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Colon cancer After therapy Liver biopsy

M Baretti, N Personeni, A Destro, A Santoro, L Rimassa
Tumors represent a dynamic system where the genomic plasticity permits to adapt to the perturbation induced by environmental pressures, supporting the importance of longitudinal tumor sampling strategies to deciphering the temporal acquisition of driver event that could impact treatment outcome. We describe the case of a metastatic colorectal cancer (mCRC) patient, RAS wild-type, who responded to anti-EGFR therapy and underwent liver surgery, revealing a KRAS mutations in the metastatic lesion, not detectable prior to initiation of therapy in the colonic biopsy...
August 3, 2018: Cancer Biology & Therapy
Deborah Repullo, Marie Diaz, Stéphane Holbrechts, Maria Gomez-Galdón, Dirk Van Gestel, Ali Bohlok, Gabriel Liberale, Vincent Donckier
BACKGROUND: The development of a second primary tumor is a potential late side effect of radiotherapy. Particularly, an increased risk of secondary cancers, mostly of digestive or breast origin, has been observed in patients treated with high-dose radiotherapy for Wilms tumor (WT) in childhood. However, hepatocellular carcinoma (HCC) has been very rarely described as a potentially radiotherapy-induced tumor. We describe the case of a patient with an aggressive HCC 50 years after the treatment of a WT...
March 7, 2018: World Journal of Surgical Oncology
Daniela Adua, Francesca Di Fabio, Giorgio Ercolani, Michelangelo Fiorentino, Elisa Gruppioni, Annalisa Altimari, Fabiola Lorena Rojas Limpe, Nicola Normanno, Antonio Daniele Pinna, Carmine Pinto
Molecular heterogeneity between primary tumors (PTs) and synchronous resected liver metastasis in colorectal cancer (CRC) has potential relevance in treatment strategies. Next-generation sequencing (NGS) may be able to increase the chances of identifying multiple molecular driver alterations, calling for therapy. The aim of the present study was to evaluate mutations in PT and synchronous resected liver metastases for patients with Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) exon 2 wild-type metastatic (m)CRC who underwent chemotherapy (CT) featuring an anti-epidermal growth factor receptor (EGFR) monoclonal antibody...
July 2017: Molecular and Clinical Oncology
Elias Nerad, Doenja M J Lambregts, Erik L J Kersten, Monique Maas, Frans C H Bakers, Harrie C M van den Bosch, Heike I Grabsch, Regina G H Beets-Tan, Max J Lahaye
BACKGROUND: Colon cancer is currently staged with CT. However, MRI is superior in the detection of colorectal liver metastasis, and MRI is standard in local staging of rectal cancer. Optimal (local) staging of colon cancer could become crucial in selecting patients for neoadjuvant treatment in the near future (Fluoropyrimidine Oxaliplatin and Targeted Receptor Preoperative Therapy trial). OBJECTIVE: The purpose of this study was to evaluate the diagnostic performance of MRI for local staging of colon cancer...
April 2017: Diseases of the Colon and Rectum
Toru Yoshikawa, Kazunori Aoki, Yuto Mitsuhashi, Satoko Tomiura, Akiko Suto, Takuya Miura, Shojirokazunori Ikenaga, Itaru Shibasaki, Masaaki Endo
A 61-year-old man was admitted to our hospital because of a complaint of blood in stool. He was diagnosed with advanced colon and gastric cancers. Computed tomography (CT) revealed a sigmoid tumor with invasion to the bladder, a metastatic tumor in the lateral segmental branch of the left hepatic lobe, and ascites. He was diagnosed with initially unresectable double cancer. Ileostomy was performed immediately, and he was treated with modified (m) FOLFOX6 regimen (oxaliplatin in combination with infusional 5-fluorouracil/Leucovorin)...
March 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Henrique Alexandrino, Domingos Oliveira, Maria Augusta Cipriano, Luís Ferreira, J Guilherme Tralhão, Francisco Castro E Sousa
BACKGROUND: Oxaliplatin based chemotherapy is often used as adjuvant therapy in colon and rectal cancer. A reported side effect is Sinusoidal Obstruction Syndrome which is characterized by a spectrum of pathologic changes, from sinusoidal dilation, peri-sinusoidal haemorrhage, peliosis and nodular regenerative hyperplasia. Very rarely it can cause the development of liver nodules mimicking liver metastases. Herein, we report a case of Sinusoidal Obstruction Syndrome causing a liver nodule suspicious of liver metastasis on imaging...
2015: BMC Cancer
Kenta Baba, Akihiko Oshita, Mohei Kohyama, Satoshi Inoue, Yuta Kuroo, Takuro Yamaguchi, Hiroyuki Nakamura, Yoichi Sugiyama, Tatsuya Tazaki, Masaru Sasaki, Yuji Imamura, Yutaka Daimaru, Hideki Ohdan, Atsushi Nakamitsu
A 72-year-old woman with a sigmoid colon cancer and a synchronous colorectal liver metastasis (CRLM), which involved the right hepatic vein (RHV) and the inferior vena cava (IVC), was referred to our hospital. The metastatic lesion was diagnosed as initially unresectable because of its invasion into the confluence of the RHV and IVC. After she had undergone laparoscopic sigmoidectomy for the original tumor, she consequently had 3 courses of modified 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus cetuximab...
