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JOURNAL ARTICLE
Ajami Gikandi, Susan N Chi, Kee Kiat Yeo, Allison F O'Neill, David S Shulman, Steven G DuBois, Natalie B Collins
BACKGROUND: Immune checkpoint inhibitors (ICI) have improved outcomes in a variety of adult cancers and are prescribed with increasing frequency across oncology. However, patterns of off-label use of ICI in pediatrics remain unclear. METHODS: This is a single-institution, retrospective cohort study evaluating off-label ICI use in pediatric and young adult patients with cancer treated at our institution from 2014 to 2022. Response was based on clinician assessment derived from clinical records...
April 2024: Cancer Medicine
#2
JOURNAL ARTICLE
Doff B McElhinney, Matthew J Gillespie, Jamil A Aboulhosn, Allison K Cabalka, Brian H Morray, David T Balzer, Athar M Qureshi, Arvind K Hoskoppal, Bryan H Goldstein
BACKGROUND: Anatomic selection for Harmony valve implant is determined with the aid of a screening report and perimeter plot (PP) that depicts the perimeter-derived radius along the right ventricular outflow tract (RVOT) and projects device oversizing. The PP provides an estimation of suitability for implant, but its sensitivity as a screening method is unknown. This study was performed to describe anatomic features and outcomes in patients who underwent Harmony TPV25 implant despite a PP that predicted inadequate oversizing...
April 12, 2024: Circulation. Cardiovascular Interventions
#3
JOURNAL ARTICLE
Daniel L Smith, Yongbin Yang, Luis M Mestre, Beate Henschel, Erik Parker, Stephanie Dickinson, Amit Patki, David B Allison, Tim R Nagy
OBJECTIVE: The objective of this study was to investigate body composition changes with weight cycling (WC) among adult C57BL/6J mice with diet-induced obesity. METHODS: A total of 555 single-housed mice were fed a high-fat diet ad libitum (AL) from 8 to 43 weeks of age. The 200 heaviest mice of each sex were randomized to the following four groups: ever obese (EO, continued AL feeding); obese weight loser (OWL, calorie-restricted); obese weight loser moderate (OWLM, body weight halfway between EO and OWL); and WC (diet restricted to OWL followed by AL refeeding cycles)...
April 10, 2024: Obesity
#4
JOURNAL ARTICLE
Jessica E Ma, Lindsay Schlichte, Marie Haverfield, Julia Gambino, Allison Lange, Kelly Blanchard, Brianne Morgan, David B Bekelman
BACKGROUND: Documenting goals of care in the electronic health record is meant to relay patient preferences to other clinicians. Evaluating the content and documentation of nurse and social worker led goals of care conversations can inform future goals of care initiative efforts. METHODS: As part of the ADvancing symptom Alleviation with Palliative Treatment trial, this study analyzed goals of care conversations led by nurses and social workers and documented in the electronic health record...
April 9, 2024: Journal of the American Geriatrics Society
#5
JOURNAL ARTICLE
Arunima Kapoor, Shubir Dutt, John Paul M Alitin, Isabel J Sible, Anisa Marshall, Fatemah Shenasa, Allison C Engstrom, Aimée Gaubert, Xingfeng Shao, David Robert Bradford, Kathleen Rodgers, Mara Mather, Danny J J Wang, Daniel A Nation
Cerebrovascular reactivity (CVR) deficits may contribute to small vessel disease, such as white matter hyperintensities (WMH). Moreover, apolipoprotein-e4 (APOE4) carriers at genetic risk for Alzheimer's disease exhibit cerebrovascular dysfunction relative to non-carriers. We examined whether older adults, and APOE4 carriers specifically, with diminished CVR would exhibit higher WMH burden. Independently living older adults (N = 125, mean age = 69.2 years; SD = 7.6; 31.2% male) free of dementia or clinical stroke underwent brain MRI to quantify cerebral perfusion during CVR to hypercapnia and hypocapnia and determine WMH volume...
