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Infection anxiety

Gianluca Franceschini, Alba Di Leone, Daniela Terribile, Martin Alessandro Sanchez, Riccardo Masetti
Aim of this paper is to allows to analyze a topic of great relevance and media interest such as the role of prophylactic mastectomy in healthy women with BRCA mutation proposing to the surgeons some useful informations for decision-making. Less than 15% of all breast cancers are associated with germline genetic mutations. The majority of hereditary breast tumors are due to mutations in BRCA1 and BRCA2 genes that are responsible for only one third of hereditary cases. The risk estimates are extremely heterogeneous with a mean cumulative lifetime breast cancer risk of approximately 72% in BRCA1 and 69% in BRCA2 by age 80...
2019: Annali Italiani di Chirurgia
Pauline Bosco-Lévy, Amandine Gouverneur, Claire Langlade, Ghada Miremont, Antoine Pariente
OBJECTIVE: To compare the risk of all-cause death, hospitalizations (any cause), ectopic pregnancy, pelvic inflammatory disease or infection, uterine perforation, device removal, neuro-psychiatric drugs initiation, or new psychiatric visit(s) between levonorgestrel (LNG) 52mg intrauterine system (IUS) and copper intrauterine device (IUD) users in France. STUDY DESIGN: We identified a historical cohort of women aged 20-55years with a first dispensing of either LNG 52mg IUS or copper-IUD between January 1, 2010 and December 31, 2014, in the French National Claims database, SNDS...
March 11, 2019: Contraception
Lek Dysoley, Saorin Kim, Sergio Lopes, Nimol Khim, Steven Bjorges, Samphornarann Top, Chea Huch, Huy Rekol, Nelli Westercamp, Mark M Fukuda, Jimee Hwang, Arantxa Roca-Feltrer, Mavuto Mukaka, Didier Menard, Walter R Taylor
BACKGROUND: The WHO recommends single low-dose primaquine (SLDPQ, 0.25 mg/kg body weight) in falciparum-infected patients to block malaria transmission and contribute to eliminating multidrug resistant Plasmodium falciparum from the Greater Mekong Sub region (GMS). However, the anxiety regarding PQ-induced acute haemolytic anaemia in glucose-6-phosphate dehydrogenase deficiency (G6PDd) has hindered its use. Therefore, we assessed the tolerability of SLDPQ in Cambodia to inform national policy...
March 12, 2019: BMC Infectious Diseases
Alexandra C Battersby, Helen Braggins, Mark S Pearce, Fiona McKendrick, Mari Campbell, Siobhan Burns, Catherine M Cale, David Goldblatt, Andrew R Gennery
X-linked chronic granulomatous disease (XL-CGD), a rare primary immunodeficiency due to a defect in the gp91phox NADPH oxidase subunit, results in recurrent, severe infection, inflammation, and autoimmunity. Patients have an absent, or significantly reduced, neutrophil oxidative burst. Due to lyonization, XL-CGD carriers have a dual population of functional and non-functional phagocytes and experience a range of symptoms including increased risk of autoimmunity, fatigue, and infection. Patients with CGD have poorer quality of life (QoL) than normal controls...
March 13, 2019: Journal of Clinical Immunology
Hsin-Chung Lin, Kuo-Yang Huang, Chi-Hsiang Chung, Hsin-An Lin, Rei-Min Chen, Chang-Huei Tsao, Wu-Chien Chien, Tzong-Shi Chiueh
BACKGROUND: Trichomonas vaginalis is a protozoan parasite that causes trichomoniasis and annually infects approximately 276 million people worldwide. We observed an ambiguously higher probability of trichomoniasis in patients from the psychiatric department of Tri-Service General Hospital. Herein, we aimed to investigate the association between trichomoniasis and the risk of developing psychiatric disorders. METHODS: The nationwide population-based study utilized the database of the National Health Insurance (NHI) programme in Taiwan...
March 12, 2019: Parasites & Vectors
Mallory O Johnson, Torsten B Neilands, Kimberly A Koester, Troy Wood, John A Sauceda, Samantha E Dilworth, Michael J Mugavero, Heidi M Crane, Rob J Fredericksen, Kenneth H Mayer, William Christopher Mathews, Richard D Moore, Sonia Napravnik, Katerina A Christopoulos
BACKGROUND: Engagement in care is critical to achieving and sustaining optimal benefits of efficacious antiretroviral therapies (ART) for HIV infection. Current metrics of engagement in care, including problematic patterns of retention in care, adherence to treatment, and viral suppression, are often detected late in the disengagement process. We sought to develop and validate a patient-centered screener of engagement in care that can be used to identify deficits in patient perceptions of engagement prior to the development of poor outcomes, including loss to follow-up, treatment nonadherence, virologic failure, and the resulting increased likelihood of HIV-associated morbidity and mortality and onward transmission of HIV...
