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H Cao, T W Ji, Q Lan, F Lin, Y Dong, A J Xu, J Liu, H Y Ding, H M Fan, Z M Liu
Objective: To evaluate the changes of rat renal function and cardiac function after transabdominal subtotal nephrectomy (STNx) and provide an ideal animal model for the study of chronic kidney disease (CKD) and cardiorenal syndrome (CRS). Methods: The SD rats (male, 5-6 weeks) were randomly divided into Sham group ( n= 10) and STNx group ( n= 10). The rats from Sham group underwent sham surgery, and the right nephrectomy plus the 2/3 left kidney artery ligation through abdominal incision were performed in the rats from STNx group...
February 12, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Florian M E Wagenlehner, Daniel J Cloutier, Allison S Komirenko, Deborah S Cebrik, Kevin M Krause, Tiffany R Keepers, Lynn E Connolly, Loren G Miller, Ian Friedland, Jamie P Dwyer
BACKGROUND: The increasing multidrug resistance among gram-negative uropathogens necessitates new treatments for serious infections. Plazomicin is an aminoglycoside with bactericidal activity against multidrug-resistant (including carbapenem-resistant) Enterobacteriaceae. METHODS: We randomly assigned 609 patients with complicated urinary tract infections (UTIs), including acute pyelonephritis, in a 1:1 ratio to receive intravenous plazomicin (15 mg per kilogram of body weight once daily) or meropenem (1 g every 8 hours), with optional oral step-down therapy after at least 4 days of intravenous therapy, for a total of 7 to 10 days of therapy...
February 21, 2019: New England Journal of Medicine
Wei Ren, Chen Zhao, Yan Wang, Yuan Fang, Zhenzhen Huang, Wei Chen, Lihua Wang, Wen Hu, Ke Wang, Lijun Ni
PURPOSE: To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN). METHODS: The Sprague Dawley rats were divided into normal control (NC) group (n = 12), DN group (n = 11), and DN+RAM group (n = 12). The ratio of renal weight to body weight (RBT), fasting blood glucose (FBG), HbA1c, 24-h urine protein (TPU), blood urea nitrogen (BUN), creatinine (Cr), renal pathological changes, the levels of IGF-1, fibronectin (FN), type IV collagen (Col-IV), and matrix metalloproteinases (MMP)-2 were compared among the groups...
February 14, 2019: Acta Cirúrgica Brasileira
Xiaodong Wang, Zhaoliang Li, Xiaolei Huang, Fenghua Li, Jinbo Liu, Zhenzuo Li, Dongfang Bai
PURPOSE: To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats. METHODS: Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 rats in each group. The diabetic nephropathy model was constructed in later 4 groups. Then, the later 3 groups were treated with 2, 4 and 8 μg/kg exenatide for 8 weeks, respectively. The serum and urine biochemical indexes and oxidative stress and inflammatory indexes in renal tissue were determined...
February 14, 2019: Acta Cirúrgica Brasileira
Araceli Jarquin Campos, Lorenz Risch, Marc Baumann, Mette-Triin Purde, Sebastian Neuber, Harald Renz, Beatrice Mosimann, Luigi Raio, Markus Mohaupt, Daniel Surbek, Martin Risch
Shrunken pore syndrome (SPS) is a condition that manifests itself as the decreased renal clearance of low-molecular-weight proteins but normal clearance of creatinine. Pregnant women with evidence of SPS during the first trimester have an increased risk of developing preeclampsia (PE). The nitric oxide (NO) metabolism markers arginine and ADMA, especially their ratio (Arg/ADMA), are recognized markers of endothelial dysfunction. The aim of this nested case-control study was to establish first-trimester reference intervals (RI) for markers of NO metabolism and to study these markers in women with evidence of SPS at the end of the first trimester...
February 20, 2019: Scandinavian Journal of Clinical and Laboratory Investigation
Wenbei Han, Qian Ma, Yinglu Liu, Wei Wu, Yue Tu, Lu Huang, Yan Long, Wenwen Wang, Hongyun Yee, Ziyue Wan, Renmao Tang, Yigang Wan, Haitao Tang
BACKGROUND: Huangkui capsule (HKC), an anti-inflammatory Chinese modern patent medicine, has been now widely applied to the clinical therapy of diabetic nephropathy (DN). However, the overall therapeutic mechanisms in vivo are still unclear. Renal tubular epithelial-to-mesenchymal transition (EMT) is one of the major pathogenesis of renal interstitial fibrosis in DN. Recently, the physiological roles of NLRP3 inflammasome activation and toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signaling are closely linked to EMT...
