Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Sergio D Ezquerra Riega, Matías E Gutierrez Suburu, Hernán B Rodríguez, Beatriz Lantaño, Martin Kleinschmidt, Christel M Marian, Cristian A Strassert
Singlet dioxygen has been widely applied in different disciplines such as medicine (photodynamic therapy or blood sterilization), remediation (wastewater treatment) or industrial processes (fine chemicals synthesis). Particularly, it can be conveniently generated by energy transfer between a photosensitizer's triplet state and triplet dioxygen upon irradiation with visible light. Among the best photosensitizers, substituted zinc(II) phthalocyanines are prominent due to their excellent photophysical properties, which can be tuned by structural modifications, such as halogen- and chalcogen-atom substitution...
April 22, 2024: Chemistry: a European Journal
#2
JOURNAL ARTICLE
Rafael Hernán Mateus-Vargas, Verónica Arias-Pérez, Iván Sandoval-Hernández, Jens Andre Hammerl, Elías Barquero-Calvo
Apex predators are exposed to antimicrobial compounds and resistant microbes, which accumulate at different trophic levels of the related ecosystems. The study aimed to characterize the presence and the antimicrobial resistance patterns of fecal Escherichia coli isolated from cloacal swab samples obtained from wild-living American crocodiles ( Crocodylus acutus ) ( n = 53). Sampling was conducted within the distinctive context of a freshwater-intensive aquaculture farm in Costa Rica, where incoming crocodiles are temporarily held in captivity before release...
2024: Frontiers in Veterinary Science
#3
Sophie C Bendrath, Hernán G Méndez, Anne M Dankert, Jose Manuel Lerma-Cabrera, Francisca Carvajal, Ana Paula Dornellas-Loper, Sophia Lee, Sofia Neira, Harold Haun, Eric Delpire, Montserrat Navarro, Thomas L Kash, Todd E Thiele
BACKGROUND: Binge alcohol drinking is a dangerous pattern of consumption that can contribute to the development of more severe alcohol use disorders (AUDs). Importantly, the rate and severity of AUDs has historically differed between men and women, suggesting that there may be sex differences in the central mechanisms that modulate alcohol (ethanol) consumption. Corticotropin releasing factor (CRF) is a centrally expressed neuropeptide that has been implicated in the modulation of binge-like ethanol intake, and emerging data highlight sex differences in central CRF systems...
April 13, 2024: bioRxiv
#4
Nathan Schmidt, Kristin Van Den Ham, Layne Bower, Shanping Li, Hernan Lorenzi, Safiatou Doumbo, Didier Doumtabe, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Peter Crompton
Malaria is a major public health problem, but many of the factors underlying the pathogenesis of this disease are not well understood. Here, we demonstrate in Malian children that susceptibility to febrile malaria following infection with Plasmodium falciparum is associated with the composition of the gut microbiome prior to the malaria season. Gnotobiotic mice colonized with the fecal samples of malaria-susceptible children had a significantly higher parasite burden following Plasmodium infection compared to gnotobiotic mice colonized with the fecal samples of malaria-resistant children...
April 4, 2024: Research Square
#5
JOURNAL ARTICLE
Amanda Maria Claro, Isabella Karoline Ribeiro Dias, Marina de Lima Fontes, Vitória Maria Medalha Colturato, Lais Roncalho Lima, Letícia Borges Sávio, Gabriela Leila Berto, Valdeir Arantes, Hernane da Silva Barud
Cellulose nanocrystals (CNCs) are crystalline domains isolated from cellulosic fibers. They have been utilized in a wide range of applications, such as reinforcing fillers, antibacterial agents and manufacturing of biosensors. Whitin this context, the aim of this work was to obtain and analyze CNCs extracted from bacterial nanocellulose (BNC) using two distinct methods combined with milling pre-treatment: an acidic hydrolysis using 64 % sulfuric acid and an enzymatic hydrolysis using a commercial cellulase enzyme mixture...
