malyan, Om Singh, Vinod Kumar
The glass manufacturing industry produces hazardous effluent that is difficult to manage and causes numerous environmental problems when disposed of in the open. In this study, an attempt was made to study the phytoremediation feasibility of water lettuce (Pistia stratiotes L.), a free-floating aquatic macrophyte, for the removal of six heavy metals from glass industry effluent (GIE) at varying concentrations (0, 25, 50, 75, and 100%). After a 40-day experiment, the results showed that 25% GIE dilution showed maximum removal of heavy metals i...
March 26, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38529707/factors-associated-with-research-productivity-and-national-institutes-of-health-funding-in-academic-otology
#12
JOURNAL ARTICLE
Lucy Revercomb, Aman M Patel, Om B Tripathi, Andrey Filimonov
OBJECTIVES: Bibliometrics, such as the Hirsch index (h-index) and the more recently developed relative citation ratio (RCR), are utilized to evaluate research productivity. Our study evaluates demographics, research productivity, and National Institutes of Health (NIH) funding in academic otology. METHODS: Academic otologists were identified, and their demographics were collected using institutional faculty profiles (N = 265). Funding data were obtained using the NIH Research Portfolio Online Reporting Tools Expenditures and Reports Database...
March 26, 2024: Laryngoscope
https://read.qxmd.com/read/38529449/exploring-the-significance-of-vitamin-d-levels-as-a-biomarker-in-ear-diseases-a-narrative-review
#13
REVIEW
Muhammad Hamayal, Saleh Khurshied, Muhammad A Zahid, Nawal Khurshid, Warda Shahid, Maesum Ali, Hammad Ahmed, Mehrun Nisa
This narrative review examines the role of vitamin D as a biomarker in ear disorders, including benign paroxysmal positional vertigo (BPPV), otitis media, bell's palsy, Meniere's disease, and hearing loss. PubMed, The Cochrane Library, and Google Scholar were utilized to conduct a comprehensive literature search, and findings were combined from studies from 2014 to 2024. As highlighted in this review, there is a consistent association between vitamin D deficiency and an increased risk and recurrence of disease especially in BPPV and otitis media...
February 2024: Curēus
https://read.qxmd.com/read/38529418/matrix-rhythm-therapy-as-a-novel-clinical-approach-in-the-rehabilitation-of-surgically-treated-distal-radius-fracture-a-single-case-study
#14
Pallavi R Bhakaney, Om C Wadhokar, Sakshi Upase
Distal radius fractures (DRFs) are prevalent among all hand injuries, commonly due to a fall on an outstretched hand. Not being treated properly can cause many complications such as malunion, non-union, reduced range of motion, and muscle strength. This case report presents a multidisciplinary approach to the physiotherapeutic management of a DRF treated with closed reduction internal fixation using K-wires. The rehabilitation protocol incorporated matrix rhythm therapy (MRT), a novel therapeutic technique, in combination with targeted therapeutic exercises...
February 2024: Curēus
https://read.qxmd.com/read/38528976/revolutionising-alcohol-use-disorder-treatment-in-developing-countries-integrating-artificial-intelligence-and-technology-driven-approaches
#15
JOURNAL ARTICLE
Akhil P Joseph, Anithamol Babu, L T Om Prakash
No abstract text is available yet for this article.
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38528470/evaluating-the-efficacy-of-different-volume-resuscitation-strategies-in-acute-pancreatitis-patients-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Roopa Kumari, Fnu Sadarat, Sindhu Luhana, Om Parkash, Abhi Chand Lohana, Zubair Rahaman, Hong Yu Wang, Yaqub N Mohammed, Sanjay Kirshan Kumar, Subhash Chander
INTRODUCTION: Acute pancreatitis poses a significant health risk due to the potential for pancreatic necrosis and multi-organ failure. Fluid resuscitation has demonstrated positive effects; however, consensus on the ideal intravenous fluid type and infusion rate for optimal patient outcomes remains elusive. METHODS: A comprehensive literature search was conducted using PubMed, Embase, the Cochrane Library, Scopus, and Google Scholar for studies published between 2005 and January 2023...
