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Hernán F J González, Aaron Yengo-Kahn, Dario J Englot
Vagus nerve stimulation (VNS) was the first neuromodulation device approved for treatment of epilepsy. In more than 20 years of study, VNS has consistently demonstrated efficacy in treating epilepsy. After 2 years, approximately 50% of patients experience at least 50% reduced seizure frequency. Adverse events with VNS treatment are rare and include surgical adverse events (including infection, vocal cord paresis, and so forth) and stimulation side effects (hoarseness, voice change, and cough). Future developments in VNS, including closed-loop and noninvasive stimulation, may reduce side effects or increase efficacy of VNS...
April 2019: Neurosurgery Clinics of North America
Hannah M Phelps, Janene M Pierce, Andrew J Murphy, Hernan Correa, Jun Qian, Pierre P Massion, Harold N Lovvorn
BACKGROUND/PURPOSE: Wilms tumor (WT) is the most common childhood kidney cancer globally. Our prior unbiased proteomic screen of WT disparities revealed increased expression of Fragile X-Related 1 (FXR1) in Kenyan specimens where survival is dismal. FXR1 is an RNA-binding protein that associates with poor outcomes in multiple adult cancers. The aim of this study therefore was to validate and characterize the FXR1 expression domain in WT. METHODS: Quantitative FXR1 gene expression was compared between WT, adjacent, adult, and fetal kidney specimens...
February 28, 2019: Journal of Pediatric Surgery
Daniel J Becker, Cecilia Nachtmann, Hernan D Argibay, Germán Botto, Marina Escalera-Zamudio, Jorge E Carrera, Carlos Tello, Erik Winiarski, Alex D Greenwood, Maria L Méndez-Ojeda, Elizabeth Loza-Rubio, Anne Lavergne, Benoit de Thoisy, Gábor Á Czirják, Raina K Plowright, Sonia Altizer, Daniel G Streicker
Quantifying how the environment shapes host immune defense is important for understanding which wild populations may be more susceptible or resistant to pathogens. Spatial variation in parasite risk, food and predator abundance, and abiotic conditions can each affect immunity, and these factors can also manifest at both local and biogeographic scales. Yet identifying predictors and the spatial scale of their effects is limited by the rarity of studies that measure immunity across many populations of broadly distributed species...
March 15, 2019: Integrative and Comparative Biology
Hernán F Gómez, Dominic A Borgialli, Mahesh Sharman, Keneil K Shah, Anthony J Scolpino, James M Oleske, John D Bogden
BACKGROUND: The toxicity of lead, like any xenobiotic, is directly linked to the duration of exposure and toxin concentration in the body. The elevation in blood lead levels (BLLs) in young Flint, Michigan children noted in time-periods before, and during the 18-month exposure to Flint River water (FRW) from 25 April 2014 to 15 October 2015 is well-known internationally. The length of time BLLs were elevated is unknown, yet key in understanding the potential health impact of the event...
March 14, 2019: Clinical Toxicology
Xabier García-Albéniz, John Hsu, Michael Bretthauer, Miguel A Hernán
No abstract text is available yet for this article.
March 14, 2019: American Journal of Epidemiology
Ana Carolina Proença da Fonseca, Gabriella de Medeiros Abreu, Verônica Marques Zembrzuski, Mario Campos Junior, João Regis Ivar Carneiro, Fernanda Cristina C Mattos Magno, Eliane Lopes Rosado, José Firmino Nogueira Neto, Giselda Maria Kalil de Cabello, Pedro Hernán Cabello
Background: Melanocortin 4 receptor gene ( MC4R ) is an important regulator of food intake, body weight, and blood pressure. Mutations in MC4R are associated with the most common form of nonsyndromic monogenic obesity. MC4R variations have an autosomal co-/dominant model of inheritance. MC4R screening could reveal individuals previously unrecognized with Mendelian form of obesity for further clinical management and genetic counseling. However, there are limited data regarding MC4R variants in patients with obesity from Brazil...
2019: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Priscila O Silva, Diego S Batista, João Henrique F Cavalcanti, Andréa D Koehler, Lorena M Vieira, Amanda M Fernandes, Carlos Hernan Barrera-Rojas, Dimas M Ribeiro, Fabio T S Nogueira, Wagner C Otoni
BACKGROUND AND AIMS: Juvenile-to-adult phase transition is marked by changes in leaf morphology, mostly due to the temporal development of the shoot apical meristem, a phenomenon known as heteroblasty. Sugars and microRNA-controlled modules are components of the heteroblastic process in Arabidopsis thaliana leaves. However, our understanding about their roles during phase-changing in other species, such as Passiflora edulis, remains limited. Unlike Arabidopsis, P. edulis (a semi-woody perennial climbing vine) undergoes remarkable changes in leaf morphology throughout juvenile-to-adult transition...