April 17, 2024: Carbohydrate Research
#6
JOURNAL ARTICLE
Pascal Schlosser, Aditya L Surapaneni, Oleg Borisov, Insa M Schmidt, Linda Zhou, Amanda Anderson, Rajat Deo, Ruth Dubin, Peter Ganz, Jiang He, Paul L Kimmel, Hongzhe Li, Robert G Nelson, Anna C Porter, Mahboob Rahman, Hernan Rincon-Choles, Vallabh Shah, Mark L Unruh, Ramachandran S Vasan, Zihe Zheng, Harold I Feldman, Sushrut S Waikar, Anna Köttgen, Eugene P Rhee, Josef Coresh, Morgan E Grams
BACKGROUND: Proteins and metabolites play crucial roles in various biological functions and are frequently interconnected through enzymatic or transport processes. METHODS: We present an integrated analysis of 4,091 proteins and 630 metabolites in the Chronic Renal Insufficiency Cohort Study (N=1,708; average follow-up for kidney failure [KF], 9.5 years, with 537 events). Proteins and metabolites were integrated using an unsupervised clustering method and we assessed associations between clusters and CKD progression and kidney failure using Cox proportional hazards models...
April 19, 2024: Journal of the American Society of Nephrology: JASN
#7
JOURNAL ARTICLE
Francesco Massari, Matteo Santoni, Hideki Takeshita, Yohei Okada, Jose Carlos Tapia, Umberto Basso, Marco Maruzzo, Sarah Scagliarini, Thomas Büttner, Giuseppe Fornarini, Zin W Myint, Luca Galli, Vinicius Carrera Souza, Renate Pichler, Ugo De Giorgi, Nathalia Gandur, Elaine T Lam, Danielle Gilbert, Lazar Popovic, Enrique Grande, Giulia Mammone, Rossana Berardi, Simon J Crabb, Robert Kemp, Javier Molina-Cerrillo, Marcelo Freitas, Murilo Luz, Roberto Iacovelli, Fabio Calabrò, Deniz Tural, Francesco Atzori, Zsófia Küronya, Rita Chiari, Saul Campos, Orazio Caffo, André P Fay, Jakub Kucharz, Paolo Andrea Zucali, José Augusto Rinck, Annalisa Zeppellini, Diogo Assed Bastos, Gaetano Aurilio, Augusto Mota, Karine Trindade, Cinzia Ortega, Juan Pablo Sade, Mimma Rizzo, Ondřej Fiala, Nuno Vau, Patrizia Giannatempo, Allan Barillas, Fernando Sabino M Monteiro, Breno Dauster, Alessia Mennitto, Lucas Nogueira, Roni de Carvalho Fernandes, Emmanuel Seront, Luís Garcia Aceituno, Francesco Grillone, Hernan Javier Cutuli, Mauricio Fernandez, Maria Bassanelli, Ray Manneh Kopp, Giandomenico Roviello, Halima Abahssain, Giuseppe Procopio, Michele Milella, Jindrich Kopecky, Angelo Martignetti, Carlo Messina, Manuel Caitano, Eva Inman, Ravindran Kanesvaran, Daniel Herchhorn, Daniele Santini, Aristotelis Bamias, Renato Bisonni, Alessandra Mosca, Franco Morelli, Fernando Maluf, Andrey Soares, Fernando Nunes, Alvaro Pinto, Anca Zgura, Lorena Incorvaia, Jawaher Ansari, Ignacio Ortego Zabalza, Johannes Landmesser, Alessandro Rizzo, Veronica Mollica, Andrea Marchetti, Matteo Rosellini, Giulia Sorgentoni, Nicola Battelli, Sebastiano Buti, Camillo Porta, Joaquim Bellmunt
BACKGROUND: Immune checkpoint inhibitors have changed previous treatment paradigm of advanced urothelial carcinoma (UC). The ARON-2 study (NCT05290038) aimed to assess the real-world effectiveness of pembrolizumab in patients recurred or progressed after platinum-based chemotherapy. PATIENTS AND METHODS: Medical records of patients with documented metastatic UC treated by pembrolizumab as second-line therapy were retrospectively collected from 88 institutions in 23 countries...
