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David B Allison

Wenming Zhu, Adrian Lawsin, Rebecca L Lindsey, Dhwani Batra, Kristen Knipe, Brian B Yoo, K Allison Perry, Lori A Rowe, David Lonsway, Maroya S Waters, J Kamile Rasheed, Alison Laufer Halpin
Four Enterobacteriaceae clinical isolates bearing mcr-1 gene-harboring plasmids were characterized. All isolates demonstrated the ability to transfer colistin resistance to E. coli; plasmids were stable in conjugants after multiple passages on non-selective media. mcr-1 was located on an IncX4 (n=3) or IncN (n=1) plasmid. The IncN plasmid harbored 13 additional antimicrobial resistance genes. Results indicate the mcr-1 -bearing plasmids in this study are highly transferable in vitro and stable in the recipients...
February 11, 2019: Antimicrobial Agents and Chemotherapy
Warren Pan, Margaret B Allison, Paul Sabatini, Alan Rupp, Jessica Adams, Christa Patterson, Justin C Jones, David P Olson, Martin G Myers
OBJECTIVES: Leptin acts via its receptor LepRb on specialized neurons in the brain to modulate food intake, energy expenditure, and body weight. LepRb activates signal transducers and activators of transcription (STATs, including STAT1, STAT3, and STAT5) to control gene expression. METHODS: Because STAT3 is crucial for physiologic leptin action, we used TRAP-seq to examine gene expression in LepRb neurons of mice ablated for Stat3 in LepRb neurons (Stat3LepRb KO mice), revealing the STAT3-dependent transcriptional targets of leptin...
January 24, 2019: Molecular Metabolism
David M Cutler, Kaushik Ghosh, Kassandra L Messer, Trivellore E Raghunathan, Susan T Stewart, Allison B Rosen
We examined trends in per capita spending for Medicare beneficiaries ages sixty-five and older in the United States in the period 1999-2012 to determine why spending growth has been declining since around 2005. Decomposing spending by condition, we found that half of the spending slowdown was attributable to slower growth in spending for cardiovascular diseases. Spending growth also slowed for dementia, renal and genitourinary diseases, and aftercare for people with acute illnesses. Using estimates from the medical literature of the impact of pharmaceuticals on acute disease, we found that roughly half of the reduction in major cardiovascular events was attributable to medications controlling cardiovascular risk factors...
February 2019: Health Affairs
Ignacio Pérez-Valero, Ronald Ellis, Robert Heaton, Reena Deutsch, Donald Franklin, David B Clifford, Ann Collier, Benjamin Gelman, Christina Marra, John Allen McCutchan, Allison Navis, Ned Sacktor, David Simpson, Igor Grant, Scott Letendre
BACKGROUND: During antiretroviral therapy, HIV RNA can be detected in cerebrospinal fluid (CSF) when it is undetectable in plasma, a condition termed 'CSF viral escape'. The aim of the current study was to determine the prevalence and risk factors for CSF viral escape in two large cohorts in the USA. METHODS: A total of 1264 HIV-infected volunteers enrolled in two US cohorts at their most recent visit between 2003 and 2011 were included in this cross-sectional analysis if their HIV RNA level in plasma was less than 50 copies/ml while receiving stable antiretroviral therapy (ART) (>6 months) and if they had HIV RNA measured in CSF at their most recent visit between 2003 and 2011...
March 1, 2019: AIDS
Allison J Hempenstall, Simon Smith, David Stanton, Josh Hanson
Burkholderia pseudomallei , a bacterium that lives in the soil of the tropics, causes the disease melioidosis. This retrospective study investigated the temporospatial epidemiology of the 49 laboratory-confirmed melioidosis cases in the Torres Straits Islands of tropical Australia between 1997 and 2017. An identifiable risk factor for the disease was present in 43/49 (88%) cases and in 35/36 (97%) cases with complete clinical data. The mean incidence of melioidosis varied across the region, from 0/100,000 persons/year in the Eastern Island Cluster to 116...
January 21, 2019: American Journal of Tropical Medicine and Hygiene
Anarina L Murillo, Olivia Affuso, Courtney M Peterson, Peng Li, Howard W Wiener, Carmen D Tekwe, David B Allison
OBJECTIVE: This study aimed to illustrate the use and value of measurement error models for reducing bias when evaluating associations between body fat and having type 2 diabetes (T2D) or being physically active. METHODS: Logistic regression models were used to evaluate T2D and physical activity among adults aged 19 to 80 years from the Photobody Study (n = 558). Self-reported T2D and physical activity were categorized as "yes" or "no." Body fat measured by two-dimensional photographs was adjusted for bias using dual-energy x-ray absorptiometry scans as a reference...
