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https://read.qxmd.com/read/30775800/long-noncoding-rna-dino-damage-induced-noncoding-represses-the-development-of-gastric-cancer-by-modulating-p21-and-bcl-2-associated-x-protein-bax-expression
#1
Qinqiang Liu, Yan Xiao, Peng Cai, Jun Li, Dawei Li
lncRNAs are responsible for a variety of diseases, including gastric cancer (GC). Many recent studies have reported that lncRNAs can serve as crucial regulators of various genes. Nevertheless, the biological function of lncRNA damage induced noncoding (DINO) remained poorly investigated in GC. Therefore, in our present study, the detailed role of DINO was investigated. It was manifested that DINO was significantly downregulated in GC tissues. Then, DINO was modulated by infecting LV-DINO or by LV-shRNA in BGC-823 and MGC-803 cells...
February 18, 2019: Journal of Cellular Biochemistry
https://read.qxmd.com/read/30775005/path-analyses-of-risk-factors-for-linear-growth-faltering-in-four-prospective-cohorts-of-young-children-in-ghana-malawi-and-burkina-faso
#2
Elizabeth L Prado, Elizabeth Yakes Jimenez, Stephen Vosti, Robert Stewart, Christine P Stewart, Jérôme Somé, Anna Pulakka, Jean Bosco Ouédraogo, Harriet Okronipa, Eugenia Ocansey, Brietta Oaks, Kenneth Maleta, Anna Lartey, Emma Kortekangas, Sonja Y Hess, Kenneth Brown, Jaden Bendabenda, Ulla Ashorn, Per Ashorn, Mary Arimond, Seth Adu-Afarwuah, Souheila Abbeddou, Kathryn Dewey
Stunting prevalence is an indicator of a country's progress towards United Nations' Sustainable Development Goal 2, which is to end hunger and achieve improved nutrition. Accelerating progress towards reducing stunting requires a deeper understanding of the factors that contribute to linear growth faltering. We conducted path analyses of factors associated with 18-month length-for-age z-score (LAZ) in four prospective cohorts of children who participated in trials conducted as part of the International Lipid-Based Nutrient Supplements Project in Ghana (n=1039), Malawi (n=684 and 1504) and Burkina Faso (n=2619)...
2019: BMJ Global Health
https://read.qxmd.com/read/30768994/latent-toxoplasmosis-aggravates-anxiety-and-depressive-like-behaviour-and-suggest-a-role-of-gene-environment-interactions-in-the-behavioural-response-to-the-parasite
#3
Cecilie Bay-Richter, Eskild Petersen, Nico Liebenberg, Betina Elfving, Gregers Wegener
Toxoplasma gondii (TOX) is an intracellular parasite which infects warm-blooded animals including humans. An increasing number of clinical studies now hypothesize that latent toxoplasmosis may be a risk factor for the development of psychiatric disease. For depression, the results have been varied and we speculate that genetic background is important for the response to latent toxoplasmosis. The main objective of this study was to elucidate gene - environment interactions in the behavioural response to TOX infection by use of genetically vulnerable animals (Flinders sensitive line, FSL) compared to control animals (Flinders resistant line, FRL)...
February 12, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30768487/insomnia-as-an-independent-predictor-of-incident-cardiovascular-disease-in-hiv-data-from-the-veterans-aging-cohort-study
#4
Brittanny M Polanka, Suman Kundu, Kaku A So-Armah, Matthew S Freiberg, Samir K Gupta, Roger J Bedimo, Matthew J Budoff, Adeel A Butt, Chung-Chou H Chang, Stephen S Gottlieb, Vincent C Marconi, Julie A Womack, Jesse C Stewart
BACKGROUND: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown. METHODS: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, "Difficulty falling or staying asleep?" (5-point scale from no difficulty to bothers a lot). Incident CVD event ICD-9 codes (acute myocardial infarction, stroke, or coronary artery revascularization) were identified with VA and Medicare administrative data and VA fee-for-service data...
February 7, 2019: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/30767224/investigation-of-the-utility-of-curcuma-caesia-in-the-treatment-of-diabetic-neuropathy
#5
REVIEW
Madhuri Grover, Karan Shah, Gaurav Khullar, Jyoti Gupta, Tapan Behl
OBJECTIVES: Curcuma caesia has shown positive results in treating number of diseases, but till date no work was reported on its activity in diabetic neuropathy. So, the present review aims at exploring several hypothesis which can be proposed to explain further its utility in diabetic neuropathy by its antioxidant property, anti-inflammatory, CNS depressant effect, antibacterial and antifungal property. For finding the accurate and exact detail, a thorough review of all the available research and review article was done...
