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https://read.qxmd.com/read/30763872/mutations-present-in-a-low-passage-zika-virus-isolate-result-in-attenuated-pathogenesis-in-mice
#1
Nisha K Duggal, Erin M McDonald, James Weger-Lucarelli, Seth A Hawks, Jana M Ritter, Hannah Romo, Gregory D Ebel, Aaron C Brault
Zika virus (ZIKV) infection can result in neurological disorders including Congenital Zika Syndrome in infants exposed to the virus in utero. Pregnant women can be infected by mosquito bite as well as by sexual transmission from infected men. Herein, the variants of ZIKV within the male reproductive tract and ejaculates were assessed in inoculated mice. We identified two non-synonymous variants at positions E-V330L and NS1-W98G. These variants were also present in the passage three PRVABC59 isolate and infectious clone relative to the patient serum PRVABC59 sequence...
February 7, 2019: Virology
https://read.qxmd.com/read/30763294/increased-methamphetamine-injection-drug-and-heroin-use-among-women-and-heterosexual-men-with-primary-and-secondary-syphilis-united-states-2013-2017
#2
Sarah E Kidd, Jeremy A Grey, Elizabeth A Torrone, Hillard S Weinstock
During 2013-2017, the national annual rate of reported primary and secondary (P&S) syphilis cases in the United States increased 72.7%, from 5.5 to 9.5 cases per 100,000 population (1). The highest rates of P&S syphilis are seen among gay, bisexual, and other men who have sex with men (collectively referred to as MSM) (2), and MSM continued to account for the majority of cases in 2017 (1). However, during 2013-2017, the P&S syphilis rate among women increased 155.6% (from 0.9 to 2.3 cases per 100,000 women), and the rate among all men increased 65...
February 15, 2019: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/30747450/hair-cortisol-in-the-perinatal-period-mediates-associations-between-maternal-adversity-and-disrupted-maternal-interaction-in-early-infancy
#3
Maja Nyström-Hansen, Marianne S Andersen, Jennifer E Khoury, Kirstine Davidsen, Andrew Gumley, Karlen Lyons-Ruth, Angus MacBeth, Susanne Harder
Existing literature points to the possibility that cortisol could be one link between maternal adversity and poorer parenting quality, but most studies have examined salivary cortisol concentrations rather than hair cortisol concentrations. The current study examined hair cortisol concentration (HCC) during the third trimester of pregnancy as a mediator between maternal adversity indicators (childhood abuse, severe mental illness, symptomatic functioning) and maternal caregiving behavior at 4 months postpartum...
February 12, 2019: Developmental Psychobiology
https://read.qxmd.com/read/30746339/veiled-truths-iranian-women-and-risky-sexual-behavior-in-the-context-of-substance-use
#4
Effatf Merghati Khoei, Mansoureh Jamshidimanesh, Mohammad Hassan Emamian, Fatemeh Sheikhan, Kate Dolan, Kathleen T Brady
Background: Substance use disorders and risky sexual behavior coexist for some women. Explanatory models of women's sexuality in the context of substance use are under study. This study aimed to explore how women's sexual behavior can become risky in the context of substance use. Methods: In this ethnographic inquiry, 25 women with substance use disorders (SUDs) were included at two Drop-In-Centers (DICs) in South Tehran. Observation, semi-structured interviews and field notes were used to collect data...
October 2018: Journal of Reproduction & Infertility
https://read.qxmd.com/read/30743100/prevalence-of-bovine-trichomonosis-and-associated-risk-factors-in-bulls-from-spanish-beef-herds
#5
Esther Collantes-Fernández, Javier Moreno-Gonzalo, Roberto Sánchez-Sánchez, Ignacio García-Bocanegra, Pilar Horcajo, Luis M Ortega-Mora
Bovine trichomonosis is a sexually transmitted disease considered as an important cause of early reproductive failure in beef cattle. To investigate the occurrence of the infection in different Spanish beef cattle-producing areas, retrospective data from the SALUVET veterinary diagnostic laboratory (Veterinary Faculty, Madrid, Spain) derived from the analysis of samples from beef bulls that were routinely tested for Tritrichomonas foetus infection, were compiled from 2011 to 2015. In addition, a number of potential risk factors were assessed...