December 17, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Wei Tong, Qingcai Liu, Guangjing Ran, Lan Liu, Shan Ren, Lin Chen, Lijun Jiang
The combustion behavior of anthracite, biomass (Ficus virens) char and their blends were investigated by thermogravimetry analysis (TGA). The combustion process mainly focused on the volatile combustion and char combustion. The addition of char reduced the initial temperature and final temperature of fuels. The interactions firstly inhibited and then facilitated. When the blending ratio was 70AN30FV, the antagonism was the minimum, and synergism was the strongest at 830 K for the random ratio. The kinetic models of Coats-Redfern (CR), Doyle equation (Doyle), Friedman (FR), Kissinger-Akahira-Sunose (KAS), Flynn-Wall-Ozawa (FWO) and distributed activation energy model (DAEM) were used to calculate the kinetic parameters...
February 15, 2019: Bioresource Technology
Yi Tao, Surun Huang, Jizhong Yan, Weidong Li, Baochang Cai
ETHNOPHARMACOLOGICAL RELEVANCE: Achyranthes bidentata Blume (AB) is a well-known traditional Chinese medicine for treating osteoporosis and bone fracture. In the current, researches on pharmacological mechanism of AB mostly focused on molecular pathways, knowledge about its metabolic signatures is largely unclear. This study aims to develop an integrative metabolomics and metallomic approach for deciphering the biochemical basis of anti-osteoporosis effects of raw and salt-processed AB...
February 19, 2019: Journal of Ethnopharmacology
Yuechen Chang, Ziwei Han, Yang Zhang, Ying Zhou, Ziyi Feng, Long Chen, XueRui Li, Li Li, Jun-Qiang Si
OBJECTIVE: This work aimed to investigate whether G protein-coupled estrogen receptor (GPER) can improve the renal interlobular artery vascular function by increasing the NO content, thereby protecting against renal ischemia-reperfusion (IR) injury. METHODS: This study classified ovariectomised (OVX) female Sprague-Dawley rats into OVX, OVX + IR, OVX + IR + G1 (the GPER agonist G1), OVX + IR + G1+G15 (GPER blocker) and OVX + IR + G1+L-NAME (eNOS blocker) groups...
February 20, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ziyuan Ni, Lihua Guo, Feng Liu, Opeyemi Joshua Olatunji, Min Yin
The objective of this study was to evaluate the effect of the butanol fraction from Allium tuberosum (BFAT) in high fat diet/streptozotocin (HFD/STZ) induced diabetic nephropathy. Wistar rats were fed with HFD for 4 weeks and thereafter administered with 35 mg/kg STZ intraperitoneally. Diabetic rats were treated with BFAT (100 or 400 mg/kg) and metformin (150 mg/kg) for 40 days. After treatment, the blood, urine and kidney tissues were obtained for biochemical and histological analysis. BFAT markedly decreased blood glucose, serum creatinine, blood urea nitrogen and urinary albumin levels in diabetic rats...
February 19, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Izhar Muhammad, Wen-Qiang Li, Xiu-Qing Jing, Meng-Ru Zhou, Abdullah Shalmani, Muhammad Ali, Xiao-Yong Wei, Rahat Sharif, Wen-Ting Liu, Kun-Ming Chen
The GASA (GA-stimulated Arabidopsis) gene family is highly specific to plants, signifying a crucial role in plant growth and development. Herein, we retrieved 119 GASA genes in 10 different plant species in two major lineages (monocots and eudicots). Further, in the phylogenetic tree we classified these genes into four well-conserved subgroups. All the proteins contain a conserved GASA domain with similar characteristics and a highly specific 12-cysteine residue of the C-terminus position. According to the global microarray data and qRT-PCR based analysis, the OsGASA gene family was dominantly expressed in the seedling and transition phase of floral stages...
February 13, 2019: Journal of Plant Physiology
Jörg Rinklebe, Vasileios Antoniadis, Sabry M Shaheen, Oliver Rosche, Manfred Altermann
Floodplain soils across Central Elbe River (CER), Germany, vary considerably in potentially toxic element (PTE) content. However, there has never been a comprehensive study that links PTE levels with human health risk for children and adults. Our objective was to determine the contamination of 13 PTEs in 94 soil profiles along CER and assess the associated health risk via diverse indices for adults and children. Of 94 soil profiles, we measured soil properties and total content of arsenic, barium, chromium, copper, nickel, lead, rubidium, tin, strontium, vanadium, zinc, and zirconium using x-ray fluorescence spectrometer (XRF)...
February 18, 2019: Environment International
Enfeng Liu, Xiaoyu Wang, Huiji Liu, Mengyao Liang, Yuxin Zhu, Zijun Li
Pollution of potentially toxic metals (PTMs) in road dust (RD) is becoming an important threat to the urban environmental quality and human health. The chemical speciation of PTMs is an important index charactering the risks, which may also closely relate to the pollution level and source but it was poorly understood. In this study, the chemical speciation of Cd, Cr, Cu, Ni, Pb and Zn in the RD of a megacity (Nanjing), China was determined following an optimized BCR (proposed by the European Community Bureau of Reference) sequential extraction procedure to assess their pollution and potential eco-risk and to explore the variations of metal chemical speciation with the pollution levels and sources...
