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Erectile AND Dysfunction

Fabiola Zakia Mónica, Gilberto De Nucci
In men, lower urinary tract symptoms (LUTS) are primarily attributed to benign prostatic hyperplasia (BPH). Therapeutic options are targeted to relax prostate smooth muscle and/or reduce prostate enlargement. Areas covered: This article reviews the major preclinical and clinical data on PDE5 inhibitors with a specific focus on tadalafil. It includes details of the role of the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) - PDE5 pathway in the LUT organs (bladder and prostate) in addition to the available data on tadalafil in patients with LUTS secondary to BPH with or without erectile dysfunction (ED)...
March 22, 2019: Expert Opinion on Pharmacotherapy
Marco Capece, Roberto La Rocca, Vincenzo Mirone, Trinity J Bivalacqua, Fabio Castiglione, Maarten Albersen, David J Ralph, Asif Muneer, Giulio Garaffa
INTRODUCTION: Ischemic priapism (IP) is the most common form of priapism. In cases of priapism persisting for >36 hours, conservative management usually fails, and the patients' erectile tissue will be inevitably compromised, resulting in corporal fibrosis, shortening of the penis, and refractory erectile dysfunction. In this subset of patients, early implantation of a penile prosthesis (PP) could be a solution for both the priapic episode and the erectile dysfunction. AIM: To analyze the current literature with regard to the correlation between refractory ischemic priapism and immediate implantation of PP...
March 19, 2019: Sexual Medicine Reviews
Maya V Epifanova, Badri R Gvasalia, Maksim A Durashov, Sergey A Artemenko
INTRODUCTION: Platelet-rich plasma (PRP) found its use in treating different conditions and diseases, because concentrated plasma PRP consists of many growth factors. Their interaction with surrounding cells, intracellular matrix, and mediators at the site of injection leads to tissue regeneration. Angiogenic, vasculogenic, and regenerative effects of PRP may be used for erectile dysfunction (ED) and Peyronie's disease (PD) treatment. AIM: To present a current data review of preclinical and clinical trials on PRP use for treating ED and PD...
March 19, 2019: Sexual Medicine Reviews
Kirtishri Mishra, Aram Loeb, Laura Bukavina, Adam Baumgarten, Jonathan Beilan, Melissa Mendez, Lorenzo DiGiorgio, Liying Fu, Rafael Carrion
INTRODUCTION: Current management of ischemic priapism revolves around 3 principles: resolving the acute event, preserving erectile function, and reducing the risk of future recurrences. Although more conservative management options, such as aspiration, irrigation, and surgical shunts, are effective in many patients, those who are refractory to these interventions or have prolonged priapism may benefit from placement of a penile prosthesis (PP). AIM: To provide a comprehensive overview of priapism management, highlight the current literature on the utility of penile implants for refractory priapism, and provide insight from a high-volume center on surgical decision making and technique...
March 19, 2019: Sexual Medicine Reviews
Dorota J Hawksworth, Arthur L Burnett
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is considered a hallmark of metabolic syndrome (MetS) and a significant contributor to cardiovascular disease (CVD). With the alarming rates of obesity in the United States and worldwide, efforts at understanding, preventing, and treating MetS and its components are being increasingly undertaken by scientists and clinicians. A strong association between MetS and male sexual problems is already well established. More recent animal and human studies have further evaluated the relationship of NAFLD with male sexual problems and infertility...
March 19, 2019: Sexual Medicine Reviews
Brian Dick, Peter Tsambarlis, Amit Reddy, Wayne Jg Hellstrom
Penile prosthesis placement is the gold standard for the treatment of erectile dysfunction (ED) refractory to medical therapy; however, limited data exists on the long-term outcomes of these devices. Areas Covered: A PubMed search focused on long-term outcomes of penile prosthetics was performed. Studies with a follow-up of less than 5 years were excluded. Included studies were arranged chronologically by implant date to identify trends in device lifetime. Data was further scrutinized to separate device failure secondary to mechanical malfunction from device failure secondary to infection...
March 21, 2019: Expert Review of Medical Devices
Akio Horiguchi
Pelvic fractures from high-energy blunt force trauma can cause injury to the posterior urethra, known as pelvic fracture urethral injury, which is most commonly associated with unstable pelvic fractures. Pelvic fracture urethral injury should be suspected if a patient with pelvic trauma has blood at the meatus and/or difficulty voiding, and retrograde urethrography should be carried out if the patient is stable. Once urethral injury is confirmed, urinary drainage should be established promptly by placement of a suprapubic tube or primary realignment of the urethra over a urethral catheter...