February 2, 2019: Theriogenology
https://read.qxmd.com/read/30742556/the-experience-of-maltreatment-in-young-children-whose-mothers-have-borderline-personality-disorder-reflections-in-their-narrative-representations
#6
Jenny Macfie, Gretchen Kurdziel
Child maltreatment is an etiological factor in borderline personality disorder (BPD), which may be transmitted to the children of mothers with BPD. We assessed maltreatment in 36 children aged 4-7 whose mothers have BPD and in 34 normative comparisons. Children whose mothers have BPD were more likely to have experienced sexual abuse, physical abuse, and neglect than were normative comparisons. Mothers' self-reported borderline features were significantly correlated with children's maltreatment. Neglect was associated with mothers' affective instability, identity disturbance, negative relationships, and self-harm; sexual abuse was associated with mothers' identity disturbance, and negative relationships; and physical abuse was associated with mothers' self-harm...
February 11, 2019: Journal of Personality Disorders
https://read.qxmd.com/read/30740750/dsm-5-alcohol-use-disorder-severity-as-a-function-of-sexual-orientation-discrimination-a-national-study
#7
Sean Esteban McCabe, Tonda L Hughes, Brady T West, Phil Veliz, Carol J Boyd
BACKGROUND: Sexual minorities are more likely than their heterosexual counterparts to develop alcohol use disorder (AUD), and understanding the underlying reasons for this heightened risk is a public health priority. This study examined relationships between sexual orientation discrimination and DSM-5 AUD severity. METHODS: The 2012 to 2013 National Epidemiologic Survey on Alcohol and Related Conditions III conducted in-person interviews with a nationally representative sample of U...
February 11, 2019: Alcoholism, Clinical and Experimental Research
https://read.qxmd.com/read/30739585/determining-sexual-offender-profiles-from-life-trajectories
#8
Julien Eloir, Claire Ducro, Jean-Louis Nandrino
To study qualitatively the development of a heteroaggressive behavior, we applied retrospective analytical method based on categorization of life events. The aim of this study was to establish the life trajectories of sexual offenders through interviews with second sources: the inmate's relatives and psychologists. The life trajectories of incarcerated sexual offenders were retraced to build individual life charts. These life charts grouped individual life events into four main domains: health, life events, the relational sphere, and the judicial and prison sphere...
February 9, 2019: Sexual Abuse: a Journal of Research and Treatment
https://read.qxmd.com/read/30738551/early-sexual-trauma-exposure-and-neural-response-inhibition-in-adolescence-and-young-adults-trajectories-of-frontal-theta-oscillations-during-a-go-no-go-task
#9
Jacquelyn Meyers, Vivia V McCutcheon, Ashwini K Pandey, Chella Kamarajan, Stacey Subbie, David Chorlian, Jessica Salvatore, Gayathri Pandey, Laura Almasy, Andrey Anokhin, Lance Bauer, Annah Bender, Danielle M Dick, Howard J Edenberg, Victor Hesselbrock, John Kramer, Samuel Kuperman, Arpana Agrawal, Kathleen Bucholz, Bernice Porjesz
OBJECTIVE: Trauma, particularly when experienced early in life, can alter neurophysiologic and behavioral development, thereby increasing risk for substance use disorders and related psychopathology. However, few studies have empirically examined trauma using well-characterized developmental samples that are followed longitudinally. METHOD: The association of assaultive, non-assaultive, and sexual assaultive experiences before 10 years of age with developmental trajectories of brain function during response inhibition was examined by measuring electrophysiologic theta and delta oscillations during no-go and go conditions in an equal probability go/no-go task...
February 2019: Journal of the American Academy of Child and Adolescent Psychiatry
https://read.qxmd.com/read/30738547/alcohol-use-and-disordered-eating-in-a-us-sample-of-heterosexual-and-sexual-minority-adolescents
#10
Jerel P Calzo, Blair C Turner, Rachel Marro, Gregory L Phillips
OBJECTIVE: To expand knowledge of co-occurring alcohol use and disordered eating behaviors (DEB) among sexual minority (ie, nonheterosexual) youth. METHOD: Using pooled 2009 to 2015 US Youth Risk Behavior Surveys (322,687 students; 7.3% lesbian, gay, bisexual), multivariable logistic regression models examined the following: (1) associations of age of onset of drinking and past month binge drinking with past year DEB (fasting, diet pill use, purging, steroid use); and (2) effect modification by sexual orientation...