February 20, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Ramazan Mercan, Sibel Mercan, Birsen Durmaz, Haydar Sur, Can Misel Kilciksiz, Anil Safak Kacar, Zuhal Apaydin, Cem Ayhan, Baris Ata
Human papilloma virus infection (HPV) is the most common sexually transmitted disease. It may increase the risk of several cancers, including those of the cervix, vulva, vagina, head and neck. HPV is usually transmitted during sexual intercourse; there are limited data about sexual dysfunction (SD) after infection with this virus. We aimed to measure the incidence of SD in women with HPV. In this study, we evaluated 67 HPV-infected female patients and 66 healthy controls. The Arizona Sexual Experience Scale (ASEX), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Socio Demographic Form were used for evaluation...
March 11, 2019: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Kathleen Kate Zink, Barbara Chini, Joyce Cowens, Lois Kremer, Li Lin
Background: Cystic Fibrosis (CF) is an autosomal recessive disorder of exocrine glands characterized by abnormal production of thick mucus, primarily in bronchi of the lungs. Individuals experience recurrent respiratory infections, increased work of breathing, cough and musculoskeletal changes with pain. Previous research found that massage therapy (MT) decreased pain, muscle tightness, and anxiety in individuals with CF, but did not use valid/reliable measurements of quality of life (QOL)...
March 2019: International Journal of Therapeutic Massage & Bodywork
Stefan Bushuven, Andreas Dietz, Stefanie Bushuven, Markus Dettenkofer, Thorsten Langer
BACKGROUND: Hospital-acquired infections caused by multidrug-resistant organisms (MDROs) are a threat to patient safety and hospital economy. Training in hygiene precautions is known to limit MDRO spread and patient morbidity. As infection prevention is a collaborative task, we developed an interprofessional educational intervention, including a reflective unit about MDRO. This article reports on the perceptions of professionals for MDRO management. METHODS: In 2017, we conducted 8 trainings, including facilitated group discussions focusing on the question how participants think others experience MDRO...
March 5, 2019: American Journal of Infection Control
Santiago Mora, Elena Martín-González, Pilar Flores, Margarita Moreno
In recent years, clinical studies have shown strong epidemiological evidence of an increased risk of developing neuropsychiatric disorders after childhood exposure to streptococcal infection, including the Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection (PANDAS). New preclinical studies on Group A streptococcus (GAS) exposure investigate how to disentangle the influences of immune activation to induce long-term neurobehavioral effects associated with neuropsychiatric disorders such as obsessive-compulsive disorder, schizophrenia or autism...
February 25, 2019: Brain, Behavior, and Immunity
Kyle D Webster, Miko M de Bruyn, Sarah K Zalwango, Alla Sikorski, Jennifer L Barkin, Itziar Familiar-Lopez, Philippa Musoke, Bruno Giordani, Michael J Boivin, Amara E Ezeamama
OBJECTIVE: Caregiver socio-emotional attributes are major determinants of child-wellbeing. This investigation in vulnerable school-aged Ugandan children estimates relationships between children's wellbeing and their caregiver's anxiety, depression and social-support. METHODS: Perinatally HIV-infected, HIV-exposed uninfected, and HIV-unexposed Ugandan children and their caregivers were enrolled. Perinatal HIV status was determined by 18 months of age using DNA-polymerase chain-reaction test; status was confirmed via HIV rapid diagnostic test when children were 6-18 years old...
February 27, 2019: Tropical Medicine & International Health: TM & IH
William D Kernan
Dental education is a challenging experience that places significant demands on students' intellectual, financial, and psychosocial well-being. Dental students who simultaneously experience physical illness, emotional upset, or interpersonal difficulty may be at greater risk of experiencing negative academic consequences. It is well documented that stress affects student learning, however, the impact of other health concerns on academic success is less understood. The purpose of this manuscript is to document the prevalence and perceived academic impact of 24 health concerns on the academic performance of a sample of 130 undergraduate dental students as measured by the National College Health Assessment (NCHA)...
January 2019: Journal of Prevention & Intervention in the Community
Lily Chu, Ian J Valencia, Donn W Garvert, Jose G Montoya
Background: Epidemiologic studies of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) have examined different aspects of this disease separately but few have explored them together. Objective: Describe ME/CFS onset and course in one United States-based cohort. Methods: One hundred and fifty subjects fitting Fukuda 1994 CFS criteria completed a detailed survey concerning the initial and subsequent stages of their illness. Descriptive statistics, graphs, and tables were used to illustrate prevalence and patterns of characteristics...
