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https://read.qxmd.com/read/30783299/editor-speaks
#1
Om Prakash Singh
No abstract text is available yet for this article.
January 2019: Indian Journal of Psychiatry
https://read.qxmd.com/read/30779267/comparing-outcomes-the-clinical-outcome-in-routine-evaluation-from-an-international-point-of-view
#2
Marina Zeldovich, Rainer W Alexandrowicz
OBJECTIVES: The Clinical Outcome in Routine Evaluation-Outcome Measure (CORE-OM) is a freely accessible self-assessment questionnaire with a total of 34 items measuring the progress of psychological or psychotherapeutic treatments according to four scales (well-being, problems, functioning, and risk). The CORE-OM originated in the United Kingdom and has been translated into 54 languages and dialects. The aim of this study is to systematically compare the translated versions. METHOD: A total of 21 translations were compared using methods of systematic review and meta-analysis...
February 19, 2019: International Journal of Methods in Psychiatric Research
https://read.qxmd.com/read/30778911/influence-of-obesity-and-type-2-diabetes-mellitus-on-the-pharmacokinetics-of-tramadol-after-single-oral-dose-administration
#3
Joanna Porażka, Edyta Szałek, Wojciech Połom, Mateusz Czajkowski, Tomasz Grabowski, Marcin Matuszewski, Edmund Grześkowiak
BACKGROUND AND OBJECTIVES: The number of overweight, obese and diabetic patients is constantly increasing. Metabolic disorders may affect the pharmacokinetics of drugs, e.g., by altering the activity of cytochrome P450 (CYP) isoenzymes. Tramadol is a commonly used analgesic metabolised mainly via CYP2D6 to its active metabolite, O-desmethyltramadol. The aim of the study was to assess the influence of overweight, obesity and type 2 diabetes mellitus on tramadol and O-desmethyltramadol pharmacokinetics...
February 18, 2019: European Journal of Drug Metabolism and Pharmacokinetics
https://read.qxmd.com/read/30777951/confounding-sizing-in-posterior-chamber-phakic-lens-selection-due-to-white-to-white-measurement-bias
#4
JoaquIn Fernández, Manuel Rodríguez-Vallejo, Javier Martínez, Ana Tauste, Elisa Hueso, David P Piñero
Purpose: To assess the agreement in the white-to-white (WTW) measurement with two different devices, the reproducibility and the probability of confusing sizing (PCS) in selecting a different implantable collamer lens (ICL). Study Design: Retrospective observational case series. Methods: Images of 192 eyes were captured with both devices. The WTW was measured automatically (OA) and manually (OM) with the Orbscan and Keratograph (KA and KM) by one examiner who repeated a total of four measures...
March 2019: Indian Journal of Ophthalmology
https://read.qxmd.com/read/30776953/sacubitril-valsartan-entresto%C3%A2-induced-hyponatremia
#5
Ilana Fuzaylova, Chester Lam, Om Talreja, Amgad N Makaryus, Deborah Ahern, Manouchkathe Cassagnol
Sacubitril/valsartan (Entresto®) is the first commercially available angiotensin receptor neprilysin inhibitor (ARNI) approved for use in heart failure patients with a reduced ejection fraction. It is a combination drug that contains sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. Our report outlines a case of probable ARNI-induced hyponatremia occurring in an elderly woman with heart failure with a reduced ejection fraction. According to Naranjo Adverse Drug Reaction Assessment, score indicated a likely association between patient's hyponatremia and her use of sacubitril/valsartan...
February 18, 2019: Journal of Pharmacy Practice
https://read.qxmd.com/read/30776861/-clinical-diagnosis-and-surgical-management-of-110-cases-of-facial-nerve-schwannomas
#6
N Sai, W J Han, M M Wang, X Qin, T Zhang, W D Shen, J Liu, P Dai, S M Yang, D Y Han
Objective: To elucidate the clinical behavior, causes of misdiagnosis, surgical management, and outcomes of facial nerve schwannomas (FNS). Methods: A retrospective review in Chinese People's Liberation Army General Hospital from January 1, 2002 to December 31, 2015 was carried out and evaluated 110 patients with FNS, including 50 males and 60 females, aged 16-67 years old. The appropriate surgical strategy was selected based on each patient's clinical manifestations, facial nerve function, and imaging characteristics...
