Peng Zhang, Erik J Liu, Caroline Tsao, Shane A Kasten, Michael V Boeri, Thuy L Dao, Sandra J DeBus, C Linn Cadieux, Cetara A Baker, Tamara C Otto, Douglas M Cerasoli, Yantao Chen, Priyesh Jain, Fang Sun, Wenchen Li, Hsiang-Chieh Hung, Zhefan Yuan, Jinrong Ma, Andrew N Bigley, Frank M Raushel, Shaoyi Jiang
Nerve agents are a class of organophosphorus compounds (OPs) that blocks communication between nerves and organs. Because of their acute neurotoxicity, it is extremely difficult to rescue the victims after exposure. Numerous efforts have been devoted to search for an effective prophylactic nerve agent bioscavenger to prevent the deleterious effects of these compounds. However, low scavenging efficiency, unfavorable pharmacokinetics, and immunological problems have hampered the development of effective drugs...
January 2, 2019: Science Translational Medicine