February 14, 2019: Journal of Pharmacy and Pharmacology
https://read.qxmd.com/read/30763800/t-lymphocytes-response-persists-following-plasmodium-berghei-strain-anka-infection-resolution-and-may-contribute-to-later-experimental-cerebral-malaria-outcomes
#6
Aline Silva de Miranda, Rodrigo Novaes Ferreira, Érica Leandro Marciano Vieira, Larissa Katharina Sabino Abreu, Fátima Brant, Luciene Bruno Vieira, Fabíola Mara Ribeiro, Fabiana Simão Machado, Milene Alvarenga Rachid, Antônio Lúcio Teixeira
Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade of glutamate NMDA receptors by its noncompetitive antagonist MK801 modulates cytokine and neurotrophic factors expression preventing cognitive and depressive-like behavior in experimental CM. Herein, we aim to investigate the role of T lymphocytes in later outcomes in CM, and whether the protective role of MK801 is associated with T lymphocytes response...
February 7, 2019: Journal of Neuroimmunology
https://read.qxmd.com/read/30760220/cognitive-screening-in-treatment-na%C3%A3-ve-hiv-infected-individuals-in-hong-kong-a-single-center-study
#7
Fiona C C Chan, Phillip Chan, Iris Chan, Andrew Chan, Tommy H C Tang, Wilson Lam, W C Fong, M P Lee, Patrick Li, Germaine H F Chan
BACKGROUND: HIV-associated neurocognitive disorder (HAND) remains prevalent in the era of combination antiretroviral therapy (cART). The prevalence of HAND in Hong Kong is not known. METHODS: Between 2013 and 2015, 98 treatment-naïve HIV-1-infected individuals were referred to and screened by the AIDS Clinical Service, Queen Elizabeth Hospital with (1) the International HIV Dementia Scale (IHDS), a screening tool that targets moderate to severe HAND, (2) the Montreal Cognitive Assessment (MoCA), a frequently used cognitive screening test and (3) the Patient Health Questionnare-9 (PHQ-9), a 9-item questionnaire that evaluates depression symptoms...
February 13, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30758812/sex-differences-in-neurocognitive-screening-among-adults-living-with-hiv-in-china
#8
Xiaotong Qiao, Haijiang Lin, Xiaoxiao Chen, Chenxi Ning, Keran Wang, Weiwei Shen, Xiaohui Xu, Xiaoyi Xu, Xing Liu, Na He, Yingying Ding
HIV-infected (HIV+) women may be more vulnerable to neurocognitive impairment (NCI) due to psychological and physiological factors but previous studies show mixed findings. We investigated the neurocognitive performances in HIV+ versus HIV- women and men. This cross-sectional analysis included 669 HIV+ patients (223 women) and 1338 HIV-uninfected (HIV-) controls (446 women) which were frequency matched on sex, education, and 5-year age categories. NCI was screened using the Mini-mental State Examination. Psychomotor speed was assessed using timed alternating hand sequence test...
February 13, 2019: Journal of Neurovirology
https://read.qxmd.com/read/30747596/association-between-periprocedural-neutropenia-and-early-infection-related-chest-port-removal
#9
Andrew W Perez, Jennifer M Watchmaker, Daniel B Brown, Filip Banovac
Background Patients who require long-term central venous access can present for port placement with depressed immune function as a result of their treatment or disease process. At present, there is no consensus regarding whether neutropenia at the time of port placement confers a higher risk for early infection-related port removal. Purpose To compare the incidence of early infection-related chest port removal in adults when placed in neutropenic versus nonneutropenic patient groups. Materials and Methods This retrospective cohort study examined 2580 port placements in 1081 men (41...
February 12, 2019: Radiology
https://read.qxmd.com/read/30745174/association-between-clinician-specialization-in-nursing-home-care-and-nursing-home-clinical-quality-scores
#10
Kira L Ryskina, Christine Lam, Hye-Young Jung
IMPORTANCE: While the number of prescribing clinicians (physicians and nurse practitioners) who provide any nursing home care remained stable over the past decade, the number of clinicians who focus their practice exclusively on nursing home care has increased by over 30%. OBJECTIVES: To measure the association between regional trends in clinician specialization in nursing home care and nursing home quality. DESIGN: Retrospective cross-sectional study...
