Andrea M Cappellano, Natalia Dassi, Bruna M Mançano, Sidnei Epelman, Daniela B Almeida, Sergio Cavalheiro, Patricia A Dastoli, Maria T S Alves, Jardel M Nicacio, Marcos D S Costa, Frederico A Silva, Simone S Aguiar, Maria L Figueiredo, Michael Chen, Nasjla S Silva, Jonathan L Finlay
BACKGROUND: Non-germinomatous germ cell tumors (NGGCT) accounts for one third of intracranial GCT. While the germinoma group have an excellent overall survival, the standard of practice for children with NGGCT is still under evaluation. AIMS: Describe the results of the of the Brazilian consortium protocol. METHODS: Since 2013, 15 patients with a diagnosis of NGGCT by histopathology and/or serum/cerebrospinal fluid (CSF) tumor markers, βHCG >200mlU/ml and/or positive alpha-fetoprotein were treated with neoadjuvant chemotherapy with carboplatin, cyclophosphamide and etoposide followed by ventricular radiotherapy (RTV) of 18Gy with boost (32Gy) to the primary site...
2024: Frontiers in Oncology