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Pineal tumors

Mara Ventura, Leonor Gomes, Joana Rosmaninho-Salgado, Luísa Barros, Isabel Paiva, Miguel Melo, Diana Oliveira, Francisco Carrilho
Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma and a 16p11.2 microdeletion. His initial complaints were related to obesity, loss of facial hair and polydipsia. He also had a history of social-interaction difficulties during childhood. His blood tests were consistent with hypogonadotropic hypogonadism and secondary adrenal insufficiency, and he had been previously diagnosed with hypothyroidism...
February 7, 2019: Endocrinology, Diabetes & Metabolism Case Reports
Nathália Martins Sonehara, Jéssica Zani Lacerda, Bruna Victorasso Jardim-Perassi, Rubens de Paula Jr, Marina Gobbe Moschetta-Pinheiro, Ynaiá Santos Traba Souza, Júlia Carolina Junqueira de Andrade, Debora Aparecida Pires De Campos Zuccari
Breast cancer progression is composed of multiple steps that are influenced by tumor cell adaptations to survive under acidic conditions in the tumor microenvironment. Regulation of this cell survival behavior is a promising strategy to avoid cancer development. Melatonin is a natural hormone produced and secreted by the pineal gland capable of modulating different biological pathways in cancer. Although the anti-cancer effects of melatonin are currently widespread, its role in the acid tumor microenvironment remains poorly understood...
February 2019: Oncology Letters
Mohammad Hossein Pourhanifeh, Mostafa Mahdavinia, Russel J Reiter, Zatollah Asemi
Skin cancer, particularly melanoma, is a leading cause of death worldwide. The therapeutic methods for this malignancy are not effective, and due to the side effects of these treatments, applying an appropriate alternative or complementary treatment is important. According to available data, melatonin as the main product of the pineal gland has oncostatic and antitumoral properties. Also, melatonin acts as an anti-inflammatory and reactive oxygen species inducer agent which suppresses the growth of tumors. It also has apoptosis induction characteristics through regulating signaling pathways, including heat shock protein 70, nuclear factor-erythroid 2 p45-related factor 2 and others...
January 7, 2019: Journal of Cellular Physiology
Jiao Cheng, Hui-Li Yang, Chun-Jie Gu, Yu-Kai Liu, Jun Shao, Rui Zhu, Yin-Yan He, Xiao-Yong Zhu, Ming-Qing Li
Angiogenesis is an essential process involved in various physiological, including placentation, and pathological, including cancer and endometriosis, processes. Melatonin (MLT), a well‑known natural hormone secreted primarily in the pineal gland, is involved in regulating neoangiogenesis and inhibiting the development of a variety of cancer types, including lung and breast cancer. However, the specific mechanism of its anti‑angiogenesis activity has not been systematically elucidated. In the present study, the effect of MLT on viability and angiogenesis of human umbilical vein endothelial cells (HUVECs), and the production of vascular endothelial growth factor (VEGF) and reactive oxygen species (ROS), under normoxia or hypoxia was analyzed using Cell Counting kit 8, tube formation, flow cytometry, ELISA and western blot assays...
December 10, 2018: International Journal of Molecular Medicine
Junmin Wang, Chao Jiang, Kun Zhang, Xi Lan, Xuemei Chen, Weidong Zang, Zhongyu Wang, Fangxia Guan, Changlian Zhu, Xiuli Yang, Hong Lu, Jian Wang
Traumatic brain injury (TBI) is a principal cause of death and disability worldwide. Melatonin, a hormone made by the pineal gland, is known to have anti-inflammatory and antioxidant properties. In this study, using a weight-drop model of TBI, we investigated the protective effects of ramelteon, a melatonin MT1/MT2 receptor agonist, and its underlying mechanisms of action. Administration of ramelteon (10mg/kg) daily at 10:00 am alleviated TBI-induced early brain damage on day 3 and long-term neurobehavioral deficits on day 28 in C57BL/6 mice...
December 13, 2018: Free Radical Biology & Medicine
Qin Wang, Zhijuan Sun, Liqing Du, Chang Xu, Yan Wang, Bing Yang, Ningning He, Jinhan Wang, Kaihua Ji, Yang Liu, Qiang Liu
Colorectal cancer is the most commonly reported gastrointestinal malignancy, with a recent, rapid increase of the annual incidence all over the world. Enhancing the radiosensitivity of cancer cells while preserving the health of normal cells is one of the most important tasks in clinical radiobiology. However, resistance to radiotherapy for colorectal cancer greatly decreases the therapeutic outcome. Melatonin ( N -acetyl-5-methoxytryptamine), a natural secretory product that the pineal gland in the brain normally produces, has been reported to have anticancer properties...