February 2019: Journal of the American Academy of Child and Adolescent Psychiatry
https://read.qxmd.com/read/30738540/editorial-why-assessing-co-occurring-eating-disorders-and-alcohol-use-in-sexual-minority-youth-is-important
#11
EDITORIAL
Melissa A Munn-Chernoff
The prevalence of psychiatric disorders, such as major depression and anxiety, is higher in sexual minority individuals (eg, those who identify as gay, lesbian, or bisexual or are unsure of their orientation) than heterosexual individuals.1 Eating disorders and alcohol use also are more common in sexual minority groups, yet the extent to which they co-occur in these individuals is limited. The co-occurrence of eating and alcohol use disorders results in increased morbidity than either disorder alone2 and increased mortality for eating disorders...
February 2019: Journal of the American Academy of Child and Adolescent Psychiatry
https://read.qxmd.com/read/30735080/development-of-a-novel-tool-to-assess-intimate-partner-violence-against-transgender-individuals
#12
Sarah M Peitzmeier, Jaclyn M W Hughto, Jennifer Potter, Madeline B Deutsch, Sari L Reisner
Intimate partner violence (IPV) takes on unique dimensions when directed against transgender individuals, with perpetrators leveraging transphobia to assert power and control. Standard IPV measurement tools do not assess this type of IPV. Four questions to assess transgender-related IPV (T-IPV) were developed: (a) being forced to conform to an undesired gender presentation or to stop pursuing gender transition; (b) being pressured to remain in a relationship by being told no one would date a transgender person; (c) being "outed" as a form of blackmail; and (d) having transition-related hormones, prosthetics, or clothing hidden or destroyed...
February 8, 2019: Journal of Interpersonal Violence
https://read.qxmd.com/read/30734130/the-combined-polymorphisms-of-interleukin-6-174gg-genotype-and-interleukin-10-ata-haplotype-are-associated-with-a-poor-quality-of-life-in-patients-with-chronic-hepatitis-c
#13
Diego Alves Vieira, Luciana Rodrigues da Cunha, Cliviany Borges da Silva, Maria Thereza Bastos Almeida, Adriana Dias Gomes, César Lúcio Lopes de Faria, Rosângela Teixeira, Fernando Silva Neves, Gifone Aguiar Rocha, Fabrício Freire de Melo, Dulciene Maria de Magalhães Queiroz, Luciana Diniz Silva
PURPOSE: Chronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHC patients has not been studied, we investigated the combined IL10-1082G/A, - 819C/T, and - 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demographic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHC patients...
February 7, 2019: Quality of Life Research
https://read.qxmd.com/read/30724428/the-castro-study-unsafe-sexual-behaviors-and-illicit-drug-use-among-gay-and-bisexual-men-who-use-anabolic-steroids
#14
Eric J Ip, Shadi Doroudgar, Bijal Shah-Manek, Mitchell J Barnett, Michael J Tenerowicz, Marvin Ortanez, Harrison G Pope
BACKGROUND AND OBJECTIVES: The majority of anabolic androgenic steroid (AAS) studies have focused on the general male population. Approximately 15% of gay or bisexual men are seropositive for HIV and many AASs are administered via injection. Thus, AAS use among gay and bisexual men likely poses a greater risk of spreading infectious disease. Gay and bisexual men who use AAS were compared with non-users regarding self-reported seropositivity for HIV and hepatitis B and C, sexual behaviors and injection practices, illicit drug and alcohol use, and psychiatric disorders...
February 6, 2019: American Journal on Addictions
https://read.qxmd.com/read/30719763/euroinf-2-subthalamic-stimulation-apomorphine-and-levodopa-infusion-in-parkinson-s-disease
#15
Haidar S Dafsari, Pablo Martinez-Martin, Alexandra Rizos, Maja Trost, Maria Gabriela Dos Santos Ghilardi, Prashanth Reddy, Anna Sauerbier, Jan Niklas Petry-Schmelzer, Milica Kramberger, Robbert W K Borgemeester, Michael T Barbe, Keyoumars Ashkan, Monty Silverdale, Julian Evans, Per Odin, Erich Talamoni Fonoff, Gereon R Fink, Tove Henriksen, Georg Ebersbach, Zvezdan Pirtošek, Veerle Visser-Vandewalle, Angelo Antonini, Lars Timmermann, K Ray Chaudhuri
OBJECTIVE: Real-life observational report of clinical efficacy of bilateral subthalamic stimulation (STN-DBS), apomorphine (APO), and intrajejunal levodopa infusion (IJLI) on quality of life, motor, and nonmotor symptoms (NMS) in Parkinson's disease (PD). METHODS: In this prospective, multicenter, international, real-life cohort observation study of 173 PD patients undergoing STN-DBS (n = 101), IJLI (n = 33), or APO (n = 39) were followed-up using PDQuestionnaire-8, NMSScale (NMSS), Unified PD Rating Scale (UPDRS)-III, UPDRS-IV, and levodopa equivalent daily dose (LEDD) before and 6 months after intervention...