March 30, 2024: Neurobiology of Aging
#6
JOURNAL ARTICLE
Ashley L Ramos, Eric R Goedken, Kristine E Frank, Maria A Argiriadi, Sana Bazzaz, Zhiguo Bian, Jesse T C Brown, Paolo A Centrella, Hui-Ju Chen, Jeremy S Disch, Pamela L Donner, David B Duignan, Diana Gikunju, Stephen N Greszler, Marie-Aude Guié, Sevan Habeshian, Hajnalka E Hartl, Christopher D Hein, Charles W Hutchins, Rachael Jetson, Anthony D Keefe, Hasan Khan, Huan-Qiu Li, Allison Olszewski, Benjamin J Ortiz Cardona, Augustine Osuma, Sanjay C Panchal, Ryan Phelan, Wei Qiu, J Brad Shotwell, Anurupa Shrestha, Myron Srikumaran, Zhi Su, Chaohong Sun, Anup K Upadhyay, Michael D Wood, Haihong Wu, Ruijie Zhang, Ying Zhang, Gang Zhao, Haizhong Zhu, Matthew P Webster
Dysregulation of IL17A drives numerous inflammatory and autoimmune disorders with inhibition of IL17A using antibodies proven as an effective treatment. Oral anti-IL17 therapies are an attractive alternative option, and several preclinical small molecule IL17 inhibitors have previously been described. Herein, we report the discovery of a novel class of small molecule IL17A inhibitors, identified via a DNA-encoded chemical library screen, and their subsequent optimization to provide in vivo efficacious inhibitors...
April 4, 2024: Journal of Medicinal Chemistry
#7
MULTICENTER STUDY
Early Outcomes From a Multicenter Transcatheter Self-Expanding Pulmonary Valve Replacement Registry.
Bryan H Goldstein, Doff B McElhinney, Matthew J Gillespie, Jamil A Aboulhosn, Daniel S Levi, Brian H Morray, Allison K Cabalka, Barry A Love, Jeffrey D Zampi, David T Balzer, Mark A Law, Mary D Schiff, Arvind Hoskoppal, Athar M Qureshi
BACKGROUND: Transcatheter pulmonary valve replacement (TPVR) with the self-expanding Harmony valve (Medtronic) is an emerging treatment for patients with native or surgically repaired right ventricular outflow tract (RVOT) pulmonary regurgitation (PR). Limited data are available since U.S. Food and Drug Administration approval in 2021. OBJECTIVES: In this study, the authors sought to evaluate the safety and short-term effectiveness of self-expanding TPVR in a real-world experience...
April 9, 2024: Journal of the American College of Cardiology
#8
JOURNAL ARTICLE
Jonas L Fowler, Sherry Li Zheng, Alana Nguyen, Angela Chen, Xiaochen Xiong, Timothy Chai, Julie Y Chen, Daiki Karigane, Allison M Banuelos, Kouta Niizuma, Kensuke Kayamori, Toshinobu Nishimura, M Kyle Cromer, David Gonzalez-Perez, Charlotte Mason, Daniel Dan Liu, Leyla Yilmaz, Lucile Miquerol, Matthew H Porteus, Vincent C Luca, Ravindra Majeti, Hiromitsu Nakauchi, Kristy Red-Horse, Irving L Weissman, Lay Teng Ang, Kyle M Loh
The developmental origin of blood-forming hematopoietic stem cells (HSCs) is a longstanding question. Here, our non-invasive genetic lineage tracing in mouse embryos pinpoints that artery endothelial cells generate HSCs. Arteries are transiently competent to generate HSCs for 2.5 days (∼E8.5-E11) but subsequently cease, delimiting a narrow time frame for HSC formation in vivo. Guided by the arterial origins of blood, we efficiently and rapidly differentiate human pluripotent stem cells (hPSCs) into posterior primitive streak, lateral mesoderm, artery endothelium, hemogenic endothelium, and >90% pure hematopoietic progenitors within 10 days...
April 1, 2024: Developmental Cell
#9
RANDOMIZED CONTROLLED TRIAL
Yasaman Jamshidi-Naeini, Lilian Golzarri-Arroyo, Deependra K Thapa, Andrew W Brown, Daniel E Kpormegbey, David B Allison
No abstract text is available yet for this article.
