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Corneal confocal microscopy

Theo G van Kooten, Steven A Koopmans, Thom Terwee, Sönke Langner, Oliver Stachs, Rudolf F Guthoff
PURPOSE: To reduce capsular opacification by a peri-surgical treatment of the lens capsule with drugs in an in vivo rabbit model. Lens-refilling surgery is a potential therapeutic intervention to treat patients with a cataract lens. The lens material is replaced with an injectable (bio)polymer that retains the natural mechanical and optical lens properties, therewith allowing accommodation. The occurrence of capsular opacification mediated by lens epithelial cells negatively affects accommodation and vision and should be avoided in this lens restoration approach...
March 22, 2019: Acta Ophthalmologica
A Yan, T Issar, S S Tummanapalli, M Markoulli, N C G Kwai, A M Poynten, A V Krishnan
AIMS: To investigate changes in corneal nerve morphology in Type 2 diabetes and to establish relationships between in vivo corneal confocal microscopy and markers of peripheral nerve structure and function. PARTICIPANTS AND METHODS: We recruited 57 participants with Type 2 diabetes and 26 healthy controls of similar age and sex distribution. We also recruited a disease control group of 54 participants with Type 1 diabetes. All participants were assessed for distal symmetrical polyneuropathy using the Total Neuropathy Score...
March 21, 2019: Diabetic Medicine: a Journal of the British Diabetic Association
Almamoun Abdelkader
PURPOSE: To evaluate and compare the influence of the wound healing process at the graft edge on corneal biomechanics after primary penetrating keratoplasty (PK) and repeat PK. METHODS: This retrospective comparative study included 95 eyes: 35 eyes of 35 patients had PK, 40 eyes of 40 patients underwent repeat PK, and 20 eyes of 20 normal subjects served as the control group. The ocular response analyzer was used to measure and compare corneal hysteresis and corneal resistance factor among the study groups at least 6 months after all sutures were removed...
March 18, 2019: Cornea
Hoda Gad, Adnan Khan, Naveed Akhtar, Saadat Kamran, Ahmed El-Sotouhy, Soha R Dargham, Ioannis N Petropoulos, Georgios Ponirakis, Ashfaq Shuaib, Leopold J Streletz, Rayaz A Malik
OBJECTIVE: To determine if corneal confocal microscopy can identify corneal nerve and endothelial cell abnormalities and may be useful in the prognostication of patients with transient ischemic attack [1] or minor ischemic stroke (IS). METHODS: Thirty-six patients admitted with TIA (n = 14) or minor IS (n = 22) underwent transcranial Doppler evaluation and corneal confocal microscopy and were compared with 18 healthy controls. RESULTS: Corneal nerve fiber density (P = 0...
2019: PloS One
Iben Bach Damgaard, Yu-Chi Liu, Andri Kartasasmita Riau, Ericia Pei Wen Teo, Min Li Tey, Chan Lwin Nyein, Jodhbir Singh Mehta
Implantation of biological corneal inlays, derived from small incision lenticule extraction, may be a feasible method for surgical management of refractive and corneal diseases. However, the refractive outcome is dependent on stromal remodelling of both the inlay and recipient stroma. This study aimed to investigate the refractive changes and tissue responses following implantation of 2.5-mm biological inlays with or without corneal collagen crosslinking (CXL) in a rabbit model. Prior to implantation, rotational rheometry demonstrated an almost two-fold increase in corneal stiffness after CXL...
March 14, 2019: Scientific Reports
Tao Zhang, Chang Liu, Jingliang He, Yanwei Kang, Feng Wang, Shaowei Li
PURPOSE: The aim of this study was to analyze the relevant gene mutations in a Chinese family with special phenotypic variants of granular corneal dystrophy type 2 with cornea guttata. METHODS: A total of 11 individuals from the affected family underwent complete ophthalmic examination. Genomic DNA was extracted from peripheral leukocytes of affected and unaffected family members. High-throughput sequencing was performed to screen for mutations in 290 genes associated with inherited ophthalmic diseases...
March 14, 2019: European Journal of Ophthalmology
Gemma Caterina Maria Rossi, Luigia Scudeller, Chiara Lumini, Alessandra Venera Mirabile, Erica Picasso, Federica Bettio, Gian Maria Pasinetti, Paolo Emilio Bianchi
The aim of this study was to evaluate the in vivo effects at 3 years of preservative-free tafluprost on corneal health. It was a prospective, masked, study on consecutive patients with a new prescription of preservative-free (PF) tafluprost (naïve-N or switched-S, 44 and 14 patients), and preserved (P) bimatoprost 0.003% or travoprost 0.004% (P-group, 35 patients). A complete ophthalmic examination and an in vivo corneal confocal microscopy evaluation were performed at baseline and every 6 months for 3 years...
