keyword
https://read.qxmd.com/read/38535833/correlation-between-oxidative-stress-markers-and-periodontal-disease-in-dogs
#1
JOURNAL ARTICLE
Cosmin Petru Peștean, Hélène Pocquet, Daria Antonia Dumitraș, Andreea Georgiana Morohoschi, Laura Cristina Ștefănuț, Sanda Andrei
In dogs, periodontal disease (PD) is a highly common condition whose prevalence rises significantly with age. Studies on rats with experimentally induced PD and human clinical trials have found an association between oxidative stress (OS) and PD, as has been observed in many other inflammatory disorders. The objective of this research was to assess the main indicators of oxidative stress detected in the saliva of dogs and to compare them to the degree of inflammation and tartar amount on their teeth and gums...
February 22, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535817/red-orange-and-lemon-extract-ameliorates-the-renal-oxidative-stress-and-inflammation-induced-by-ochratoxin-a-through-the-modulation-of-nrf2
#2
JOURNAL ARTICLE
Consiglia Longobardi, Sara Damiano, Simona Fabroni, Serena Montagnaro, Valeria Russo, Emanuela Vaccaro, Antonio Giordano, Salvatore Florio, Roberto Ciarcia
BACKGROUND: The presence of ochratoxin A (OTA) in food and feed is a public health concern. OTA intoxication is caused by several mechanisms, one of which consists of the alteration of the antioxidant activity of the cell due to the oxidative stress (OS). In this context, the use of natural antioxidant substances could be a potential biological decontamination method of mitigating the negative outcomes induced by OTA. METHODS: we aimed to investigate how a red orange and lemon extract (RLE), rich in anthocyanins, would affect OTA-treated rats...
March 14, 2024: Toxins
https://read.qxmd.com/read/38535083/a-histological-evaluation-of-the-efficiency-of-using-periprosthetic-autologous-fat-to-prevent-capsular-contracture-compared-to-other-known-methods-an-experimental-study
#3
JOURNAL ARTICLE
Mihaela Pertea, Nadia Aladari, Oxana Madalina Grosu, Stefana Luca, Raluca Tatar, Andrei-Nicolae Avadanei, Madalina Palaghia, Ana Maria Trofin, Sorinel Lunca, Nina Filip
BACKGROUND: Capsular contracture remains a common complication in silicone breast implantation. The etiology, formation mechanisms, predisposing and favoring factors are still subjects of research. This study aims to demonstrate the effectiveness of using autologous fat introduced periprosthetically in preventing capsular contracture compared to other known methods: antibiotics and corticosteroids. METHODS: A cohort of 80 Wistar rats was included in the study, divided into four subgroups...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38534756/inflammation-factors-and-genistein-supplementation-in-cancer-preliminary-research
#4
JOURNAL ARTICLE
Karolina Banyś, Małgorzata Jelińska, Małgorzata Wrzosek, Dorota Skrajnowska, Robert Wrzesień, Wojciech Bielecki, Barbara Bobrowska-Korczak
The purpose of this study was to evaluate the effect of genistein in nano, micro, and macro forms on the intensity of the DMBA-induced tumor process in rats and to understand the mechanisms of this action. The effect of genistein supplementation on the content of selected eicosanoids (HETEs, HODE, and HEPE) in the serum of rats was evaluated. The levels and expression of genes encoding various pro-inflammatory cytokines (IL-1, IL-6) and MMP-9 in the blood of rats were also investigated. The biological material for the study was blood obtained from female rats of the Sprague Dawley strain (n = 32)...
March 7, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534436/morphofunctional-alteration-of-mesenteric-lymph-nodes-in-the-inflammation-of-the-abdominal-cavity
#5
JOURNAL ARTICLE
Serik N Abdreshov, Georgii A Demchenko, Anar N Yeshmukhanbet, Makpal A Yessenova, Sandugash A Mankibaeva, Gulshat K Atanbaeva, Marzhan S Kulbayeva
This paper provides data regarding the ratios of the functional structures of lymph nodes after inflammation in the abdominal organs. Lymph systems, including lymph nodes, function as filters of tissues and tissue fluids and are places of origin and lymphocyte production for normal physiological functions. They display specific morphological and functional responses in reaction to endogenous and exogenous substances. The morphological pattern of the mesenteric lymph node in experimental rat groups reflects a decrease in its immune function due to the processes of inflammation in the abdominal cavity...