April 3, 2024: Journal of Medical Internet Research
#10
Claudio Tripodo, Valeria Cancila, Gaia Morello, Giorgio Bertolazzi, Allison Si-Yu Chan, Giulia Bastianello, Daniel Paysan, Patrick William Jaynes, Giovanna Schiavoni, Fabrizio Mattei, Silvia Piconese, Maria Revuelta, Francesco Noto, Adele De Ninno, Ilenia Cammarata, Fabio Pagni, Saradha Venkatachalapathy, Sabina Sangaletti, Arianna Di Napoli, Davide Vacca, Silvia Lonardi, Luisa Lorenzi, Andrés J M Ferreri, Beatrice Belmonte, Gabriele Varano, Mario Paolo Colombo, Silvio Bicciato, Giorgio Inghirami, Leandro Cerchietti, Maurilio Ponzoni, Roberta Zappasodi, Fabio Facchetti, Marco Foiani, Stefano Casola, Anand D Jeyasekharan
The germinal center (GC) dark zone (DZ) and light zone (LZ) regions spatially separate expansion and diversification from selection of antigen-specific B-cells to ensure antibody affinity maturation and B cell memory. The DZ and LZ differ significantly in their immune composition despite the lack of a physical barrier, yet the determinants of this polarization are poorly understood. This study provides novel insights into signals controlling asymmetric T-cell distribution between DZ and LZ regions. We identify spatially-resolved DNA damage response and chromatin compaction molecular features that underlie DZ T-cell exclusion...
March 18, 2024: Research Square
#11
JOURNAL ARTICLE
Agnieszka Mlodnicka, Maxwell Mansolf, Aruna Chandran, Izzuddin M Aris, Catrina A Calub, Shaikh Ahmad, Allison Shapiro, David Cochran, Bibiana Restrepo, Rebecca Schmidt, Irva Hertz-Picciotto, Deborah Bennett, Diane R Gold, T Michael O'Shea, Leslie Leve, Julie B Schweitzer
Limited analyses based on national samples have assessed whether early attention-deficit/hyperactivity disorder (ADHD) symptoms predict later internalizing and externalizing symptoms in youth and the influence of sex and pubertal timing on subsequent psychiatric symptoms. This study analyzed data ( n = 2818) from the Environmental influences on Child Health Outcomes Program national cohort. Analyses used data from early childhood (mean age = 5.3 years) utilizing parent-reported ADHD symptoms to predict rates of internalizing and externalizing symptoms from late childhood/adolescence (mean age = 11...
March 27, 2024: Development and Psychopathology
#12
JOURNAL ARTICLE
Michael Sargent Binkley, Jamie E Flerlage, Kerry J Savage, Saad Akhtar, Raphael Steiner, Xiao-Yin Zhang, Michael Dickinson, Anca Prica, Ajay Major, Peter G Hendrickson, David Hopkins, Andrea Ng, Carla Casulo, Jonathan Baron, Kenneth B Roberts, Jalila Al Kendi, Alex Balogh, Umberto Ricardi, Pallawi Torka, Lena Specht, Ravindu De Silva, Keir Pickard, Lindsay J Blazin, Michael Henry, Christine M Smith, Daniel Halperin, Jessica Brady, Bernadette Brennan, Maria Anatolevna Senchenko, Marie Reeves, Bradford S Hoppe, Stephanie Terezakis, Dipti Talaulikar, Marco Picardi, Youlia Kirova, Paige Fergusson, Eliza A Hawkes, Denise Lee, Nicole Wong Doo, Allison Barraclough, Chan Y Cheah, Matthew Ku, Nada Hamad, Howard Mutsando, Michael Gilbertson, Tamara Marconi, Nicholas Viiala, Matthew J Maurer, Dennis A Eichenauer, Richard T Hoppe
PURPOSE: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and large international cooperative efforts are needed to evaluate the significance of clinical risk factors and immunoarchitectural patterns (IAPs) for all stages of pediatric and adult patients with NLPHL. METHODS: Thirty-eight institutions participated in the Global nLPHL One Working Group retrospective study of NLPHL cases from 1992 to 2021. We measured progression-free survival (PFS), overall survival (OS), transformation rate, and lymphoma-specific death rate...