2019: Frontiers in Pediatrics
Cedric Yves Barrey, Jean-Charles Le Huec
BACKGROUND: The objectives of this study were to define the role for surgery in the treatment of chronic low back pain (cLBP) and to develop a new classification of cLBP based on the pattern of injury. HYPOTHESIS: Surgery may benefit patients with cLBP, and a new classification based on the injury pattern may be of interest. METHOD: A systematic literature review was performed by searching Medline, the Cochrane Library, the French public health database (Banque de Données en Santé Publique), Science Direct, and the National Guideline Clearinghouse...
February 18, 2019: Orthopaedics & Traumatology, Surgery & Research: OTSR
Cara Exten Rice, Sara A Vasilenko, Jessica N Fish, Stephanie T Lanza
PURPOSE: Sexual minorities experience significant health disparities across a variety of mental, behavioral, and physical health indicators. Yet, an understanding of the etiology and progression of sexual minority health disparities across the lifespan is limited. METHODS: We used the U.S. National Epidemiologic Survey of Alcohol and Related Conditions III to evaluate the association between sexual minority status and seven past-year health outcomes (alcohol use disorder, tobacco use disorder, drug use disorder, major depressive episode, generalized anxiety disorder, sexually transmitted infection, and cardiovascular conditions)...
January 8, 2019: Annals of Epidemiology
Eugene Kinyanda, Tatiana T Salisbury, Jonathan Levin, Noeline Nakasujja, Richard S Mpango, Catherine Abbo, Soraya Seedat, Ricardo Araya, Seggane Musisi, Kenneth D Gadow, Vikram Patel
PURPOSE: To describe the rates, types and comorbidity of emotional and behavioural disorders among perinatally HIV-infected children and adolescents attending care at five HIV youth clinics in Central and Southwestern Uganda. METHODS: 1339 CA-HIV attending care at HIV youth clinics in Uganda were interviewed using the DSM-5-based Child and Adolescent Symptom Inventory-5 (CASI-5; caregiver reported) and the Youth Inventory-4R (YI-4R; youth reported). Prevalence, risk factors and comorbidity for psychiatric disorders were estimated using logistic regression models...
February 20, 2019: Social Psychiatry and Psychiatric Epidemiology
Adam Gleason, Kristen Bishop, Yin Xi, David T Fetzer
OBJECTIVE: Unilateral left varicoceles are common and considered benign. Unilateral right varicoceles are reportedly associated with a pathologic process, namely malignancy affecting the retroperitoneum, for which further imaging is often recommended. The purpose of this study was to test the hypothesis that this correlation between unilateral right varicocele and malignancy may be weaker than once suggested, particularly in the absence of other clinical signs of malignancy. MATERIALS AND METHODS: Medical charts and imaging at one institution were reviewed for all patients reported to have right varicocele...
February 19, 2019: AJR. American Journal of Roentgenology
Cecilie Bay-Richter, Eskild Petersen, Nico Liebenberg, Betina Elfving, Gregers Wegener
Toxoplasma gondii (TOX) is an intracellular parasite which infects warm-blooded animals including humans. An increasing number of clinical studies now hypothesize that latent toxoplasmosis may be a risk factor for the development of psychiatric disease. For depression, the results have been varied and we speculate that genetic background is important for the response to latent toxoplasmosis. The main objective of this study was to elucidate gene - environment interactions in the behavioural response to TOX infection by use of genetically vulnerable animals (Flinders sensitive line, FSL) compared to control animals (Flinders resistant line, FRL)...
February 12, 2019: Behavioural Brain Research
Paul K Drain, Ting Hong, Anjum Hajat, Meighan Krows, Sabina Govere, Hilary Thulare, Mahomed Yunus S Moosa, Ingrid Bassett, Connie Celum
BACKGROUND: Guidelines recommend integrating hypertension screening for HIV-infected adults, but blood pressure measurements may be dynamic around the time of HIV testing. METHODS: We measured a seated resting blood pressure in adults (≥18 years) prior to HIV testing, and again after receiving HIV test results, in an ambulatory HIV clinic in KwaZulu-Natal, South Africa. We assessed sociodemographics, smoking, body mass index, diabetes, substance abuse, and anxiety/depression...
2019: PloS One
John S Lambert, Ross Murtagh, Dee Menezes, Austin O'Carroll, Carol Murphy, Walter Cullen, Tina McHugh, Gordana Avramovic, Willard Tinago, Marie Claire Van Hout
BACKGROUND: Hepatitis C virus (HCV) is one of the main causes of chronic liver disease worldwide. Prevalence of HCV in homeless populations ranges from 3.9 to 36.2%. The HepCheck study sought to investigate and establish the characterisation of HCV burden among individuals who attended an intensified screening programme for HCV in homeless services in Dublin, Ireland. METHODS: The HepCheck study was conducted as part of a larger European wide initiative called HepCare Europe...
February 7, 2019: BMC Infectious Diseases
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