March 20, 2019: International Journal of Urology: Official Journal of the Japanese Urological Association
Catriona Duncan, Ghadir J Omran, Jiasian Teh, Niall F Davis, Damien M Bolton, Nathan Lawrentschuk
PURPOSE: Data assessing the effectiveness of intracavernosal injections (ICIs) for the treatment of erectile dysfunction (ED) are limited. This study evaluates intracavernosal injectable therapies for ED and reviews available guidelines that inform clinical practice. METHODS: A systematic search using electronic databases (Medline, Pubmed) was performed for studies investigating injectable management strategies for ED published after 1990. Primary outcome measures were to comparatively evaluate clinical efficacy, continuation rates and adverse event profiles of each injectable agent as monotherapy or in combination...
March 20, 2019: World Journal of Urology
Elizabeth Dawson, Sonja E Stutzman, DaiWai M Olson, Ryan S Hays
BACKGROUND: Approximately 18 million men suffer from some type of erectile dysfunction (ED), which is primarily attributed to age, comorbid health conditions, or medications. Men with epilepsy encounter all of these issues, yet ED literature and research in men with epilepsy is not yet robust. The purpose of this study was to test the utility of a validated ED screening tool in a population of men with epilepsy, as well as to assess additional parameters that may contribute to ED in this specific patient population...
March 17, 2019: Epilepsy & Behavior: E&B
André Luiz Farinhas Tomé, Eduardo P Miranda, José de Bessa Júnior, Carlos Alberto Bezerra, Antônio Carlos Lima Pompeo, Sidney Glina, Cristiano Mendes Gomes
OBJECTIVES: To assess the prevalence and interrelationship between lower urinary tract symptoms and sexual dysfunction in men with multiple sclerosis (MS). METHODS: In a cross-sectional study, we evaluated 41 men (mean age 41.1±9.9 years) with MS from February 2011 to March 2013, who were invited to participate irrespective of the presence of lower urinary tract symptoms or sexual dysfunction. Neurological impairment was assessed with the Expanded Disability Status Scale; lower urinary tract symptoms were evaluated with the International Continence Society male short-form questionnaire, and sexual dysfunction was evaluated with the International Index of Erectile Function...
March 14, 2019: Clinics
Patrick G Rice, Bhaskar K Somani, Rowland W Rees
INTRODUCTION: Plaque incision and grafting (PIG) is indicated for men with complex or severe penile curvature and, despite a multitude of incision types and grafting materials having been used, no individual technique has proven superiority. AIM: To assess outcomes following PIG and to understand the operative technique. METHODS: A systematic review was performed to find all relevant studies reporting on use of the PIG technique to correct curvature resulting from Peyronie's disease...
March 16, 2019: Sexual Medicine
Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Babatunji Emmanuel Oyinloye, Basiru Olaitan Ajiboye, Omosola Olufisayo Anifowose, Ayodeji Akawa, Oluranti Esther Olaiya, Oluwaseun Ruth Olasehinde, Abidemi Paul Kappo
BACKGROUND: Ocimum gratissimum L. is a medicinal plant widely grown in tropical and subtropical regions with the leaf decoction usually taken in folk medicine to enhance erectile performance in men although the probable mechanism of actions remains undetermined. This study examined the inhibitory potentials of Ocimum gratissimum leaves on some key enzymes associated with erectile dysfunction in penile and testicular tissues of the rat. METHODS: Inhibitory effect of aqueous extract (1:10 w/v) of O...
March 19, 2019: BMC Complementary and Alternative Medicine
Maud J M Geerkens, Hoda H M Al-Itejawi, Jakko A Nieuwenhuijzen, Eric J M Meuleman, Birgit I Lissenberg-Witte, R J A van Moorselaar, André N Vis
CONTEXT: Therapies initiated by urologists, medical as well as surgical, may cause adverse effects in different sexual domains. Sexual domains that are often affected are sexual interest, sexual activity, and erectile functioning. As many elderly men undergo these therapies, it is important to know the prevalence of sexual dysfunction (SD) in these domains and its impact in the healthy elderly male population. This may help healthcare providers counsel their patients properly on possible adverse effects...