February 4, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30719458/inflamm-aging-a-new-mechanism-affecting-premature-ovarian-insufficiency
#16
REVIEW
Yaoqi Huang, Chuan Hu, Haifeng Ye, Ruichen Luo, Xinxin Fu, Xiaoyan Li, Jian Huang, Weiyun Chen, Yuehui Zheng
The normal function of ovaries, along with the secretion of sex hormones, is among the most important endocrine factors that maintain the female sexual characteristics and promote follicular development and ovulation. Premature ovarian insufficiency (POI) is a common cause in the etiology of female infertility. It is defined as the loss of ovarian function before the age of 40. The characteristics of POI are menstrual disorders, including amenorrhea and delayed menstruation, accompanied by a raised gonadotrophin level and decreased estradiol level...
2019: Journal of Immunology Research
https://read.qxmd.com/read/30719367/polypharmacy-leading-to-priapism-in-hiv-patient-with-schizoaffective-disorder-a-cyp450-cascade
#17
Vinod Sharma, Aditi Sharma
With increasing trend of polypharmacy, there are higher chances of drug-drug interactions leading to adverse effects, especially in psychiatric patients with co-morbid chronic medical problems. This case demonstrates a schizoaffective 30-year-old male on highly active antiretroviral therapy (HAART) who reported an incident of priapism potentially caused by an interaction between previously prescribed atypical antipsychotic, trazodone, norepinephrine dopamine reuptake inhibitor (NDRI), HAART, and newly added selective serotonin reuptake inhibitor (SSRI)...
2019: Case Reports in Psychiatry
https://read.qxmd.com/read/30718080/male-fertility-preservation-in-dsd-xxy-pre-gonadotoxic-treatments-update-methods-ethical-issues-current-outcomes-future-directions
#18
REVIEW
Maria Grazia Giudice, Federico Del Vento, Christine Wyns
This paper aims at reviewing the fertility preservation strategies that could be considered in several conditions at risk of spermatogonial depletion such as 46,XY disorders of sexual development, Klinefelter syndrome and after gonadotoxic treatment in males highlighting current knowledge on diseases and processes involved in infertility as well as future directions along with their specific ethical issues. While sperm cryopreservation after puberty is the only validated technique for fertility preservation, for prepubertal boys facing gonadotoxic therapies or at risk of testicular tissue degeneration where testicular sperm is not present, cryopreservation of spermatogonial cells may be an option to ensure future parenthood...
January 23, 2019: Best Practice & Research. Clinical Endocrinology & Metabolism
https://read.qxmd.com/read/30718028/work-related-burn-injuries-and-claims-for-post-traumatic-stress-disorder-in-korea
#19
Kang Soo Lee, So Young Joo, Cheong Hoon Seo, Joo-Eon Park, Boung Chul Lee
OBJECTIVE: The objective of this study is to broaden our understanding of psychiatric disorders due to work-related burn injury compensated by the Industrial Accident Compensation Insurance operated by the Korea Workers' Compensation and Welfare Service (KCOMWEL). METHODS: Using the KCOMWEL electronic database, we collected data on psychiatric disorders due to work-related burn injury based on workers' compensation records from 2005 to 2014 and analyzed the characteristics of the claims...
February 1, 2019: Burns: Journal of the International Society for Burn Injuries
https://read.qxmd.com/read/30717245/metabolic-alterations-in-male-sterile-potato-as-compared-to-male-fertile
#20
Maria Shishova, Roman Puzanskiy, Olga Gavrilova, Shamuhommed Kurbanniazov, Kirill Demchenko, Vladislav Yemelyanov, Galina Pendinen, Alexey Shavarda, Tatjana Gavrilenko
The common potato, Solanum tuberosum L., is the fourth most important agricultural crop worldwide. Until recently, vegetative propagation by tubers has been the main method of potato cultivation. A shift of interest to sexual potato reproduction by true botanical seeds is due to the appearance of a new hybrid seed breeding strategy whose successful application for many crop species has been supported by male sterility. This investigation was focused on the study of differences in the metabolite profiles of anthers at the mature pollen stage from male-fertile and male-sterile genotypes of S...
February 1, 2019: Metabolites
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