March 12, 2019: Scientific Reports
He Jin, Miao He, Hongshan Liu, Xiaoying Zhong, Junshu Wu, Liangping Liu, Hui Ding, Chi Zhang, Xingwu Zhong
PURPOSE: To evaluate the feasibility and efficacy of small-incision femtosecond laser-assisted intracorneal concave lenticule implantation (SFII) and penetrating keratoplasty (PKP) in patients with progressive keratoconus. METHODS: All the patients were clinically diagnosed with progressive keratoconus. Twenty patients underwent PKP (PKP group), and 11 patients underwent SFII (SFII group). Visual acuity, intraocular pressure, corneal topography, corneal visualization Scheimpflug technology, anterior segment optical coherence tomography, and in vivo confocal microscopy were analyzed...
April 2019: Cornea
Gyule Han, Dong Hui Lim, Chan Min Yang, Gil Ho Park, Dae-Young Park, Hyun Seung Moon, Jae Myung Lee, Jong Ho Lee, Tae-Young Chung
BACKGROUND: To evaluate the 6-month clinical outcomes of Flexivue Microlens refractive corneal inlay in emmetropic patients in Asia for the surgical compensation of presbyopia. METHODS: In this retrospective study, corneal inlay implantation was done using a femtosecond laser. The follow-up period was 6 months. Near/intermediate/distant visual acuities, refraction, keratometry, defocus curve, wavefront aberrations, contrast sensitivity, Scheimpflug corneal scanning, endothelial cell density, dry eye test, confocal microscopy scanning, and patient questionnaires were evaluated...
March 5, 2019: BMC Ophthalmology
Els Deklerck, Hannelore Denys, Elke O Kreps
PURPOSE: Ado-trastuzumab emtansine (T-DM1/Kadcyla® ;Genentech) is an antibody-drug conjugate used in the treatment of human epidermal growth factor receptor-2-positive metastasized breast cancer. Few studies report a spectrum of corneal changes in patients treated with this drug. Our aim is to specify the nature and prevalence of corneal features of T-DM1 treatment in order to formulate guidelines as to which findings necessitate systemic treatment cessation or dose reduction. METHODS: We performed a cross-sectional, prospective study in all patients currently treated with T-DM1 or recently stopped in Ghent University Hospital, Belgium...
February 28, 2019: Breast Cancer Research and Treatment
Eszter A Deák, Eszter Szalai, Noémi Tóth, Rayaz A Malik, András Berta, Adrienne Csutak
Purpose: We have previously used in vivo corneal confocal microscopy (IVCCM) to demonstrate significant alterations in the corneal epithelial cells, stromal keratocytes, and subbasal nerves in young patients with type 1 diabetes mellitis (T1DM), especially those with diabetic retinopathy (DR). We have evaluated the change in corneal cellular and subbasal nerve morphology over 2 years in young patients with T1DM with or without DR. Methods: A total of 19 patients with T1DM, without (n = 12) and with (n = 7) DR and 19 age- and sex-matched healthy control subjects underwent quantification of corneal cellular and subbasal nerve plexus morphology by using IVCCM at baseline and after 2 years...
February 1, 2019: Investigative Ophthalmology & Visual Science
Kai Liao, Min Hu, Fen Chen, Pei Li, Peng Song, Qing-Yan Zeng
AIM: To compare the clinical and microstructural changes induced by different transepithelial iontophoresis-assisted corneal cross-linking (I-CXL) methods for keratoconus. METHODS: A total of 42 eyes of 42 patients with progressive keratoconus were divided into two groups. Group A received I-CXL for 5min, while group B received I-CXL for 10min. Visual acuity, optical coherence tomography (OCT), specular microscopy and confocal microscopy were evaluated preoperatively and at 1, 3, 6, and 12mo postoperatively...
2019: International Journal of Ophthalmology
Xiaodan Jiang, Yuexin Wang, Weiqiang Qiu, Chen Huang, Ziyuan Liu, Tong Ding, Danna Shi, Xuemin Li
BACKGROUND: To investigate the transparency, biocompatibility, and safety of human-derived acellular dermal matrix for application in corneal stromal transplantation. METHODS: Twenty-four patients (24 eyes) with pellucid marginal corneal degeneration were enrolled, and intrastromal keratoplasty was performed with human-derived acellular dermal matrix. The ocular symptoms and signs as well as graft characteristics were evaluated at baseline and at 1 day, 1 week, 1 month, 3 months, and 6 months postoperatively...