February 7, 2019: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://read.qxmd.com/read/30776766/cost-effectiveness-comparison-of-pneumococcal-conjugate-vaccines-in-turkish-children
#7
Alen Marijam, Jan Olbrecht, Alev Ozakay, Volkan Eken, Kinga Meszaros
BACKGROUND: The 13-valent pneumococcal conjugate vaccine (PCV13) is used for universal infant vaccination in Turkey. OBJECTIVES: To assess the cost effectiveness of replacing PCV13 with pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV). METHODS: A Markov cohort model with monthly cycles following 1 cohort of infants over a 10-year time horizon was used. Local input parameters were obtained from published sources and expert consultation whenever possible...
February 15, 2019: Value in Health Regional Issues
https://read.qxmd.com/read/30776474/il-17c-is-involved-in-olfactory-mucosa-responses-to-poly-i-c-mimicking-virus-presence
#8
Bertrand Bryche, Aurélie Dewaele, Audrey Saint-Albin, Claire Le Poupon Schlegel, Patrice Congar, Nicolas Meunier
At the interface of the environment and the nervous system, the olfactory mucosa (OM) is a privileged pathway for environmental toxicants and pathogens towards the central nervous system. The OM is known to produce antimicrobial and immunological components but the mechanisms of action of the immune system on the OM remain poorly explored. IL-17c is a potent mediator of respiratory epithelial innate immune responses, whose receptors are highly expressed in the OM of mice. We first characterized the presence of the IL-17c and its receptors in the OM...
February 15, 2019: Brain, Behavior, and Immunity
https://read.qxmd.com/read/30774256/effect-of-probiotic-pediococcus-acidilactici-ft28-on-growth-performance-nutrient-digestibility-health-status-meat-quality-and-intestinal-morphology-in-growing-pigs
#9
Mamata Joysowal, B N Saikia, Runjun Dowarah, S Tamuly, D Kalita, K B Dev Choudhury
Aim: The experiment was conducted to evaluate the effect of swine-origin probiotic Pediococcus acidilactici FT28 on growth, nutrient utilization, health status, meat quality and intestinal morphology in growing female pigs. Materials and Methods: Pigs (n=27) were distributed into three groups (3 replicates of 3 each) and supplemented with basal diet either without probiotics (C) or with a probiotic of dairy-based ( Lactobacillus acidophilus NCDC-15; TLact ) or swine based ( P...
December 2018: Veterinary World
https://read.qxmd.com/read/30772606/pyranocarbazole-derivatives-as-potent-anti-cancer-agents-triggering-tubulin-polymerization-stabilization-induced-activation-of-caspase-dependent-apoptosis-and-downregulation-of-akt-mtor-in-breast-cancer-cells
#10
Om P S Patel, Ashutosh Arun, Pankaj K Singh, Deepika Saini, Sharanbasappa Shrimant Karade, Manish K Chourasia, Rituraj Konwar, Prem P Yadav
A series of new pyranocarbazole derivatives were synthesized via semi-synthetic modification of koenimbine (1a) and koenidine (1b) isolated from the leaves of Murraya koenigii. Among all, compound 3bg displayed significant anti-cancer activity against MDA-MB-231, DU145 and PC3 cell lines with the IC50 values of 3.8, 7.6 and 5.8 μM, respectively. It was also observed that the halogenated-benzyl substitution at N-9 position, C-3 Methyl and C-7 methoxy group on carbazole motif are favoured for anti-cancer activity...
February 7, 2019: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/30772448/polymicrobial-anaerobic-meningitis-caused-by-bacteroides-fragilis-bacteroides-thetaiotaomicron-fusobacterium-necrophorum-and-slackia-exigua-in-a-patient-with-mastoiditis-following-otitis-media
#11
G N Kalay, N Dalgic, T Bozan, N Ulger-Toprak, B Bayraktar, G Soyletir
We have reported a case of mastoiditis which progressed to meningitis in a 16-year old male patient. CSF (cerebrospinal fluid) anaerobic culture revealed four species of isolated anaerobic bacteria. This is the first case in the literature in which a patient survived childhood polymicrobial anaerobic meningitis diagnosed by MALDI-TOF MS (Matrix Assisted Laser Desorption Ionization - Time of Flight Mass Spectrometry) .