March 4, 2024: Biology
https://read.qxmd.com/read/38534387/all-but-small-mirnas-from-wharton-s-jelly-mesenchymal-stromal-cell-small-extracellular-vesicles-rescue-premature-white-matter-injury-after-intranasal-administration
#6
JOURNAL ARTICLE
Vera Tscherrig, Marel Steinfort, Valérie Haesler, Daniel Surbek, Andreina Schoeberlein, Marianne Simone Joerger-Messerli
White matter injury (WMI) is a common neurological issue in premature-born neonates, often causing long-term disabilities. We recently demonstrated a key beneficial role of Wharton's jelly mesenchymal stromal cell-derived small extracellular vesicles (WJ-MSC-sEVs) microRNAs (miRNAs) in WMI-related processes in vitro. Here, we studied the functions of WJ-MSC-sEV miRNAs in vivo using a preclinical rat model of premature WMI. Premature WMI was induced in rat pups through inflammation and hypoxia-ischemia. Small EVs were purified from the culture supernatant of human WJ-MSCs...
March 19, 2024: Cells
https://read.qxmd.com/read/38533280/evaluation-of-effect-of-montelukast-in-the-model-of-streptozotocin-induced-diabetic-nephropathy-in-rats
#7
JOURNAL ARTICLE
Dhananjay Kokate, Padmaja Marathe
BACKGROUND: Diabetic nephropathy is a progressive condition and a leading cause of end-stage renal disease. Oxidative stress and inflammation play an important role in its pathogenesis. In pre-clinical studies, Montelukast had shown renoprotective and anti-oxidant properties, hence the study was planned to evaluate the effect of Montelukast in a Streptozotocin (STZ) induced model of diabetic nephropathy. METHODS: 40 Wistar rats of either sex were randomly divided into four groups viz ...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532711/infection-microenvironment-responsive-coating-on-titanium-surfaces-for-on-demand-release-of-therapeutic-gas-and-antibiotic
#8
JOURNAL ARTICLE
Kun Wang, Fan Rong, Haowei Peng, Zhang Yuan, Jingjing Huo, Pengxiang Liu, Rui Ding, Cuiping Yan, Guming Liu, Tengjiao Wang, Peng Li
Aseptic loosening and bacterial infection pose significant challenges in the clinical application of titanium (Ti) orthopedic implants, which are primarily caused by insufficient osseointegration and bacterial contamination. To address these issues, we constructed a responsive coating on Ti surface, which achieved enhanced osseointegration and infection elimination by on-demand release of therapeutic gas hydrogen sulfide (H2 S) and antibiotic. TiO2 nanotubes (TNT) were anodized on the Ti surface to enhance its bioactivity and serve as reservoirs for the antibiotic...
March 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38532054/atp-releasing-channels-and-the-ameliorative-effects-of-high-intensity-interval-training-on-diabetic-heart-a-multifaceted-analysis
#9
JOURNAL ARTICLE
Siyavash Joukar, Mohammad Amin Rajizadeh, Mohammad Abbas Bejeshk, Samaneh Sadat Alavi, Fatemeh Bagheri, Mohammad Rami, Kayvan Khoramipour
Type 2 diabetes (T2D) can cause severe cardiac complications at functional, histologic and molecular levels. These pathological complications could be mediated by ATP-releasing channels such as Panx1 and ATP receptors, in particular P2X7. The aim of our study was to investigate the effect of high-intensity interval training (HIIT) on T2D-induced cardiac complications at the functional, histopathological and molecular levels, with a particular focus on ATP-releasing channels. 48 male Wistar rats at the age of 8 weeks were randomly allocated into four groups: control (Con), Diabetes (T2D), Training (TR), and Diabetes + Training (T2D + TR)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531959/longitudinal-long-term-follow-up-investigation-on-the-carcinogenic-impact-of-polyhexamethylene-guanidine-phosphate-in-rat-models
#10
JOURNAL ARTICLE
Sang Hoon Jeong, Hong Lee, Yoon Jeong Nam, Ja Young Kang, Hyejin Lee, Jin Young Choi, Yu-Seon Lee, Jaeyoung Kim, Yoon Hee Park, Su A Park, Hangseok Choi, Eun-Kee Park, Yong-Wook Baek, Jungyun Lim, Suejin Kim, Cherry Kim, Ju-Han Lee
Polyhexamethylene guanidine phosphate (PHMG-p) is a major component in humidifier disinfectants, which cause life-threatening lung injuries. However, to our knowledge, no published studies have investigated associations between PHMG-p dose and lung damage severity with long-term follow-up. Therefore, we evaluated longitudinal dose-dependent changes in lung injuries using repeated chest computed tomography (CT). Rats were exposed to low (0.2 mg/kg, n = 10), intermediate (1.0 mg/kg, n = 10), and high (5...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531791/melatonin-s-protective-effects-on-neurons-in-an-in-vitro-cell-injury-model
#11
JOURNAL ARTICLE
Wei Gu, Mimi Wu, Shihe Cui, Jinhua Bo, Hao Wu
BACKGROUND: Currently, the role of melatonin (MT) in neuronal damage remains unclear and this study aimed to explore the protective effects of MT on neurons in an in vitro cell injury model. METHODS: The Sprague Dawley (SD) rat traumatic brain injury (TBI) model was prepared, and brain tissue extract (BTE) from the injured area were generated. To establish a cell injury model in vitro , the BTE was added to the culture medium during the neuron culture process. MT was introduced into the culture medium of the cell injury model to observe its protective effects on neurons...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531619/the-investigation-of-the-molecular-changes-during-lipopolysaccharide-induced-systemic-inflammation-on-rat-hippocampus-by-using-ftir-spectroscopy
#12
JOURNAL ARTICLE
Gulgun Cakmak-Arslan, Yildiray Kaya, Soner Mamuk, Eyup Sabri Akarsu, Feride Severcan
The aim of this study is to reveal the molecular changes accompanying the neuronal hyper-excitability during lipopolysaccharide (LPS)-induced systemic inflammation on rat hippocampus using Fourier transform infrared (FTIR) spectroscopy. For this aim, the body temperature of Wistar albino rats administered LPS or saline was recorded by radiotelemetry. The animals were decapitated when their body temperature began to decrease by 0.5°C after LPS treatment and the hippocampi of them were examined by FTIR spectroscopy...
