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TAFRO syndrome

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https://read.qxmd.com/read/30799408/tafro-syndrome-with-an-anterior-mediastinal-mass-and-lethal-autoantibody-mediated-thrombocytopenia-an-autopsy-case-report
#1
Kaoru Morita, Shin-Ichiro Fujiwara, Takashi Ikeda, Shin-Ichiro Kawaguchi, Yumiko Toda, Shoko Ito, Shin-Ichi Ochi, Takashi Nagayama, Kiyomi Mashima, Kento Umino, Daisuke Minakata, Hirofumi Nakano, Ryoko Yamasaki, Yasufumi Kawasaki, Miyuki Sugimoto, Masahiro Ashizawa, Chihiro Yamamoto, Kaoru Hatano, Kazuya Sato, Iekuni Oh, Ken Ohmine, Kazuo Muroi, Kentaro Ashizawa, Yu Yamamoto, Hisashi Oshiro, Yoshinobu Kanda
TAFRO syndrome, a rare systemic inflammatory disease, can lead to multiorgan failure without appropriate treatment. Although thrombocytopenia is frequently seen in patients with TAFRO syndrome, little is known about its pathogenesis. Moreover, while recent studies have reported the presence of an anterior mediastinal mass in some patients, the pathological status of this remains unclear. Here, we report a case of fatal bleeding in a patient with TAFRO syndrome accompanied by an anterior mediastinal mass. A 55-year-old female was transferred to our hospital with a 2-week history of fever, epistaxis, and dyspnea...
February 20, 2019: Acta Haematologica
https://read.qxmd.com/read/30774824/tafro-syndrome-a-case-report-from-turkey-and-review-of-the-literature
#2
Zeki Islamoğlu, Ali Erkan Duman, Göktuğ Sirin, Hasan Yılmaz, Meral Uluköylü Mengüç, Yiğit Erçetin, Süheyla Bozkurt, Sadettin Hülagü, Altay Çelebi
TAFRO syndrome is a rare subtype of the Castleman's disease which has been described over the last years. The name of TAFRO syndrome comes from thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly. We report a young Turkish male patient presented with fever, night sweats, fatigue, nausea, bilateral pretibial pitting edema, abdominal pain and watery diarrhea. PET/CT revealed multiple lymphadenopathies in cervical, axillary, mediastinal, paraaortic, mesenteric and inguinal lymph nodes...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
https://read.qxmd.com/read/30680669/clinicopathological-features-of-tafro-syndrome-complicated-by-acquired-hemophilia-a-and-development-of-cardiopulmonary-arrest-that-were-successfully-treated-with-va-ecmo-and-tocilizumab
#3
Kei Suzuki, Takeshi Matsumoto, Yoshiaki Iwashita, Ken Ishikura, Masaki Fujioka, Hideo Wada, Naoyuki Katayama, Hiroshi Imai
TAFRO syndrome and acquired hemophilia A (AHA) are rare, life-threatening diseases; however, the relationship between these two diseases is unknown. A 25-year-old man was transferred to our hospital because of bleeding tendency accompanied by multiple organ failure with generalized edema, massive pleural effusion, and ascites. He was diagnosed with AHA. Bypass therapy for hemostasis and cyclophosphamide with prednisolone to eradicate possible inhibitors were provided. However, he suffered from cardiopulmonary arrest...
January 24, 2019: International Journal of Hematology
https://read.qxmd.com/read/30642741/an-extranodal-histopathological-analysis-of-idiopathic-multicentric-castleman-disease-with-and-without-tafro-syndrome
#4
REVIEW
Nozomu Kurose, Ken-Ichi Mizutani, Motona Kumagai, Akihiro Shioya, Xin Guo, Satoko Nakada, Shino Fujimoto, Hiroshi Kawabata, Yasufumi Masaki, Kazue Takai, Sadao Aoki, Masaru Kojima, Shigeo Nakamura, Masatoshi Kida, Sohsuke Yamada
Thrombocytopenia, anasarca, fever, renal failure or reticulin fibrosis, and organomegaly (TAFRO) syndrome, a poor prognostic clinical condition showing similar histopathological findings to idiopathic multicentric Castleman disease (iMCD), has been reported in Japan. In our previous report, a clinicopathological analysis was performed on 70 nodal cases of iMCD with/without TAFRO. iMCD is classified into three types based on histopathology: (i) plasmacytic (PC), (ii) mixed, and (iii) hypervascular (hyperV). In this report, extranodal histopathological changes of iMCD with/without TAFRO were analyzed...