April 18, 2024: Cancer Immunology, Immunotherapy: CII
#8
JOURNAL ARTICLE
Sonia Hernández-Díaz, Krista F Huybrechts, Miguel A Hernán
No abstract text is available yet for this article.
May 1, 2024: Epidemiology
#9
JOURNAL ARTICLE
Diede de Haan, Nahuel-Hernán Ramos, Yu-Feng Meng, Ron Rotkopf, Yoseph Addadi, Irit Rosenhek-Goldian, Assaf Gal
Unicellular organisms are known to exert tight control over their cell size. In the case of diatoms, abundant eukaryotic microalgae, two opposing notions are widely accepted. On the one hand, the rigid silica cell wall that forms inside the parental cell is thought to enforce geometrical reduction of the cell size. On the other hand, numerous exceptions cast doubt on the generality of this model. Here, we monitored clonal cultures of the diatom Stephanopyxis turris for up to 2 yr, recording the sizes of thousands of cells, in order to follow the distribution of cell sizes in the population...
April 15, 2024: New Phytologist
#10
REVIEW
Lindsey M Vogt, Kathryn Yang, Gabriel Tse, Vicente Quiroz, Zainab Zaman, Laura Wang, Rasha Srouji, Amy Tam, Elicia Estrella, Shannon Manzi, Alfonso Fasano, Weston T Northam, Scellig Stone, Mahendranath Moharir, Hernan Gonorazky, Brian McAlvin, Monica Kleinman, Kerri L LaRovere, Carolina Gorodetsky, Darius Ebrahimi-Fakhari
Status dystonicus is the most severe form of dystonia with life-threatening complications if not treated promptly. We present consensus recommendations for the initial management of acutely worsening dystonia (including pre-status dystonicus and status dystonicus), as well as refractory status dystonicus in children. This guideline provides a stepwise approach to assessment, triage, interdisciplinary treatment, and monitoring of status dystonicus. The clinical pathways aim to: (1) facilitate timely recognition/triage of worsening dystonia, (2) standardize supportive and dystonia-directed therapies, (3) provide structure for interdisciplinary cooperation, (4) integrate advances in genomics and neuromodulation, (5) enable multicenter quality improvement and research, and (6) improve outcomes...
April 15, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#11
REVIEW
Hernán Gallego, Sergio Arango, Andrés Combalia, Salvador Fuster, Catalina Jaramillo, Ana Milena Herrera
BACKGROUND: Failed back surgery syndrome (FBSS) is a common and incapacitating condition affecting patients with previous spine surgery in whom treatment approach can be challenging. This study aimed to summarize existing secondary studies and up-to-date randomized clinical trials (RCTs) that assess the effectiveness of available treatment options for FBSS. METHODS: Systematic searches were carried out in five databases (PubMed, Cochrane, Scielo, Epistemonikos, and Google scholar) for all systematic reviews on the effectiveness of treatment options for FBSS published after 2012...
March 27, 2024: Spine surgery and related research
#12
JOURNAL ARTICLE
Saulo Duarte Ozelin, Tábata Rodrigues Esperandim, Fernanda Gosuen Gonçalves Dias, Lucas de Freitas Pereira, Cristiane Buzatto Garcia, Thiago Olímpio de Souza, Larissa Fernandes Magalhães, Hernane da Silva Barud, Rafael Miguel Sábio, Denise Crispim Tavares
Wound healing is an important and complex process, containing a multifaceted process governed by sequential yet overlapping phases. Certain treatments can optimize local physiological conditions and improve wound healing. Silver nanoparticles (AgNP) are widely known for their antimicrobial activity. On the other hand, bacterial cellulose (BC) films have been used as a dressing that temporarily substitutes the skin, offering many advantages in optimizing wound healing, in addition to being highly biocompatible...