December 10, 2018: International Journal of Molecular Sciences
Syed Ijlal Ahmed, Gohar Javed, Altaf Ali Laghari, Syeda Beenish Bareeqa, Kashif Aziz, Mehreen Khan, Syeda Sana Samar, Raja Azhar Humera, Alizay Rashid Khan, Muhammad Osama Farooqui, Amir Shahbaz
Third ventricle tumors are uncommon and account for 0.6 - 0.9% of all the brain tumors. Tumors of the third ventricle are classified into primary tumors, such as colloid cysts, choroid plexus papillomas, and ependymomas, or secondary tumors, such as craniopharyngiomas, optic nerve gliomas, pineal tumors, and meningiomas. Third ventricular tumors are uncommon, and their treatment involves significant morbidity and mortality. The colloid cyst has a better surgical outcome and many approaches are available to achieve a complete cure...
October 5, 2018: Curēus
Diego Mendez-Rosito
Falcotentorial meningiomas originate in the junction of the falx cerebri and the tentorium. Due to its anatomic vicinity, these tumors have a close relationship with important neurovascular structures surrounding the pineal region including the deep venous system. Surgical approaches would normally consider posterior midline corridors, but decision between supra or infratentorial access should be considered by the size, anatomic displacement of structures, and the infiltration of the dural attachment.This surgical video1,2 demonstrates the surgical technique and pearls to achieve a stepwise resection of a complex falcotentorial meningioma...
November 28, 2018: Operative Neurosurgery (Hagerstown, Md.)
Elizabeth Hogan, Isabel Almira-Suarez, Siyuan Li, Sean P Collins, Walter C Jean
BACKGROUND: Prostate Cancer is the most common cancer among American men, with an incidence of approximately 233,000 cases per year.Intracranial metastases are rare and specifically, metastasis to the pineal gland has only been reported in 2 post mortem cases in the literature. CASE DESCRIPTION: We present the first documented case of confirmed prostate cancer metastasis to the pineal gland in a living patient. The patient underwent an endoscopic third ventriculostomy and pineal lesion biopsy with complete resolution of his hydrocephalus and presenting symptoms...
November 23, 2018: World Neurosurgery
Katherine Kunigelis, Alexander Yang, A Samy Youssef
This case is a 20-year-old male, who presented with 1 month of right facial weakness (HB4) and complaints of ipsilateral eye dryness. He was initially treated for Bell's palsy with steroids and antiviral agents, but subsequently developed diplopia with right lateral gaze and underwent an MRI (magnetic resonance imaging). MRI demonstrated a 4.5 cm irregular lesion in the right cerebellopontine angle consistent with an epidermoid cyst. Because the tumor had grown with the development of the central nervous system, it has extended into different compartments, including the tentorial incisura and pineal region...
December 2018: Journal of Neurological Surgery. Part B, Skull Base
Ruiqi Chen, Chuanyuan Tao, Chao You, Yan Ju
BACKGROUND: Intracranial germinomas are uncommon and constitute less than 1% of all intracranial tumors. They usually arise in the midline of the brain, most commonly in the pineal region. Pineal germinomas tend to spread through the cerebrospinal fluid (CSF). However, pineal germinomas with fast-developing diffuse subarachnoid/leptomeningeal dissemination are extremely rare, especially in young children. METHODS: The case of a 4-year-old boy with a pineal germinoma who died of diffuse subarachnoid/leptomeningeal dissemination 1 month after radiotherapy is reported...
November 19, 2018: British Journal of Neurosurgery
Tao Jiang, Raynald, Hongchao Yang, Wenhui Zhang, Chunde Li
The incidence of primary intracranial pure choriocarcinoma (PIPC) is extremely rare. Only several case and case series have been previously reported; therefore, there is still lack of knowledge about the prognosis and its standard treatment. We performed a collective study of all reported cases of PIPC to identify the predictive factors related with OS. A comprehensive search was performed on Pubmed's electronic database using the terms "primary intracranial choriocarcinoma" and "malignant germ cell tumor"...