February 19, 2019: Transplantation
Chareenun Chirapapaisan, Alessandro Abbouda, Arsia Jamali, Rodrigo T Müller, Bernardo M Cavalcanti, Clara Colon, Deborah Witkin, Afsun Sahin, Reza Dana, Andrea Cruzat, Pedram Hamrah
PURPOSE: Diagnosis of graft rejection is based on patient symptoms and on clinical signs by the slit-lamp biomicroscopy. The purpose of this study is to investigate whether laser in vivo confocal microscopy (IVCM) can aid in the diagnosis of corneal graft rejection by detecting cellular corneal changes that take place after transplantation. DESIGN: Prospective case-control study. SUBJECTS: Thirty-eight eyes of 38 patients with penetrating keratoplasty (PKP) (15 eyes with corneal graft rejection, 23 eyes without rejection) and nine age-matched normal controls...
February 18, 2019: American Journal of Ophthalmology
Cem Simsek, Takashi Kojima, Taeko Nagata, Murat Dogru, Kazuo Tsubota
Purpose: To evaluate the morphologic changes in the corneal subbasal nerve (CSN) plexus in wild-type (WT) mice after exposure to scopolamine-induced dry eye stress (DES) by using in vivo confocal microscopy. Methods: Twenty right eyes of twenty (n = 20) 8-week-old WT BALB/c male mice were investigated. The mice were divided into two experimental groups; 10 eyes of 10 mice exposed to DES for 28 days and 10 eyes of 10 mice were used as a control group. All mice underwent examinations for aqueous tear secretion quantity, tear film breakup time (TBUT), corneal vital staining...
February 1, 2019: Investigative Ophthalmology & Visual Science
Lian-Qun Wu, Pei Mou, Zi-Yu Chen, Jin-Wei Cheng, Qi-Hua Le, Ji-Ping Cai, Rui-Li Wei
BACKGROUND Thyroid-associated ophthalmopathy (TAO) is a common endocrine autoimmune disease. The present study explored corneal nerve changes in TAO patients. MATERIAL AND METHODS Thirty-eight Chinese TAO patients and 20 healthy individuals were included in the study. Central corneal subbasal nerve density and morphology were evaluated with in vivo laser scanning confocal microscopy and quantified using automated CCmetrics software. RESULTS The values of the central corneal subbasal nerve plexus parameters of both active and inactive TAO patients were significantly decreased compared with those of controls, including corneal nerve fiber density (CNFD) (P<0...
February 6, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Claudia Busse, Christiane Kafarnik, Rose Linn-Pearl, Christelle Volmer, Kaspar Matiasek, Johana E Premont, Thomas Dulaurent, Jean-Yves Douet, Ida Gilbert, Sari Jalomäki, Katrin Trost, Pierre-Francois Isard, Ryan Boyd, Isabelle Raymond
OBJECTIVE: To describe the phenotype of canine macular corneal dystrophy (MCD) including the clinical presentation, multimodal ocular imaging, histopathology, and ultrastructural analysis in ten Labrador Retrievers. PROCEDURE: Multicentered data collection. RESULTS: Labrador Retrievers affected by MCD were presented between the age of 4.5 and 6 years of age with a history of cloudy eyes and/or visual impairment. Findings on ophthalmic examination included a diffuse haze of the corneal stroma and multiple, well-demarcated, off-white to yellow-brown, punctate corneal opacities heterogeneous in size...
January 30, 2019: Veterinary Ophthalmology
Shruti Aggarwal, Clara Colon, Ahmad Kheirkhah, Pedram Hamrah
OBJECTIVE: Corneal nerve damage may result in neuropathic corneal pain (NCP). Autologous serum tears (AST) have been shown to results in nerve regeneration and may help alleviate corneal pain. This study aimed to evaluate the efficacy of AST in the treatment of NCP. METHODS: This was a retrospective case-control study. Sixteen patients suffering from severe NCP and no current ocular surface disease were compared to 12 controls. In vivo confocal microscopy (IVCM) (HRT3/RCM; Heidelberg, Germany) of the central corneas was performed bilaterally...
January 24, 2019: Ocular Surface
Pinnita Prabhasawat, Angkoon Luangaram, Pattama Ekpo, Kaevalin Lekhanont, Wimolwan Tangpagasit, Chawikan Boonwong, Naharuthai Inthasin, Chareenun Chirapapaisan
Simple limbal epithelial transplantation (SLET) is a relatively new treatment for severe limbal stem cell deficiency. Outcomes of treatment are typically determined based on clinical manifestations. In this prospective-multicenter study, we aimed to analyze the epithelial phenotypes of the corneas after SLET using IVCM and IC, and correlated them with clinical findings. Ten eyes of nine patients, who underwent SLET (five autologous SLET and five living-related SLET) were recruited. A set of examinations included slit-lamp biomicroscopy, corneal in vivo confocal microscopy (IVCM), and impression cytology (IC) was performed in all eyes at least twice (≥ 3-month interval) postoperatively...
January 24, 2019: Cell and Tissue Banking
R Atia, L Jouve, C Georgon, L Laroche, V Borderie, N Bouheraoua
No abstract text is available yet for this article.
January 21, 2019: Journal Français D'ophtalmologie
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