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Ni Bing, Hu Yonsheng, Tao Wei, Shu Wei, Zhu Hongwei
OBJECTIVE: To retrospectively evaluate long-term efficacy and safety of dorsal root entry zone (DREZ) lesion for treatment of neuropathic pain within the lower extremities and perineal region following thoracolumbar spine fracture. METHODS: 42 patients were treated with posterior laminectomy under general anesthesia. The DREZ regions of spinal cord segments were ablated under a microscope. Data regarding pain relief, pain variation over time, and postoperative complications were collected...
February 15, 2019: World Neurosurgery
Gustavo Roberto Villas Boas, Roseli Boerngen de Lacerda, Marina Meirelles Paes, Priscila Gubert, Wagner Luis da Cruz Almeida, Vanessa Cristina Rescia, Pablinny Moreira Galdino de Carvalho, Adryano Augustto Valladao de Carvalho, Silvia Aparecida Oesterreich
Major depressive disorder (MDD), also known as unipolar depression, is one of the leading causes of disability and disease worldwide. The signs and symptoms are low self‑esteem, anhedonia, feeling of worthlessness, sense of rejection and guilt, suicidal thoughts, among others. This review focuses on studies with molecular-based approaches involving MDD to obtain an integrated, more detailed and comprehensive view of the brain changes produced by this disorder and its treatment and how the Central Nervous System (CNS) produces neuroplasticity to orchestrate adaptive defensive behaviors...
February 15, 2019: European Journal of Pharmacology
Jan Bellows, Mary L Berg, Sonnya Dennis, Ralph Harvey, Heidi B Lobprise, Christopher J Snyder, Amy E S Stone, Andrea G Van de Wetering
The 2019 AAHA Dental Care Guidelines for Dogs and Cats outline a comprehensive approach to support companion animal practices in improving the oral health and often, the quality of life of their canine and feline patients. The guidelines are an update of the 2013 AAHA Dental Care Guidelines for Dogs and Cats. A photographically illustrated, 12-step protocol describes the essential steps in an oral health assessment, dental cleaning, and periodontal therapy. Recommendations are given for general anesthesia, pain management, facilities, and equipment necessary for safe and effective delivery of care...
March 2019: Journal of the American Animal Hospital Association
Eric R Coon, Ricardo A Quinonez, Daniel J Morgan, Sanket S Dhruva, Timmy Ho, Nathan Money, Alan R Schroeder
Importance: Efforts to combat medical overuse have gained traction in recent years, but success has been intermittent and shortcomings have been recognized. A commitment to a strong evidence base is needed to more broadly engage clinicians and reduce overuse. Observations: A structured MEDLINE search and a manual review of tables of contents from selected high-impact journals was performed to identify original research published in 2017 relevant to pediatric overuse...
February 18, 2019: JAMA Pediatrics
Filipe Espinheira Gomes, Stephen Parry, Eric Ledbetter
OBJECTIVE: To describe and to establish normative data for the feline optic nerve and peripapillary retina using SD-OCT (Spectralis® HRA+OCT2). METHODS: Slit-lamp biomicroscopy and rebound tonometry were performed in seven male-intact (0.65 ± 0.02 years;4.34 ± 0.33 kg) and seven female-spayed (0.74 ± 0.03 years; 3.13 ± 0.28 kg) cats. All eyes were pharmacologically dilated with 1% tropicamide prior to indirect ophthalmoscopy examination. Animals were then placed under general anesthesia...
February 18, 2019: Veterinary Ophthalmology
Wen-Jun Yan, Da-Bin Wang, Dong-Qing Ren, Ling-Kai Wang, Zhong-Yuan Hu, Ya-Bing Ma, Jin-Wen Huang, Shao-Li Ding
Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients who undergo surgery involving anesthesia. Its underlying mechanisms remain unclear. Autophagy plays an important role in the damage and repair of the nervous system and is associated with the development of POCD. Using a rat model, adenosine monophosphate-activated protein kinase α1 (AMPKα1), an important autophagy regulator, was found to be significantly downregulated in rats with POCD that was induced by sevoflurane anesthesia or by appendectomy...