February 14, 2015: World Journal of Gastroenterology: WJG
Yutaka Yagi, Toshiyuki Yamazaki, Akira Iwaya, Shoichi Manabe
A 40-year-old woman visited her primary care physician because she had pain in the upper right part of the abdomen. She was diagnosed with descending colon cancer with multiple liver metastases, and was referred to our department. After a laparoscopic abdominal colectomy for removal of the original lesion, chemotherapy was initiated with a modified combination of folinic acid, 5-fluorouracil, and oxaliplatin (mFOLFOX6) + panitumumab. After 12 courses of treatment with the mFOL FOX6 + panitumumab combination, followed by 13 courses of the simplified biweekly 5-fluorouracil and Leucovorin (sLV5FU2) + panitumumab combination, her liver tumors had regressed to about 90% of their original size...
January 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Anne Marie C Flaherty
A 65-year-old Polish immigrant named T. J. was diagnosed with metastatic colon cancer in January 2012 when he presented with obstructing sigmoid colon cancer and liver metastases. A diverting colostomy as well as biopsy of his liver metastases was performed and chemotherapy with FOLFOX (5-fluorouracil [5-FU], leucovorin, oxaliplatin) and bevacizumab was initiated. After three months, he transitioned to maintenance therapy with infusional 5-FU and bevacizumab until he progressed in August 2012. Oxaliplatin was reintroduced and he responded until he developed progressive neuropathy in November and his therapy was changed to FOLFIRI (5-FU, leucovorin, irinotecan) and bevacizumab...
January 2015: Oncology Nursing Forum
Kazuaki Harada, Kazuteru Hatanaka, Kenji Kinoshita, Yasuyuki Kawamoto, Hiroaki Yamato, Koji Ogawa, Yoshiya Yamamoto, Hirohito Naruse
The prognosis for patients diagnosed with advanced colorectal cancer with liver metastases is poor. Chemotherapy should be administered with caution in such patients because of complications due to severe liver dysfunction. We report here the successful management of a case of advanced sigmoid colon cancer, with icterus due to severe liver metastases, treated with cetuximab as first-line therapy. A 72-year-old man presented at our institution with complaints of severe general fatigue, tarry stools, and abdominal distention...
July 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
S Schwarz, M Suppan, W Höbling, A Grünberger, R Nömeyer, D Hubner, P Knoflach
After having received adjuvant FOLFOX treatment consisting of oxaliplatin, folinic acid and fluoruracil following hemicolectomy in colon cancer 7 years ago, the findings of non-cirrhotic portal hypertension presented by acute upper gastrointestinal bleeding in a 49-year old woman were interpreted as oxaliplatin-associated. Imaging techniques, hepatic venous pressure measurement and liver biopsy supported pre-sinusoidal damage due to NRH (nodular regenerative hyperplasia) as the underlying cause, even though histological findings were moderate...
July 2014: Zeitschrift Für Gastroenterologie
María Rojas-Feria, Manuel Castro, Emilio Suárez, Javier Ampuero, Manuel Romero-Gómez
Abnormal liver biochemical tests are present in up to 30% of patients with inflammatory bowel disease (IBD), and therefore become a diagnostic challenge. Liver and biliary tract diseases are common extraintestinal manifestations for both Crohn's disease and ulcerative colitis (UC), and typically do not correlate with intestinal activity. Primary sclerosing cholangitis (PSC) is the most common hepatobiliary manifestation of IBD, and is more prevalent in UC. Approximately 5% of patients with UC develop PSC, with the prevalence reaching up to 90%...
November 14, 2013: World Journal of Gastroenterology: WJG
Philipp Lingohr, Thomas Galetin, Hanno Matthaei, Eberhard Straub, Azin Jafari, Edwin Bölke, Jörg C Kalff, Karl-Heinz Vestweber
A 62 year-old patient with therapy-refractory pouchitis after proctocolectomy for ulcerative colitis was admitted with hematochezia and abdominal discomfort. A malignant melanoma (MM) was found after repeated biopsies of the pouch. Complete staging revealed no evidence for distant metastases and the patient underwent abdominoperineal pouch resection. Six weeks later, the patient was readmitted because of severe general deterioration and diffuse metastatic spread to the liver was found. The patient died of hepatorenal syndrome shortly thereafter...