February 14, 2019: Anaerobe
https://read.qxmd.com/read/30771553/regulatory-t-lymphocytes-are-associated-with-increased-nasopharyngeal-colonization-in-children
#12
Jessica Jane Browne, Evan Howard Matthews, Andrew William Taylor-Robinson, Jennelle Maree Kyd
OBJECTIVES: Regulatory T lymphocytes (Treg ) have been linked to survival of commensal bacteria at mucosal sites, but their presence and role in chronic otitis media (COM) and their response to otopathogens has not been evaluated previously. We investigated the association between Treg lymphocytes and otopathogens in COM prone and non-COM prone children. METHODS: Forty children, 2-7 years of age, scheduled for adenoidectomy were enrolled into COM (n = 20) or non-COM (n = 20) groups...
February 5, 2019: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/30771552/quality-of-life-in-swedish-children-receiving-grommets-an-analysis-of-pre-and-postoperative-results-based-on-a-national-quality-register
#13
Job van Brink, Marie Gisselsson-Solen
BACKGROUND: Otitis media with effusion (OME) and recurrent otitis media (rAOM) are two common diagnoses in childhood, both of which are treated with grommets, or ventilation tubes. It is known that affected children have a worse quality of life (QoL), and various questionnaires have been used to evaluate this. The national Swedish quality register for grommet insertions contains some QoL questions that have hitherto never been analysed. METHODS: Data from 2010 to 2016 was extracted from the register and analysed with regards to QoL questions, reasons for surgery, hearing levels and number of AOM episodes...
February 6, 2019: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/30771540/the-first-case-report-of-bilateral-spontaneous-otogenic-pneumocephalus
#14
Richard Voldřich, Martin Májovský, Martin Chovanec, David Netuka
BACKGROUND: Pneumocephalus is commonly associated with cranial trauma including surgical interventions. Spontaneous pneumocephalus on the other hand is a rare diagnosis. Reported cases were predominantly unilateral. We report unique case of a bilateral spontaneous pneumocephalus probably related to bilateral tegmen defect related to repeated Politzer maneuvers. CASE DESCRIPTION: A 78-year-old man suffered from vertigo, tinnitus, instability and mild expressive aphasia...
February 13, 2019: World Neurosurgery
https://read.qxmd.com/read/30771218/concomitant-radiotherapy-and-tki-in-metastatic-egfr-or-alk-mutated-non-small-cell-lung-cancer-a-multicentric-analysis-on-behalf-of-airo-lung-cancer-study-group
#15
Paolo Borghetti, Marco Lorenzo Bonù, Rachele Giubbolini, Niccolo' Giaj Levra, Rosario Mazzola, Marco Perna, Luca Visani, Fiammetta Meacci, Maria Taraborrelli, Luca Triggiani, Davide Franceschini, Carlo Greco, Alessio Bruni, Stefano Maria Magrini, Vieri Scotti
PURPOSE: To investigate the role of radiotherapy (RT) in the management of EGFR- or ALK-mutated metastatic non-small cell lung cancer (NSCLC) treated with TKI. MATERIALS AND METHODS: Clinical data of 106 patients (pts) from five Institutions treated with RT concomitant to TKI were retrospectively revised. Overall survival (OS) and toxicities were analyzed as endpoints of the study. RESULTS: Median age of pts was 65 years. TKIs were given for EGFR (81%)- or ALK (19%)-mutated metastatic NSCLC...