February 18, 2019: Journal of Cellular Biochemistry
Nabeel Humayun Hassan, Rahila Usman, Muhammad Yousuf, Ahmad Nawaz Ahmad, Ismail Hirani
Objective: To determine the accuracy of transoral flexible laryngoscope (TFL) biopsy and also to identify the safety as office based procedure in terms of complications. Methods: This is a diagnostic study; the type of intervention is outpatient department based biopsy of laryngeal lesions. All patients seen in ENT outpatient department of Lyari General Hospital with suspicious lesions of Larynx were referred for Transoral Flexible Laryngoscopy Biopsy under local anesthesia...
March 2019: World Journal of Otorhinolaryngology—Head and Neck Surgery
A Demertzi, E Tagliazucchi, S Dehaene, G Deco, P Barttfeld, F Raimondo, C Martial, D Fernández-Espejo, B Rohaut, H U Voss, N D Schiff, A M Owen, S Laureys, L Naccache, J D Sitt
Adopting the framework of brain dynamics as a cornerstone of human consciousness, we determined whether dynamic signal coordination provides specific and generalizable patterns pertaining to conscious and unconscious states after brain damage. A dynamic pattern of coordinated and anticoordinated functional magnetic resonance imaging signals characterized healthy individuals and minimally conscious patients. The brains of unresponsive patients showed primarily a pattern of low interareal phase coherence mainly mediated by structural connectivity, and had smaller chances to transition between patterns...
February 2019: Science Advances
Juli A Lambert, Allison A Vanderbilt, Thomas J Papadimos
Emotional intelligence (EI) is the processing of emotional information. It reflects the ability to 1) monitor one's own and others' emotions, 2) discriminate among them, 3) and use this information to guide one's thinking and actions. Higher EI contributes to the doctor-patient relationship, increased empathy, stress management, and leadership. Although EI has been shown to be beneficial in a hospital setting, little work has been done specifically on EI and its efficacy in the perioperative period. There are instances during perioperative care where rise and conflict occur, an environment where EI skills can play an important role...
2019: Advances in Medical Education and Practice
Aimei Li, Feng Yang, Jiaying Xin, Xuebo Bai
Purpose: Local anesthetics are used clinically for the control of pain following operation (including gastrointestinal surgery) or for the management of other acute and chronic pain. This study aimed to develop a kind of lipid-polymer hybrid nanoparticles (LPNs), which were constructed using poly(ethylene glycol)-distearoylphosphatidylethanolamine (PEG-DSPE) as the hydrophilic lipid shell and poly-ε-caprolactone (PCL) as the hydrophobic polymeric core. Methods: Ropivacaine (RPV) was entrapped in the LPNs (RPV-LPNs) and the physicochemical and biochemical properties such as size, zeta potential, drug release, and cytotoxicity were studied...
2019: International Journal of Nanomedicine
Jonathan Lévesque, Anestis Antoniadis, Pei Zhi Li, Frédéric Herengt, Christophe Brosson, Jean-Marie Grosbois, Alain Bernady, Anthony Bender, Murielle Favre, Antoine Guerder, Pascale Surpas, Thomas Similowski, Bernard Aguilaniu
Background: The 3-minute chair rise test (3-minute CRT) and the Disability Related to COPD Tool (DIRECT) are two reproducible and valid short tests that can assess the benefit of pulmonary rehabilitation (PR) in terms of functional capacity and dyspnea in everyday activities. Methods: We determined the minimal clinically important difference (MCID) of the DIRECT questionnaire and 3-minute CRT using distribution methods and anchor encroaches with a panel of eight standard tests in a cohort of 116 COPD patients who completed a PR program in real-life settings...
2019: International Journal of Chronic Obstructive Pulmonary Disease
Vinod Kumar, Rakesh Garg, Rajiv Mishra, Nishkarsh Gupta
No abstract text is available yet for this article.
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
Vrushali Rajgire, Sushama Raghunath Tandale, Kalpana Kelkar, Rahul Band
No abstract text is available yet for this article.