March 2019: Pathology, Research and Practice
https://read.qxmd.com/read/30632181/tufted-angioma-like-lesion-associated-with-vascular-endothelial-growth-factor-and-interleukin-6-in-tafro-syndrome-is-it-a-common-histological-feature-of-multicentric-castleman-disease-poems-syndrome
#5
Kumi Fujita, Kazuhiro Hatta
The histology of skin lesions of TAFRO (thrombocytopenia, anasarca, reticulin fibrosis/renal failure, and organomegaly) syndrome has rarely been reported. We report herein two cases of TAFRO syndrome with characteristic vascular skin lesions. The lesions resembled a tufted angioma, although those of case 1 partially resembled a glomeruloid hemangioma, which was known as a specific lesion in POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes), a variant of multicentric Castleman disease (MCD)...
January 10, 2019: Journal of Cutaneous Pathology
https://read.qxmd.com/read/30531139/-thrombotic-microangiopathy-developing-subsequent-to-tocilizumab-therapy-in-a-patient-with-tafro-syndrome
#6
Shinichi Ito, Yutaka Tsutsumi, Ryo Kikuchi, Satomi Matsuoka, Norihiko Shimoyama
We report a case of a 60-year-old male who presented with fever and anasarca as well as hepatosplenomegaly, general lymphadenopathy, and disseminated intravascular coagulation (DIC), and was, therefore, admitted to our hospital. In addition, the patient suffered from respiratory failure and renal dysfunction and had pleural effusion and ascites. The pathological diagnosis from lymph node biopsy suggested multicentric Castleman's disease of the plasma cell type; however, the presence of high IL-6 levels, myelofibrosis, thrombocytopenia, anasarca, renal dysfunction, and hepatosplenomegaly led to a definitive diagnosis of TAFRO syndrome...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://read.qxmd.com/read/30293532/the-first-case-of-thrombocytopenia-anasarca-fever-renal-impairment-or-reticulin-fibrosis-and-organomegaly-tafro-syndrome-with-unilateral-adrenal-necrosis-a-case-report
#7
Yu Fujiwara, Kanae Ito, Akito Takamura, Kaoru Nagata
BACKGROUND: TAFRO syndrome, which was first reported in 2010 in Japan, is a relatively rare disease characterized by thrombocytopenia, anasarca, fever, renal impairment, reticulin fibrosis, and organomegaly. Although this disease is considered similar to multicentric Castleman disease, some of the clinical features, such as thrombocytopenia, are different from typical cases of multicentric Castleman disease. In addition, the etiology of TAFRO syndrome remains unknown and controversial...
October 8, 2018: Journal of Medical Case Reports
https://read.qxmd.com/read/30244358/an-autopsy-case-of-tafro-syndrome-with-membranoproliferative-glomerulonephritis-like-lesions
#8
Keiko Hashimoto, Takashi Sano, Yukari Honma, Maoko Ida, Hiroshi Tominaga, Aya Sawada, Tetsuya Abe, Haruka Takahashi, Yoshitaka Shimada, Takanori Masaki, Mariko Kamata, Shokichi Naito, Togo Aoyama, Yasuo Takeuchi, Masashi Akiya, Madoka Inukai, Norihiro Nakata
TAFRO syndrome (thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly) is an atypical manifestation of multicentric Castleman's disease. Although overproduction of interleukin-6, vascular endothelial growth factor, and other cytokines may partially explain the pathophysiology of this rare syndrome, the precise mechanisms underlying the renal dysfunction associated with the condition remain unclear. Here, we describe a case of a 69-year-old male with TAFRO syndrome. He was treated with immunosuppressive agents and his renal function improved...
September 22, 2018: CEN Case Reports
https://read.qxmd.com/read/30222681/fdg-pet-ct-findings-in-tafro-syndrome
#9
Masatoshi Hotta, Ryogo Minamimoto, Arisa Yashima, Masahiro Nakano, Hiroyuki Yamashita
A 67-year-old woman with prolonged fever, thrombocytopenia, and renal dysfunction underwent FDG PET/CT to evaluate underlying causes, including malignancy. PET/CT showed FDG uptake in ascites, subcutaneous edema, lymph nodes, spleen, and bone marrow. Subsequent bone marrow biopsy revealed myelofibrosis, and laboratory testing showed elevated concentrations of interleukin 6 in serum and ascites. These findings led to the diagnosis of TAFRO syndrome, a variant of multicentric Castleman disease, characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, and organomegaly...