April 12, 2024: Journal of Pharmaceutical Sciences
#13
JOURNAL ARTICLE
Paulo Álvarez Cecco, Marianela Balbi, Martín Bonamy, Andrés Rogberg Muñoz, Hernán Olivera, Guillermo Giovambattista, María Elena Fernández
Heat stress is a major factor that negatively affects animal welfare and production systems. Livestock should adapt to tropical and subtropical areas and to meet this, composite breeds have been developed. This work aimed to evaluate gene expression profiles in the skin of Brangus cattle under heat stress using a case-control design, and to correlate this with skin histological characteristics. Two groups of bulls were set using rectal temperature as a criterion to define stress conditions: stressed (N = 5) and non-stressed (N = 5) groups...
April 10, 2024: Journal of Thermal Biology
#14
REVIEW
Leandro Luongo Matos, Luiz Paulo Kowalski, Aline Lauda Freitas Chaves, Thiago Bueno de Oliveira, Gustavo Nader Marta, Maria Paula Curado, Gilberto de Castro Junior, Terence P Farias, Gustavo Sarria Bardales, Mario Avila Cabrera, Renato de Castro Capuzzo, Genival Barbosa de Carvalho, Claudio Roberto Cernea, Rogério Aparecido Dedivitis, Fernando Luiz Dias, Andrés Munyo Estefan, Agustin Horacio Falco, Gustavo Alberto Ferraris, Alejandro Gonzalez-Motta, Andre Guimarães Gouveia, Alexandre Arthur Jacinto, Marco Aurelio Vamondes Kulcsar, Ana Kober Leite, Renan Bezerra Lira, Milena Perez Mak, Pedro De Marchi, Evandro Sobroza de Mello, Fátima Cristina Mendes de Matos, Pablo H Montero, Eduardo Dias de Moraes, Fabio Ynoe de Moraes, Diego Chaves Rezende Morais, Fernando Miguel Poenitz, Adela Poitevin, Hernán Ortiz Riveros, Álvaro Sanabria, Miguel Ticona-Castro, José Guilherme Vartanian, Gustavo Viani, Eugenio F Vines, William Nassib William Junior, David Conway, Shama Virani, Paul Brennan
Head and neck squamous cell carcinoma (HNSCC) is well known as a serious health problem worldwide, especially in low-income countries or those with limited resources, such as most countries in Latin America. International guidelines cannot always be applied to a population from a large region with specific conditions. This study established a Latin American guideline for care of patients with head and neck cancer and presented evidence of HNSCC management considering availability and oncologic benefit. A panel composed of 41 head and neck cancer experts systematically worked according to a modified Delphi process on (1) document compilation of evidence-based answers to different questions contextualized by resource availability and oncologic benefit regarding Latin America (region of limited resources and/or without access to all necessary health care system infrastructure), (2) revision of the answers and the classification of levels of evidence and degrees of recommendations of all recommendations, (3) validation of the consensus through two rounds of online surveys, and (4) manuscript composition...
April 2024: JCO global oncology
#15
JOURNAL ARTICLE
María Victoria Esteban-Mendoza, Victor Hernán Arcila-Quiceno, Catalina Ríos Chacón, Jeiczon Elim Jaimes Dueñez, Marisol Tique Oviedo, Alejandro Díaz Bustos, María Fernanda Castellanos, Rodrigo Morchón
Canine filariosis is caused by filiform nematodes and affects several species of animals as well as humans. The disease produces a wide range of symptoms that can often be confused with other diseases, which increases the complexity of its diagnosis. The search for methodologies to facilitate its diagnosis is a challenge, and specific and differential identification of the parasite species causing the disease holds key to a successful diagnosis. In Colombia, there is a problem of underdiagnosis of filariosis in microfilaremic dogs infected by Dirofilaria immitis and Acanthocheilonema reconditum , and of microfilaremias not related to heartworm disease...