February 7, 2019: Journal of the American Medical Directors Association
https://read.qxmd.com/read/30741374/dissociable-contributions-of-precuneus-and-cerebellum-to-subjective-and-objective-neuropathy-in-hiv
#11
Natalie M Zahr, Kilian M Pohl, Adolf Pfefferbaum, Edith V Sullivan
Neuropathy, typically diagnosed by the presence of either symptoms or signs of peripheral nerve dysfunction, remains a frequently reported complication in the antiretroviral (ART)-treated HIV population. This study was conducted in 109 healthy controls and 57 HIV-infected individuals to investigate CNS regions associated with neuropathy. An index of objective neuropathy was computed based on 4 measures: deep tendon ankle reflex, vibration sense (great toes), position sense (great toes), and 2-point discrimination (feet)...
February 11, 2019: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/30735896/safety-and-efficacy-of-glecaprevir-pibrentasvir-in-patients-with-chronic-hepatitis-c-genotypes-1-6-receiving-opioid-substitution-therapy
#12
Jason Grebely, Gregory J Dore, Negar N Alami, Brian Conway, John F Dillon, Michael Gschwantler, Franco Felizarta, Christophe Hézode, Krzysztof Tomasiewicz, Linda M Fredrick, Emily O Dumas, Federico J Mensa
BACKGROUND: International guidelines recommend treatment of hepatitis C virus (HCV) infection in people who inject drugs (PWID), including those on opioid substitution therapy (OST). The pangenotypic combination of glecaprevir and pibrentasvir has shown high sustained virologic response at post-treatment Week 12 (SVR12) in clinical trials. Herein, we evaluate the safety and efficacy of glecaprevir/pibrentasvir in patients receiving OST. METHODS: Pooled data from patients with HCV genotypes 1-6 who were treated with glecaprevir/pibrentasvir for 8, 12, or 16 weeks in eight Phase 2 and 3 trials were categorized by use of OST...
February 5, 2019: International Journal on Drug Policy
https://read.qxmd.com/read/30735518/integrating-hypertension-screening-at-the-time-of-voluntary-hiv-testing-among-adults-in-south-africa
#13
Paul K Drain, Ting Hong, Anjum Hajat, Meighan Krows, Sabina Govere, Hilary Thulare, Mahomed Yunus S Moosa, Ingrid Bassett, Connie Celum
BACKGROUND: Guidelines recommend integrating hypertension screening for HIV-infected adults, but blood pressure measurements may be dynamic around the time of HIV testing. METHODS: We measured a seated resting blood pressure in adults (≥18 years) prior to HIV testing, and again after receiving HIV test results, in an ambulatory HIV clinic in KwaZulu-Natal, South Africa. We assessed sociodemographics, smoking, body mass index, diabetes, substance abuse, and anxiety/depression...
2019: PloS One
https://read.qxmd.com/read/30735256/the-impact-of-past-and-current-alcohol-consumption-patterns-on-progression-of-carotid-intima-media-thickness-among-women-and-men-living-with-hiv-infection
#14
Natalie E Chichetto, Michael W Plankey, Alison G Abraham, David S Sheps, Nicole Ennis, Xinguang Chen, Kathleen M Weber, Steven Shoptaw, Robert C Kaplan, Wendy S Post, Robert L Cook
BACKGROUND: The relationship between alcohol consumption and atherosclerosis has not been sufficiently examined among people living with HIV (PLWH). METHODS: We analyzed data from PLWH in the Women's Interagency HIV Study (WIHS; n=1164) and the Multicenter AIDS Cohort Study (MACS; n=387) with no history of cardiovascular disease (CVD). Repeated measures of intima-media thickness of the right common carotid artery (CCA-IMT) were assessed using B-mode ultrasound from 2004-2013...
February 8, 2019: Alcoholism, Clinical and Experimental Research
https://read.qxmd.com/read/30735080/development-of-a-novel-tool-to-assess-intimate-partner-violence-against-transgender-individuals
#15
Sarah M Peitzmeier, Jaclyn M W Hughto, Jennifer Potter, Madeline B Deutsch, Sari L Reisner
Intimate partner violence (IPV) takes on unique dimensions when directed against transgender individuals, with perpetrators leveraging transphobia to assert power and control. Standard IPV measurement tools do not assess this type of IPV. Four questions to assess transgender-related IPV (T-IPV) were developed: (a) being forced to conform to an undesired gender presentation or to stop pursuing gender transition; (b) being pressured to remain in a relationship by being told no one would date a transgender person; (c) being "outed" as a form of blackmail; and (d) having transition-related hormones, prosthetics, or clothing hidden or destroyed...