November 2018: Clinical Nuclear Medicine
https://read.qxmd.com/read/30185716/-clinical-significance-of-chronologic-immature-platelet-fraction-analysis-in-tafro-syndrome
#10
Tomoyuki Saga, Toshimichi Ishihara, Michiyo Kanagawa, Yutaro Hiratsuka, Takeshi Matsuura, Shinichi Yashiro, Satoshi Kano
TAFRO syndrome is characterized by thrombocytopenia with unknown etiology. The assessment of immature platelet fraction (IPF) is useful for differential diagnoses that include thrombocytopenia. However, the significance of IPF in cases of TAFRO syndrome remains to be reported. We present a case of TAFRO syndrome wherein the patient demonstrated a marked increase in IPF without thrombocytopenia, which offers vital information concerning TAFRO diagnosis and the serial measurements of IPF during treatment. A 65-year-old man presenting with fever was admitted to our hospital...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://read.qxmd.com/read/30009125/successful-rituximab-treatment-of-tafro-syndrome-with-pathological-findings-of-glomerular-endothelial-damage
#11
Yuhei Noda, Yosuke Saka, Akihisa Kato, Tetsushi Mimura, Tomohiko Naruse
Thrombocytopenia, anasarca, fever, renal insufficiency, and organomegaly constitute TAFRO syndrome, a variant of Castleman disease. We describe a patient with TAFRO syndrome who underwent renal biopsy. A 79-year-old woman was referred to us with fever and leg edema. She also had thrombocytopenia, pleural effusion, ascites, and acute kidney injury, and was admitted to our hospital. Her response to initial therapy with corticosteroid and cyclosporine was poor. Therefore, she received 4 doses of rituximab per week, which resulted in clinical improvement, including recovery of thrombocytopenia...
2018: Clinical nephrology. Case studies
https://read.qxmd.com/read/29973444/-systemic-lupus-erythematosus-with-marked-eosinophilia-and-clinical-features-mimicking-tafro-syndrome
#12
Masahiro Tokunaga, Masahide Yamada, Shinichi Yoshikawa, Atsushi Kondo, Mai Mishima, Shinya Inoue, Takako Morita, Nobuhiko Tominaga
A 76-year-old woman was referred to our hospital because of fever, hemorrhagic skin lesion with pruritus, and severe thrombocytopenia. Anemia; marked eosinophilia; and elevated ALP, CRP, and soluble IL-2 receptor levels were observed on admission. Both anti-nuclear antibody and Coombs tests were positive. Computed tomography revealed bilateral pleural effusion, ascites, abdominal lymphadenopathy, and mild hepatosplenomegaly. A thorough examination for the initial differential diagnoses excluded the possibility of myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement, infectious diseases, and eosinophilic granulomatosis with polyangiitis...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://read.qxmd.com/read/29958635/tafro-syndrome-critical-review-for-clinicians-and-pathologists
#13
REVIEW
Semra Paydas
TAFRO is an acrostic and includes thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R) and organomegaly (O) (Takai et al., 2013). TAFRO syndrome has been described firstly by Takai in Japanese patients. However TAFRO cases have been reported from US, Europe and other countries (Takai et al., 2010; Iwaki et al., 2016; Abdo et al., 2014). Three major and at least one minor criteria and exclusion of infectious, rheumatologic and neoplastic diseases are required for the diagnosis of TAFRO. In fact TAFRO must be thought in clinically undiagnosed and unsolved problemmatic cases...
August 2018: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/29952292/multiple-haemangiomas-in-tafro-syndrome-with-atypical-features-of-glomeruloid-and-epithelioid-haemangiomas
#14
Yoshiyuki Nakamura, Kazuma Iwamoto, Yasuhiro Fujisawa, Naoko Okiyama, Rei Watanabe, Yosuke Ishitsuka, Hiroshi Maruyama, Yoshiyuki Ishii, Yuya Kondo, Shingo Sakashita, Manabu Fujimoto
No abstract text is available yet for this article.
June 1, 2018: European Journal of Dermatology: EJD
https://read.qxmd.com/read/29901607/membranoproliferative-glomerulonephritis-like-findings-for-tafro-syndrome-associated-with-an-anterior-mediastinal-tumor-a-case-report
#15
Yoshitaka Furuto, Hirotsugu Hashimoto, Hajime Horiuti, Yuko Shibuya
RATIONALE: TAFRO syndrome is a systemic inflammatory disease proposed recently from Japan. The cause of TAFRO syndrome is unclear. Moreover, the disease characteristics and kidney pathology are yet unknown well and there are few cases. Herein, we report a patient with TAFRO syndrome and present the features of the renal histopathology. PATIENT CONCERNS: A 55-year-old woman presented to our hospital with the main complaint of subacute dyspnoea. DIAGNOSIS: Physical findings included a low-grade fever and generalised oedema...