2024: Frontiers in Veterinary Science
#16
JOURNAL ARTICLE
Nidia Benítez Candia, María Gabriela Ulke Mayans, Pablo Hernán Sotelo, Eva Nara Pereira, Andrea Alejandra Arrúa Alvarenga, Danilo Fernández Ríos
This study analyzes Paraguay's biotechnology regulatory framework and its alignment with international standards amid biotechnological advancements. It also identifies areas of improvement for enhancing framework effectiveness. Through this work, we aim to provide a resource for policymakers, stakeholders, and researchers navigating Paraguay's biotechnology regulation.
2024: Frontiers in Bioengineering and Biotechnology
#17
REVIEW
Shahira M Ezzat, Rana M Merghany, Passent M Abdel Baki, Nariman Ali Abdelrahim, Sohaila M Osman, Mohamed A Salem, Sheila I Peña-Corona, Hernán Cortés, Lashyn Kiyekbayeva, Gerardo Leyva-Gómez, Javad Sharifi-Rad, Daniela Calina
Phenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, has garnered attention for its anticancer properties. This review synthesizes existing research on PEITC, focusing on its mechanisms of action in combatting cancer. PEITC has been found to be effective against various cancer types, such as breast, prostate, lung, colon, and pancreatic cancers. Its anticancer activities are mediated through several mechanisms, including the induction of apoptosis (programmed cell death), inhibition of cell proliferation, suppression of angiogenesis (formation of new blood vessels that feed tumors), and reduction of metastasis (spread of cancer cells to new areas)...
April 11, 2024: Molecular Nutrition & Food Research
#18
JOURNAL ARTICLE
Bryant Avila, Matteo Serafino, Pedro Augusto, Manuel Zimmer, Hernán A Makse
Capturing how the Caenorhabditis elegans connectome structure gives rise to its neuron functionality remains unclear. It is through fiber symmetries found in its neuronal connectivity that synchronization of a group of neurons can be determined. To understand these we investigate graph symmetries and search for such in the symmetrized versions of the forward and backward locomotive sub-networks of the Caenorhabditi elegans worm neuron network. The use of ordinarily differential equations simulations admissible to these graphs are used to validate the predictions of these fiber symmetries and are compared to the more restrictive orbit symmetries...
2024: PloS One
#19
JOURNAL ARTICLE
Juan Pablo Velasquez-Minoli, Natalia Cardona-Ramirez, Hernan Felipe Garcia-Arias, Feliza Restrepo-Restrepo, Gloria Liliana Porras-Hurtado
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) appears in neurological conditions where some brain areas are likely to be injured, such as deep grey matter, basal ganglia area, and white matter subcortical periventricular áreas. Moreover, modeling these brain areas in a newborn is challenging due to significant variability in the intensities associated with HIE conditions. This paper aims to evaluate functional measurements and 3D machine learning models of a given HIE case by correlating the affected brain areas with the pathophysiology and clinical neurodevelopmental...
April 9, 2024: Italian Journal of Pediatrics
#20
REVIEW
Ricardo Corral, Enrique Bojórquez, Marcelo Cetkovich-Bakmas, Rodrigo Córdoba, Julio Chestaro, Clarissa Gama, Gerardo García Bonetto, Carlos López Jaramillo, Ricardo Alberto Moreno, Bernardo Ng, Edilberto Pena de Leon, Luis Risco, Hernán Silva, Gustavo Vazquez
UNLABELLED: Despite the abundance of literature on treatment-resistant depression (TRD), there is no universally accepted definition of TRD, and available treatment pathways for the management of TRD vary across the Latin American region, highlighting the need for a uniform definition and treatment principles to optimize the management of TRD in Latin America. METHODS: Following a thematic literature review and pre-meeting survey, a Latin America expert panel comprising 14 psychiatrists with clinical experience in managing patients with TRD convened and utilized the RAND/UCLA appropriateness method to develop consensus-based recommendations on the appropriate definition of TRD and principles for its management...
September 22, 2023: Span J Psychiatry Ment Health
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