February 20, 2019: Ecotoxicology and Environmental Safety
Yuanyuan Zhao, Chengxiao Hu, Xu Wang, Xuejiao Qing, Peng Wang, Ying Zhang, Xuan Zhang, Xiaohu Zhao
Excessive chromium (Cr) causes toxicity to plants, while the beneficial effects of selenium (Se) have been verified in plants under various adverse conditions. Under Cr stress, the impacts of exogenous Se on root morphology and metal element uptake were investigated in root of Chinese cabbage by cellular and biochemical approaches. Exogenous Se alleviated Cr-induced irreversible damage to root morphology, plasma membrane integrity and ultrastructure of root tip cells. Compared with Cr treatment alone, exogenous Se reduced root Cr content by 17%...
February 18, 2019: Ecotoxicology and Environmental Safety
Lorenzo Tosti, André van Zomeren, Jan R Pels, Joris J Dijkstra, Rob N J Comans
The pH-dependent availability and leaching of major and trace elements was investigated for a wide range of biomass ash from different fuels and conversion technologies. A technical and environmental assessment of selected biomass ash for application in soil or cement mortars was performed, using both the total content and leaching of elements. A large variation in biomass ash composition, yet consistent pH dependent leaching patterns were observed for most elements and conversion technologies. Chromium showed a distinct behaviour which was hypothesized to reflect redox conditions during conversion of the biomass...
February 11, 2019: Chemosphere
Mingming Zhang, Pei He, Guo Qiao, Jintian Huang, Xiutang Yuan, Qiang Li
This study investigated heavy metals (Ni, Zn, Cr, Cu, As, Pb, Cd and Hg) concentrations in surface sediment of Subei Shoal, China, to illustrate their spatial distribution characteristics, sources and potential ecological risk of pollution. Contents of total organic carbon (TOC), clay, silt and sand were 1.7 ± 0.8%, 3.3 ± 3.2%, 13.6 ± 14.2% and 83.1 ± 17.4%, respectively. The spatial distribution of TOC, clay and silt were similar; however, distribution of Hg was inverse. Concentrations of Ni, Zn, Cr, Cu, As, Pb, Cd and Hg were 47...
February 13, 2019: Chemosphere
Germaine Wong, Wai H Lim
Accurate assessment of true kidney function allows early identification, management, and prognostication of persons at risk of having kidney disease. Estimation of glomerular filtration rate using serum creatinine-based equations is frequently used in clinical practice. The majority of these equations are developed in white populations, with very few that are specific to patients of Chinese ethnic backgrounds. This new study has developed a novel estimated glomerular filtration rate equation in a multicenter, multiethnic Chinese population...
March 2019: Kidney International
Tania Deis, Louise Balling, Søren Boesgaard, Kasper Rossing, Morten Schou, Peter Oturai, Emil Wolsk, Finn Gustafsson
The interaction between hemodynamics and kidney function in heart failure (HF) is incompletely understood. We investigated the association between invasive hemodynamic parameters and measured glomerular filtration rate (mGFR) by plasma clearance of 51-chromium-labeled ethylenediamine tetra-acetic acid (51 Cr-EDTA) in patients with advanced HF and tested the hypothesis that patients with reduced mGFR have lower cardiac index (CI) and mean arterial pressure (MAP) as well as higher central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP)...
February 20, 2019: Scandinavian Journal of Clinical and Laboratory Investigation
Xueping Chen, Qian-Qian Wei, Yongping Chen, Bei Cao, RuWei Ou, Yanbing Hou, Xiaoqin Yuan, Lingyu Zhang, Hui Liu, Huifang Shang
OBJECTIVE: Little is known whether disease clinical stage would influence the serological values in Amyotrophic lateral sclerosis (ALS). We aimed to explore the association between the levels of serological factors with clinical progression determined by the King's College staging system. METHODS: ALS Patients were registered from May 2008 to December 2016. The differences of serological values between patients and healthy controls, and the correlation of these serological values with disease stage were examined...
February 20, 2019: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Naman Dogra, Manik Sharma, Anket Sharma, Ali Keshavarzi, Minakshi, Renu Bhardwaj, Ashwani Kumar Thukral, Vinod Kumar
The present work studied the pH, organic carbon, phosphorus (P), calcium (Ca), magnesium (Mg), and heavy metals Cu, Cr, Co and Pb in roadside agricultural soils of Jalandhar environs of Punjab, India. A total of 120 samples in triplicates were collected from different sites for assessment of heavy metal pollution. The mean values of Cu, Cr, Co and Pb were found below the permissible limits of Indian and Swedish soil limits. Principal component analysis (PCA) showed that heavy metals have different sources of origin...
February 20, 2019: International Journal of Environmental Health Research
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