March 26, 2024: Journal of Clinical Oncology
#13
Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Michael Lush, Amber M Aeilts, Kristiina Aittomäki, Nadine Andrieu, Irene L Andrulis, Hoda Anton-Culver, Adalgeir Arason, Banu K Arun, Judith Balmaña, Elisa V Bandera, Rosa B Barkardottir, Lieke P V Berger, Amy Berrington de Gonzalez, Pascaline Berthet, Katarzyna Białkowska, Line Bjørge, Amie M Blanco, Marinus J Blok, Kristie A Bobolis, Natalia V Bogdanova, James D Brenton, Henriett Butz, Saundra S Buys, Maria A Caligo, Ian Campbell, Carmen Castillo, Kathleen B M Claes, Sarah V Colonna, Linda S Cook, Mary B Daly, Agnieszka Dansonka-Mieszkowska, Miguel de la Hoya, Anna deFazio, Allison DePersia, Yuan Chun Ding, Susan M Domchek, Thilo Dörk, Zakaria Einbeigi, Christoph Engel, D Gareth Evans, Lenka Foretova, Renée T Fortner, Florentia Fostira, Maria Cristina Foti, Eitan Friedman, Megan N Frone, Patricia A Ganz, Aleksandra Gentry-Maharaj, Gord Glendon, Andrew K Godwin, Anna González-Neira, Mark H Greene, Jacek Gronwald, Aliana Guerrieri-Gonzaga, Ute Hamann, Thomas V O Hansen, Holly R Harris, Jan Hauke, Florian Heitz, Frans B L Hogervorst, Maartje J Hooning, John L Hopper, Chad D Huff, David G Huntsman, Evgeny N Imyanitov, Louise Izatt, Anna Jakubowska, Paul A James, Ramunas Janavicius, Esther M John, Siddhartha Kar, Beth Y Karlan, Catherine J Kennedy, Lambertus A L M Kiemeney, Irene Konstantopoulou, Jolanta Kupryjanczyk, Yael Laitman, Ofer Lavie, Kate Lawrenson, Jenny Lester, Fabienne Lesueur, Carlos Lopez-Pleguezuelos, Phuong L Mai, Siranoush Manoukian, Taymaa May, Iain A McNeish, Usha Menon, Roger L Milne, Francesmary Modugno, Jennifer M Mongiovi, Marco Montagna, Kirsten B Moysich, Susan L Neuhausen, Finn C Nielsen, Catherine Noguès, Edit Oláh, Olufunmilayo I Olopade, Ana Osorio, Laura Papi, Harsh Pathak, Celeste L Pearce, Inge S Pedersen, Ana Peixoto, Tanja Pejovic, Pei-Chen Peng, Beth N Peshkin, Paolo Peterlongo, C Bethan Powell, Darya Prokofyeva, Miquel Angel Pujana, Paolo Radice, Muhammad U Rashid, Gad Rennert, George Richenberg, Dale P Sandler, Naoko Sasamoto, Veronica W Setiawan, Priyanka Sharma, Weiva Sieh, Christian F Singer, Katie Snape, Anna P Sokolenko, Penny Soucy, Melissa C Southey, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Christian Sutter, Manuel R Teixeira, Kathryn L Terry, Liv Cecilie V Thomsen, Marc Tischkowitz, Amanda E Toland, Toon Van Gorp, Ana Vega, Digna R Velez Edwards, Penelope M Webb, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Stacey J Winham, Anna H Wu, Siddhartha Yadav, Yao Yu, Argyrios Ziogas, Andrew Berchuck, Fergus J Couch, Ellen L Goode, Marc T Goodman, Alvaro N Monteiro, Kenneth Offit, Susan J Ramus, Harvey A Risch, Joellen M Schildkraut, Mads Thomassen, Jacques Simard, Douglas F Easton, Michelle R Jones, Georgia Chenevix-Trench, Simon A Gayther, Antonis C Antoniou, Paul D P Pharoah
BACKGROUND: Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium (OCAC), Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA), UK Biobank (UKBB), and FinnGen to identify novel HGSOC susceptibility loci and develop polygenic scores (PGS). METHODS: We analyzed >22 million variants for 398,238 women. Associations were assessed separately by consortium and meta-analysed...