February 8, 2019: Journal of Interpersonal Violence
https://read.qxmd.com/read/30733765/-feline-panleukopenia-viral-infection-in-cats-application-of-some-molecular-methods-used-for-its-diagnosis
#16
Romane A Awad, Wagdy K B Khalil, Ashraf G Attallah
Forty diseased cats and seven healthy control cats from different sex, ages and breeds had examined clinically to confirm presence or absence of clinical symptoms of Feline panleukopenia disease (FP). Several tools including ELISA, gene expression analysis (qRT-PCR), DNA fragmentation test and apoptosis assay were conducted to determine the Feline panleukopenia disease in cat tissues. Clinical symptoms in the form of depression, fever, anorexia, vomiting, diarrhea, dehydration, anaemia and leucopenia were recorded in the diseased cats while no clinical sings were observed in control healthy cats...
December 2018: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/30732573/-hepcheck-dublin-an-intensified-hepatitis-c-screening-programme-in-a-homeless-population-demonstrates-the-need-for-alternative-models-of-care
#17
John S Lambert, Ross Murtagh, Dee Menezes, Austin O'Carroll, Carol Murphy, Walter Cullen, Tina McHugh, Gordana Avramovic, Willard Tinago, Marie Claire Van Hout
BACKGROUND: Hepatitis C virus (HCV) is one of the main causes of chronic liver disease worldwide. Prevalence of HCV in homeless populations ranges from 3.9 to 36.2%. The HepCheck study sought to investigate and establish the characterisation of HCV burden among individuals who attended an intensified screening programme for HCV in homeless services in Dublin, Ireland. METHODS: The HepCheck study was conducted as part of a larger European wide initiative called HepCare Europe...
February 7, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30725397/the-longitudinal-effects-of-non-injection-substance-use-on-sustained-hiv-viral-load-undetectability-among-msm-and-heterosexual-men-in-brazil-and-thailand-the-role-of-art-adherence-and-depressive-symptoms-hptn-063
#18
Kiyomi Tsuyuki, Steven J Shoptaw, Yusuf Ransome, Gordon Chau, Carlos E Rodriguez-Diaz, Ruth K Friedman, Kriengkrai Srithanaviboonchai, Sue Li, Matthew J Mimiaga, Kenneth H Mayer, Steven A Safren
The effect of non-injection substance use on HIV viral load (VL) is understudied in international settings. Data are from HPTN063, a longitudinal observational study of HIV-infected individuals in Brazil, Thailand, and Zambia, with focus on men with VL data (Brazil = 146; Thailand = 159). Generalized linear mixed models (GLMM) assessed whether non-injection substance use (stimulants, cannabis, alcohol, polysubstance) was associated with VL undetectability. ART adherence and depressive symptoms were examined as mediators of the association...
February 6, 2019: AIDS and Behavior
https://read.qxmd.com/read/30723014/prenatal-maternal-psychological-distress-and-offspring-risk-for-recurrent-respiratory-infections
#19
Laura S Korhonen, Linnea Karlsson, Noora M Scheinin, Riikka Korja, Mimmi Tolvanen, Jussi Mertsola, Ville Peltola, Hasse Karlsson
OBJECTIVE: To assess the relation between maternal prenatal psychological distress, comprising depression and anxiety symptoms and relationship quality, and the risk of recurrent respiratory infections (RRIs) in children up to 2 years of age. Children with RRIs frequently use health care services and antibiotics. Prenatal maternal psychological distress can be one, previously unidentified risk factor for RRIs. STUDY DESIGN: The study population was drawn from a population-based pregnancy cohort in Finland (www...
February 2, 2019: Journal of Pediatrics
https://read.qxmd.com/read/30719348/prevalence-of-depressive-symptoms-and-associated-factors-among-hiv-positive-youth-attending-art-follow-up-in-addis-ababa-ethiopia
#20
Helina Abebe, Shegaye Shumet, Zebiba Nassir, Melkamu Agidew, Dessie Abebaw
Depression is most frequently and highly occurring common mental disorder in HIV/AIDS patients especially youth living with HIV/AIDS. This study aimed to assess the prevalence and associated factors of depressive symptoms among youth living with Human Immunodeficiency Virus (HIV) attending Antiretroviral Therapy (ART) follow-up at public hospitals in Addis Ababa, Ethiopia. Objective . To assess the prevalence and associated factors of depressive symptoms among youth living with Human Immunodeficiency Virus (HIV) attending Antiretroviral Therapy (ART) follow-up at public hospitals Addis Ababa, Ethiopia, 2016...
2019: AIDS Research and Treatment
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