2013: European Journal of Medical Research
Harold J Wanebo, Mark LeGolvan, Philip B Paty, Sukamal Saha, Markus Zuber, Michael I D'Angelica, Nancey E Kemeny
An overview of colorectal cancer discussed (Philip Paty) the good outcome after primary management with local control in 90-95 % of colon and 85 % in rectal cancer patients with major progression to metastases and to death related to hematogenous dissemination. The major disease pathways include the APC, aneuploid pathway involving mutations of P53, KRAS, SMAD 4, or the CMP/MSI pathway, mismatched repair defect as characterized by Lynch syndrome, the major hereditary form which may also have KRAS and P53 mutations...
October 2012: Clinical & Experimental Metastasis
Adam Charles Critchley, James Harvey, Michael Carr, Obi Iwuchukwu
Breast cancer is the most common malignancy in women and the main cause of cancer death in the UK. Gastrointestinal (GI) tract metastasis and carcinomatosis from primary breast cancer are rare but breast cancer is the second most common primary malignancy to metastasise to the GI tract after malignant melanoma. The metastatic patterns of invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) have been shown to differ considerably. Liver, lung and brain metastases are more common in IDC. Most series report a greater prediliction for lobular carcinoma to metastasise to the GI tract, gynaecological organs or peritoneum...
July 2011: Annals of the Royal College of Surgeons of England
Shoko Akiyama, Tomohito Niitani, Toshiaki Narasaka, Takashi Ohto, Makio Gamoh
We present the case of a 76-year-old woman with a poorly-differentiated neuroendocrine carcinoma (PDNEC) of the ascending colon with liver metastases responding to calboplatin (CBDCA)/etoposide (ETP). She was admitted to our hospital with bloody stools, and was diagnosed with ascending colon cancer and multiple liver tumors. Total colonoscopy showed a Type 2 tumor in the ascending colon, and histological findings revealed adenocarcinoma from biopsy specimens. Right hemicolectomy with lymph nodes dissection was performed...
July 2011: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Masako Ishikawa, Kentaro Nakayama, Mohammed Tanjimur Rahman, Munmun Rahman, Atsuko Katagiri, Kouji Iida, Khoji Miyazaki
Cerebralmetastases from primary cervical carcinomas are very rare with a repeated incidence of 0. 5-1. 2% in various studies. A 46-year-old woman was initially diagnosed and treated for FIGO clinical stage II a cervical carcinoma. She was two gravid, two para. When 40 years old, she had a right hemicolectomy and chemotherapy, due to colon cancer. Her mother also had colon cancer, cervical cancer, and stomach cancer. She had habitually smoked ten/day for 26 years. First, she went to the outpatient clinic, due to abnormal vaginal bleeding...
January 2011: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Yukihiko Tokunaga, Hirokazu Sasaki, Shigeki Matsueda, Toshihiko Kawasahi, Tohru Saito
BACKGROUNDS/AIMS: Laparoscopic hepatectomy may provid a less invasive treatment and diagnostic modality. To date, however, few reports have been published on a clinical usefulness of laproscopic hepatectomy using vessel sealer (VS) and soft-coagulation system (SC) for small hepatic tumors suspected of malignancy. METHODOLOGY: Case 1; A 58-year-old man presented with a small hepatic tumor, detected during a medical examination. Image sutdies including ultrasonography, magnetic resonance image and angiography suspected it as hepatocellular carcinoma (HCC), adenoma, angiomyolipoma, or focal nodular hyperplasia (FNH)...
November 2009: Hepato-gastroenterology
Takumi Miyahira, Natsuki Teruya, Fumiaki Matsuura, Shigemi Murayama, Hiroyuki Aka, Jun Teruya, Naoji Hanashiro, Minoru Nishihara, Norihiko Okushima, Yoshitaka Toda, Masaya Kiyuna
A 73-year-old man had undergone right hemicolectomy for advanced colon cancer in May 2006, and he concurrently had multiple liver metastases. After the operation, the patient was given chemotherapy with FOLFIRI. A partial response was achieved for twelve months, and then the liver tumors enlarged. Second-line chemotherapy with FOLFOX was delivered. After several months the liver tumors further enlarged and a new pulmonary lesion appeared with an increased serum CEA level. Therefore, chemotherapy with S-1 (120 mg/day) was started, with 2 weeks' administration followed by a one-week drug-free period...
February 2010: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Katsuyoshi Furumoto, Hidenobu Kojima, Haruo Takaya, Masayuki Okuno, Hiroaki Fuji, Rei Mizuno, Tomohiko Mori, Daisuke Ito, Masafumi Kogire
We report a resected case of ascending colon cancer with left supraclavicular and paraaortic lymph nodes and liver metastases which completely responded in terms of metastases but not the primary tumor to FOLFOX4 therapy. A 62-year-old woman with epigastric discomfort was initially diagnosed as malignant lymphoma by FDG-PET with abnormal accumulation at left supraclavicular and paraaortic lesions. Pathological examination of the supraclavicular lymph nodes showed undifferentiated adenocarcinoma, and ascending colon cancer was detected by colonoscopy which was a mixture of various types of differentiation...
February 2010: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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