March 4, 2024: medRxiv
#14
JOURNAL ARTICLE
David B Sarwer, Thomas A Wadden, Rebecca Ashare, Jacqueline C Spitzer, Courtney McCuen-Wurst, Caitlin LaGrotte, Noel Williams, Rohit Soans, Colleen Tewksbury, Jingwei Wu, Gabriel Tajeu, Kelly C Allison
BACKGROUND: The relationship between theoretically relevant psychosocial and behavioral variables and outcomes of metabolic and bariatric surgery remains unclear. Some studies have found that the presence of psychopathology, disordered eating, and impulsivity, either before surgery or during the early postoperative period, is associated with suboptimal postoperative weight loss. Other studies have not found these relationships. OBJECTIVE: Examine the relationship between psychopathology, disordered eating, impulsivity, and weight loss 24 months postoperatively...
February 7, 2024: Surgery for Obesity and Related Diseases
#15
JOURNAL ARTICLE
Julia M W Wong, David S Ludwig, David B Allison, Navneet Baidwan, Lisa Bielak, Chia-Ying Chiu, Stephanie L Dickinson, Lilian Golzarri-Arroyo, Steven B Heymsfield, Lauren Holmes, Lisa T Jansen, Donna Lesperance, Tapan Mehta, Megan Sandman, Sarah K Steltz, William W Wong, Shui Yu, Cara B Ebbeling
BACKGROUND: Evaluating effects of different macronutrient diets in randomized trials requires well defined infrastructure and rigorous methods to ensure intervention fidelity and adherence. METHODS: This controlled feeding study comprised two phases. During a Run-in phase (14-15 weeks), study participants (18-50 years, BMI, ≥27 kg/m2 ) consumed a very-low-carbohydrate (VLC) diet, with home delivery of prepared meals, at an energy level to promote 15 ± 3% weight loss...
March 6, 2024: Contemporary Clinical Trials
#16
JOURNAL ARTICLE
Robert J Hayashi, Michelle L Hermiston, Brent L Wood, David Trent Teachey, Meenakshi Devidas, Zhiguo Chen, Robert D Annett, Barbara L Asselin, Keith August, Steve Cho, Kimberly P Dunsmore, Jason Lawrence Freedman, Paul J Galardy, Paul Harker-Murray, Terzah M Horton, Alok Jaju, Allison Lam, Yoav H Messinger, Rodney R Miles, Maki Okada, Samir Patel, Eric Stephen Schafer, Tal Schechter, Kristin A Shimano, Neelam Singh, Amii Steele, Maria Luisa Sulis, Sarah Vargas, Stuart S Winter, Charlotte Wood, Patrick A Zweider-McKay, Mignon L Loh, Stephen P Hunger, Elizabeth A Raetz, Catherine M Bollard, Carl E Allen
Defining prognostic variables in T-lymphoblastic lymphoma (T-LL) remains a challenge. AALL1231 was a COG phase 3 clinical trial for newly diagnosed with T Acute Lymphoblastic leukemia or T-LL patients randomizing children and young adults to a modified augmented BFM backbone to receive standard therapy (Arm A) or with addition of bortezomib (Arm B). Optional bone marrow (BM) samples to assess minimal residual disease (MRD) at the end of induction (EOI) were collected in T-LL analyzed to assess the correlation of MRD at the EOI to event-free survival (EFS)...
March 8, 2024: Blood
#17
JOURNAL ARTICLE
Yehudis Stokes, Paula Cloutier, Dhiraj Aggarwal, Jean Daniel Jacob, Erin Hambrick, Andrea C Tricco, Michelle K Ward, Allison Kennedy, Stephanie Greenham, Marjorie Robb, Roxanna Sheppard, David Murphy, Jennifer Boggett, Ian D Graham, Krystina B Lewis
AIMS: To explore youth, caregiver and staff perspectives on their vision of trauma-informed care, and to identify and understand potential considerations for the implementation of a trauma-informed care programme in an inpatient mental health unit within a paediatric hospital. DESIGN AND METHODS: We applied the Interpretive Description approach, guided by complexity theory and the Implementation Roadmap, and used Applied Thematic Analysis methods. FINDINGS: Twenty-five individuals participated in individual or group interviews between March and June 2022, including 21 healthcare professionals, 3 youth and 1 caregiver...