January 22, 2019: Obesity
David S Kroll, Escel Stanghellini, Stephanie L DesRoches, Charles Lydon, Allison Webster, Molly O'Reilly, Shelley Hurwitz, Patricia M Aylward, Jennifer A Cartright, Elizabeth J McGrath, Linda Delaporta, Anna T Meyer, Michael S Kristan, Laurie J Falaro, Colin Murphy, Jennifer Karno, Daniel J Pallin, Adam Schaffer, Sejal B Shah, Barbara E Lakatos, Monique T Mitchell, Christine A Murphy, Janet M Gorman, David F Gitlin, Deborah F Mulloy
OBJECTIVE: To determine whether continuous virtual monitoring, an intervention that facilitates patient observation through video technology, can be used to monitor suicide risk in the general hospital and emergency department (ED). METHOD: This was a retrospective analysis of a protocol in which select patients on suicide precautions in the general hospital and ED received virtual monitoring between June 2017 and March 2018. The primary outcome was the number of adverse events among patients who received virtual monitoring for suicide risk...
January 14, 2019: General Hospital Psychiatry
Scott D Tiegs, David M Costello, Mark W Isken, Guy Woodward, Peter B McIntyre, Mark O Gessner, Eric Chauvet, Natalie A Griffiths, Alex S Flecker, Vicenç Acuña, Ricardo Albariño, Daniel C Allen, Cecilia Alonso, Patricio Andino, Clay Arango, Jukka Aroviita, Marcus V M Barbosa, Leon A Barmuta, Colden V Baxter, Thomas D C Bell, Brent Bellinger, Luz Boyero, Lee E Brown, Andreas Bruder, Denise A Bruesewitz, Francis J Burdon, Marcos Callisto, Cristina Canhoto, Krista A Capps, María M Castillo, Joanne Clapcott, Fanny Colas, Checo Colón-Gaud, Julien Cornut, Verónica Crespo-Pérez, Wyatt F Cross, Joseph M Culp, Michael Danger, Olivier Dangles, Elvira de Eyto, Alison M Derry, Veronica Díaz Villanueva, Michael M Douglas, Arturo Elosegi, Andrea C Encalada, Sally Entrekin, Rodrigo Espinosa, Diana Ethaiya, Verónica Ferreira, Carmen Ferriol, Kyla M Flanagan, Tadeusz Fleituch, Jennifer J Follstad Shah, André Frainer Barbosa, Nikolai Friberg, Paul C Frost, Erica A Garcia, Liliana García Lago, Pavel Ernesto García Soto, Sudeep Ghate, Darren P Giling, Alan Gilmer, José Francisco Gonçalves, Rosario Karina Gonzales, Manuel A S Graça, Mike Grace, Hans-Peter Grossart, François Guérold, Vlad Gulis, Luiz U Hepp, Scott Higgins, Takuo Hishi, Joseph Huddart, John Hudson, Samantha Imberger, Carlos Iñiguez-Armijos, Tomoya Iwata, David J Janetski, Eleanor Jennings, Andrea E Kirkwood, Aaron A Koning, Sarian Kosten, Kevin A Kuehn, Hjalmar Laudon, Peter R Leavitt, Aurea L Lemes da Silva, Shawn J Leroux, Carri J LeRoy, Peter J Lisi, Richard MacKenzie, Amy M Marcarelli, Frank O Masese, Brendan G McKie, Adriana Oliveira Medeiros, Kristian Meissner, Marko Miliša, Shailendra Mishra, Yo Miyake, Ashley Moerke, Shorok Mombrikotb, Rob Mooney, Tim Moulton, Timo Muotka, Junjiro N Negishi, Vinicius Neres-Lima, Mika L Nieminen, Jorge Nimptsch, Jakub Ondruch, Riku Paavola, Isabel Pardo, Christopher J Patrick, Edwin T H M Peeters, Jesus Pozo, Catherine Pringle, Aaron Prussian, Estefania Quenta, Antonio Quesada, Brian Reid, John S Richardson, Anna Rigosi, José Rincón, Geta Rîşnoveanu, Christopher T Robinson, Lorena Rodríguez-Gallego, Todd V Royer, James A Rusak, Anna C Santamans, Géza B Selmeczy, Gelas Simiyu, Agnija Skuja, Jerzy Smykla, Kandikere R Sridhar, Ryan Sponseller, Aaron Stoler, Christopher M Swan, David Szlag, Franco Teixeira-de Mello, Jonathan D Tonkin, Sari Uusheimo, Allison M Veach, Sirje Vilbaste, Lena B M Vought, Chiao-Ping Wang, Jackson R Webster, Paul B Wilson, Stefan Woelfl, Marguerite A Xenopoulos, Adam G Yates, Chihiro Yoshimura, Catherine M Yule, Yixin X Zhang, Jacob A Zwart
River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth's biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes...