March 26, 2024: Journal of Biophotonics
https://read.qxmd.com/read/38531522/chitosan-thermogelation-and-cascade-mineralization-via-sequential-caco-3-incorporations-for-wound-care
#13
JOURNAL ARTICLE
Chengkun Liu, Menghan Li, Zhiyuan Liu, Zhuang Shi, Xiaoqiang Wang, Fang Huang
Physically crosslinked hydrogels have shown great potential as excellent and eco-friendly matrices for wound management. Herein, we demonstrate the development of a thermosensitive chitosan hydrogel system using CaCO3 as a gelling agent, followed by CaCO3 mineralization to fine-tune its properties. The chitosan hydrogel effectively gelled at 37 °C and above after an incubation period of at least 2 h, facilitated by the CaCO3 -mediated slow deprotonation of primary amine groups on chitosan polymers...
March 24, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38531501/effects-of-moderate-ethanol-exposure-on-risk-factors-for-cardiovascular-disease-and-colorectal-cancer-in-adult-wistar-rats
#14
JOURNAL ARTICLE
Anna J Kwon, Lani Morales, Louise Chatagnier, Jacqueline Quigley, Jeremy Pascua, Natalie Pinkowski, Susan M Brasser, Mee Young Hong
While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of CVDs and CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned to either an ethanol group, which consisted of voluntary access to a 20% (v/v) ethanol solution on alternate days, or a water control group (n = 12/group) for 13 weeks...
March 24, 2024: Alcohol
https://read.qxmd.com/read/38530976/exosomes-derived-from-caerulein-stimulated-pancreatic-acinar-cells-mediate-peritoneal-macrophage-m1-polarization-and-pyroptosis-via-an-mir-24-3p-march3-nlrp3-axis-in-acute-pancreatitis
#15
JOURNAL ARTICLE
Xiao-Ju Su, Yan Chen, Qi-Chen Zhang, Xiao-Bo Peng, Ya-Ping Liu, Lei Wang, Yi-Qi Du
OBJECTIVES: Acute pancreatitis (AP) has a high incidence of hospitalizations, morbidity, and mortality worldwide. A growing number of studies on AP pathogenesis are based on caerulein-induced experimental model, which simulates human AP in vivo. It has been demonstrated that both pancreatic acinar cells and peritoneal macrophages are involved in pancreatic inflammation and damage. However, their connection has not been well understood. METHODS: A caerulein-induced AP model was established on the pancreatic acinar cell line AR42J...
March 27, 2024: Pancreas
https://read.qxmd.com/read/38530594/prdx6-alleviated-heart-failure-by-inhibiting-doxorubicin-induced-ferroptosis-through-the-jak2-stat1-pathway-inactivation
#16
JOURNAL ARTICLE
Jie Xiong, Rong Zhou, Xu Deng
Peroxiredoxin 6 (PRDX6) is a protective biomarker associated with ferroptosis in heart failure (HF). This study investigated the specific mechanism of PRDX6 on doxorubicin (DOX)-induced ferroptosis in HF. Wistar rats and H9c2 cells were induced by DOX to construct HF models. Pathological changes and collagen deposition in myocardium were investigated using HE and Masson staining. PRDX6 levels, indexes of ferroptosis, and JAK2/STAT1 pathway were detected by qRT-PCR, Western blot, and biochemical kits. DOX promoted heart weight/body weight, increased inflammation and collagen deposition, increased PTGS2 and MDA levels, and decreased SLC7A11, GPX4, FTH1, and PRDX6 levels in myocardium...