November 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Joham Choque-Velasquez, Julio C Resendiz-Nieves, Behnam Rezai Jahromi, Roberto Colasanti, Rahul Raj, Olli Tynninen, Juhani Collan, Juha Hernesniemi
BACKGROUND: Pineal parenchymal tumors of intermediate differentiation (PPTIDs) are rare lesions with particular features compared to other pineal parenchymal tumors. METHODS: We present a retrospective review of the patients with histologically confirmed PPTIDs that were operated on in our department between 1997 and 2015. A demographic analysis, and an evaluation of preoperative status, surgical treatment, as well as immediate and long-term clinical and radiological outcomes were conducted...
October 31, 2018: World Neurosurgery
Javier Menéndez-Menéndez, Carlos Martínez-Campa
Melatonin (N-acetyl-5-methoxytryptamine) is a hormone synthesized and secreted by the pineal gland mainly during the night, since light exposure suppresses its production. Initially, an implication of this indoleamine in malignant disease was described in endocrine-responsive breast cancer. Data from several clinical trials and multiple experimental studies performed both in vivo and in vitro have documented that the pineal hormone inhibits endocrine-dependent mammary tumors by interfering with the estrogen signaling-mediated transcription, therefore behaving as a selective estrogen receptor modulator (SERM)...
2018: International Journal of Endocrinology
Farrokh Seilanian Toosi, Behzad Aminzadeh, Mohammad Faraji Rad, Sirous Nekooei, Mahsa Nahidi, Ehsan Keykhosravi
Germinoma is the most common type of intracranial germ cell tumors (GCTs). Pineal gland and suprasellar region are the most frequent sites of central nervous system (CNS) involvement. Intracranial masses caused by Langerhans cell histiocytosis (LCH) mimics features of CNS GCTs. LCH frequently involve spine and is the most common cause of vertebra plana in children. A 15-year-old boy presented with progressing symptoms of polydipsia, polyuria, general headache, nausea and severe back pain. Brain MRI showed brain tumor with simultaneous involvement of suprasellar region and pineal gland...
October 2018: Brain Tumor Research and Treatment
Nadir Koçak, Hüseyin Dönmez, İbrahim Halil Yildirim
Melatonin is a hormone of the pineal gland that has a wide range of biological effects such as antioxidant, anti-inflammatory, and anti-tumor activity. Previous studies have shown that melatonin also affects survival, proliferation, and apoptosis of the cells. In this study, we investigated the effect of melatonin on apoptosis, self-renewal, and differentiation. For this purpose, MCF-7 and HEK293 cells were subjected to melatonin treatment. Expression of genes related to apoptosis (Bax and Bcl2) and self-renewal and differentiation (Oct4, Sox2, and Nanog) analyzed after the sorting of cancer stem cells from MCF-7 cells...
September 30, 2018: Cellular and Molecular Biology
Mattias Belting, Anna Bång-Rudenstam, Elisabet Englund, Torsten Pietsch
No abstract text is available yet for this article.
October 5, 2018: Neuro-oncology
Joham Choque-Velasquez, Juha Hernesniemi
Background: In this video abstract, we present a one burr-hole craniotomy for the posterior interhemispheric approach developed in Helsinki Neurosurgery to access posteriorly the medial surface of cerebral hemispheres, falx cerebri, and deep midline cerebrovascular structures. Therefore, preoperative imaging is essential to achieve an optimal operative corridor for a safest and more effcient approach. Case Description: The patient with a papillary tumor of the pineal region is placed in sitting position...
2018: Surgical Neurology International
Reza Akhavan-Sigari, Hesam Abdolhoseinpour, Werner Meyer, Veit Rohde, Walter Schulz-Schaeffer
Carcinosarcomas are tumors comprising part adenocarcinoma and part sarcoma; the presence of carcinosarcoma in the head-and-neck region is very rare. These tumors are typically highly aggressive (G3) and arise most frequently from the salivary gland. Here, we present a case report on a brain metastasis as the primary manifestation of a carcinosarcoma. Magnetic resonance imaging showed a tumor of the pineal region with infiltration of the brainstem and the corpus. The staging following the histopathological diagnosis revealed the origin of the tumor in the left parotid gland...
July 2018: Asian Journal of Neurosurgery
Kaleigh Fetcko, Mahua Dey
Importance: Primary central nervous system (CNS) germ cell tumors (GCT) are a heterogeneous group of tumors that are still poorly understood. In North America, GCTs comprise approximately 1% of primary brain tumors in pediatric and young adult patients. GCTs can occur as pure or mixed subtypes; they are divided into germinomas, which are the most common subtype, and non-germinomatous germ cell tumors (NGGCTs), which consist of approximately one-third of GCTs and include teratomas, embryonal carcinomas, choriocarcinomas, and yolk sac tumors...
March 2018: Medical Research Archives
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