March 13, 2019: European Urology Focus
Jonathan Clavell-Hernandez, Bahadır Ermeç, Ateş Kadıoğlu, Run Wang
Radical prostatectomy has significantly improved prostate cancer survival rates but continues to have a negative impact on the patient's erectile function (EF). In attempts to improve erectile dysfunction (ED), clinicians have incorporated different treatment modalities to restore EF. Penile rehabilitation consists of understanding the mechanisms that affect post-prostatectomy EF and utilizing pharmacologic agents, devices, and interventions to promote the male sexual function. This article aims to summarize the available scientific research involving penile rehabilitation...
January 22, 2019: Turkish Journal of Urology
Ayinuer Reheman, Ze-Yu Gao, Xirali Tursun, Xiao-Ping Pu, Tao Wu, Fei He, Xin Zhao, Haji Akber Aisa
We used Box-Behnken design-based (BBD) response surface methodology (RSM) in this research to optimize the extraction process of Traditional medicine Majun Mupakhi Ela (MME) and evaluate its effect on hydrocortisone-induced kidney yang deficiency. Three independent parameters were applied to evaluate the maximum phosphodiesterase type 5 (PDE5) inhibition activity of MME extracts in vitro. The optimal processing conditions (extraction time 2 h, solid-liquid ratio 1:16, extraction once) gave a maximum PDE5 inhibition rate of 84...
March 15, 2019: Scientific Reports
Jin Zhang, Xinglin Wu, Tingsheng Lu, Hui Song, Zhuojia Zhou, Bo Li
Objective: To evaluate the safety and effectiveness of one-stage posterior surgery via unilateral musculussacrospinalis iliac flap approach in treatment of lumbosacral tuberculosis. Methods: Between August 2011 and October 2014, 13 patients with lumbosacral tuberculosis were treated by one-stage posterior reserved posterior ligament complex, lesion debridement, bone graft fusion, and internal fixation via unilateral musculussacrospinalis iliac flap approach. There were 8 males and 5 females, aged from 22 to 57 years, with an average age of 35 years...
March 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
Ylenia Duca, Aldo E Calogero, Rossella Cannarella, Filippo Giacone, Laura M Mongioi, Rosita A Condorelli, Sandro La Vignera
Erectile dysfunction could be an early sign of endothelial dysfunction and, therefore, of cardiovascular disease, with which it shares many risk factors. Among reversible risk factors, physical inactivity is one of the most important. Regular physical exercise has been shown to improve erectile function through different mechanisms involving glucose and lipid metabolism, regulation of arterial pressure, production of nitric oxide and hormonal modulation. Furthermore, exercise shows a synergistic effect with the drugs commonly used in the treatment of impotence...
March 15, 2019: Andrologia
Zhongbao Zhou, Yuanshan Cui, Jitao Wu, Rui Ding, Tong Cai, Zhenli Gao
BACKGROUND: We performed a meta-analysis to confirm the efficacy and safety of the combination of tamsulosin plus dutasteride compared with tamsulosin monotherapy in treating benign prostatic hyperplasia (BPH) during a treatment cycle of at least 1 year. METHODS: Randomized controlled trials were searched by using MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. Systematic review was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-analyses...
March 11, 2019: BMC Urology
Ji Hyun Lee, Han Na Park, Ok Rim Park, Nam Sook Kim, Sung-Kwan Park, Hoil Kang
The worldwide spread of illegal sexual enhancement products is posing a threat to public health. The aim of this study was to investigate illegal products claiming to be effective in improving sexual performance through the online or offline markets between 2014 and 2017; these products include foods, dietary supplements, counterfeit drugs, and herbal medicines. These samples were analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the presence of 80 PDE-5 inhibitors (PDE-5i) and analogues...
February 22, 2019: Forensic Science International
Juhyun Park, Hwancheol Son, Ji Sun Chai, Soo Woong Kim, Jae-Seung Paick, Min Chul Cho
We evaluated whether chronic administration of LIMK2-inhibitors could improve erectile function by alleviating CVOD through suppressing cavernosal fibrosis in a rat model of cavernosal nerve crush-injury (CNCI). Forty-two 12-week-old rats were equally categorized into the three groups: sham-surgery (S), CNCI (I), and CNCI treated with LIMK2-inhibitors (L). The L-group was treated with daily intraperitoneal injection of LIMK2-inhibitors (10.0 mg/kg) for 30-days after surgery. Erectile function was assessed using dynamic-infusion-cavernosometry (DIC)...
2019: PloS One
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