June 2018: Medicine (Baltimore)
https://read.qxmd.com/read/29879072/successful-treatment-with-tacrolimus-in-tafro-syndrome-two-case-reports-and-literature-review
#16
REVIEW
Taiichiro Shirai, Akira Onishi, Daisuke Waki, Jun Saegusa, Akio Morinobu
RATIONALE: TAFRO syndrome is a systemic inflammatory disorder characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly. In contrast to that in multicentric Castleman disease, interleukin-6 targeting strategies seem ineffective in some TAFRO syndrome cases; however, the optimal treatment remains unclear. Here, we report 2 cases of TAFRO syndrome, where 1 with cardiomyopathy, successfully treated with tacrolimus. This is the first case report of successful treatment with tacrolimus in TAFRO syndrome...
June 2018: Medicine (Baltimore)
https://read.qxmd.com/read/29877281/serial-manifestation-of-acute-kidney-injury-and-nephrotic-syndrome-in-a-patient-with-tafro-syndrome
#17
Seigo Ito, Takahiro Uchida, Hiroki Itai, Aoi Yamashiro, Akira Yamagata, Hidehito Matsubara, Toshihiko Imakiire, Hideyuki Shimazaki, Hiroo Kumagai, Naoki Oshima
A 76-year-old woman suddenly developed anasarca and a fever, and an examination revealed thrombocytopenia, reticulin fibrosis, and acute kidney injury, yielding the diagnosis of thrombocytopenia, anasarca, fever, reticulin fibrosis, organomegaly (TAFRO) syndrome. Renal replacement therapy and steroid treatment were soon started. Her proteinuria was minor at first; however, once the kidney function improved, nephrotic syndrome occurred. A kidney biopsy showed membranoproliferative glomerulonephritis-like glomerulopathy with massive macrophage infiltration...
November 1, 2018: Internal Medicine
https://read.qxmd.com/read/29766467/thrombotic-microangiopathy-on-kidney-biopsy-in-a-patient-with-tafro-syndrome
#18
Toshikazu Ozeki, Masashi Tsuji, Junichiro Yamamoto, Chisato Shigematsu, Shoichi Maruyama
TAFRO syndrome represents a characteristic constellation of symptoms comprising Thrombocytopenia, Anasarca, myeloFibrosis, Renal dysfunction, and Organomegaly, and is considered to be a clinicopathologic variant of idiopathic multicentric Castleman disease. A 51-year-old woman was admitted to the hospital complaining of abdominal distension. Findings on physical examination were indicative of anasarca. Computed tomography revealed mild splenomegaly, pericardial effusion, pleural effusion, ascites, and paraaortic lymphadenopathy...
May 15, 2018: CEN Case Reports
https://read.qxmd.com/read/29702119/glomeruloid-hemangioma-associated-with-tafro-syndrome
#19
Aya Shinozaki-Ushiku, Takaaki Higashihara, Masako Ikemura, Junichiro Sato, Masaomi Nangaku, Tetsuo Ushiku, Masashi Fukayama
Glomeruloid hemangioma is a rare cutaneous lesion that has been considered as a specific cutaneous marker of POEMS syndrome. Herein, we present the first case of glomeruloid hemangioma associated with TAFRO syndrome, a unique variant of idiopathic multicentric Castleman disease. The patient is a 74-year-old woman presented with fever, cervical lymphadenopathy, thrombocytopenia, bilateral pleural effusions and ascites. Biopsy of the lymph node revealed multicentric Castleman disease-like histology and bone marrow biopsy showed mild reticulin fibrosis, consistent with TAFRO syndrome...
December 2018: Human Pathology
https://read.qxmd.com/read/29684500/the-clinicopathological-comparison-among-nodal-cases-of-idiopathic-multicentric-castleman-disease-with-and-without-tafro-syndrome
#20
Nozomu Kurose, Chizuru Futatsuya, Ken-Ichi Mizutani, Motona Kumagai, Akihiro Shioya, Xin Guo, Akane Aikawa, Satoko Nakada, Shino Fujimoto, Hiroshi Kawabata, Yasufumi Masaki, Kazue Takai, Sadao Aoki, Masaru Kojima, Shigeo Nakamura, Sohsuke Yamada
Multicentric Castleman disease (MCD) is a systemic inflammatory disease potentially caused by an increase in the serum interleukin-6 (IL-6) level. Idiopathic MCD (iMCD) is histopathologically classified into three types: plasmacytic (PC), mixed, and hypervascular (hyperV) types. Recently, a unique clinical phenotype with a poor prognosis overlap with iMCD, thrombocytopenia, anasarca, fever, renal failure or reticulin fibrosis, and organomegaly (TAFRO syndrome), has been reported from Japan, but its detailed clinicopathological features remain unclear...
July 2018: Human Pathology
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