January 2019: Science Advances
Amika K Sood, Allison J Burbank, Charity G Duran, Kimberly Enders, Haibo Zhou, David B Peden, Michelle L Hernandez
Gamma tocopherol may be beneficial as a primary or complementary therapeutic agent in conditions with neutrophilic airway inflammation. Its effects are not modified by BMI or GSTM1 genotype, allowing for its use in a broader population.
January 17, 2019: Journal of Allergy and Clinical Immunology
Doff B McElhinney, Jamil A Aboulhosn, Danny Dvir, Brian Whisenant, Yulin Zhang, Andreas Eicken, Flavio Ribichini, Aphrodite Tzifa, Michael R Hainstock, Mary H Martin, Ran Kornowski, Stephan Schubert, Azeem Latib, John D R Thomson, Alejandro J Torres, Jeffery Meadows, Jeffrey W Delaney, Mayra E Guerrero, Stefano Salizzoni, Howaida El-Said, Ariel Finkelstein, Isaac George, Marc Gewillig, Maria Alvarez-Fuente, Luke Lamers, Asim N Cheema, Jacqueline N Kreutzer, Tanja Rudolph, David Hildick-Smith, Allison K Cabalka
BACKGROUND: Transcatheter aortic and pulmonary valves have been used to treat stenosis or regurgitation after prior surgical tricuspid valve (TV) replacement or repair. Little is known about intermediate-term valve-related outcomes after transcatheter tricuspid valve replacement (TTVR), including valve function, thrombus, and endocarditis. OBJECTIVES: The authors sought to evaluate mid-term outcomes in a large cohort of patients who underwent TTVR after surgical TV repair or replacement, with a focus on valve-related outcomes...
January 22, 2019: Journal of the American College of Cardiology
Daniel J Landsburg, Mitchell E Hughes, Alexa Koike, David Bond, Kami J Maddocks, Ling Guo, Allison M Winter, Brian T Hill, Sarah L Ondrejka, Eric D Hsi, Sunita D Nasta, Jakub Svoboda, Stephen J Schuster, Agata M Bogusz
No abstract text is available yet for this article.
January 22, 2019: Blood Advances
David C Gershlick, Morié Ishida, Julie R Jones, Allison Bellomo, Juan S Bonifacino, David B Everman
GARP and EARP are related heterotetrameric protein complexes that associate with the cytosolic face of the trans-Golgi network and recycling endosomes, respectively. At these locations, GARP and EARP function to promote the fusion of endosome-derived transport carriers with their corresponding compartments. GARP and EARP share three subunits, VPS51, VPS52 and VPS53, and each has an additional complex-specific subunit, VPS54 or VPS50, respectively. The role of these complexes in human physiology, however, remains poorly understood...
January 8, 2019: Human Molecular Genetics
Mauricio A Martins, Lucas Gonzalez-Nieto, Young C Shin, Aline Domingues, Martin J Gutman, Helen S Maxwell, Diogo M Magnani, Michael J Ricciardi, Núria Pedreño-Lopez, Varian K Bailey, John D Altman, Christopher L Parks, David B Allison, Keisuke Ejima, Eva G Rakasz, Saverio Capuano, Ronald C Desrosiers, Jeffrey D Lifson, David I Watkins
Approximately 50% of rhesus macaques (RMs) expressing the major histocompatibility complex class I (MHC-I) allele Mamu-B*08 spontaneously control chronic phase viremia after infection with the pathogenic simian immunodeficiency virus (SIV)mac239 clone. CD8+ T-cell responses in these animals are focused on immunodominant Mamu-B*08-restricted SIV epitopes in Vif and Nef, and prophylactic vaccination with these epitopes increases the incidence of elite control in SIVmac239-infected Mamu-B*08+ RMs. Here we evaluated if robust vaccine-elicited CD8+ T-cell responses against Vif and Nef can prevent systemic infection in Mamu-B*08+ RMs following mucosal SIV challenges...
December 12, 2018: Journal of Virology
Katherine M Ryan, Melanie J Zimmer-Gembeck, David L Neumann, Allison M Waters
Fear extinction studies in youth have yielded mixed results due to developmental processes and variations in design, methodology and dependent measures. This systematic review focused on studies with healthy youth between 2 and 17 years of age to identify experimental parameters of studies documenting extinction effects. Thirty-five studies met inclusion criteria and the following themes emerged (a) some studies employed parameters and task demands that are complex and require active participant involvement whereas others involved simple stimulus configurations and passive participant involvement, and (b) variation exists among dependent measures in units of measurement, timing and type of measurement...