March 12, 2019: Annals of Botany
Elisa Fernández Fernández, Diego Benavent Núñez, Gema Bonilla Hernán, Irene Monjo Henry, Sara García Carazo, Miguel Bernad Pineda, Alejandro Balsa Criado, Pilar Aguado Acín
OBJECTIVES: Analyse clinical and bone metabolism features in a case series of patients with multiple vertebral fractures after discontinuation of denosumab (DMab). METHODS: An observational descriptive study analysing data from ten patients with multiple vertebral fractures after DMab discontinuation that were admitted to our rheumatology department between 2015 and 2018. RESULTS: There were a total of 49 spontaneous fractures after an average of 6 DMab doses and 10...
March 4, 2019: Reumatología Clinica
Saramati Narasimhan, Jared A Weis, Hernán F J González, Reid C Thompson, Michael I Miga
The purpose of this investigation is to test whether a poroelastic model with enhanced structure can capture in vivo interstitial pressure dynamics in a brain undergoing mock surgical loads. Using interstitial pressure data from a porcine study, we use an inverse model to reconstruct material properties in an effort to capture these in vivo brain tissue dynamics. Four distinct models for the reconstruction of parameters are investigated (full anatomical condition description, condition without dural septa description, condition without ventricle boundary description, and the conventional fully saturated model)...
October 2018: Journal of Medical Imaging
David Maeso, Sahar Pakdel, Hernán Santos, Nicolas Agrait, Juan Jose Palacios, Elsa Prada, Gabino Rubio-Bollinger
Few-layer GaSe is one of the latest additions to the family of 2D semiconducting crystals whose properties under strain are still relatively unexplored. Here, we study rippled nanosheets that exhibit a periodic compressive and tensile strain of up to 5%. The strain profile modifies the local optoelectronic properties of the alternating compressive and tensile regions, which translates into a remarkable shift of the optical absorption band-edge of up to 1.2 eV between crests and valleys. Our experimental observations are supported by theoretical results from density functional theory calculations performed for monolayers and multilayers (up to 7 layers) under tensile and compressive strain...
March 1, 2019: Nanotechnology
Victoria Esteso, Sol Carretero Palacios, Priyadarshini Thiyam, Hernan Miguez, Drew Francis Parsons, Iver H Brevik, Mathias Boström
Gas bubbles in a water filled cavity move upwards due to buoyancy. Near the roof, additional forces come into play, such as Lifshitz, double layer, and hydrodynamic forces. Below uncharged metallic surfaces, repulsive Lifshitz forces combined with buoyancy forces provide a way to trap micrometer sized bubbles. We demonstrate how bubbles of this size can be stably trapped at experimentally accessible distances; the distances being tunable with the surface material. By contrast, large bubbles (≥100 μm) are usually pushed towards the roof by buoyancy forces and adhere to the surface...
March 1, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Mari Sveen Kvam, Jose Hernán Alfonso, Teresa Løvold Berents, Britt Grethe Randem, Eva Stylianou
No abstract text is available yet for this article.
February 26, 2019: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Gema Hernán, Inés Castejón, Jorge Terrados, Fiona Tomas
Numerous hypotheses have been posited to explain the observed variation in plant defense strategies against herbivory. Under resource-rich environments, plants are predicted to increase their tolerance (limiting resource model; LRM) and, while the resource availability hypothesis (RAH) predicts a decrease in constitutive resistance in plant species growing in resource-rich environments, at the intraspecific level, plants are predicted to follow an opposite pattern (intraspecific RAH). Furthermore, the effect of multiple factors in modulating plant defense strategies has been scarcely explored and is more difficult to predict...
February 26, 2019: Oecologia
Hernán F Peñaloza, Loreani P Noguera, Danielle Ahn, Omar P Vallejos, Raquel M Castellanos, Yaneisi Vazquez, Francisco J Salazar-Echegarai, Liliana González, Isidora Suazo, Catalina Pardo-Roa, Geraldyne A Salazar, Alice Prince, Susan M Bueno
Carbapenem-resistant Klebsiella pneumoniae ST258 (CRKP-ST258) can cause chronic infections in lungs and airways, with repeated episodes of bacteremia. In this report we addressed whether the recruitment of myeloid cells producing the anti-inflammatory cytokine interleukin 10 (IL-10) modulates the clearance of CKRP-ST258 in the lungs and establishes bacterial persistence. Our data demonstrate that during pneumonia caused by a clinical isolate of CRKP-ST258 (KP35) there is an early recruitment of Monocyte-Myeloid Derived Suppressor Cells (M-MDSCs) and neutrophils that actively produce IL-10...
February 25, 2019: Infection and Immunity
Alejandro Cruz-Utrilla, Hernán Mejía-Rentería, Alejandro Travieso-González
No abstract text is available yet for this article.
