James T Morton, Dong-Min Jin, Robert H Mills, Yan Shao, Gibraan Rahman, Daniel McDonald, Qiyun Zhu, Metin Balaban, Yueyu Jiang, Kalen Cantrell, Antonio Gonzalez, Julie Carmel, Linoy Mia Frankiensztajn, Sandra Martin-Brevet, Kirsten Berding, Brittany D Needham, María Fernanda Zurita, Maude David, Olga V Averina, Alexey S Kovtun, Antonio Noto, Michele Mussap, Mingbang Wang, Daniel N Frank, Ellen Li, Wenhao Zhou, Vassilios Fanos, Valery N Danilenko, Dennis P Wall, Paúl Cárdenas, Manuel E Baldeón, Sébastien Jacquemont, Omry Koren, Evan Elliott, Ramnik J Xavier, Sarkis K Mazmanian, Rob Knight, Jack A Gilbert, Sharon M Donovan, Trevor D Lawley, Bob Carpenter, Richard Bonneau, Gaspar Taroncher-Oldenburg
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut-brain axis (GBA) has been implicated in ASD although with limited reproducibility across studies. In this study, we developed a Bayesian differential ranking algorithm to identify ASD-associated molecular and taxa profiles across 10 cross-sectional microbiome datasets and 15 other datasets, including dietary patterns, metabolomics, cytokine profiles and human brain gene expression profiles...
June 26, 2023: Nature Neuroscience