February 15, 2019: La Radiologia Medica
https://read.qxmd.com/read/30770847/mapb-the-brucella-suis-tamb-homologue-is-involved-in-cell-envelope-biogenesis-cell-division-and-virulence
#16
Magalí Graciela Bialer, Verónica Ruiz-Ranwez, Gabriela Sycz, Silvia Marcela Estein, Daniela Marta Russo, Silvia Altabe, Rodrigo Sieira, Angeles Zorreguieta
Brucella species are Gram-negative, facultative intracellular pathogens responsible for a worldwide zoonosis. The envelope of Brucella exhibits unique characteristics that make these bacteria furtive pathogens and resistant to several host defence compounds. We have identified a Brucella suis gene (mapB) that appeared to be crucial for cell envelope integrity. Indeed, the typical resistance of Brucella to both lysozyme and the cationic lipopeptide polymyxin B was markedly reduced in a ∆mapB mutant. MapB turned out to represent a TamB orthologue...
February 15, 2019: Scientific Reports
https://read.qxmd.com/read/30770840/comparative-studies-of-catalytic-pathways-for-streptococcus-pneumoniae-sialidases-nana-nanb-and-nanc
#17
Kela Xiao, Xingyong Wang, Haibo Yu
Streptococcus pneumoniae (S. pneumoniae) is a leading human pathogen, which takes large responsibility for severe otitis media, acute meningitis and septicaemia. It encodes up to three distinct sialidases: NanA, NanB and NanC, which are promising drug targets. Recent experimental studies have shown that these three sialidases might work together up to the ultimate step, where NanA and NanB produce N-acetylneuraminic acid (Neu5Ac) and 2,7-anhydro-Neu5Ac following the functions of sialidase and intramolecular trans-sialidase, whilst NanC carries on a ping-pong mechanism that produces or removes 2-deoxy-2,3-didehydro-Neu5AC...
February 15, 2019: Scientific Reports
https://read.qxmd.com/read/30770718/etiology-of-acute-otitis-media-and-phenotypic-molecular-characterization-of-streptococcus-pneumoniae-isolated-from-children-in-liuzhou-china
#18
Jinjian Fu, Ling Li, Zhuoxin Liang, Shaolin Xu, Nan Lin, Peixu Qin, Xiaohua Ye, Eric McGrath
BACKGROUND: The etiology and epidemiology of acute otitis media (AOM) are poorly understood in China. This study aimed to describe the etiology of AOM and the phenotypic and molecular characteristics of AOM-causing Streptococcus pneumoniae (S.pneumoniae) recovered from Chinese children. METHODS: A retrospective study was conducted to enrol patients younger than 18 years diagnosed as AOM. Middle ear fluid specimens were collected then cultured for bacterial pathogens...
February 15, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30770533/changes-in-otitis-media-episodes-and-pressure-equalization-tube-insertions-among-young-children-following-introduction-of-the-13-valent-pneumococcal-conjugate-vaccine-a-birth-cohort-based-study
#19
Andrew D Wiese, Xiang Huang, Chang Yu, Edward F Mitchel, Moe H Kyaw, Marie R Griffin, Carlos G Grijalva
INTRODUCTION: The impact of 13-valent pneumococcal conjugate vaccine (PCV13) introduction on the occurrence of first and subsequent otitis media (OM) episodes in early childhood is unclear. We compared the risk of OM episodes among children age <2 years before and after PCV13 introduction accounting for the dependence between OM episodes. METHODS: We identified consecutive annual (July-June) cohorts of Tennessee Medicaid-enrolled children (2006-2014) from birth through age two years...
February 16, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://read.qxmd.com/read/30769308/spatial-and-temporal-dynamics-of-nutrients-in-riparian-soils-after-nine-years-of-operation-of-the-three-gorges-reservoir-china
#20
Chen Ye, Chengrong Chen, Orpheus M Butler, Mehran Rezaei Rashti, Maryam Esfandbod, Ming Du, Quanfa Zhang
The construction and operation of the Three Gorges Reservoir (TGR), the largest hydropower dam in the world, has had significant consequences for the hydrology of riparian zones along the Yangtze river. Little is known about how such changes in hydrology might affect the levels of nutrients and organic matter (OM) in riparian soils. We conducted a nine-year study on the spatio-temporal dynamics and dominant environmental correlates of nutrients and OM in riparian soils along a 600 km section of the Yangtze...
February 4, 2019: Science of the Total Environment
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