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
Bhagyalakshmi Ramesh, Viji S Pillai, Rachel C Koshy, K M Jagathnath Krishna
Background and Aims: The aim of the study was to evaluate the efficacy and usefulness of the current practice of various investigations and consultations being done during preanesthetic evaluation in patients undergoing oncosurgical procedures in our hospital. We also evaluated the delay caused due to these and its value in predicting postoperative complications. Material and Methods: The preanesthetic charts of 300 elderly patients >65 years of age were reviewed, and the incidence of abnormal investigations and number of consultations advised were noted...
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
Shrinivas Kulkarni, C L Gurudatt, Deepika Prakash, Jincy A Mathew
Background and Aims: Many unilateral lower limb orthopedic surgeries are conducted under unilateral spinal anesthesia with full flexion of spine and immediate extension after local anesthetic administration into the subarachnoid space. Studies have shown that extension of the spine in lateral decubitous position makes cauda equina to sink to the dependent side due to gravity. Continuous flexion of the spine causes sunken cauda equina to be suspended in the middle of the subarachnoid space increasing the possibility of unilateralization of the block...
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
Lhamo Dolma, Rashmi Salhotra, Rajesh S Rautela, Ashim Banerjee
Background and Aims: Dexmedetomidine has a promising role as an intrathecal adjuvant. However it's role as an adjuvant to ropivacaine has not been evaluated extensively. This study is designed to find out the effect of addition of dexmedetomidine 5 μ g to isobaric ropivacaine 18.75 mg on block characteristics and hemodynamic parameters in patients undergoing surgeries for fracture neck of femur under subarachnoid block (SAB). Material and Methods: Sixty-one American Society of Anesthesiologists (ASA) Class I or II patients between 18-60 years undergoing surgeries for fracture neck of femur under SAB were recruited and randomized into two groups...
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
David M Rosenfeld, Kathleen E Knapp, Joshua A Spiro, Andrew W Gorlin, Harish Ramakrishna, Terrence L Trentman
Background and Aims: There are limited data on the effect of ampule size on drug dosing. The objective of this study is to determine the effect of ampule size on perioperative opioid dosing and post-anesthesia care unit (PACU) outcomes. Material and Methods: This was a retrospective review of patients undergoing robotically assisted laparoscopic radical prostatectomy before and after a 5-ml fentanyl ampule was discontinued. The primary outcome was intraoperative opioid administration divided into fentanyl at induction of anesthesia, total fentanyl, and total opioid...
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
Borzoo Farhang, Alex C Lesiak, Daniel J Ianno, Hayk Minasyan, Adam B Shafritz, Christopher M Viscomi
Background and Aims: Intravenous regional anesthesia (IVRA) is utilized for upper extremity surgery, but higher tourniquet pressure and longer inflation time increase the risk of soft tissue and nerve injury. We investigated the duration and magnitude of elevated venous pressure during IVRA to assess the possibility of safely lowering the tourniquet pressure during surgery. Material and Methods: Twenty adult patients scheduled for distal upper extremity surgery were enrolled...
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
Behrooz Farzanegan, Majid Golestani Eraghi, Samira Abdollahi, Jahangir Ghorbani, Ali Khalili, Reza Moshari, Alireza Jahangirifard
Background and Aims: Controlled hypotensive anesthesia in endoscopic sinus surgery would provide a clean surgical field. Cerebral oxygen saturation (ScO2 ) is important in endoscopic sinus surgery patients and it may be low during controlled hypotension. The aim of the present study was to assess ScO2 in these patients. Material and Methods: In this observational study, 41 patients who underwent endoscopic sinus surgery with hypotensive anesthesia were enrolled for the study and all of the patients received the same anesthetic medication, nitroglycerin for controlled hypotension...
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
Dhritiman Chakrabarti, Sriganesh Kamath, K R Madhusudan Reddy, Deepti B Srinivas, Nitin Manohar, Dheeraj Masapu
Background and Aims: The study was conceived to elucidate the effects of dexmedetomidine as an anesthetic adjunct to propofol (total intravenous anesthesia) on anesthetic dose reduction and anesthesia recovery parameters in cerebello-pontine angle (CPA) surgeries. Material and Methods: This prospective randomized study was conducted on 49 patients (25 with dexmedetomidine, 24 without). After standardized anesthetic induction, anesthesia was maintained using propofol (via target controlled infusion, titrated to maintain BIS between 40 and 60), fentanyl (0...
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
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