March 2019: Revista Española de Cardiología
Maria E Grillet, Juan V Hernández-Villena, Martin S Llewellyn, Alberto E Paniz-Mondolfi, Adriana Tami, Maria F Vincenti-Gonzalez, Marilianna Marquez, Adriana C Mogollon-Mendoza, Carlos E Hernandez-Pereira, Juan D Plaza-Morr, Gabriella Blohm, Mario J Grijalva, Jaime A Costales, Heather M Ferguson, Philipp Schwabl, Luis E Hernandez-Castro, Poppy H L Lamberton, Daniel G Streicker, Daniel T Haydon, Michael A Miles, Alvaro Acosta-Serrano, Harry Acquattela, Maria G Basañez, Gustavo Benaim, Luis A Colmenares, Jan E Conn, Raul Espinoza, Hector Freilij, Mary C Graterol-Gil, Peter J Hotez, Hirotomo Kato, John A Lednicky, Clara E Martinez, Santiago Mas-Coma, J Glen Morris, Juan C Navarro, Jose L Ramirez, Marlenes Rodriguez, Julio A Urbina, Leopoldo Villegas, Maikell J Segovia, Hernan J Carrasco, James L Crainey, Sergio L B Luz, Juan D Moreno, Oscar O Noya Gonzalez, Juan D Ramírez, Belkisyolé Alarcón-de Noya
In the past 5-10 years, Venezuela has faced a severe economic crisis, precipitated by political instability and declining oil revenue. Public health provision has been affected particularly. In this Review, we assess the impact of Venezuela's health-care crisis on vector-borne diseases, and the spillover into neighbouring countries. Between 2000 and 2015, Venezuela witnessed a 359% increase in malaria cases, followed by a 71% increase in 2017 (411 586 cases) compared with 2016 (240 613). Neighbouring countries, such as Brazil, have reported an escalating trend of imported malaria cases from Venezuela, from 1538 in 2014 to 3129 in 2017...
February 21, 2019: Lancet Infectious Diseases
W Dana Flanders, Michael D Garber
In their commentary, Pearce, Vandenbroucke, and Lawlor [PVL] discuss methods that they argue have been and should be useful for making causal inferences in environmental epidemiology. We point to many aspects of causal inference in environmental epidemiology with which we agree and with which, we argue, many, perhaps all, contributors to modern causal-inference methods would also agree. These areas of agreement include the idea that causal-inference methods should represent a range approaches such as studies that emulate randomized experiments if possible and use of instrumental variables...
February 15, 2019: Epidemiology
Luz-Ma-Adriana Balderas-Peña, Claudia Miranda-Ruvalcaba, Andrea Isabel Robles-Espinoza, Daniel Sat-Muñoz, Miguel Garcés Ruiz, Eduardo García-Luna, Arnulfo Hernan Nava-Zavala, Benjamín Rubio-Jurado
Multiple myeloma (MM) is characterized by bone pain, pathologic fractures, bone destruction, and secondary hypercalcemia, all these conditions impact on health-related quality of life of patients. The objective was to evaluate the global health state and health-related quality of life in a group of patients with MM who attended a tertiary health-care center of the Instituto Mexicano del Seguro Social in Mexico, through the questionnaires designed by European Organization for Research and Treatment of Cancer (EORTC) quality of life group...
January 2019: Cancer Control: Journal of the Moffitt Cancer Center
Aline Picolotto, Dafiner Pergher, Guilherme Pacheco Pereira, Keilla Gomes Machado, Hernane da Silva Barud, Mariana Roesch-Ely, Mário Henrique Gonzalez, Leandro Tasso, Jozi Godoy Figueiredo, Sidnei Moura
Since early times, propolis has been used in folk medicine. The red propolis, collected in the northeast region of Brazil has been highlighted due to its popular use as an antimicrobial, with anti-inflammatory and healing properties, which are associated with its chemical composition. Here, we combine a bacterial membrane with red propolis to treat wounds of diabetic mice. This work aims to evaluate a biocurative from bacterial cellulose associated with red propolis in diabetic mice as wound healing model. Biocuratives from bacterial cellulose membrane and different extracts of red propolis were produced...
February 19, 2019: Biomedicine & Pharmacotherapy
Agustina Alaimo, Guadalupe García Liñares, Juan Marco Bujjamer, Roxana Mayra Gorojod, Soledad Porte Alcon, Jimena Hebe Martínez, Alicia Baldessari, Hernán Edgardo Grecco, Mónica Lidia Kotler
Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been associated to A2E accumulation, which sensitizes RPE to blue light photodamage. Mitochondrial quality control mechanisms have evolved to ensure mitochondrial integrity and preserve cellular homeostasis. Particularly, mitochondrial dynamics involve the regulation of mitochondrial fission and fusion to preserve a healthy mitochondrial network...
February 18, 2019: Archives of Toxicology
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