Zhong-Ping Jiang, Rui Su, Meng-Ting Chen, Jun-Yi Li, Han-Yu Chen, Lu Yang, Fei-Fei Liu, Jin Liu, Cong-Jun Xu, Wan-Shan Li, Yong Rao, Ling Huang
In this study, twenty-three ent-eudesmane sesquiterpenoids (1-23) including fifteen previously undescribed ones, named eutypelides A-O (1-15) were isolated from the marine-derived fungus Eutypella sp. F0219. Their planar structures and relative configurations were established by HR-ESIMS and extensive 1D and 2D NMR investigations. The absolute configurations of the previously undescribed compounds were determined by single-crystal X-ray diffraction analyses, modified Mosher's method, and ECD calculations. Structurally, eutypelide A (1) is a rare 1,10-seco-ent-eudesmane, whereas 2-15 are typically ent-eudesmanes with 6/6/-fused bicyclic carbon nucleus...
May 1, 2024: Phytochemistry