November 20, 2018: Behaviour Research and Therapy
Nicholas Bien, Pranav Rajpurkar, Robyn L Ball, Jeremy Irvin, Allison Park, Erik Jones, Michael Bereket, Bhavik N Patel, Kristen W Yeom, Katie Shpanskaya, Safwan Halabi, Evan Zucker, Gary Fanton, Derek F Amanatullah, Christopher F Beaulieu, Geoffrey M Riley, Russell J Stewart, Francis G Blankenberg, David B Larson, Ricky H Jones, Curtis P Langlotz, Andrew Y Ng, Matthew P Lungren
BACKGROUND: Magnetic resonance imaging (MRI) of the knee is the preferred method for diagnosing knee injuries. However, interpretation of knee MRI is time-intensive and subject to diagnostic error and variability. An automated system for interpreting knee MRI could prioritize high-risk patients and assist clinicians in making diagnoses. Deep learning methods, in being able to automatically learn layers of features, are well suited for modeling the complex relationships between medical images and their interpretations...
November 2018: PLoS Medicine
Elke Platz, Allison Merz, Montane Silverman, Eldrin Lewis, John D Groarke, Aaron Waxman, David Systrom
AIMS: Dyspnoea is common in heart failure (HF) but non-specific. Lung ultrasound (LUS) could represent a non-invasive tool to detect subclinical pulmonary congestion in patients with undifferentiated dyspnoea. METHODS AND RESULTS: We assessed the feasibility of an abbreviated LUS protocol (eight and two zones) in a prospective pilot study of 25 ambulatory patients with undifferentiated dyspnoea undergoing clinically indicated invasive cardiopulmonary exercise testing (iCPET) at rest (LUS 1) and after peak exercise (LUS 2)...
November 26, 2018: ESC Heart Failure
Greg Pavela, David B Allison, Michelle I Cardel
No abstract text is available yet for this article.
January 1, 2019: Appetite
Benjamin J Matthews, Olga Dudchenko, Sarah B Kingan, Sergey Koren, Igor Antoshechkin, Jacob E Crawford, William J Glassford, Margaret Herre, Seth N Redmond, Noah H Rose, Gareth D Weedall, Yang Wu, Sanjit S Batra, Carlos A Brito-Sierra, Steven D Buckingham, Corey L Campbell, Saki Chan, Eric Cox, Benjamin R Evans, Thanyalak Fansiri, Igor Filipović, Albin Fontaine, Andrea Gloria-Soria, Richard Hall, Vinita S Joardar, Andrew K Jones, Raissa G G Kay, Vamsi K Kodali, Joyce Lee, Gareth J Lycett, Sara N Mitchell, Jill Muehling, Michael R Murphy, Arina D Omer, Frederick A Partridge, Paul Peluso, Aviva Presser Aiden, Vidya Ramasamy, Gordana Rašić, Sourav Roy, Karla Saavedra-Rodriguez, Shruti Sharan, Atashi Sharma, Melissa Laird Smith, Joe Turner, Allison M Weakley, Zhilei Zhao, Omar S Akbari, William C Black, Han Cao, Alistair C Darby, Catherine A Hill, J Spencer Johnston, Terence D Murphy, Alexander S Raikhel, David B Sattelle, Igor V Sharakhov, Bradley J White, Li Zhao, Erez Lieberman Aiden, Richard S Mann, Louis Lambrechts, Jeffrey R Powell, Maria V Sharakhova, Zhijian Tu, Hugh M Robertson, Carolyn S McBride, Alex R Hastie, Jonas Korlach, Daniel E Neafsey, Adam M Phillippy, Leslie B Vosshall
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance...
November 14, 2018: Nature
Molly B Richardson, Peng Li, Julia M Gohlke, David B Allison
OBJECTIVE: It was hypothesized that exposure to mild temperatures above the human thermoneutral zone would decrease caloric intake in a sedentary office environment. METHODS: Women (n = 25) were randomized in a crossover design to perform seated office work for 7 hours in a thermoneutral condition (control, 19°C-20°C) and a condition above the thermoneutral zone (warm, 26°C-27°C). Food intake was estimated by weight and bomb calorimetry, peripheral temperature by thermal imaging, and thermal comfort and productivity by questionnaires...
December 2018: Obesity
Elisabeth Cole, Alexandra Dreyzin, Amber D Shaffer, Allison B J Tobey, David H Chi, Tony Tarchichi
OBJECTIVES: To improve the recognition of differences in presentation amongst patients with type 1 laryngeal clefts of various ages and better understand the age dependent outcomes of injection laryngoplasty. A second aim was to analyze the discrepancies between swallow assessment modalities in various age groups with type I laryngeal clefts undergoing injection laryngoplasty. METHODS: A retrospective review of electronic medical records of patients who underwent injection laryngoplasty from 2009 through 2015 at a tertiary care children's hospital...
December 2018: International Journal of Pediatric Otorhinolaryngology
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