Liping Zhang, Shaoxin Liang, Zhi Zhang, Kai Wang, Junhan Cao, Mengke Yao, Ling Qin, Changfeng Qu, Jinlai Miao
The previous study successfully established an expression strain of ζ-carotene-like compounds (CLC) and demonstrated its remarkable antioxidant activity, which exhibited resistance to photodamage caused by UVB radiation on the skin following gavage administration. The objective of this study was to investigate the impact and mechanism of CLC on UVB-induced skin damage through topical application. Cell viability, anti-apoptotic activity, ROS scavenging ability, the inhibition of melanin synthesis, the regulation of inflammatory factors and collagen deposition were assessed in cells and mice using qRT-PCR, WB, Elisa assays, immunohistochemistry staining and biochemical kits, etc...
September 12, 2023: International Journal of Molecular Sciences