March 26, 2024: In Vitro Cellular & Developmental Biology. Animal
https://read.qxmd.com/read/38530591/glutamine-mediated-modulation-of-xo-uric-acid-nf-kb-signaling-pathway-ameliorates-intestinal-i-r-induced-bacterial-translocation-and-cardiorenal-inflammatory-injury
#17
JOURNAL ARTICLE
Moses Agbomhere Hamed, Oyedele Oladipo Adegboyega, Olalekan Isreal Ojo, Tunmise Maryanne Akhigbe, Folakemi Dorcas Fajuyitan, Omolade Christianah Adeyemo, Tomisin Folashade Odebunmi, Oluwapelumi Sarah Adeniyi, Isaac Ayomide Omole, Roland Eghoghosoa Akhigbe
This study explored the effect of intestinal ischaemia/reperfusion (I/R) on cardiorenal tissues. The involvement of xanthine oxidase/uric acid/NF-kB signaling in intestinal I/R was also investigated. In addition, the possible protective effect of glutamine was also evaluated. Twenty-four male Wistar rats were acclimatized and then randomly assigned to four groups (n = 6); sham-operated, glutamine-treated rats (GLUT), I/R, and I/R + GLUT. The sham-operated rats were sham-operated and received 0.5 mL of distilled water, GLUT rats were sham-operated and had 1 g/kg b...
March 26, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38530304/independent-and-combined-effects-of-obesity-and-traumatic-joint-injury-to-the-structure-and-composition-of-rat-knee-cartilage
#18
JOURNAL ARTICLE
Kalle Karjalainen, Petri Tanska, Kelsey H Collins, Walter Herzog, Rami K Korhonen, Eng Kuan Moo
Osteoarthritis (OA) is a multifactorial joint disease characterized by articular cartilage degradation. Risk factors for OA include joint trauma, obesity, and inflammation, each of which can affect joint health independently, but their interaction and the associated consequences of such interaction were largely unexplored. Here, we studied compositional and structural alterations in knee joint cartilages of Sprague-Dawley rats exposed to two OA risk factors: joint injury and diet-induced obesity. Joint injury was imposed by surgical transection of anterior cruciate ligaments (ACLx), and obesity was induced by a high fat/high sucrose diet...
March 26, 2024: Connective Tissue Research
https://read.qxmd.com/read/38529844/a-whole-course-repair-system-based-on-ros-glucose-stimuli-responsive-egcg-release-and-tunable-mechanical-property-for-efficient-treatment-of-chronic-periodontitis-in-diabetic-rats
#19
JOURNAL ARTICLE
Qingchen Feng, Mei Zhang, Guanning Zhang, Hongxiang Mei, Chongying Su, Lisa Liu, Xiaoxia Wang, Ziqianhong Wan, Zhengyi Xu, Liangkui Hu, Yu Nie, Juan Li
Elevated glucose levels, multiple pro-inflammatory cytokines and the generation of excessive reactive oxygen species (ROS) are pivotal characteristics within the microenvironments of chronic periodontitis with diabetes mellitus (CPDM). Control of inflammation and modulation of immune system are required in the initial phase of CPDM treatment, while late severe periodontitis requires a suitable scaffold to promote osteogenesis, rebuild periodontal tissue and reduce alveolar bone resorption. Herein, a whole-course-repair system is introduced by an injectable hydrogel using phenylboronic acid functionalized oxidized sodium alginate (OSA-PBA) and carboxymethyl chitosan (CMC)...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38529842/emulsion-template-fabricated-heterogeneous-bilayer-gelatin-based-scaffolds-with-sustained-delivery-of-lycium-barbarum-glycopeptide-for-periodontitis-treatment
#20
JOURNAL ARTICLE
Siqi He, Nan Wen, Xun Chen, Cong Liu, Xun Xiao, Xinlun Li, Lun Yuan, Yandong Mu
Periodontitis is a chronic inflammatory disease raising the risks of tooth-supporting structures destruction and even tooth loss. The way to reconstruct periodontal bone tissues in inflammatory microenvironment has been long in demand for periodontitis treatment. In this study, the lycium barbarum glycopeptide (LbGP) loaded gelatin-based scaffolds were fabricated for periodontitis treatment. Gelatin microspheres with suitable size were prepared by emulsification and gathered by oxidized sodium alginate to prepare heterogeneous bilayer gelatin-based scaffolds, and then they were loaded with LbGP...
March 26, 2024: Journal of Biomaterials Science. Polymer Edition
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