March 25, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38527226/antimicrobial-lasso-peptide-cloacaenodin-utilizes-a-unique-tonb-dependent-transporter-to-access-susceptible-bacteria
#17
JOURNAL ARTICLE
Drew V Carson, Reecan J Juarez, Truc Do, Zhongyue J Yang, A James Link
The development of new antimicrobial agents effective against Gram-negative bacteria remains a major challenge in drug discovery. The lasso peptide cloacaenodin has potent antimicrobial activity against multiple strains in the Enterobacter genus, one of the ESKAPE pathogens. Here, we show that cloacaenodin uses a previously uncharacterized TonB-dependent transporter, which we name CloU, to cross the outer membrane (OM) of susceptible bacteria. Inner membrane transport is mediated by the protein SbmA. CloU is distinct from the known OM transporters (FhuA and PupB) utilized by other antimicrobial lasso peptides and thus offers important insight into the spectrum of activity of cloacaenodin...
March 25, 2024: ACS Chemical Biology
https://read.qxmd.com/read/38526572/first-exploration-of-the-altered-microbial-gut-lung-axis-in-the-pathogenesis-of-human-refractory-chronic-cough
#18
JOURNAL ARTICLE
Simone Baldi, Alessio Fabbrizzi, Leandro Di Gloria, Marco Pallecchi, Giulia Nannini, Mario D'Ambrosio, Cristina Luceri, Gianluca Bartolucci, Matteo Ramazzotti, Giovanni Fontana, Claudia Mannini, Federico Lavorini, Amedeo Amedei
PURPOSE: Cough represents a natural mechanism that plays an important defensive role in the respiratory tract, but in some conditions, it may become persistent, nonproductive, and harmful. In general, refractory chronic cough (RCC) occurs in about 20% of individuals; hence, we aimed to assess the presence of altered gut-lung communication in RCC patients through a compositional and functional characterization of both gut (GM) and oral microbiota (OM). METHODS: 16S rRNA sequencing was used to characterize both GM and OM composition of RCC patients and healthy controls (HC)...
March 25, 2024: Lung
https://read.qxmd.com/read/38526032/quantitative-1-h-magnetic-resonance-imaging-on-normal-and-pathologic-rat-bones-by-solid-state-1-h-zte-sequence-with-water-and-fat-suppression
#19
JOURNAL ARTICLE
Víctor B Kassey, Matthias Walle, Jonathan Egan, Diana Yeritsyan, Indeevar Beeram, Sharon P Kassey, Yaotang Wu, Brian D Snyder, Edward K Rodriguez, Jerome L Ackerman, Ara Nazarian
BACKGROUND: Osteoporosis (OP) and osteomalacia (OM) are metabolic bone diseases characterized by mineral and matrix density changes. Quantitative bone matrix density differentiates OM from OP. MRI is a noninvasive and nonionizing imaging technique that can measure bone matrix density quantitatively in ex vivo and in vivo. PURPOSE: To demonstrate water + fat suppressed 1 H MRI to compute bone matrix density in ex vivo rat femurs in the preclinical model...
March 25, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38525889/an-evaluation-of-survive-and-thrive-a-10-week-group-psychoeducational-course-for-adult-interpersonal-trauma-survivors-in-scotland
#20
JOURNAL ARTICLE
Frederick O'Donald, Elise Gunter, Ailie Castle, Rachel Warner, Fhionna Moore
Emerging evidence supports a phased approach to trauma treatment, including manualised group-based interventions, to facilitate symptom reduction resulting from complex trauma sequelae. This study investigates the efficacy of Survive and Thrive , a 10-week group psychoeducational course for adult survivors of interpersonal trauma. Between August 2019 and February 2022, participants were enrolled on the course. The Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM) and Difficulties in Emotion Regulation Scale-Short Form (DERS-SF) were administered pre-intervention and immediately post-intervention...
March 25, 2024: Cognitive Behaviour Therapy
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