March 7, 2024: Journal of Advanced Nursing
#18
EDITORIAL
Arthur Lupia, David B Allison, Kathleen Hall Jamieson, Jennifer Heimberg, Magdalena Skipper, Susan M Wolf
In recent years, many questions have been raised about whether public confidence in science is changing. To clarify recent trends in the public's confidence and factors that are associated with these feelings, an effort initiated by the National Academies' Strategic Council for Research Excellence, Integrity, and Trust (the Strategic Council) analyzed findings from multiple survey research organizations. The Strategic Council's effort, which began in 2022, found that U.S. public confidence in science, the scientific community, and leaders of scientific communities is high relative to other civic, cultural, and governmental institutions for which researchers regularly collect such data...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
#19
JOURNAL ARTICLE
Jennifer DeCuir, Amanda B Payne, Wesley H Self, Elizabeth A K Rowley, Kristin Dascomb, Malini B DeSilva, Stephanie A Irving, Shaun J Grannis, Toan C Ong, Nicola P Klein, Zachary A Weber, Sarah E Reese, Sarah W Ball, Michelle A Barron, Allison L Naleway, Brian E Dixon, Inih Essien, Daniel Bride, Karthik Natarajan, Bruce Fireman, Ami B Shah, Erica Okwuazi, Ryan Wiegand, Yuwei Zhu, Adam S Lauring, Emily T Martin, Manjusha Gaglani, Ithan D Peltan, Samuel M Brown, Adit A Ginde, Nicholas M Mohr, Kevin W Gibbs, David N Hager, Matthew Prekker, Amira Mohamed, Vasisht Srinivasan, Jay S Steingrub, Akram Khan, Laurence W Busse, Abhijit Duggal, Jennifer G Wilson, Steven Y Chang, Christopher Mallow, Jennie H Kwon, Matthew C Exline, Cristie Columbus, Ivana A Vaughn, Basmah Safdar, Jarrod M Mosier, Estelle S Harris, Jonathan D Casey, James D Chappell, Carlos G Grijalva, Sydney A Swan, Cassandra Johnson, Nathaniel M Lewis, Sascha Ellington, Katherine Adams, Mark W Tenforde, Clinton R Paden, Fatimah S Dawood, Katherine E Fleming-Dutra, Diya Surie, Ruth Link-Gelles
In September 2023, CDC's Advisory Committee on Immunization Practices recommended updated 2023-2024 (monovalent XBB.1.5) COVID-19 vaccination for all persons aged ≥6 months to prevent COVID-19, including severe disease. However, few estimates of updated vaccine effectiveness (VE) against medically attended illness are available. This analysis evaluated VE of an updated COVID-19 vaccine dose against COVID-19-associated emergency department (ED) or urgent care (UC) encounters and hospitalization among immunocompetent adults aged ≥18 years during September 2023-January 2024 using a test-negative, case-control design with data from two CDC VE networks...
February 29, 2024: MMWR. Morbidity and Mortality Weekly Report
#20
JOURNAL ARTICLE
Edward A Frongillo, Hilary J Bethancourt, Andrea Norcini Pala, Sigal Maya, Katherine C Wu, Jorge R Kizer, Phyllis C Tien, Mirjam-Colette Kempf, David B Hanna, Allison A Appleton, Daniel Merenstein, Gypsyamber D'Souza, Igho Ofotokun, Deborah Konkle-Parker, Erin D Michos, Sarah Krier, Valentina Stosor, Bulent Turan, Sheri D Weiser
BACKGROUND: Social unacceptability of food access is part of the lived experience of food insecurity but is not assessed as part of the U.S. Household Food Security Survey Module (HFSSM). OBJECTIVE: The objectives were to 1) determine the psychometric properties of two additional items on social unacceptability in relation to the HFSSM items and 2) test whether these two items provided added predictive accuracy to that of the HFSSM items for mental health outcomes...
February 24, 2024: Journal of Nutrition
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